Abstract：
:Uric acid (UA) is reduced in multiple sclerosis (MS), and possibly relates to MS outcomes, with lower UA levels in subjects experiencing a relapse or presenting higher disability scores. The present retrospective longitudinal study evaluated UA variations in MS, in relation to clinical relapses, disability progression, and cognitive functions. We included 141 subjects with relapsing-remitting MS (RRMS) and performed expanded disability status scale (EDSS), symbol digit modalities test (SDMT) and UA evaluation at baseline visit and after 2-year follow-up. Paired t test showed significantly lower UA levels after 2-year follow-up than at baseline (3.987 ± 1.135 and 4.167 ± 1.207 mg/dL, respectively) (p = 0.001). The difference in UA levels between 2-year follow-up and baseline related to EDSS sustained progression (p < 0.001; OR = 0.099), and presented a trend for clinical relapses at logistic regression (p = 0.211; OR = 0.711) and for the time to relapse at Cox regression (p = 0.236; HR = 0.792). Analysis of variance showed reduced baseline UA levels in subjects with impaired SDMT at baseline (p = 0.045; adjusted R(2) = 0.473) and after 2-year follow-up (p = 0.034; adjusted R(2) = 0.470). This is the first study showing a progressive reduction of UA levels during the course of RRMS, suggesting a progressive decrease of antioxidant reserves, in relation to relapse risk, disability progression and cognitive function.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Moccia M,Lanzillo R,Costabile T,Russo C,Carotenuto A,Sasso G,Postiglione E,De Luca Picione C,Vastola M,Maniscalco GT,Palladino R,Brescia Morra Vdoi
10.1007/s00415-015-7666-ysubject
Has Abstractpub_date
2015-01-01 00:00:00pages
961-7issue
4eissn
0340-5354issn
1432-1459journal_volume
262pub_type
杂志文章abstract：BACKGROUND:Late-onset Pompe disease (LOPD) is a rare, metabolic disease primarily affecting the musculoskeletal and respiratory systems. Forced vital capacity (FVC) is commonly used to measure pulmonary function; however, associations between FVC and other LOPD outcomes remain unclear. METHODS:A systematic literature ...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析
doi：10.1007/s00415-019-09401-1
更新日期：2019-09-01 00:00:00
abstract：:Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) are the major immune neuropathies. Although a detailed understanding of the pathogenesis of these conditions is not yet available, the multiple effects of IVIg on the immune and inflamm...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-008-3003-z
更新日期：2008-07-01 00:00:00
abstract：:Horizontal eye-movement responses of four patients with Alzheimer-type dementia were recorded using the infrared oculographic technique. Abnormally frequent saccadic intrusions occurred during the fixation and slow, smooth pursuit tasks in all four patients. Saccadic intrusions have previously been reported in the lit...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313742
更新日期：1983-01-01 00:00:00
abstract：:A patient with an infarct limited to the paramedian thalamus and upper mesencephalon on the right side suffered a conjugate upgaze palsy associated with a monocular paresis of downward gaze in the ipsilateral eye (vertical "one-and-a-half" syndrome). This paresis involved tonic and phasic components. Vertical oculocep...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313651
更新日期：1984-01-01 00:00:00
abstract：:Two sexually active female patients presented with acute meningitis. The CSF abnormalities were severe and persistent. In spite of the absence of genital lesions, serological studies revealed a primary infection by herpes simplex virus type 2. An immunoblot study revealed intrathecal synthesis of anti-herpes antibodie...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314743
更新日期：1990-08-01 00:00:00
abstract：:Hemichorea-hemiballism (HCHB) was infrequently related to cortical lesions such as tumor or infarction. Although functional derangement of the basal ganglia (BG) or the thalamus (Th) was suggested, pathomechanism of HCHB secondary to cortical lesions remains uncertain. We recruited the patients with HCHB secondary to ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7096-7
更新日期：2013-12-01 00:00:00
abstract：:We investigated the muscle strength and motor unit (MU) territory of five patients with postpolio syndrome (PPS), six stable patients with prior poliomyelitis, and five healthy volunteers. The MU territory was assessed by measuring amplitudes of motor unit potentials (MUPs) recorded by the macro EMG technique. The inv...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00920572
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:An optimal management of vascular risk factors, associated with antithrombotic drugs and carotid surgery when appropriate, reduces the risk of a new vascular event after stroke. Although secondary prevention is not optimal in many patients in practice, the question of whether there is an improv...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0591-8
更新日期：2005-01-01 00:00:00
abstract：:In vivo nuclear magnetic resonance spectroscopy (MRS) of the human brain is a recently developed technique which allows to assay noninvasively in vivo key molecules of brain metabolism. After a review of the origin of the signals detected by phosphorus and proton MRS of human brain, the impact of MRS on clinical neuro...
journal_title：Journal of neurology
pub_type： 社论,评审
doi：10.1007/BF02033352
更新日期：1994-05-01 00:00:00
abstract：:Hereditary peripheral neuropathies present a group of clinically and genetically heterogeneous entities. All known forms, including the various forms of Charcot-Marie-Tooth disease (CMT) are characterized as Mendelian traits and over 35 genes have been identified thus far. The mutational mechanism of the most common C...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5401-2
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To establish differences in basal ganglia and thalamic volume between preclinical carriers and non-carriers of the Huntington's disease (HD) gene and to link the volume to motor, cognitive and behavioural characteristics in carriers. METHODS:Sixteen HD gene carriers without overt clinical motor signs and 14 ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0050-4
更新日期：2008-11-01 00:00:00
abstract：:Regional cerebral glucose metabolism (rCMRGlc) and dopamine D2 receptor binding were measured in a 31-year-old, severely affected, untreated patient with Wilson's disease of 3 years' duration using positron emission tomography and 18F-deoxyglucose and 18F-methylspiperone ([18F]MSP), respectively. There was a severe re...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00920620
更新日期：1994-10-01 00:00:00
abstract：:Acyclovir treatment was used in a randomized, double-blind, placebo-controlled clinical trial with parallel groups to test the hypothesis that herpes virus infections are involved in the pathogenesis of multiple sclerosis (MS). Sixty patients with the relapsing-remitting form of MS were randomized to either oral treat...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00868517
更新日期：1996-03-01 00:00:00
abstract：:The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer's disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patient...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050351
更新日期：1999-04-01 00:00:00
abstract：:A consecutive series of 327 patients (188 males, 139 females; mean age 68.4, SEM 1.33) were hospitalized within 12 h of the onset of their first-ever hemispheric infarct. Three groups of patients were identified: diabetics (n = 70), non-diabetic hyperglycaemics (n = 93) and normoglycaemics (n = 164). Case-fatality rat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00812155
更新日期：1992-08-01 00:00:00
abstract：:The carotid bifurcations and the common carotid arteries of 36 patients with the diagnosis hyperactive carotid sinus syndrome (HCSS) were investigated by continuous wave (CW) Doppler ultrasonography and high-resolution real-time B-scan. Using these non-invasive tests, the functional impact of luminal stenosis and the ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313874
更新日期：1985-01-01 00:00:00
abstract：:The production and release of extracellular vesicles (EV) is a property shared by all eukaryotic cells and a phenomenon frequently exacerbated in pathological conditions. The protein cargo of EV, their cell type signature and availability in bodily fluids make them particularly appealing as biomarkers. We recently dem...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-9022-5
更新日期：2018-11-01 00:00:00
abstract：:We evaluated 49 paired cerebrospinal fluid (CSF) and serum samples of 35 patients infected with the human immunodeficiency virus type 1 (HIV-1) for laboratory evidence of cytomegalovirus (CMV) infection. The patients were grouped according to clinical criteria as probable CMV encephalitis/polyradiculomyelitis, CMV ret...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00900957
更新日期：1994-06-01 00:00:00
abstract：:Three patients with postural and intention cerebellar tremor caused by a cerebellar infarction in the superior cerebellar artery distribution were studied; treatment with carbamazepine resulted in marked improvement. ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00328507
更新日期：1989-12-01 00:00:00
abstract：:A total of 21 patients with normal-pressure hydrocephalus were examined. Cerebrospinal fluid (CSF) was collected before and after operation with a ventriculoperitoneal shunt. A slight plasma-like protein pattern indicating a blood-brain barrier (BBB) dysfunction was seen in 38% of the patients before operation. No cha...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313729
更新日期：1982-01-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder of the aging population with unknown etiopathogenesis. It is assumed that the underlying pathobiochemical processes comprise multifactorial and multigenetic disturbances leading to a progressive and devastating disorder without remission. Subtypes exist suggesti...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00007777
更新日期：2000-09-01 00:00:00
abstract：:Whereas the effect of interferons (IFNs) on magnetic resonance imaging (MRI) outcome measures in patients with multiple sclerosis (MS) has been convincingly shown, little work has been done to define the between-patient heterogeneity of treatment response. Our aim was to assess the distribution of the effect of IFNbet...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/s00415-005-0885-x
更新日期：2005-12-01 00:00:00
abstract：:The highest risk of subsequent stroke after a TIA occurs within the first week after the index event. However, the risk of stroke recurrence (SR) remains high during the first year of follow-up. We studied the temporal pattern and predictors of SR (at 7 days and from 7 days to 1-year follow-up). Between April 2008 and...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7390-z
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:We report a clinical description of pure sensory stroke based on data collected from a prospective acute stroke registry. METHODS:From 2500 acute stroke patients included in a hospital-based prospective stroke registry over a 12-year period, 99 were identified as having pure sensory stroke. RESULTS:Pure sen...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0622-5
更新日期：2005-02-01 00:00:00
abstract：:A case is reported of severe agnosia for verbal and non-verbal sounds without associated aphasic disorder. A CT scan revealed bilateral, temporal lobe lesions from two ischaemic accidents that had occurred 9 months apart. The search for subtle deficits in the patient showed normal sensitivity to changes in the intensi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313543
更新日期：1982-01-01 00:00:00
abstract：BACKGROUND:The epidemiology of paraneoplastic neurological syndromes (PNS) remains to be defined. We present here the first population-based incidence study and report the clinical spectrum and antibody profile of PNS in a large area in Northeastern Italy. METHODS:We performed a 9-year (2009-2017) population-based epi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09544-1
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:Epileptogenic foci exhibit disturbed function at the level of the benzodiazepine receptor. The aim of our study was to investigate the incidence of focal reductions of temporal benzodiazepine receptor binding (BRB) as assessed by scintigraphy with 123I-iomazenil in patients with denovo temporal lobe epilepsy (T...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170136
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Brain tumors cause significant morbidity and mortality due to rapid progression and high recurrence risks. Reliable biomarkers to improve diagnosis thereof are desirable. OBJECTIVE:This work aimed to identify panels of biomarkers for diagnostic purposes using cerebrospinal fluid (CSF)-based metabolomics. M...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09665-7
更新日期：2020-04-01 00:00:00
abstract：:The gut with its variety of microbiota may serve as an etiological origin of diseases. Gut microbes may also play a role in the pathogenesis of diseases beyond their simple nutritional maintenance and support. For example, gut protein aggregation, possibly aided by microbes as well as nasal influences, might be linked...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8588-7
更新日期：2017-09-01 00:00:00
abstract：:Neuropsychological assessment is one of the main fields of activity of clinical neuropsychologists. Goals of this assessment are verification and description of cognitive and affective impairments as the consequence of brain damage. Included are examinations of basal and higher sensory functions, the intellectual prof...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-2004-7
更新日期：2007-05-01 00:00:00
