Non-CNS pathogenic origin of Parkinson's disease.

abstract：:Neurological complications following rubella are only rarely encountered. However, in many cases severe neurological impairment may occur, leading to permanent disability. In a recent epidemic of rubella in Israel during the years 1978-1979, 20 patients with severe neurological complications have been seen. We report ...

journal_title：Journal of neurology

authors： Bechar M,Davidovich S,Goldhammer G,Machtey I,Gadoth N

更新日期：1982-01-01 00:00:00

abstract：: ...

journal_title：Journal of neurology

authors： Argaet EC,Young AS,Bradshaw AP,Welgampola MS

更新日期：2019-01-01 00:00:00

abstract：:We hypothesize that cerebral microbleeds (CMB) in patients with different neuropsychological profiles (amnestic or non-amnestic) and MRI features of vascular damage could provide important information on the underlying pathological process in early Alzheimer's disease. The study was performed at two trial sites. We st...

journal_title：Journal of neurology

authors： Poliakova T,Levin O,Arablinskiy A,Vasenina E,Zerr I

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that still lacks reliable diagnostic biomarkers. This study aims to evaluate the diagnostic and prognostic potential of CSF total Tau (t-Tau), phospho-Tau (p-Tau) and p-Tau/t-Tau ratio in ALS patients using CSF neurofilament light (NFL)...

journal_title：Journal of neurology

authors： Scarafino A,D'Errico E,Introna A,Fraddosio A,Distaso E,Tempesta I,Morea A,Mastronardi A,Leante R,Ruggieri M,Mastrapasqua M,Simone IL

更新日期：2018-10-01 00:00:00

abstract：:Myotonic Dystrophy Type 1 (DM1) and 2 (DM2) present with distinct though overlapping clinical phenotypes. Comparative imaging data on skeletal muscle involvement are not at present available. We used the novel technique of whole body 3.0 Tesla (T) Magnetic Resonance Imaging (MRI) to further characterize musculoskeleta...

journal_title：Journal of neurology

authors： Kornblum C,Lutterbey G,Bogdanow M,Kesper K,Schild H,Schröder R,Wattjes MP

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:The increase in disease-modifying drugs (DMDs) allows individualization of treatment in relapsing multiple sclerosis (RMS); however, the long-term impact of different treatment sequences is not well established. This is particularly relevant for MS patients who may need to postpone more aggressive DMD strate...

journal_title：Journal of neurology

authors： Paolicelli D,Lucisano G,Manni A,Avolio C,Bonavita S,Brescia Morra V,Capobianco M,Cocco E,Conte A,De Luca G,De Robertis F,Gasperini C,Gatto M,Gazzola P,Lus G,Iaffaldano A,Iaffaldano P,Maimone D,Mallucci G,Maniscalco

更新日期：2019-12-01 00:00:00

abstract：:Neuromyelitis optica (NMO) is an inflammatory/demyelinating disorder predominantly affecting the optic nerves and spinal cord. Recent findings showed an underlying humoral abnormality in NMO, characterized by a serum antibody against aquaporin-4 (Aqp-4-Ab). In this study, we evaluated the Aqp-4-Ab status among Turkish...

journal_title：Journal of neurology

authors： Akman-Demir G,Tüzün E,Waters P,Içöz S,Kürtüncü M,Jarius S,Yapıcı Z,Mutlu M,Yeşilot N,Vincent A,Eraksoy M

更新日期：2011-03-01 00:00:00

abstract：:Vertigo is frequently associated with migraine, and sometimes it is the cardinal symptom. This type of migraine is called "vestibular migraine", "migrainous vertigo", or "migraine-associated vertigo". Earlier findings on effective prophylactic medication for such migraine attacks and their clinical features are few an...

journal_title：Journal of neurology

authors： Baier B,Winkenwerder E,Dieterich M

更新日期：2009-03-01 00:00:00

abstract：:We evaluated cyclosporine A (CsA) treatment in 9 patients (6 female and 3 male), 16-63 years old, with severe myasthenia gravis (MG) for a mean period of 2 years (range 16-36 months). All of the patients had been previously treated either with corticosteroids or by combined immunotherapy, and 5 needed periodic plasma ...

journal_title：Journal of neurology

authors： Bonifati DM,Angelini C

更新日期：1997-09-01 00:00:00

abstract：:Windmill nystagmus is characterized by a clock-like rotation of the beating direction of a jerk nystagmus suggesting separate horizontal and vertical oscillators, usually 90° out of phase. We report oculographic characteristics in three patients with variants of windmill nystagmus in whom the common denominator was pr...

journal_title：Journal of neurology

authors： Choi KD,Shin HK,Kim JS,Kim SH,Choi JH,Kim HJ,Zee DS

更新日期：2016-07-01 00:00:00

abstract：:The fluctuation in daily performance of Parkinson patients on long-term L-dopa therapy is known as the so called "off-on" phenomenon. Cotzias et al. found that a low protein diet is able to control this phenomenon in patients taking L-dopa alone but not in those receiving a combination of L-dopa and decarboxylase inhi...

journal_title：Journal of neurology

authors： Wajsbort J

更新日期：1977-04-28 00:00:00

abstract：:The prevalence of clinical and electrophysiological signs of peripheral nerve disease was evaluated in 151 patients with chronic obstructive pulmonary disease. Patients with concomitant disorders affecting the peripheral nervous system were excluded. Thirty patients had clinical signs of a mild sensorimotor and distal...

journal_title：Journal of neurology

authors： Pfeiffer G,Kunze K,Brüch M,Kutzner M,Ladurner G,Malin JP,Tackmann W

更新日期：1990-07-01 00:00:00

abstract：UNLABELLED:The objective of this study was to investigate the relationship between electrophysiological recordings and clinical as well as radiological findings in patients suggestive to suffer from a lumbar spinal stenosis (LSS). We hypothesise that the electrophysiological recordings, especially SSEP, indicate a lumb...

journal_title：Journal of neurology

authors： Egli D,Hausmann O,Schmid M,Boos N,Dietz V,Curt A

更新日期：2007-06-01 00:00:00

abstract：:Weight loss is a common symptom of Parkinson's disease and is associated with impaired quality of life. Predictors of weight loss have not been studied in large clinical cohorts. We previously observed an association between change in body mass index and change in Unified Parkinson's Disease Rating Scale (UPDRS) motor...

journal_title：Journal of neurology

authors： Wills AM,Li R,Pérez A,Ren X,Boyd J,NINDS NET-PD Investigators.

更新日期：2017-08-01 00:00:00

abstract：:Recent studies reported mutations in the gene encoding the proline-rich transmembrane protein 2 (PRRT2) to be causative for paroxysmal kinesigenic dyskinesia (PKD), PKD combined with infantile seizures (ICCA), and benign familial infantile seizures (BFIS). PRRT2 is a presynaptic protein which seems to play an importan...

journal_title：Journal of neurology

authors： Becker F,Schubert J,Striano P,Anttonen AK,Liukkonen E,Gaily E,Gerloff C,Müller S,Heußinger N,Kellinghaus C,Robbiano A,Polvi A,Zittel S,von Oertzen TJ,Rostasy K,Schöls L,Warner T,Münchau A,Lehesjoki AE,Zara F,Lerch

更新日期：2013-05-01 00:00:00

abstract：:Rapid-eye-movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by complex motor activity associated with dreaming during REM sleep. RBD may be idiopathic or associated with various neurological diseases involving the brainstem. The association of RBD and limbic system impairment was unclear. We r...

journal_title：Journal of neurology

authors： Lin FC,Liu CK,Hsu CY

更新日期：2009-07-01 00:00:00

abstract：:Treatment of multiple sclerosis (MS) with interferon beta (IFNbeta) can be associated with the development of binding antibodies (BAbs) and neutralizing antibodies (NAbs). NAbs are a subset of BAbs that prevent IFNbeta from effectively binding to or activating its receptor, thereby blocking its biologic effects and in...

journal_title：Journal of neurology

authors： Deisenhammer F,Schellekens H,Bertolotto A

更新日期：2004-06-01 00:00:00

abstract：:Although numerous clinical, laboratory, and pharmacological variables have been reported as significant risk factors for critical illness polyneuromyopathy (CIPM), there is still no consensus on the aetiology of this condition. Objectives of the study were to assess the clinical and electrophysiological incidence and ...

journal_title：Journal of neurology

authors： Bednarík J,Vondracek P,Dusek L,Moravcova E,Cundrle I

更新日期：2005-03-01 00:00:00

abstract：:Collective evidence supports the notion that multiple sclerosis is principally an autoimmune disease. Much of it stems from models of experimental autoimmune encephalomyelitis, generated by inoculation of animals with central nervous system antigens such as MBP, PLP, S100 and MOG or peptides thereof. Different ways of...

journal_title：Journal of neurology

authors： Hartung HP,Kieseier BC,Hemmer B

更新日期：2005-11-01 00:00:00

abstract：:In patients with Parkinson's disease (PD) disturbances of mental state constitute some of the most difficult treatment challenges of advanced disease, often limiting effective treatment of motor symptoms and leading to increased disability and poor quality of life. This article provides an update on the current knowle...

journal_title：Journal of neurology

authors： Schrag A

更新日期：2004-07-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) can be used to manage post-stroke spasticity, but a meta-analysis of the recent randomized-controlled trials (RCTs) is lacking. Our aim is to perform a meta-analysis of the RCTs that investigated the efficacy of rTMS in...

journal_title：Journal of neurology

authors： Xu P,Huang Y,Wang J,An X,Zhang T,Li Y,Zhang J,Wang B

更新日期：2020-07-11 00:00:00

abstract：OBJECTIVE:Near occlusion (NO) of the internal carotid artery (ICA) with full collapse (NOFC) is a rare condition, with a prevalence of around 1%. Guidelines on carotid stenosis recommend a conservative treatment in patients with a single-event ipsilateral to a NOFC, but the optimal treatment for patients with recurrent...

journal_title：Journal of neurology

authors： Meershoek AJA,Vonken EPA,Nederkoorn PJ,Kappelle LJ,de Borst GJ

更新日期：2018-08-01 00:00:00

abstract：:Activation studies with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) represent a powerful tool to study the functional anatomy of Parkinson's disease (PD). Activation studies offer the opportunity to study regional cerebral function in man in vivo under different conditions with ...

journal_title：Journal of neurology

authors： Ceballos-Baumann AO

更新日期：2003-02-01 00:00:00

abstract：:The history of our understanding of the pathogenesis and pathophysiology of multiple sclerosis are reviewed in the context of Charcot's contribution. The implications for treatment of the new knowledge gained from studies during life of pathology and pathogenesis (by MRI) and pathophysiology (by evoked potentials) are...

journal_title：Journal of neurology

authors： McDonald WI

更新日期：1993-01-01 00:00:00

abstract：:We conducted an open-labeled clinical trial of interferon beta-1b (IFNB) treatment in 20 patients with primary progressive multiple sclerosis (PPMS) and longitudinally monitored autoantibodies against double-stranded DNA (dsDNA), thyroid peroxidase (TPO),myelin basic protein (MBP), myelin oligodendrocyte glycoprotein ...

journal_title：Journal of neurology

authors： Bitsch A,Dressel A,Meier K,Bogumil T,Deisenhammer F,Tumani H,Kitze B,Poser S,Weber F

更新日期：2004-12-01 00:00:00

abstract：:Three cases of Fahr's syndrome are described. All patients had disturbances of calcium metabolism and had had a meningoencephalitis in childhood. It is suggested that gliovascular changes, induced by cerebral inflammation, can later facilitate the occurrence of calcification of the striopallidodentate system when abno...

journal_title：Journal of neurology

authors： Morgante L,Vita G,Meduri M,Di Rosa AE,Galatioto S,Coraci MA,Di Perri R

更新日期：1986-02-01 00:00:00

abstract：:Unlike most neurodegenerative disorders, individuals at risk from Huntington's disease can be identified prior to the onset of clinical signs of the disease by virtue of it being an autosomal dominant condition. This provides the hypothetical opportunity to delay disease onset and/or slow down the progression of the d...

journal_title：Journal of neurology

authors： Mason S,Barker RA

更新日期：2015-08-01 00:00:00

abstract：:Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectivel...

journal_title：Journal of neurology

authors： Gersel Stokholm M,Garrido A,Tolosa E,Serradell M,Iranzo A,Østergaard K,Borghammer P,Møller A,Parbo P,Stær K,Brooks DJ,Martí MJ,Pavese N

更新日期：2020-08-01 00:00:00

abstract：:We reviewed the records of all patients who had received an epidural catheter for management of chronic cancer pain in a 3-year period (1993-1996). Patients with nervous system infections were identified, and pertinent clinical, radiological (magnetic resonance imaging), and bacteriological data were analyzed. We iden...

journal_title：Journal of neurology

authors： Sillevis Smitt P,Tsafka A,van den Bent M,de Bruin H,Hendriks W,Vecht C,Teng-van de Zande F

更新日期：1999-09-01 00:00:00

abstract：:Brains from 54 patients with organic dementia were examined systematically. As in previous investigations a predominance of Alzheimer type changes was observed. Seventeen patients showed Lewy bodies in the nucleus basalis, the substantia nigra and the locus coeruleus as well as other lesions of parkinsonian type. In 5...

journal_title：Journal of neurology

authors： Ulrich J,Probst A,Wüest M

更新日期：1986-04-01 00:00:00