Abstract:
:Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectively. Comparisons were made with healthy controls. Five LRRK2-NMCs had subclinical reductions of putaminal 18F-DOPA uptake. Three of them had significantly raised nigral 11C-PK11195 binding bilaterally. These findings indicate that nigrostriatal dysfunction and neuroinflammation occur in LRRK2-NMCs. Studies in larger cohorts with appropriate follow-up are needed to elucidate the significance of neuroinflammation in the premotor phase of LRRK2-PD.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Gersel Stokholm M,Garrido A,Tolosa E,Serradell M,Iranzo A,Østergaard K,Borghammer P,Møller A,Parbo P,Stær K,Brooks DJ,Martí MJ,Pavese Ndoi
10.1007/s00415-020-09830-3subject
Has Abstractpub_date
2020-08-01 00:00:00pages
2296-2300issue
8eissn
0340-5354issn
1432-1459pii
10.1007/s00415-020-09830-3journal_volume
267pub_type
杂志文章abstract::The clinical features of 31 cases of syringomyelic syndrome, confirmed by metrizamide CT myelography (CTM) or magnetic resonance imaging (MRI), were analysed. Bilateral suspended sensory disturbance, previously regarded as a characteristic feature, was encountered in only 2 cases (6.5%). Thirteen patients (41.9%) show...
journal_title:Journal of neurology
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,评审
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