Abstract：
:We examined the effect of bilateral subthalamic nucleus stimulation on levodopa-resistant balance impairment in 14 patients with Parkinson's disease and 18 matched controls. Instability was quantitatively assessed using standardized multidirectional dynamic posturography. Patients were tested after taking a suprathreshold dose of levodopa, both with stimulators turned on and off. Patients with stimulators turned off were more unstable than controls following backward directed perturbations. Overall, patients' instability did not improve with STN stimulation, and considerable inter-individual variability was noted. Of note, marked levodopa- resistant axial motor symptoms before surgery correlated with an adverse treatment effect. We conclude that STN stimulation does not alleviate levodopa-resistant postural instability in Parkinson's disease.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Visser JE,Allum JH,Carpenter MG,Esselink RA,Speelman JD,Borm GF,Bloem BRdoi
10.1007/s00415-008-0636-xsubject
Has Abstractpub_date
2008-02-01 00:00:00pages
205-10issue
2eissn
0340-5354issn
1432-1459journal_volume
255pub_type
杂志文章abstract：OBJECTIVE:The main aim was to explore the changes in hand-grip strength in patients with Duchenne muscular dystrophy (DMD) aged 5-29 years. Secondary aims were to test the effect of mutation, ambulatory status and glucocorticoid use on grip strength and its changes over time and to compute the number of subjects needed...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09800-9
更新日期：2020-07-01 00:00:00
abstract：:The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer's disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patient...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050351
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Epilepsy in children negatively impacts on caregiver quality of life (QOL). The study aimed to evaluate the relationships between patient factors [demographics, clinical factors, health-related quality of life (HRQL)], contextual factors (socio-economic factors), caregiver mood, and caregiver QOL, and whethe...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8979-4
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVES:Resistance to activated protein C (APC) is the most frequent cause of thrombophilia and a well known risk factor for deep and cerebral vein thrombosis. Its causative role in ischaemic stroke is still a matter of debate. We undertook this study to determine the prevalence of APC-resistance in a cohort of cons...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150170117
更新日期：2001-08-01 00:00:00
abstract：:Inborn errors of metabolism in 40 children have been investigated by computed tomography to obtain data on the degree of cerebral involvement in neurodegenerative and storage disorders: 20 children had various mucopolysaccharidoses, 8 sphingolipidoses , 3 mucolipidoses, 2 oligosaccharidoses , 3 ceroidlipofuscinoses an...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313718
更新日期：1984-01-01 00:00:00
abstract：:The similar localization of intracranial calcification in hypoparathyroidism and in Fahr disease without parathyroid gland disorder suggests that in these two disorders the pathomechanism of calcium phosphate deposition in the brain may be similar. It may be that in Fahr disease some factors, such as chronic respirato...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314315
更新日期：1988-01-01 00:00:00
abstract：:We investigated the efficacy of botulinum toxin A (BtxA) therapy in patients with atypical parkinsonian disorders (APD) exhibiting different types of disabling focal dystonia unresponsive to oral drug therapy. Eight patients with functionally disabling focal dystonia out of a series of 60 consecutive patients with APD...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150200009
更新日期：2002-03-01 00:00:00
abstract：:To investigate the role of endogenous opioid peptides in the pathophysiology of cerebral ischaemia, the CSF levels of immunoreactive beta-endorphin and leu-enkephalin in 16 patients with cerebral infarction were measured. Both the CSF beta-endorphin and leu-enkephalin levels in the acute stage of cerebral infarction w...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314282
更新日期：1987-06-01 00:00:00
abstract：:Absence of AMP-deaminase was demonstrated by histochemical and biochemical methods in a muscle biopsy of a 25-year-old woman with facial and limb girdle myopathy. Venous ammonia failed to rise after ischaemic exercise. This patient further contributes to the variety of clinical pictures associated with AMP-deaminase d...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313744
更新日期：1981-01-01 00:00:00
abstract：:This meta-analysis aims to compare percutaneous transluminal angioplasty (PTA) to medical treatment (MT) for symptomatic vertebral artery stenosis (SVAS) treatment. We searched PubMed, Springer, Google Scholar, Clinical Trials, Cochrane Central, Chinese National Knowledge Infrastructure, and China Biological Medicine ...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00415-016-8267-0
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:The mechanisms of early neurologic deterioration (END) and prevention strategies for END are not completely understood. The aim of this study was to investigate the association between CYP2C19*2 variants and END, and the effectiveness of antiplatelet therapy for prevention of END according to CYP2C19*2 genot...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00415-018-8998-1
更新日期：2018-10-01 00:00:00
abstract：:Neuropsychological deficits and the relationship to brain pathology were examined in 13 primary progressive (PP) and 12 secondary progressive (SP) multiple sclerosis patients with a similar duration of the progressive phase and comparable physical disability. A battery of neuropsychological tests to assess attention, ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/pl00007804
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:Volume loss in the deep gray matter (DGM) has been reported in patients with multiple sclerosis (MS) already at early stages of the disease and is thought to progress throughout the disease course. OBJECTIVE:To investigate the impact and predictive value of volume loss in DGM and thalamic subnuclei on disab...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09740-4
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:Near occlusion (NO) of the internal carotid artery (ICA) with full collapse (NOFC) is a rare condition, with a prevalence of around 1%. Guidelines on carotid stenosis recommend a conservative treatment in patients with a single-event ipsilateral to a NOFC, but the optimal treatment for patients with recurrent...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8939-z
更新日期：2018-08-01 00:00:00
abstract：:Rodent oligodendrocytes have a unique susceptibility among glia to the lytic effects of complement, due in part to a deficiency in CD59 (protectin), a key surface inhibitor of the complement membrane attack complex (MAC). The possibility that shedding of CD59 by human oligodendrocytes contributes to complement-mediate...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00873519
更新日期：1994-08-01 00:00:00
abstract：:Autonomic dysfunction is frequently observed in patients with multiple sclerosis (MS), but clinical studies disagree on the frequency and type of abnormalities in autonomic function tests. Orthostatic dizziness (OD) has been reported in up to 49% of patients, but the pathophysiological mechanisms are poorly understood...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050407
更新日期：1999-07-01 00:00:00
abstract：:Four patients with aphasia due to small circumscribed thalamic lesions are presented. A review of the literature on thalamic aphasia revealed 16 similar cases. While the general consensus that only left-sided thalmic lesions are associated with aphasia is confirmed, analysis of the sites of the thalamic infarctions an...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF00314212
更新日期：1989-01-01 00:00:00
abstract：:We present evidence that Willy Loman, the protagonist of Arthur Miller's play "Death of a Salesman", meets current diagnostic criteria for probable dementia with Lewy bodies. In particular, he presents with attentional deficits and executive dysfunction (with additional subtle visuoperceptual deficits) in addition to ...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-019-09343-8
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:To characterize the relation between brain functional connectivity and disability in patients with multiple sclerosis; to investigate the existence of critical values of both disability and functional connectivity corresponding to exhaustion of functional adaptive mechanisms. METHODS:Hundred-and-nineteen pat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-9075-5
更新日期：2018-12-01 00:00:00
abstract：:Five patients are described who developed unilateral narrowing of the palpebral fissure that was aggravated by smiling. They had ischaemic lesions involving mainly the contralateral lenticulocapsular area. This rare but distinct symptom may be an action induced focal eyelid dystonia, and could be described as'smile-wi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170179
更新日期：2001-05-01 00:00:00
abstract：:Cerebellar ataxia can have many genetic causes among which are the congenital disorders of glycosylation type I (CDG-I). In this group of disorders, a multisystem phenotype is generally observed including the involvement of many organs, the endocrine, hematologic and central nervous systems. A few cases of CDG-Ia have...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-0546-3
更新日期：2007-10-01 00:00:00
abstract：:Auto-oxidation of levodopa generates toxic metabolites, such as free radicals, semiquinones and quinones. In vitro, levodopa is a powerful toxin that is lethal to cultures of neurones. This raises the concern that levodopa may also be toxic in vivo, and that chronic treatment with levodopa could induce further damage ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00022914
更新日期：2000-04-01 00:00:00
abstract：:Hirayama's disease is a benign juvenile form of focal amyotrophy affecting the upper limbs. Previous studies have suggested that the disorder is a neck flexion induced cervical myelopathy. We report clinical and magnetic resonance imaging findings in nine patients with Hirayama's disease. Cervical imaging of seven pat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050514
更新日期：1999-11-01 00:00:00
abstract：:Posterior leukoencephalopathy typically denotes neurotoxicity from immunosuppressive agents, malignant hypertension or eclampsia. It has not been documented in central nervous system angiitis. We present three cases associated with isolated cerebral angiitis after review of all cases of isolated CNS angiitis from 1998...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-1021-4
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:One of the goals in treating subarachnoid hemorrhage patients is to prevent or minimize vasospasm-induced ischemia. Intracerebral microdialysis is a rapidly developing tool to monitor physiological and pathophysiological changes in chemical processes associated with ischemia. OBJECTIVE:To determine the diag...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-003-1079-z
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Dermic fibroblasts have been proposed as a potential genetic-ALS cellular model. This study aimed to explore whether dermic fibroblasts from patients with sporadic-ALS (sALS) recapitulate alterations typical of ALS motor neurons and exhibit abnormal DNA-damage response. METHODS:Dermic fibroblasts were obtai...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09704-8
更新日期：2020-05-01 00:00:00
abstract：:Surface antigens on peripheral blood lymphocytes from myasthenia gravis patients were investigated. The expression of DR+ and CD8+/DR+ T lymphocytes was increased and the expression of CD4+ T cells reduced. Neither thymectomy, clinical condition nor anti-acetylcholine receptor antibody titre correlated with any of the...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00863771
更新日期：1994-02-01 00:00:00
abstract：:Production of reactive oxygen species after cerebral blood flow disruption may enhance tissue damage through multiple molecular pathways. Changes in nitric oxide (NO) metabolism and oxidative stress status were investigated in 47 patients with ischemic stroke by measuring plasma nitric oxide (NO) and peroxynitrite (ON...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-0700-y
更新日期：2008-01-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disease, leaving the patient in a partially or completely deafferented state. In an explorative study, we investigated responses to visual socio-emotional stimuli in ALS patients. Pictures from the International Affective Picture System (IAPS) were verbally judged by 12 m...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0907-8
更新日期：2005-12-01 00:00:00
abstract：:Eighty patients were studied by angiography within 6 h of an ischaemic stroke. Angiography was carried out with digital equipment and was usually limited to the vascular territory responsible for the neurological deficits. In 12 of 19 patients with internal carotid occlusion, the contralateral side was also studied. T...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314376
更新日期：1989-09-01 00:00:00
