Volume loss in the deep gray matter and thalamic subnuclei: a longitudinal study on disability progression in multiple sclerosis.


BACKGROUND:Volume loss in the deep gray matter (DGM) has been reported in patients with multiple sclerosis (MS) already at early stages of the disease and is thought to progress throughout the disease course. OBJECTIVE:To investigate the impact and predictive value of volume loss in DGM and thalamic subnuclei on disability worsening in patients MS over a 6-year follow-up period. METHODS:Hundred and seventy-nine patients with RRMS (132 women; median Expanded Disability Status Scale, EDSS: 2.5) and 50 with SPMS (27 women; median EDSS: 4.5) were included in the study. Patients underwent annual EDSS assessments and annual MRI at 1.5 T. DGM/thalamic subnuclei volumes were identified on high-resolution T1-weighted. A hierarchical linear mixed model for each anatomical DGM area and each thalamic subnucleus was performed to investigate the associations with disability scores. Cox regression was used to estimate the predictive properties of volume loss in DGM and thalamic subnuclei on disease worsening. RESULTS:In the whole sample and in RRMS, volumes of the thalamus and the striatum were associated with the EDSS; however, only thalamic volume loss was associated with EDSS change at follow-up. Regarding thalamic subnuclei, volume loss in the anterior nucleus, the pulvinar and the ventral anterior nucleus was associated with EDSS change in the whole cohort. A trend was observed for the ventral lateral nucleus. Volume loss in the anterior and ventral anterior nuclei was associated with EDSS change over time in patients with RRMS. Moreover, MS phenotype and annual rates of volume loss in the thalamus and ventral lateral nucleus were predictive of disability worsening. CONCLUSION:These results highlight the relevance of volume loss in the thalamus as a key metric for predicting disability worsening as assessed by EDSS (in RRMS). Moreover, the volume loss in specific nuclei such as the ventral lateral nucleus seems to play a role in disability worsening.


J Neurol


Journal of neurology


Magon S,Tsagkas C,Gaetano L,Patel R,Naegelin Y,Amann M,Parmar K,Papadopoulou A,Wuerfel J,Stippich C,Kappos L,Chakravarty MM,Sprenger T




Has Abstract


2020-05-01 00:00:00














  • Recent advances in the diagnosis, genetics and treatment of restless legs syndrome.

    abstract::Knowledge of restless legs syndrome (RLS) has greatly increased in recent years due to the many advances that have been made in diagnosis, management and genetics. Tools have been developed that facilitate the diagnosis and treatment of RLS, in particular the essential diagnostic criteria for RLS have been refined, se...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Trenkwalder C,Högl B,Winkelmann J

    更新日期:2009-04-01 00:00:00

  • Biomechanical response of the CNS is associated with frailty in NPH-suspected patients.

    abstract::Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) pr...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Vallet A,Del Campo N,Hoogendijk EO,Lokossou A,Balédent O,Czosnyka Z,Balardy L,Payoux P,Swider P,Lorthois S,Schmidt E

    更新日期:2020-05-01 00:00:00

  • Artistic occupations are associated with a reduced risk of Parkinson's disease.

    abstract::Parkinson's disease (PD) is preceded by a premotor phase of unknown duration. Dopaminergic degeneration during this phase may lead to subtle cognitive and behavioural changes, such as decreased novelty seeking. Consequently, premotor subjects might be most comfortable in jobs that do not require optimal dopamine level...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Haaxma CA,Borm GF,van der Linden D,Kappelle AC,Bloem BR

    更新日期:2015-09-01 00:00:00

  • Peroneal nerve neuropathy in cancer patients: a paraneoplastic syndrome?

    abstract:AIMS:To investigate the occurrence of symptomatic peroneal neuropathy (PN) in cancer patients, as well as that of cancer in PN patients and to seek possible factors in the aetiology of PN. METHODS:Clinical, neurographical, and myographical data of patients with PN, in two general neurology clinics during a 5-year peri...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Koehler PJ,Buscher M,Rozeman CA,Leffers P,Twijnstra A

    更新日期:1997-05-01 00:00:00

  • Is there neuroprotection in Parkinson syndrome?

    abstract::Parkinson's disease (PD) is a neurodegenerative disorder of the aging population with unknown etiopathogenesis. It is assumed that the underlying pathobiochemical processes comprise multifactorial and multigenetic disturbances leading to a progressive and devastating disorder without remission. Subtypes exist suggesti...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Riederer P,Sian J,Gerlach M

    更新日期:2000-09-01 00:00:00

  • Intrathecal IgG synthesis in multiple sclerosis and other neurological diseases: a comparative evaluation by IgG-index and isoelectric focusing.

    abstract::Intrathecal IgG synthesis has been investigated by determining the IgG index and by isoelectric focusing in 30 cases of definite multiple sclerosis, in 15 cases of probable multiple sclerosis and in 128 patients affected by other neurological diseases. The blood-brain barrier function was evaluated at the same time by...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Poloni M,Rocchelli B,Scelsi R,Pinelli P

    更新日期:1979-10-01 00:00:00

  • Hallervorden-Spatz disease: clinical and MRI study of 11 cases diagnosed in life.

    abstract::The diagnosis of Hallervorden-Spatz disease (HSD) has usually been made post mortem, although the recent description of characteristic abnormalities in the globus pallidus has suggested the possibility of an in vivo diagnosis. We present the clinical histories, neurological features and MRI findings of 11 patients, di...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Angelini L,Nardocci N,Rumi V,Zorzi C,Strada L,Savoiardo M

    更新日期:1992-10-01 00:00:00

  • Aetiopathogenesis of Parkinson's disease.

    abstract::Parkinson's disease (PD) is characterised both clinically and pathologically by features that distinguish it from other parkinsonian disorders including, for instance, multiple system atrophy and progressive supranuclear palsy. The aetiologies of PD includes both genetic and environmental influences. Several single ge...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Schapira AH

    更新日期:2011-05-01 00:00:00

  • Clinical and audiological findings in a case of auditory agnosia.

    abstract::A case is reported of severe agnosia for verbal and non-verbal sounds without associated aphasic disorder. A CT scan revealed bilateral, temporal lobe lesions from two ischaemic accidents that had occurred 9 months apart. The search for subtle deficits in the patient showed normal sensitivity to changes in the intensi...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Rosati G,De Bastiani P,Paolino E,Prosser S,Arslan E,Artioli M

    更新日期:1982-01-01 00:00:00

  • Systemic risk score evaluation in ischemic stroke patients (SCALA): a prospective cross sectional study in 85 German stroke units.

    abstract:BACKGROUND AND PURPOSE:Stratification of patients with transient ischemic attack (TIA) or ischemic stroke (IS) by risk of recurrent stroke can contribute to optimized secondary prevention. We therefore aimed to assess cardiovascular risk factor profiles of consecutive patients hospitalized with TIA/IS to stratify the r...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Weimar C,Goertler M,Röther J,Ringelstein EB,Darius H,Nabavi DG,Kim IH,Theobald K,Diener HC,SCALA Study Group.

    更新日期:2007-11-01 00:00:00

  • Psychosocial aspects in patients with myasthenia gravis.

    abstract::Myasthenia gravis patients usually present with fluctuating, asymmetrical stress-dependent weakness in the absence of other neurological disturbances. In weak patients psychopathological disturbances are frequently reported and misdiagnosed as a psychiatric disorder. The question to what extent psychiatric symptoms ar...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Köhler W

    更新日期:2007-05-01 00:00:00

  • Molecular mechanisms of migraine?

    abstract::Migraine is a common debilitating neurological disease characterised by attacks of severe headache with or without preceding aura. Its aetiology remains elusive; however it is clear that an interplay of genetic and environmental components play an important role. Familial hemiplegic migraine (FHM) is a rare and severe...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Ramagopalan SV,Ramscar NE,Cader MZ

    更新日期:2007-12-01 00:00:00

  • Dopamine D2 receptor binding and cerebral glucose metabolism recover after D-penicillamine-therapy in Wilson's disease.

    abstract::Regional cerebral glucose metabolism (rCMRGlc) and dopamine D2 receptor binding were measured in a 31-year-old, severely affected, untreated patient with Wilson's disease of 3 years' duration using positron emission tomography and 18F-deoxyglucose and 18F-methylspiperone ([18F]MSP), respectively. There was a severe re...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Schlaug G,Hefter H,Nebeling B,Engelbrecht V,Weiss P,Stöcklin G,Seitz RJ

    更新日期:1994-10-01 00:00:00

  • Isolated sixth nerve palsy: an uncommon presenting sign of multiple sclerosis.

    abstract::We describe three patients in whom an isolated sixth nerve palsy was the only clinical symptom or sign of multiple sclerosis (MS). Data were collected prospectively over 6 years on these three patients, who showed no other signs of brainstem dysfunction or prior symptoms; in addition. Retrospective analysis of all pat...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Barr D,Kupersmith MJ,Turbin R,Bose S,Roth R

    更新日期:2000-09-01 00:00:00

  • IVIG therapy in neurological disorders of childhood.

    abstract::There is growing evidence that intravenous immunoglobulins (IVIG) are effective in some neuroimmunological disorders of childhood. This short review summarizes the evidence-based indications and recommendations of IVIG therapy in these disorders. Despite considerable efforts to define the role and mechanisms of IVIG, ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Archelos JJ,Fazekas F

    更新日期:2006-09-01 00:00:00

  • CNS demyelination in fibrodysplasia ossificans progressiva.

    abstract::Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder of progressive heterotopic ossification (HO) caused by a recurrent activating mutation of ACVR1/ALK2, a bone morphogenetic protein (BMP) type I receptor. FOP is characterized by progressive HO, which is associated with inflammation in the setting o...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Kan L,Kitterman JA,Procissi D,Chakkalakal S,Peng CY,McGuire TL,Goldsby RE,Pignolo RJ,Shore EM,Kaplan FS,Kessler JA

    更新日期:2012-12-01 00:00:00

  • Early development of anti-natalizumab antibodies in MS patients.

    abstract::The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the efficacy of the treatment and an increase of adverse events. A total of 134 multiple sclerosis patie...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章


    authors: Oliver-Martos B,Órpez-Zafra T,Urbaneja P,Maldonado-Sanchez R,Leyva L,Fernández O

    更新日期:2013-09-01 00:00:00

  • Nerve sheath tumours.

    abstract:: ...

    journal_title:Journal of neurology

    pub_type: 评论,杂志文章


    authors: Robertson JA,Tallantyre EC

    更新日期:2018-12-01 00:00:00

  • Neutral lipid and sphingolipid composition of the brain of a patient with membranous lipodystrophy.

    abstract::Lipids were extracted from brains of a patient with membranous lipodystrophy (ML) and three normal patients and the neutral lipid and sphingolipid constituents were investigated. The storage of a large amount of free fatty acid was observed in the ML brain, but no cholesterol ester was found. Total lipid, cholesterol ...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Ohtani Y,Miura S,Tamai Y,Kojima H,Kashima H

    更新日期:1979-03-22 00:00:00

  • Acetylcholine esterase inhibitor donepezil improves dynamic cerebrovascular regulation in Alzheimer patients.

    abstract:BACKGROUND:Alzheimer's disease (AD) leads to a degeneration of the nucleus basalis of Meynert and thus to decreased cholinergic tonus in the brain. The transcription of endothelial nitric oxide synthase depends on an adequate cholinergic innervation of microvessels and vasoregulative abnormalities have been reported in...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章


    authors: Rosengarten B,Paulsen S,Molnar S,Kaschel R,Gallhofer B,Kaps M

    更新日期:2006-01-01 00:00:00

  • Disturbed benzodiazepine receptor function at the onset of temporal lobe epilepsy--lomanzenil-binding in de-novo TLE.

    abstract:PURPOSE:Epileptogenic foci exhibit disturbed function at the level of the benzodiazepine receptor. The aim of our study was to investigate the incidence of focal reductions of temporal benzodiazepine receptor binding (BRB) as assessed by scintigraphy with 123I-iomazenil in patients with denovo temporal lobe epilepsy (T...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Matheja P,Lüdemann P,Kuwert T,Weckesser M,Kellinghaus C,Weitemeyer L,Diehl B,Schuierer G,Ringelstein EB,Schober O

    更新日期:2001-07-01 00:00:00

  • The value of leukocyte adhesion molecules in patients after ischemic stroke.

    abstract::Leukocyte recruitment and inflammatory response play an important patho-physiologic role after cerebral ischemia. This study aimed to evaluate whether leukocyte adhesion molecules can predict clinical outcome in patients after ischemic stroke. We prospectively examined serial changes in p-selectin glycoprotein ligand-...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Tsai NW,Chang WN,Shaw CF,Jan CR,Huang CR,Chen SD,Chuang YC,Lee LH,Lu CH

    更新日期:2009-08-01 00:00:00

  • The presymptomatic phase of amyotrophic lateral sclerosis: are we merely scratching the surface?

    abstract::Presymptomatic studies in ALS have consistently captured considerable disease burden long before symptom manifestation and contributed important academic insights. With the emergence of genotype-specific therapies, however, there is a pressing need to address practical objectives such as the estimation of age of sympt...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Chipika RH,Siah WF,McKenna MC,Li Hi Shing S,Hardiman O,Bede P

    更新日期:2020-10-31 00:00:00

  • Measurement of the effect of a bolus dose of intrathecal baclofen by continuous measurement of force under fibreglass casts.

    abstract::Continuous intrathecal administration of baclofen with implanted programmable pump systems is recommended in the treatment of severe spasticity of cerebral origin. Prior to pump implantation, a baclofen bolus test (BBT) is used to assess the effectiveness of intrathecal baclofen using the modified Ashworth Scale (MAS)...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Pohl M,Rockstroh G,Rückriem S,Mehrholz J,Mrass G,Pause M

    更新日期:2002-09-01 00:00:00

  • Increased risk for subarachnoid hemorrhage in patients with sleep apnea.

    abstract:OBJECTIVES:Recent retrospective studies found sleep disorders, including obstructive sleep apnea and its symptoms to occur more often in patients following aneurysmal subarachnoid hemorrhage, but studies investigating the incidence of subarachnoid hemorrhage in patients with diagnosed obstructive sleep apnea [OSA] comp...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Zaremba S,Albus L,Schuss P,Vatter H,Klockgether T,Güresir E

    更新日期:2019-06-01 00:00:00

  • Juvenile seropositive myasthenia gravis with anti-MuSK antibody after thymectomy.

    abstract::We report the case of a 17.5-year old girl with generalized myasthenia gravis (MG). When she was 13, she started to complain of episodic diplopia, ptosis and mild fatigability of upper and lower extremity muscles. She was diagnosed with MG 3 years later, after exacerbation of her limb muscle weakness. Acetylcholine re...

    journal_title:Journal of neurology

    pub_type: 信件


    authors: Kostera-Pruszczyk A,Kwiecinski H

    更新日期:2009-10-01 00:00:00

  • Update on laser-evoked potential findings in fibromyalgia patients in light of clinical and skin biopsy features.

    abstract::In fibromyalgia (FM), reduced habituation of laser-evoked potentials (LEPs) suggests a dysfunction of pain processing at a central level. In this study, we aimed to further examine the nociceptive pathways at the peripheral to the central level in a large group of FM patients by means of LEPs and skin biopsy, in light...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: de Tommaso M,Nolano M,Iannone F,Vecchio E,Ricci K,Lorenzo M,Delussi M,Girolamo F,Lavolpe V,Provitera V,Stancanelli A,Lapadula G,Livrea P

    更新日期:2014-03-01 00:00:00

  • Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients.

    abstract:BACKGROUND:Anti-epileptic drug (AED) prophylaxis in the first-seven days post-traumatic brain injury (TBI) is known to reduce seizure frequency acutely. AED efficacy is equivalent; therefore, choice of AED may rest with their side-effects. We hypothesise that AEDs that impair balance will prolong recovery, shown by a l...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Harris L,Hateley S,Tsang KT,Wilson M,Seemungal BM

    更新日期:2020-06-01 00:00:00

  • The spirochetal etiology of lymphocytic meningoradiculitis of Bannwarth (Bannwarth's syndrome).

    abstract::In all the sera of four patients with meningoradiculitis of Bannwarth admitted to the neurological department of the University Clinic Grosshadern in Munich in 1983, we found antibodies against Ixodes dammini spirochetes. In three patients antibodies were also present in the CSF. In one patient, we isolated spirochete...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Pfister HW,Einhäupl K,Preac-Mursic V,Wilske B,Schierz G

    更新日期:1984-01-01 00:00:00

  • Conservative treatments of children with episodic tension-type headache. A systematic review.

    abstract:OBJECTIVE:We aimed to assess the effectiveness of conservative treatments in children with tension-type headaches (TTH). METHOD:We searched Medline, Embase and the Cochrane Library and performed reference checking. Two independent authors assessed trial quality and extracted data. Analysis was carried out according to...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Verhagen AP,Damen L,Berger MY,Passchier J,Merlijn V,Koes BW

    更新日期:2005-10-01 00:00:00