Changes in peripheral blood lymphocyte subset frequencies in myasthenia gravis patients are related to immunosuppression.

Abstract:

:Surface antigens on peripheral blood lymphocytes from myasthenia gravis patients were investigated. The expression of DR+ and CD8+/DR+ T lymphocytes was increased and the expression of CD4+ T cells reduced. Neither thymectomy, clinical condition nor anti-acetylcholine receptor antibody titre correlated with any of the changes in peripheral blood lymphocyte subsets observed. However, immunosuppressive therapy correlated with the significant reduction in CD4+ and CD2+/CD4+ T cells in these patients.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Crosti F,Armanini M,Confalonieri P,Antozzi C,Mantegazza R

doi

10.1007/BF00863771

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

218-22

issue

4

eissn

0340-5354

issn

1432-1459

journal_volume

241

pub_type

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