Abstract：
:Seventy-seven cases of the optic-spinal form of multiple sclerosis (OSMS) were collected from 6 institutes in 3 cities of Japan, and the clinical and MRI features were analyzed. Two-thirds of the OSMS patients had longitudinally extensive spinal cord MRI lesions (LESL), and had clinical features similar to those of relapsing neuromyelitis optica which often causes severe disability. In contrast, OSMS patients without LESL tended to have milder disease and had some feature commonly seen in the conventional form of MS. The percentage of OSMS without LESL in total OSMS has recently been increasing. The present study suggests that LESL is crucially important for distinguishing the two subtypes of OSMS.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Nakashima I,Fukazawa T,Ota K,Nohara C,Warabi Y,Ohashi T,Miyazawa I,Fujihara K,Itoyama Ydoi
10.1007/s00415-006-0400-zsubject
Has Abstractpub_date
2007-04-01 00:00:00pages
488-92issue
4eissn
0340-5354issn
1432-1459journal_volume
254pub_type
杂志文章,多中心研究abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) has been investigated as a tool for dysphagia recovery after stroke in several single-center randomized controlled trials (RCT). OBJECTIVE:The aim of this investigation was to quantitatively evaluate the effect of tDCS on dysphagia recovery after a stroke utili...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10142-9
更新日期：2021-01-01 00:00:00
abstract：:Multiple mononeuropathy (MM) occurs rarely during systemic lupus erythematosus (SLE) but may lead to major disability. The aim of this study was to investigate the clinic-pathological presentations of MM during SLE, as well as long-term outcomes. We conducted a multicentric retrospective study that included patients r...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-017-8519-7
更新日期：2017-06-01 00:00:00
abstract：:Continuous intrathecal administration of baclofen with implanted programmable pump systems is recommended in the treatment of severe spasticity of cerebral origin. Prior to pump implantation, a baclofen bolus test (BBT) is used to assess the effectiveness of intrathecal baclofen using the modified Ashworth Scale (MAS)...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0825-y
更新日期：2002-09-01 00:00:00
abstract：:Spinocerebellar ataxias (SCA) are a genetically heterogeneous group of neurodegenerative diseases characterised by progressive cerebellar ataxia, dysarthria and oculomotor abnormalities. Recently the prodynorphin (PDYN) gene was identified as the cause of SCA23 in four Dutch families displaying progressive gait and li...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6721-1
更新日期：2013-03-01 00:00:00
abstract：:Acyclovir treatment was used in a randomized, double-blind, placebo-controlled clinical trial with parallel groups to test the hypothesis that herpes virus infections are involved in the pathogenesis of multiple sclerosis (MS). Sixty patients with the relapsing-remitting form of MS were randomized to either oral treat...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00868517
更新日期：1996-03-01 00:00:00
abstract：:Small fibre neuropathy (SFN) has been demonstrated in sarcoidosis. However, a systematic analysis of neuropathic pain and autonomic symptoms, key features of SFN, has not been performed. Clinimetric evaluation of pain and autonomic symptoms using the neuropathic pain scale (NPS) and the modified Composite Autonomic Sy...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5664-7
更新日期：2010-12-01 00:00:00
abstract：:Alemtuzumab is an anti-CD52 monoclonal antibody recently licensed for use in relapsing-remitting multiple sclerosis. Here, we report our experience of its use in neuromyelitis optica (NMO) spectrum disorders. A retrospective case review of patients treated with alemtuzumab in Cambridge, UK, was conducted to identify t...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7925-y
更新日期：2016-01-01 00:00:00
abstract：:Clinical and experimental investigations have shown that magnesium depletion causes a marked irritability of the nervous system, eventually resulting in epileptic seizures. Although magnesium deficiency as a cause of epilepsy is uncommon, its recognition and correction may prove life-saving. Two case reports are prese...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00319737
更新日期：1991-08-01 00:00:00
abstract：:There is increasing evidence that inflammation plays an important role in the progression of acute ischemic stroke (AIS). The primary aims of this study were to examine the serum levels of 13 cytokines, C-reactive protein (CRP), glucose, and hemoglobin in AIS patients, and their relationship to stroke lateralization, ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6006-0
更新日期：2011-04-01 00:00:00
abstract：:The number of dementia patients requesting euthanasia in the Netherlands has increased over the past five years. The issue is highly controversial. In this contribution we discuss some of the main arguments: the nature of suffering, the voluntariness of the request and the role of the physician. We argue that society ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8095-2
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND AND AIMS:Most patients with multiple sclerosis presenting with a relapsing-remitting disease course at diagnosis transition to secondary progressive multiple sclerosis (SPMS) 1-2 decades after onset. SPMS is characterized by predominant neurodegeneration and atrophy. These pathogenic hallmarks result in unsa...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-09964-4
更新日期：2020-06-05 00:00:00
abstract：INTRODUCTION:The spinocerebellar ataxias (SCAs), are rare neurodegenerative disorders caused by distinct genetic mutations. Clinically, the SCAs are characterised by progressive ataxia and a variety of other features, including cognitive dysfunction. The latter is consistent with a growing body of evidence supporting a...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0680-6
更新日期：2008-03-01 00:00:00
abstract：:Multi-modality evoked potentials and computed cranial tomography (CT) were performed in ten patients with Wilson's disease to determine if any of these studies would correlate reliably with neurologic status. While all four patients with CT abnormality had neurologic signs, two additional patients with neurologic find...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314035
更新日期：1985-01-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS), which is the most serious form of degenerative motor neuron disease in adults, is characterized by upper and lower motor neuron degeneration, skeletal muscle atrophy, paralysis, and death. Some patients with respiratory-dependent ALS die of sudden cardiac arrest or anoxic encephalo...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7005-0
更新日期：2013-09-01 00:00:00
abstract：:Pompe disease is an autosomal recessive disorder in which deficiency of the lysosomal enzyme acid alpha-glucosidase results in the accumulation of glycogen mostly in muscle tissues. Several reports suggest a higher incidence of intracranial vascular abnormalities (IVAs) in this condition, as well as brain microbleeds ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8601-1
更新日期：2017-10-01 00:00:00
abstract：:We investigated the efficacy of botulinum toxin A (BtxA) therapy in patients with atypical parkinsonian disorders (APD) exhibiting different types of disabling focal dystonia unresponsive to oral drug therapy. Eight patients with functionally disabling focal dystonia out of a series of 60 consecutive patients with APD...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150200009
更新日期：2002-03-01 00:00:00
abstract：:There has been a resurgence in the use of functional neurosurgery for Parkinson's disease. An important factor that has played a role in this development is the recent understanding of the functional anatomy of the basal ganglia including a knowledge of the changes in the activities of neurons in the internal segment ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF03161079
更新日期：1999-09-01 00:00:00
abstract：:In recent years, it has been widely recognised that modern doctors are not receiving the training they need to provide appropriate and effective palliative care. Deficiencies in care have been reported in several formal studies and, anecdotally, in many professional and popular lay publications. Doctors themselves hav...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00007722
更新日期：1997-10-01 00:00:00
abstract：:A method for the preparation of a potent and specific peroxidase-labelled antihuman IgG antibody is described. CSF cells from patients with various neurological diseases were stained. Only in cases of inflammatory diseases was IgG detectable. The stained cells were so-called lymphoid cells. As the demonstrable IgG can...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313346
更新日期：1980-01-01 00:00:00
abstract：:Brains from 54 patients with organic dementia were examined systematically. As in previous investigations a predominance of Alzheimer type changes was observed. Seventeen patients showed Lewy bodies in the nucleus basalis, the substantia nigra and the locus coeruleus as well as other lesions of parkinsonian type. In 5...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313858
更新日期：1986-04-01 00:00:00
abstract：:We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00900501
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:Dermic fibroblasts have been proposed as a potential genetic-ALS cellular model. This study aimed to explore whether dermic fibroblasts from patients with sporadic-ALS (sALS) recapitulate alterations typical of ALS motor neurons and exhibit abnormal DNA-damage response. METHODS:Dermic fibroblasts were obtai...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09704-8
更新日期：2020-05-01 00:00:00
abstract：:This short review summarizes epilepsy papers published in the Journal of Neurology in 2009, covering pathophysiology (inflammation; propagation pathways), new treatments (oxcarbazepine in paediatrics; levetiracetam in status epilepticus), and non-seizure outcomes (violence; foetal/pregnancy). ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-010-5740-z
更新日期：2010-11-01 00:00:00
abstract：:Multifocal motor neuropathy (MMN) can be differentiated from motor neuron disease by electrophysiological evidence of conduction block. To increase the probability of recording conduction block, we studied the whole nerve length including proximal segments in 84 patients with pure motor syndromes, using a special stim...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00873973
更新日期：1996-10-01 00:00:00
abstract：:Multiple sclerosis (MS), a chronic inflammatory disorder of the central nervous system (CNS), 2 results in damage to axons and their surrounding myelin sheath. The exact cause of inflammation remains unclear, but an autoimmune response directed against CNS antigens is suspected. MS can affect the brain, optic nerve an...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-004-1504-y
更新日期：2004-09-01 00:00:00
abstract：:Disease management is defined as any medical or pharmaceutical intervention designed to improve both outcomes for the patient and overall cost-effectiveness of the health plan. Disease management focuses on the patient throughout the entire course of the disease, involving both health providers and third-party payers....
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00014806
更新日期：1998-08-01 00:00:00
abstract：OBJECTIVES:To evaluate daily life management and functional outcome of Idarucizumab administration in case of emergency situations in patients with Dabigatran treatment. DESIGN:Multicenter observational registry study. SETTING:All hospitals with full neurological departments (n = 6) in Munich, Germany INCLUDED PATIEN...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-019-09492-w
更新日期：2019-11-01 00:00:00
abstract：:To analyze the in vivo biological effect of anti-interferon beta (IFN-beta) neutralizing antibodies (NABs), blood concentrations of neopterin, beta2microglobulin (Beta2-MG), mRNA-dependent myxovirusresistant protein A (MxA) and dsRNA-dependent protein kinase (PKR) were measured before (predose) and 24 hours after (pos...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-006-0332-7
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:The nonischemic forearm exercise test (NIFET) has been shown to be as effective as the classic ischemic forearm exercise test (IFET) in the diagnosis of patients with McArdle disease. Recently, the lactate increase normalized to the mechanical energy production in NIFET was suggested to have a intermediate s...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-006-0101-7
更新日期：2006-06-01 00:00:00
abstract：:Multiple System Atrophy (MSA) and idiopathic Parkinson's disease (PD) can be difficult to distinguish. There is an ongoing debate about the diagnostic value of the growth-hormone response to clonidine (CGH-test) in PD and MSA. We investigated whether the CGH-test can identify individual patients in the early stages of...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0809-y
更新日期：2002-09-01 00:00:00
