Abstract：
:A method for the preparation of a potent and specific peroxidase-labelled antihuman IgG antibody is described. CSF cells from patients with various neurological diseases were stained. Only in cases of inflammatory diseases was IgG detectable. The stained cells were so-called lymphoid cells. As the demonstrable IgG can be regarded as a product of intracellular synthesis, it is justified to call these cells activated B lymphocytes. The relative portion of activated B cells tends to be high in the first half of the mononuclear phase and depends upon the type of disease. It is low in most cases of bacterial and benign viral meningitis whereas high B cell numbers were found in Bannwarth meningopolyneuritis, mumps meningitis and herpes simplex encephalitis. Albeit there exists a time lag between the maximal number of activated B lymphocytes and the demonstration of the secretory immunoglobulin fraction, quantitative correlation between these two inflammation parameters were demonstrated in cases of acute meningoencephalitis. These correlations were not seen in chronic inflammatory diseases.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Schädlich HJ,Nekić M,Felgenhauer Kdoi
10.1007/BF00313346subject
Has Abstractpub_date
1980-01-01 00:00:00pages
77-87issue
2eissn
0340-5354issn
1432-1459journal_volume
224pub_type
杂志文章abstract：:Cardiac conduction and/or rhythm abnormalities (CCRA) are the most frequent and life-threatening complications in DM1. In order to determine prevalence, incidence, characteristics, age of onset and predictors of CCRA, CCRA progression and sudden cardiac death (SCD) in DM1, we collected ECG/24hECG-Holter data from a ye...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8773-3
更新日期：2018-04-01 00:00:00
abstract：:In patients with Parkinson's disease (PD) disturbances of mental state constitute some of the most difficult treatment challenges of advanced disease, often limiting effective treatment of motor symptoms and leading to increased disability and poor quality of life. This article provides an update on the current knowle...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-004-0483-3
更新日期：2004-07-01 00:00:00
abstract：:We have investigated how the abnormal head posture and motility in spasmodic torticollis interferes with ecological movements such as combined eye-to-foot whole-body reorientations to visual targets. Eight mildly affected patients and 10 controls voluntarily rotated eyes and body in response to illuminated targets of ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-6937-8
更新日期：2013-08-01 00:00:00
abstract：:The United Nations High Commissioner for Refugees (UNHCR) recognizes 43.7 million forcibly displaced persons and asylum seekers due to conflict and persecution worldwide. Neurological disorders have rarely been described in displaced persons but likely pose a significant burden of disease. We describe the disease spec...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6248-x
更新日期：2012-04-01 00:00:00
abstract：:Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System with multifocal areas of demyelination. Although its etiology and pathogenesis remain controversial, several lines of evidence indicate that MS is mediated by a misdirected immune response against one or several myelin proteins. The invol...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150200026
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the relationship between type II diabetes mellitus (T2DM) and ALS incidence using the National Health Insurance Research Database and Serious Disabling Disease database of Taiwan. METHODS:This was a population-based cohort study. The index date was the date of the fir...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09405-x
更新日期：2019-09-01 00:00:00
abstract：: ...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-018-9103-5
更新日期：2019-01-01 00:00:00
abstract：:This review summarizes recent findings from clinical trials regarding the prevention of stroke and translates these into therapeutic guidelines. A distinction is made between patients with previous cerebrovascular disease and those without, and between patients with and those without atrial fibrillation. Although the ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050450
更新日期：1999-09-01 00:00:00
abstract：:The carotid bifurcations and the common carotid arteries of 36 patients with the diagnosis hyperactive carotid sinus syndrome (HCSS) were investigated by continuous wave (CW) Doppler ultrasonography and high-resolution real-time B-scan. Using these non-invasive tests, the functional impact of luminal stenosis and the ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313874
更新日期：1985-01-01 00:00:00
abstract：:Rodent oligodendrocytes have a unique susceptibility among glia to the lytic effects of complement, due in part to a deficiency in CD59 (protectin), a key surface inhibitor of the complement membrane attack complex (MAC). The possibility that shedding of CD59 by human oligodendrocytes contributes to complement-mediate...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00873519
更新日期：1994-08-01 00:00:00
abstract：:The aim of the study was to identify the main factors that impact mobility impairment in multiple sclerosis (MS) patients in Italy. Clinicians from a large number of Italian MS centers took part in a Delphi process aimed at obtaining consensus statements among the participants. Large consensus was obtained for stateme...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7230-6
更新日期：2014-03-01 00:00:00
abstract：:In refractory temporal lobe epilepsy (TLE) temporal lobe structures and functions are continuously or intermittently affected by abnormal brain electrical events, noxious neurochemical agents, and metabolic disturbances. There is conflicting evidence regarding the relationship between the duration of refractory mesial...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050484
更新日期：1999-10-01 00:00:00
abstract：:X-linked adrenoleukodystrophy (XALD), a neurological disorder caused by mutations in the peroxisomal membrane protein gene ABCD1, presents as a rapidly progressing, inflammatory cerebral demyelination (cerebral cases) or a slowly progressing, distal axonopathy (non-cerebral cases). Specific ABCD1 defects do not explai...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6371-8
更新日期：2012-07-01 00:00:00
abstract：INTRODUCTION:Whether different mechanisms, particularly ocular pathology, could lead to the emergence of visual hallucinations (VH) (defined as false perceptions with no external stimulus) versus visual illusions (VI) (defined as a misperception of a real stimulus) in Parkinson's disease (PD) remains debated. We assess...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09925-x
更新日期：2020-10-01 00:00:00
abstract：:The aim of this study was to assess the cognitive functions of patients with spinocerebellar ataxia type 6 (SCA6). We examined 13 patients with genetically confirmed SCA6 and 13 healthy control subjects matched for age, years of education, global cognitive status, and intellectual ability. We administered verbal memor...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8344-4
更新日期：2017-02-01 00:00:00
abstract：:Polymerase chain reaction (PCR) based automated high-resolution fragment analysis of rearranged immunoglobulin heavy-chain genes is a highly sensitive means for identifying clonal B-cell responses. We used this technique to distinguish polyclonal inflammatory from monoclonal neoplastic B-cell populations in the cerebr...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150170247
更新日期：2001-02-01 00:00:00
abstract：:Cerebral amyloid angiopathy (CAA) was found in 57% of 123 autopsy brains removed from patients aged 59-101 years. The incidence of CAA increased with age. CAA was seen most frequently in the occipital cortex. Immunohistochemically, amyloid of CAA was positive for amyloid P component and negative for human AA protein a...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314080
更新日期：1987-08-01 00:00:00
abstract：:The diagnosis of neurosarcoidosis is often difficult; the imaging signs of spinal cord sarcoidosis sometimes mimic those of cervical spondylotic myelopathy, which is common in elderly persons. We examined the characteristics of spinal cord sarcoidosis in Japanese patients with neurosarcoidosis. This case series identi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6080-3
更新日期：2011-12-01 00:00:00
abstract：:Parkinson's disease (PD) is associated with an increased risk of fragility fracture. FRAX and Qfracture are risk calculators that estimate the 10-year risk of hip and major fractures and guide definitive investigation for osteoporosis using dual X-ray absorptiometry (DEXA) imaging. It is unclear which PD patients shou...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7333-8
更新日期：2014-06-01 00:00:00
abstract：:The various clinical features of multiple system atrophy (MSA) make the diagnosis of the disease difficult, especially in its early stages, when signs of differentiated neuroanatomical system involvement have not yet appeared. Mortality studies may be affected by the variability of the diagnostic criteria and selectio...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00868999
更新日期：1996-05-01 00:00:00
abstract：:We discuss two cases receiving different anti-tumornecrosis-factor alpha antagonists (anti-TNF-alpha); one for psoriatic arthritis (PA) and the other for ankylosing spondylitis (AS). Due to neurological symptoms cerebral magnetic resonance imaging (MRI) was performed and cerebral lesions were detected. Our interpretat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-6020-z
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:Crossed aphasia (CA), usually referred to as an acquired language disturbance, is caused by a lesion in the cerebral hemisphere ipsilateral to the dominant hand, and the exact mechanism is not clear. The development of handedness is influenced by education and training and the impact of habitualization, while...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8901-0
更新日期：2018-07-01 00:00:00
abstract：:Epileptic syndromes are distinctive disorders with specific features, which when taken together, permit a specific diagnosis. There is actually a debate on that medial temporal lobe epilepsy with hippocampal sclerosis is an epileptic syndrome. To address this issue, we searched for discriminative semiological features...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8441-z
更新日期：2017-05-01 00:00:00
abstract：:The concentrations of glucose, pyruvate and lactate were determined in the blood and lumbar CSF of 63 patients with neuromuscular disorders and 40 controls. The glucose/lactate and lactate/pyruvate ratios were also calculated, in addition to the cytoplasmic NADH/NAD+ (nicotinamide-adenine dinucleotide-H/nicotinamide-a...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313438
更新日期：1981-01-01 00:00:00
abstract：:The aim of this work was to determine whether survival changed during 2002-2009 at a French amyotrophic lateral sclerosis (ALS) center. We included all patients with ALS who were seen consecutively at the center from January 2002-May 2009. Participants were followed from date of first visit through death, date of cens...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6403-4
更新日期：2012-09-01 00:00:00
abstract：:Cerebellar syndrome is one of the most disabling developments in multiple sclerosis (MS). In neurodegenerative disorders, cerebellar syndrome is thought to be related to a neurochemical deficit of 5-hydroxytryptamine (5-HT). Previous studies found that a levorotatory form of 5-hydroxytryptophan, a 5-HT precursor, and ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00415-003-0176-3
更新日期：2003-10-01 00:00:00
abstract：:Three patients developed acute Guillain-Barré syndrome while on steroid treatment. The first patient suffered from ulcerative colitis and developed Guillain-Barré syndrome when the steroid dosage was being tapered. Another patient with long-standing multiple sclerosis received steroids during relapse and the Guillain-...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314023
更新日期：1986-08-01 00:00:00
abstract：:The influence of portal-systemic shunting on maximal motor nerve conduction velocity (MCV) was analyzed in rats with portacaval shunts. At 3 and 8 weeks after the shunting there was a marked but transient fall in MCV. This was not prevented by colectomy. At 16 weeks the MCV had almost normalized, despite sustained por...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313181
更新日期：1980-01-01 00:00:00
abstract：:We examined the influence of alleles at the HLA loci, previously found to be associated with multiple sclerosis (MS) in Sardinia, on the clinical course of the disease in 835 relapsing (R) and 100 primary progressive (PP) patients. Multivariate analysis was carried out on predisposing 0301 or non-associated DPB1 allel...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0957-y
更新日期：2006-02-01 00:00:00
abstract：:Uric acid (UA) is reduced in multiple sclerosis (MS), and possibly relates to MS outcomes, with lower UA levels in subjects experiencing a relapse or presenting higher disability scores. The present retrospective longitudinal study evaluated UA variations in MS, in relation to clinical relapses, disability progression...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7666-y
更新日期：2015-01-01 00:00:00
