Abstract：
:We have investigated how the abnormal head posture and motility in spasmodic torticollis interferes with ecological movements such as combined eye-to-foot whole-body reorientations to visual targets. Eight mildly affected patients and 10 controls voluntarily rotated eyes and body in response to illuminated targets of eccentricities up to ± 180°. The experimental protocol allowed separate evaluation of the effects of target location, visibility and predictability on movement parameters. Patients' latencies of eye, head, trunk and foot motion were prolonged but showed a normal modification pattern when target location was predictable. Peak head-on-trunk displacement and velocity were reduced both ipsi- and contralaterally with respect to the direction of torticollis. Surprisingly, peak trunk velocity was also reduced, even more than in previously studied patients with Parkinson's disease. As a consequence, patients made short, hypometric gaze saccades and only exceptionally foveated initially nonvisible targets with a single large gaze shift (4 % of predictable trials as opposed to 30 % in controls). Foveation of distant targets was massively delayed by more than half a second on average. Spontaneous dystonic head movements did not interfere with the execution of voluntary gaze shifts. The results show that neck dystonia does not arise from gaze (head-eye) motor centres but the eye-to-foot turning synergy is seriously compromised. For the first time we identify significant 'secondary' complications of torticollis such as trunk bradykinesia and foveation delays, likely to cause additional disability in patients. Eye movements per se are intact and compensate for the reduced head/trunk performance in an adaptive manner.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Anastasopoulos D,Ziavra N,Pearce R,Bronstein AMdoi
10.1007/s00415-013-6937-8subject
Has Abstractpub_date
2013-08-01 00:00:00pages
2057-65issue
8eissn
0340-5354issn
1432-1459journal_volume
260pub_type
杂志文章abstract：:Clinical data and the serum and cerebrospinal fluid (CSF) findings of 71 patients with Guillain-Barré syndrome (GBS), 7 with Fisher syndrome and 24 with chronic inflammatory polyradiculoneuropathy (CIP), were analysed. Isoelectric focusing of serum and CSF together with different formulae and diagrams were applied to ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314019
更新日期：1986-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the role of MR morphometry in the characterization of cerebral microangiopathy (CMA) in relation to clinical and neuropsychological impairment. SUBJECTS AND METHODS:3D MR images of 27 patients and 27 age-matched controls were morphometrically analysed for regional thickness. The normalized values...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0671-9
更新日期：2005-04-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00810351
更新日期：1992-05-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-09964-4
更新日期：2020-06-05 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-010-5880-1
更新日期：2011-06-01 00:00:00
abstract：:The aim of our study was to compare the results obtained by intraoperative and postoperative subthalamic nucleus (STN) macrostimulation in Parkinson's disease (PD). One hundred three PD patients implanted with bilateral STN stimulation were included. The thresholds for efficacy and side effects (motor contraction; par...
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pub_type： 杂志文章
doi：10.1007/s00415-010-5543-2
更新日期：2010-09-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-009-5245-9
更新日期：2009-08-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050274
更新日期：1998-11-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313413
更新日期：1982-01-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050504
更新日期：1999-11-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8901-0
更新日期：2018-07-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314498
更新日期：1989-05-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00839213
更新日期：1992-01-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7578-2
更新日期：2015-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00415-020-09740-4
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7622-2
更新日期：2015-03-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-1057-5
更新日期：2003-06-01 00:00:00
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journal_title：Journal of neurology
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doi：10.1007/s00415-011-6371-8
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journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150170068
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pub_type： 杂志文章
doi：10.1007/BF00936890
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF00819560
更新日期：1992-01-01 00:00:00
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doi：10.1007/s00415-013-7006-z
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09405-x
更新日期：2019-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00812155
更新日期：1992-08-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313858
更新日期：1986-04-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0779-9
更新日期：2008-07-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314023
更新日期：1986-08-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2010-05-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314743
更新日期：1990-08-01 00:00:00
abstract：:The similar localization of intracranial calcification in hypoparathyroidism and in Fahr disease without parathyroid gland disorder suggests that in these two disorders the pathomechanism of calcium phosphate deposition in the brain may be similar. It may be that in Fahr disease some factors, such as chronic respirato...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314315
更新日期：1988-01-01 00:00:00
