Abstract：
OBJECTIVE:The aim of this study was to investigate the relationship between type II diabetes mellitus (T2DM) and ALS incidence using the National Health Insurance Research Database and Serious Disabling Disease database of Taiwan. METHODS:This was a population-based cohort study. The index date was the date of the first T2DM diagnosis + 365 days. We included T2DM patients diagnosis between 2000 and 2013 (n = 2,135,427). These patients were matched by sex, age, urbanization, and insurance premium at a ratio of 1:1 to include patients without diabetes mellitus. Competing risk-adjusted Cox regression analysis was performed to investigate the association between T2DM and the incidence of ALS. RESULTS:In the patients not stratified by age, T2DM was not associated with the incidence of ALS after controlling for confounding factors. The interaction test of age subgroup (< 55 and ≥ 55 years) and T2DM on ALS risk was significance (p < 0.001). Subgroup analysis showed that T2DM was negatively associated with ALS in patients whose age at the first T2DM diagnosis was ≥ 55 years. Among T2DM patients, T2DM combined with hypertension was negatively associated with ALS among patients whose age at the first T2DM diagnosis was ≥ 55 years. Among T2DM patients, T2DM combined with hyperlipidemia was positively associated with ALS among patients whose age at the first T2DM diagnosis was < 55 years. CONCLUSIONS:The late-onset of T2DM may exert negative association with ALS, especially when combined with hypertension. The early-onset of T2DM may exert positive association with ALS, especially when combined with hyperlipidemia.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Tsai CP,Lee JK,Lee CTdoi
10.1007/s00415-019-09405-xsubject
Has Abstractpub_date
2019-09-01 00:00:00pages
2233-2243issue
9eissn
0340-5354issn
1432-1459pii
10.1007/s00415-019-09405-xjournal_volume
266pub_type
杂志文章abstract：:To disclose the neuropathological progression course of Machado-Joseph disease (MJD), magnetic resonance imaging (MRI) findings of six genetically confirmed MJD cases (four males and two females, including an autopsied female, all unrelated to one another) were further investigated on neurodegeneration. Brain MRI stud...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-5992-2
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:To establish differences in basal ganglia and thalamic volume between preclinical carriers and non-carriers of the Huntington's disease (HD) gene and to link the volume to motor, cognitive and behavioural characteristics in carriers. METHODS:Sixteen HD gene carriers without overt clinical motor signs and 14 ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0050-4
更新日期：2008-11-01 00:00:00
abstract：:Multi-modality evoked potentials and computed cranial tomography (CT) were performed in ten patients with Wilson's disease to determine if any of these studies would correlate reliably with neurologic status. While all four patients with CT abnormality had neurologic signs, two additional patients with neurologic find...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314035
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Progression of parkinsonian motor impairment is usually rapid and relentless in multiple system atrophy (MSA). However, it may also be subject to considerable variation. Prospective natural history studies using validated rating scales are required to accurately determine the progression of parkinsonism in M...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0617-2
更新日期：2005-01-01 00:00:00
abstract：:Various parameters of histamine metabolism were studied in patients with migraine, cluster headache and chronic paroxysmal hemicrania. These included urinary excretion of radioactivity and of 14C histamine and its metabolites, exhaled 14CO2 and fecal radioactivity after oral as well as subcutaneous administration of r...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312944
更新日期：1977-09-12 00:00:00
abstract：: ...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-018-9066-6
更新日期：2018-12-01 00:00:00
abstract：:Two right-handed patients who exhibited language disability after left frontal infarction are described. The patients spoke fluently and exhibited excellent repetition ability from the onset of infarction without exhibiting any oral apraxia, but had deficits in auditory comprehension, naming, reading and writing. In b...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050180
更新日期：1998-02-01 00:00:00
abstract：OBJECTIVE:To assess metabolite levels in normal-appearing white matter in sporadic and familial multiple sclerosis (MS). METHODS:Using H-MRS and applying one voxel measure we assessed NAA/Cho, NAA/Cr and Cho/Cr ratios in 26 patients with sporadic and in 25 with familial MS and compared them with healthy subjects. RES...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0754-7
更新日期：2005-07-01 00:00:00
abstract：:Eye movements were studied in 13 patients with Friedreich's ataxia and correlated with MRI findings to investigate whether oculomotor abnormalities can be traced to cerebellar disturbances in this disease. One of the most prominent eye signs was fixation instability (square-wave jerks, SWJ.). Besides SWJ the patients ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00867423
更新日期：1995-08-01 00:00:00
abstract：PURPOSE:Epileptogenic foci exhibit disturbed function at the level of the benzodiazepine receptor. The aim of our study was to investigate the incidence of focal reductions of temporal benzodiazepine receptor binding (BRB) as assessed by scintigraphy with 123I-iomazenil in patients with denovo temporal lobe epilepsy (T...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170136
更新日期：2001-07-01 00:00:00
abstract：:After head injuries, particularly mild or moderate ones, a range of post-concussion symptoms (PCS) are often reported by patients. Such symptoms may significantly affect patients' psychosocial functioning. To date, no measure of the severity of PCS has been developed. This study presents the Rivermead Post Concussion ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00868811
更新日期：1995-09-01 00:00:00
abstract：:Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System with multifocal areas of demyelination. Although its etiology and pathogenesis remain controversial, several lines of evidence indicate that MS is mediated by a misdirected immune response against one or several myelin proteins. The invol...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150200026
更新日期：2002-04-01 00:00:00
abstract：:A total of 15 patients affected by idiopathic dystonia (7 with generalized and 8 with focal or segmental dystonia) were subjected to therapy with bromocriptine at low doses, pimozide and trihexyphenidyl. The symptoms were evaluated by giving a progressive score in relation to the intensity of the dystonic symptom to e...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313391
更新日期：1982-01-01 00:00:00
abstract：:The symptomatology of 18 patients with the severest clinical course after subarachnoid hemorrhage (SAH) is described and analyzed. Seventeen patients died, five with an acute bulbar syndrome with cardiac arrest, and 12 with irreversible breakdown of brain function. One patient had an apallic syndrome with minimal sign...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313005
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVES:There are varying reports on whether monoclonal gammopathy of undetermined significance-associated neuropathy (MGUSN) patients are distinguishable from those with chronic inflammatory demyelinating polyneuropathy (CIDP) and whether specific MGUSN subclasses are associated with specific clinical phenotypes. ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7357-0
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:The frontal assessment battery (FAB) test is a composite tool for assessing executive functions related to the frontal lobe. Neuropsychological and blood-flow studies indicate distinct patterns of deterioration of anterior and posterior cortical function in Alzheimer's disease (AD) and subcortical vascular d...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0251-7
更新日期：2006-11-01 00:00:00
abstract：:Functional changes in the organisation of neuronal circuitries are generally used to explain parkinsonian motor symptoms and levodopa-induced dyskinesias. Based on information from histology and neurophysiological microrecordings of specific basal ganglia nuclei, the most widely accepted scheme is based on a central l...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00007765
更新日期：2000-04-01 00:00:00
abstract：INTRODUCTION:Intracranial lipomas are rare, mostly congenital lesions. Sporadic case reports suggest an association with focal epilepsy. METHODS:All admissions to our epilepsy monitoring unit who had had brain MRI were reviewed for intracranial lipomas during 6 consecutive years. RESULTS:Five patients with intracrani...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0065-7
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To identify the most responsive and sensitive clinical outcome measures in GNE myopathy. METHODS:ClinBio-GNE is a natural history study in GNE myopathy. Patients were assessed prospectively by clinical, functional and quantitative nuclear magnetic resonance imaging (qNMRI) evaluations. Strengt...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09569-6
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:One of the goals in treating subarachnoid hemorrhage patients is to prevent or minimize vasospasm-induced ischemia. Intracerebral microdialysis is a rapidly developing tool to monitor physiological and pathophysiological changes in chemical processes associated with ischemia. OBJECTIVE:To determine the diag...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-003-1079-z
更新日期：2003-07-01 00:00:00
abstract：:Chronic neuropathy is the most frequent condition affecting the peripheral nervous system. It includes symmetrical polyneuropathies, multifocal mononeuropathies, mononeuropathies and radiculopathies. Mononeuropathies are mainly due to compression or entrapment and are not discussed in this review, which focuses on pol...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050326
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:Conflicting findings have been reported on the prognostic significance of serum 25-hydroxyvitamin D level in patients with stroke. The objective of this meta-analysis was to evaluate the prognostic utility of serum 25-hydroxyvitamin D in stroke patients. METHODS:PubMed and Embase databases were systematical...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-019-09599-0
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Putaminal iron deposition is a histopathological feature of multiple system atrophy (MSA), which is not observed in patients with idiopathic Parkinson's disease (PD). T2*-weighted magnetic resonance imaging (MRI) gradient echo (GE) sequences are sensitive for paramagnetic susceptibility changes and therefore...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0496-1
更新日期：2007-09-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS), which is the most serious form of degenerative motor neuron disease in adults, is characterized by upper and lower motor neuron degeneration, skeletal muscle atrophy, paralysis, and death. Some patients with respiratory-dependent ALS die of sudden cardiac arrest or anoxic encephalo...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7005-0
更新日期：2013-09-01 00:00:00
abstract：:The gut with its variety of microbiota may serve as an etiological origin of diseases. Gut microbes may also play a role in the pathogenesis of diseases beyond their simple nutritional maintenance and support. For example, gut protein aggregation, possibly aided by microbes as well as nasal influences, might be linked...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8588-7
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The association between anticardiolipin antibodies (aCL) and thrombosis is well recognized, but its role as an independent risk factor for stroke is not. The study's aim was to investigate the presence of antiphospholipid antibodies (aPL) and ischemic vascular events by using both traditional mea...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-1045-9
更新日期：2003-05-01 00:00:00
abstract：:Leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate (LBSL) is a rare, autosomal recessive disorder caused by mutations in the gene encoding a mitochondrial aspartyl-tRNA synthetase, DARS2. The disease is characterized by progressive spastic ataxia and magnetic resonance imaging (MRI) sh...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6176-9
更新日期：2012-02-01 00:00:00
abstract：:We report two cases of unilateral spatial neglect associated with an isolated right frontal lobe lesion. Case 1 was a 59-year-old, right-handed man, who developed a left hemiplegia, disorientation, and frontal lobe neglect associated with a haemorrhagic contusion following a head injury. Case 2 was a 55-year-old, righ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF00866909
更新日期：1995-10-01 00:00:00
abstract：INTRODUCTION:PCT is used in the diagnosis of acute neurological syndromes, particularly stroke. We aimed to evaluate PCT abnormalities in patients with acute epileptic seizures or status epilepticus (SE). METHODS:We collected patients undergoing acute PCT for the suspicion of acute ischemic stroke (AIS), who received ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-9095-1
更新日期：2018-12-01 00:00:00
abstract：AIMS:To investigate the occurrence of symptomatic peroneal neuropathy (PN) in cancer patients, as well as that of cancer in PN patients and to seek possible factors in the aetiology of PN. METHODS:Clinical, neurographical, and myographical data of patients with PN, in two general neurology clinics during a 5-year peri...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050096
更新日期：1997-05-01 00:00:00
