Diagnosis of chronic neuropathy.

abstract：OBJECTIVE:In order to define the predictors of prolonged survival available at the time of first examination we performed a historical cohort study of amyotrophis sclerosis (ALS) patients referred to our ALS Clinic over the last 20 years. METHODS:In a group of 1034 patients with the diagnosis of definite or probable A...

journal_title：Journal of neurology

authors： Czaplinski A,Yen AA,Appel SH

更新日期：2006-11-01 00:00:00

abstract：:Dementia has a reversible cause in some cases, and these should be diagnosed without over-investigating the many patients with irreversible disease. We prospectively studied the prevalence of reversible dementia in a memory clinic, determined the added value of investigations compared with clinical examination and ass...

journal_title：Journal of neurology

authors： Walstra GJ,Teunisse S,van Gool WA,van Crevel H

更新日期：1997-01-01 00:00:00

abstract：:Acute relapses of multiple sclerosis (MS) are treated with intravenous methylprednisolone (IVMP), which speeds recovery from exacerbation. It is known that IVMP suppresses the immunological activation which occurs during an acute attack of MS. However, the specific target genes affected by this therapy remain obscure....

journal_title：Journal of neurology

authors： Airla N,Luomala M,Elovaara I,Kettunen E,Knuutila S,Lehtimäki T

更新日期：2004-10-01 00:00:00

abstract：:Although awareness of non-motor symptoms in Parkinson's disease (PD) has recently increased, little is known about their recognition and treatment in routine clinical practice. We therefore applied non-motor rating scales for dementia, depression, anxiety and excessive daytime sleepiness to a community-ascertained coh...

journal_title：Journal of neurology

authors： Hu M,Cooper J,Beamish R,Jones E,Butterworth R,Catterall L,Ben-Shlomo Y

更新日期：2011-08-01 00:00:00

abstract：:Multiple System Atrophy (MSA) and idiopathic Parkinson's disease (PD) can be difficult to distinguish. There is an ongoing debate about the diagnostic value of the growth-hormone response to clonidine (CGH-test) in PD and MSA. We investigated whether the CGH-test can identify individual patients in the early stages of...

journal_title：Journal of neurology

authors： Strijks E,van't Hof M,Sweep F,Lenders JW,Oyen WJ,Horstink MW

更新日期：2002-09-01 00:00:00

abstract：:Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) pr...

journal_title：Journal of neurology

authors： Vallet A,Del Campo N,Hoogendijk EO,Lokossou A,Balédent O,Czosnyka Z,Balardy L,Payoux P,Swider P,Lorthois S,Schmidt E

更新日期：2020-05-01 00:00:00

abstract：:Recent years have seen substantial news and updates in the genetics and diagnosis of schwannomas, even a new hereditary disease with schwannomas; Schwannomatosis has been defined. These developments have consequently led to better evaluation of the incidence of schwannomas. Although there has also been progress in the...

journal_title：Journal of neurology

authors： Hanemann CO,Evans DG

更新日期：2006-12-01 00:00:00

abstract：:Silver syndrome/SPG17 is a motor manifestation of mutations in the BSCL2 gene and usually presents as a complicated form of hereditary spastic paraplegia (HSP). We present clinical data, follow-up, and genetic results of seven patients with Silver syndrome/SPG17 including a family with a variable intrafamilial phenoty...

journal_title：Journal of neurology

authors： Musacchio T,Zaum AK,Üçeyler N,Sommer C,Pfeifroth N,Reiners K,Kunstmann E,Volkmann J,Rost S,Klebe S

更新日期：2017-01-01 00:00:00

abstract：:The mechanism underlying the motor fluctuations that develop after long-term L-dopa therapy is not fully known. It has been speculated that malabsorption of L-dopa from the small intestine occurs. It was reported that gastric retention in Parkinson's disease (PD) patients with motor fluctuations is increased as compar...

journal_title：Journal of neurology

authors： Tanaka Y,Kato T,Nishida H,Araki H,Murase M,Nagaki M,Moriwaki H,Inuzuka T

更新日期：2009-12-01 00:00:00

abstract：:A double-blind, placebo-controlled multicentre study was carried out to evaluate the efficacy and tolerability of 100, 200 and 300 mg sumatriptan, a selective 5-hydroxytryptamine (5-HT)1-like receptor agonist, given in an oral dispersible form in the acute treatment of migraine attacks. A total of 1130 patients were r...

journal_title：Journal of neurology

authors： Patten JP

更新日期：1991-01-01 00:00:00

abstract：:Little is known about the relationship between cognitive dysfunctions and the non-motor complex in subjects with newly diagnosed untreated Parkinson's disease (PD). The aim of this study was to explore the association between non-motor symptoms (NMS) and cognitive dysfunctions in an incident cohort of de novo, drug-na...

journal_title：Journal of neurology

authors： Erro R,Santangelo G,Picillo M,Vitale C,Amboni M,Longo K,Costagliola A,Pellecchia MT,Allocca R,De Rosa A,De Michele G,Santoro L,Barone P

更新日期：2012-09-01 00:00:00

abstract：:Four patients with aphasia due to small circumscribed thalamic lesions are presented. A review of the literature on thalamic aphasia revealed 16 similar cases. While the general consensus that only left-sided thalmic lesions are associated with aphasia is confirmed, analysis of the sites of the thalamic infarctions an...

journal_title：Journal of neurology

authors： Bruyn RP

更新日期：1989-01-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) of hand movements in amyotrophic lateral sclerosis (ALS) has repeatedly demonstrated increased activation in cortical and subcortical areas, whereas a single study has suggested decreased rather than increased activations for tongue movements in patients with bulbar involve...

journal_title：Journal of neurology

authors： Kollewe K,Münte TF,Samii A,Dengler R,Petri S,Mohammadi B

更新日期：2011-05-01 00:00:00

abstract：:Suicide is a leading cause of death in Huntington's disease (HD), following pneumonia. Up to one-fifth of individuals with HD report suicidal ideation. Identifying the risk factors of suicidal ideation in this clinical population is thus pivotal. Here, we review the literature on prevalence rates and risk factors of s...

journal_title：Journal of neurology

authors： Honrath P,Dogan I,Wudarczyk O,Görlich KS,Votinov M,Werner CJ,Schumann B,Overbeck RT,Schulz JB,Landwehrmeyer BG,Gur RE,Habel U,Reetz K,Enroll-HD investigators.

更新日期：2018-11-01 00:00:00

abstract：:18FDG-positron emission tomography performed at different stages in the course of subacute sclerosing panencephalitis revealed a changing pattern of metabolic disturbance. In clinical stage II patients the inflammation in the basal ganglia appeared to lead to neuronal excitation accompanied by hypermetabolism. Widespr...

journal_title：Journal of neurology

authors： Huber M,Pawlik G,Bamborschke S,Fink GR,Karbe H,Schlenker M,Bewermeyer H,Heiss WD

更新日期：1992-03-01 00:00:00

abstract：:A total of 15 patients affected by idiopathic dystonia (7 with generalized and 8 with focal or segmental dystonia) were subjected to therapy with bromocriptine at low doses, pimozide and trihexyphenidyl. The symptoms were evaluated by giving a progressive score in relation to the intensity of the dystonic symptom to e...

journal_title：Journal of neurology

authors： Girotti F,Scigliano G,Nardocci N,Angelini L,Broggi G,Giovannini P,Caraceni T

更新日期：1982-01-01 00:00:00

abstract：:Cerebral atrophy calculated from serial MRI is a marker of Alzheimer's disease (AD) progression, and a potential outcome measure for therapeutic trials. Reducing within-subject variability in cerebral atrophy rates by acquiring more than two serial scans could allow for shorter clinical trials requiring smaller patien...

journal_title：Journal of neurology

authors： Schott JM,Frost C,Whitwell JL,Macmanus DG,Boyes RG,Rossor MN,Fox NC

更新日期：2006-09-01 00:00:00

abstract：:In order to learn more on the occurrence of pains and motor deficit in severe diabetic polyneuropathy we reviewed the data of a series of 30 diabetic patients with an uncommonly severe length-dependent diabetic polyneuropathy (LDDP). Extensive sensory loss predominated with pains and temperature sensations and affecte...

journal_title：Journal of neurology

authors： Said G,Baudoin D,Toyooka K

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:D-dimer levels are used in several clinical settings, such as in predicting venous thrombosis, cardioembolic stroke and cancer status. In the present study, we investigated the associations between plasma D-dimer levels at admission, clinical characteristics and mortality at discharge in cryptogenic stroke p...

journal_title：Journal of neurology

authors： Nezu T,Kitano T,Kubo S,Uemura J,Yamashita S,Iwanaga T,Inoue T,Hosomi N,Maruyama H,Matsumoto M,Kimura K,Yagita Y

更新日期：2018-03-01 00:00:00

abstract：:Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease with an estimated incidence of 1 in 8000 and is the most common form of muscular dystrophy affecting adults. An unstable, untranslated part of the myotonic dystrophy protein kinase gene on the long arm of chromosome 19, composed of CTG repeats, is ...

journal_title：Journal of neurology

authors： Brugnoni R,Morandi L,Brambati B,Briscioli V,Cornelio F,Mantegazza R

更新日期：1998-05-01 00:00:00

abstract：:Multiple system atrophy and progressive supranuclear palsy are disabling neurodegenerative disorders, also known as atypical parkinsonian syndromes. Currently, no health economic evaluations of these diseases are available. The objective of this study was to evaluate disease-related costs in German patients with multi...

journal_title：Journal of neurology

authors： Winter Y,Stamelou M,Cabanel N,Sixel-Döring F,Eggert K,Höglinger GU,Herting B,Klockgether T,Reichmann H,Oertel WH,Dodel R,Spottke AE

更新日期：2011-10-01 00:00:00

abstract：:A myasthenia gravis (MG) patient who seems to have recovered can later have recurrence of myasthenic signs. Clearly clinical remission does not always correspond to the normalization of all the factors involved in the pathogenesis of the disease. In ten patients who had apparently recovered from MG, electromyographic ...

journal_title：Journal of neurology

authors： Scoppetta C,Bartoccioni E,David P,Flamini G,Lo Monaco M,Scuderi F,Tonali P

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Anti-myelin oligodendrocyte glycoprotein antibodies (anti-MOG), directed against a component of the myelin sheath, are sometimes detected in the blood or cerebrospinal fluid (CSF) of patients with acute demyelinating conditions. Cortical encephalitic presentations in anti-MOG-antibody-positive patients are reco...

journal_title：Journal of neurology

authors： Doig D,McNamara C,Mewasingh L,Beri S,Jones B,Kachramanoglou C,Jan W

更新日期：2020-10-14 00:00:00

abstract：:We measured changes in brain magnetization transfer ratio (MTR) as a potential indicator of myelin density in brain tissue of patients with relapsing-remitting multiple sclerosis (RRMS) treated with delayed-release dimethyl fumarate (DMF) in the Phase 3 DEFINE study. DEFINE was a randomized, double-blind, placebo-cont...

journal_title：Journal of neurology

authors： Arnold DL,Gold R,Kappos L,Bar-Or A,Giovannoni G,Selmaj K,Yang M,Zhang R,Stephan M,Sheikh SI,Dawson KT

更新日期：2014-12-01 00:00:00

abstract：:A method for the preparation of a potent and specific peroxidase-labelled antihuman IgG antibody is described. CSF cells from patients with various neurological diseases were stained. Only in cases of inflammatory diseases was IgG detectable. The stained cells were so-called lymphoid cells. As the demonstrable IgG can...

journal_title：Journal of neurology

authors： Schädlich HJ,Nekić M,Felgenhauer K

更新日期：1980-01-01 00:00:00

abstract：:Forty-four patients (mean age 66, SD 8 years) with either clinical evidence of a focal lacunar syndrome (n = 36) or with disorders of memory or gait (n = 8) in the presence of a lacunar infarct on CT were studied for cognitive functioning and for the presence of white matter lesions on MRI. MR images were assessed by ...

journal_title：Journal of neurology

authors： van Swieten JC,Staal S,Kappelle LJ,Derix MM,van Gijn J

更新日期：1996-02-01 00:00:00

abstract：:This study aimed at an analysis of the release of Braintype and Heart-type Fatty Acid- Binding Proteins (B-FABP and HFABP) in acute ischaemic stroke and their potential value as neurobiochemical markers of brain damage. We investigated 42 consecutive patients admitted within 6 hours after ischaemic stroke. Serial veno...

journal_title：Journal of neurology

authors： Wunderlich MT,Hanhoff T,Goertler M,Spener F,Glatz JF,Wallesch CW,Pelsers MM

更新日期：2005-06-01 00:00:00

abstract：:Adolescent-onset spastic ataxia is a proposed novel phenotype in compound heterozygous carriers of an intronic mutation (c.1909 + 22G > A) in the POLR3A gene. Here, we present ten new cases of POLR3A-related spastic ataxia and discuss the genetic, clinical and imaging findings. Patients belonged to six pedigrees with ...

journal_title：Journal of neurology

authors： Infante J,Serrano-Cárdenas KM,Corral-Juan M,Farré X,Sánchez I,de Lucas EM,García A,Martín-Gurpegui JL,Berciano J,Matilla-Dueñas A

更新日期：2020-02-01 00:00:00

abstract：:Relapses are a characteristic clinical feature of multiple sclerosis (MS), but an appreciation of factors that cause them remains elusive. In this study, we have examined seasonal variation of relapse in a large population-based MS cohort and correlated observed patterns with age, sex, disease course, and climatic fac...

journal_title：Journal of neurology

authors： Harding K,Tilling K,MacIver C,Willis M,Joseph F,Ingram G,Hirst C,Wardle M,Pickersgill T,Ben-Shlomo Y,Robertson N

更新日期：2017-06-01 00:00:00

abstract：CONTEXT:Polyneuropathy is a common disease and is more prevalent (at least 3 %) in elderly people. However, routine neurological examination of healthy elderly people may show distal sensory loss and absent tendon reflexes, which can obscure the distinction from polyneuropathy. OBJECTIVE:To investigate the relation be...

journal_title：Journal of neurology

authors： Vrancken AF,Kalmijn S,Brugman F,Rinkel GJ,Notermans NC

更新日期：2006-05-01 00:00:00