Abstract：
:Little is known about the relationship between cognitive dysfunctions and the non-motor complex in subjects with newly diagnosed untreated Parkinson's disease (PD). The aim of this study was to explore the association between non-motor symptoms (NMS) and cognitive dysfunctions in an incident cohort of de novo, drug-naive, PD patients. Sixty-six non-demented, early, untreated PD patients completed a semi-structured interview on NMS and a battery of neuropsychological tests that assess verbal memory, visuospatial abilities, and attention/executive functions. Scores were age- and education-corrected. Patients who failed at least two tests for each cognitive domain were diagnosed as having mild cognitive impairment (MCI). All but three (95.4%) PD patients complained of at least one NMS. A total of 37.8% was diagnosed with MCI. There was a relationship between sleep-NMS and cognitive dysfunctions. Specifically, both REM behavioral sleep disorders (RBD) and insomnia were associated with lower scores on several cognitive tests. Moreover, RBD was closely related to MCI. NMS and MCI are very common even in the early phase of PD, before patients are treated. Given the correlation between sleep disturbances and cognitive impairment, it is possible that sleep symptoms in PD patients might be considered as an early marker of dementia.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Erro R,Santangelo G,Picillo M,Vitale C,Amboni M,Longo K,Costagliola A,Pellecchia MT,Allocca R,De Rosa A,De Michele G,Santoro L,Barone Pdoi
10.1007/s00415-011-6407-0subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1808-13issue
9eissn
0340-5354issn
1432-1459journal_volume
259pub_type
杂志文章abstract：BACKGROUND:Adequate cerebral blood flow (CBF) is mainly governed by neurovascular coupling (NC) which adapts local CBF to underlying cortical activity,and cerebral autoregulation (CA)that tends to maintain constant CBF despite changes in arterial blood pressure (BP). Since it was suggested that resistance vessels play ...
journal_title：Journal of neurology
pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s00415-008-5006-1
更新日期：2008-09-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314376
更新日期：1989-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00415-020-10265-z
更新日期：2020-10-13 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of neurology
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pub_type： 临床试验,杂志文章
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更新日期：2013-01-01 00:00:00
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