Epidemiology of neuroimmunological diseases.

abstract：:Recent studies reported mutations in the gene encoding the proline-rich transmembrane protein 2 (PRRT2) to be causative for paroxysmal kinesigenic dyskinesia (PKD), PKD combined with infantile seizures (ICCA), and benign familial infantile seizures (BFIS). PRRT2 is a presynaptic protein which seems to play an importan...

journal_title：Journal of neurology

authors： Becker F,Schubert J,Striano P,Anttonen AK,Liukkonen E,Gaily E,Gerloff C,Müller S,Heußinger N,Kellinghaus C,Robbiano A,Polvi A,Zittel S,von Oertzen TJ,Rostasy K,Schöls L,Warner T,Münchau A,Lehesjoki AE,Zara F,Lerch

更新日期：2013-05-01 00:00:00

abstract：:Genetic evidence indicates a central role of cerebral accumulation of beta-amyloid (Abeta) in the pathogenesis of Alzheimer's disease (AD). Beside presenilin 1 and 2, three other recently discovered proteins (Aph 1, PEN 2 and nicastrin) are associated with gamma-secretase activity, the enzymatic complex generating Abe...

journal_title：Journal of neurology

authors： Sala Frigerio C,Piscopo P,Calabrese E,Crestini A,Malvezzi Campeggi L,Civita di Fava R,Fogliarino S,Albani D,Marcon G,Cherchi R,Piras R,Forloni G,Confaloni A

更新日期：2005-09-01 00:00:00

abstract：:During the last few years, deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as a promising therapy, alleviating major motor symptoms of Parkinson's disease (PD). However, in times of growing budgetary limitations, medical decisions are no longer merely based on clinical efficacy, but also on c...

journal_title：Journal of neurology

authors： Meissner W,Schreiter D,Volkmann J,Trottenberg T,Schneider GH,Sturm V,Deuschl G,Kupsch A

更新日期：2005-02-01 00:00:00

abstract：:Stavudine (2',3'-didehydro-3'deoxythymidine) is a pyrimidine analogue that may be of great value in combination antiretroviral therapy (ART) for treating patients infected with human immunodeficiency virus type 1 (HIV-1). We assessed potential neurotoxic side effects by comparing peripheral nerve function in patients ...

journal_title：Journal of neurology

authors： von Giesen HJ,Hefter H,Jablonowski H,Arendt G

更新日期：1999-03-01 00:00:00

abstract：:The neutrotrophins stimulate survival and differentiation of a range of target neurons. A wealth of evidence suggests that central cholinergic neurons depend on nerve growth factor (NGF) for trophic support. Grafts of NGF-producing cells rescue axotomized basal forebrain cholinergic neurons and reduce cholinergic cell...

journal_title：Journal of neurology

authors： Ebendal T,Lönnerberg P,Pei G,Kylberg A,Kullander K,Persson H,Olson L

更新日期：1994-12-01 00:00:00

abstract：:Natalizumab (NAT) is an effective therapy for relapsing-remitting multiple sclerosis (MS), but is associated with an increased risk of progressive multifocal leucoencephalopathy after 2 years therapy. Thus, NAT treated patients often decide to stop NAT therapy after 2 years. Reports on recurrence of disease activity a...

journal_title：Journal of neurology

authors： Havla J,Gerdes LA,Meinl I,Krumbholz M,Faber H,Weber F,Pellkofer HL,Hohlfeld R,Kümpfel T

更新日期：2011-09-01 00:00:00

abstract：:58 patients with various underlying neurological diseases, who had an impairment of attention, were examined. 12 patients without clinically evident disorders of attention were examined as a control group. The aim of the study was the development of a standardized procedure for the assessment of impaired attention. An...

journal_title：Journal of neurology

authors： von Cramon D,Brinkmann R,Schulz H

更新日期：1975-01-01 00:00:00

abstract：:To analyze the in vivo biological effect of anti-interferon beta (IFN-beta) neutralizing antibodies (NABs), blood concentrations of neopterin, beta2microglobulin (Beta2-MG), mRNA-dependent myxovirusresistant protein A (MxA) and dsRNA-dependent protein kinase (PKR) were measured before (predose) and 24 hours after (pos...

journal_title：Journal of neurology

authors： Scagnolari C,Duda P,Bagnato F,De Vito G,Alberelli A,Lavolpe V,Girardi E,Durastanti V,Trojano M,Kappos L,Antonelli G

更新日期：2007-05-01 00:00:00

abstract：:A total of 21 patients with normal-pressure hydrocephalus were examined. Cerebrospinal fluid (CSF) was collected before and after operation with a ventriculoperitoneal shunt. A slight plasma-like protein pattern indicating a blood-brain barrier (BBB) dysfunction was seen in 38% of the patients before operation. No cha...

journal_title：Journal of neurology

authors： Wikkelsø C,Blomstrand C

更新日期：1982-01-01 00:00:00

abstract：:In order to identify the precise location of the primary motor area for the diaphragm with respect to the classical motor homunculus, functional magnetic resonance imaging (fMRI) experiments were performed utilizing independent component-cross correlation- sequential epoch (ICS) analysis on a high-field (3.0 Tesla) sy...

journal_title：Journal of neurology

authors： Nakayama T,Fujii Y,Suzuki K,Kanazawa I,Nakada T

更新日期：2004-06-01 00:00:00

abstract：:The short-term benefits of levodopa/carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) are well documented, but the long-term benefits are still uncertain. The aim of this study was to investigate the motor and cognitive outcome of LCIG treatment in advanced PD after a follow-up period ...

journal_title：Journal of neurology

authors： Cáceres-Redondo MT,Carrillo F,Lama MJ,Huertas-Fernández I,Vargas-González L,Carballo M,Mir P

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, autoimmune-inflammatory disease of the peripheral nervous system. Recently, various immunoglobulin G4 (IgG4) type auto-antibodies have been described in patients with CIDP which can effectively be removed by immunoadsorption (IA). Therefore, ...

journal_title：Journal of neurology

authors： Dorst J,Ludolph AC,Senel M,Tumani H

更新日期：2018-12-01 00:00:00

abstract：:Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System with multifocal areas of demyelination. Although its etiology and pathogenesis remain controversial, several lines of evidence indicate that MS is mediated by a misdirected immune response against one or several myelin proteins. The invol...

journal_title：Journal of neurology

authors： Correale J,de los Milagros Bassani Molinas M

更新日期：2002-04-01 00:00:00

abstract：:The concentration of neopterin was measured in serum samples taken from individuals infected with HTLV-I: 5 from asymptomatic individuals, 1 from a patient with adult T-cell leukaemia and 30 from patients with tropical spastic paraparesis (TSP). In addition, cerebrospinal fluid (CSF) was available from 22 of the TSP p...

journal_title：Journal of neurology

authors： Ali A,Rudge P,Dalgleish AG

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Adequate cerebral blood flow (CBF) is mainly governed by neurovascular coupling (NC) which adapts local CBF to underlying cortical activity,and cerebral autoregulation (CA)that tends to maintain constant CBF despite changes in arterial blood pressure (BP). Since it was suggested that resistance vessels play ...

journal_title：Journal of neurology

authors： Azevedo E,Rosengarten B,Santos R,Freitas J,Kaps M

更新日期：2007-02-01 00:00:00

abstract：:Four cases of mild botulinus type B intoxication are reported with the clinical neurophysiological studies. Electromyographically tetanic stimulation of the N. ulnaris initially led to tetanic potentiation of the muscle action potential. After an interval without any symptoms tetanic reduction became apparent between ...

journal_title：Journal of neurology

authors： Hagenah R,Müller-Jensen A

更新日期：1978-02-14 00:00:00

abstract：:The cause of idiopathic intracranial hypertension (IIH) remains unknown, and no consensus exists on how patients should be monitored and treated. Acetazolamide is a common treatment but has never been examined in a randomised controlled trial. The objectives of this pilot trial are to prospectively evaluate the use of...

journal_title：Journal of neurology

authors： Ball AK,Howman A,Wheatley K,Burdon MA,Matthews T,Jacks AS,Lawden M,Sivaguru A,Furmston A,Howell S,Sharrack B,Davies MB,Sinclair AJ,Clarke CE

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVES:A study of cognitive, psychological and social aspects in benign multiple sclerosis (MS). Methods One hundred and sixty three patients with benign MS (defined as disease duration > or = 15 years and Expanded Disability Status Scale (EDSS) score < or = 3.0 ) underwent neuropsychological testing on the Rao's B...

journal_title：Journal of neurology

authors： Amato MP,Zipoli V,Goretti B,Portaccio E,De Caro MF,Ricchiuti L,Siracusa G,Masini M,Sorbi S,Trojano M

更新日期：2006-08-01 00:00:00

abstract：:Based on the observation of bilateral temporoparietal hypoperfusion in Alzheimer's disease (AD), single photon emission computed tomography (SPECT) is advocated by some as a powerful diagnostic tool in the evaluation of demented patients. We studied whether routine brain SPECT in elderly, mildly demented outpatients i...

journal_title：Journal of neurology

authors： Van Gool WA,Walstra GJ,Teunisse S,Van der Zant FM,Weinstein HC,Van Royen EA

更新日期：1995-06-01 00:00:00

abstract：:Amyloid positron emission tomography ([18F] florbetaben (FBB) PET) can be used to determine concomitant Alzheimer's disease (AD) in idiopathic normal pressure hydrocephalus (iNPH) patients. FBB PET scans and the tap test were performed in 31 patients with clinically suspected iNPH, and amyloid positive (iNPH/FBB+) and...

journal_title：Journal of neurology

authors： Jang H,Park SB,Kim Y,Kim KW,Lee JI,Kim ST,Lee KH,Kang ES,Choe YS,Seo SW,Kim HJ,Kim YJ,Yoon CW,Na DL

更新日期：2018-01-01 00:00:00

abstract：:Presymptomatic studies in ALS have consistently captured considerable disease burden long before symptom manifestation and contributed important academic insights. With the emergence of genotype-specific therapies, however, there is a pressing need to address practical objectives such as the estimation of age of sympt...

journal_title：Journal of neurology

authors： Chipika RH,Siah WF,McKenna MC,Li Hi Shing S,Hardiman O,Bede P

更新日期：2020-10-31 00:00:00

abstract：:We review the neuronal antibodies described in CNS disorders in order to clarify their diagnostic value, emphasize potentials pitfalls and limitations in the diagnosis of paraneoplastic neurological syndromes (PNS), and examine the current evidence for a possible pathogenic role. We propose to classify the neuronal an...

journal_title：Journal of neurology

authors： Graus F,Saiz A,Dalmau J

更新日期：2010-04-01 00:00:00

abstract：:Continuous intrathecal administration of baclofen with implanted programmable pump systems is recommended in the treatment of severe spasticity of cerebral origin. Prior to pump implantation, a baclofen bolus test (BBT) is used to assess the effectiveness of intrathecal baclofen using the modified Ashworth Scale (MAS)...

journal_title：Journal of neurology

authors： Pohl M,Rockstroh G,Rückriem S,Mehrholz J,Mrass G,Pause M

更新日期：2002-09-01 00:00:00

abstract：:Autonomic dysfunction is frequently observed in patients with multiple sclerosis (MS), but clinical studies disagree on the frequency and type of abnormalities in autonomic function tests. Orthostatic dizziness (OD) has been reported in up to 49% of patients, but the pathophysiological mechanisms are poorly understood...

journal_title：Journal of neurology

authors： Flachenecker P,Wolf A,Krauser M,Hartung HP,Reiners K

更新日期：1999-07-01 00:00:00

abstract：:Few regional and seasonal Guillain-Barré syndrome (GBS) clusters have been reported so far. It is unknown whether patients suffering from sporadic GBS differ from GBS clusters with respect to clinical and paraclinical parameters, HLA association and antibody response to glycosphingolipids and Campylobacter jejuni (Cj)...

journal_title：Journal of neurology

authors： Schirmer L,Worthington V,Solloch U,Loleit V,Grummel V,Lakdawala N,Grant D,Wassmuth R,Schmidt AH,Gebhardt F,Andlauer TF,Sauter J,Berthele A,Lunn MP,Hemmer B

更新日期：2016-10-01 00:00:00

abstract：:Cardiac conduction and/or rhythm abnormalities (CCRA) are the most frequent and life-threatening complications in DM1. In order to determine prevalence, incidence, characteristics, age of onset and predictors of CCRA, CCRA progression and sudden cardiac death (SCD) in DM1, we collected ECG/24hECG-Holter data from a ye...

journal_title：Journal of neurology

authors： Bucci E,Testa M,Licchelli L,Frattari A,El Halabieh NA,Gabriele E,Pignatelli G,De Santis T,Fionda L,Vanoli F,Morino S,Garibaldi M,Di Pasquale A,Vanacore N,Botta A,Antonini G

更新日期：2018-04-01 00:00:00

abstract：:We hypothesize that cerebral microbleeds (CMB) in patients with different neuropsychological profiles (amnestic or non-amnestic) and MRI features of vascular damage could provide important information on the underlying pathological process in early Alzheimer's disease. The study was performed at two trial sites. We st...

journal_title：Journal of neurology

authors： Poliakova T,Levin O,Arablinskiy A,Vasenina E,Zerr I

更新日期：2016-10-01 00:00:00

abstract：:A woman affected by chronic progressive external ophthalmoplegia and muscle mitochondrial DNA deletion was studied by phosphorus magnetic resonance spectroscopy (31P-MRS) prior to and after 1 and 7 months of treatment with oral lipoic acid. Before treatment a decreased phosphocreatine (PCr) content was found in the oc...

journal_title：Journal of neurology

authors： Barbiroli B,Medori R,Tritschler HJ,Klopstock T,Seibel P,Reichmann H,Iotti S,Lodi R,Zaniol P

更新日期：1995-07-01 00:00:00

abstract：:The age-related structural changes of the human hippocampus are not entirely understood. The goal of the present investigation was to understand better the nature of age-related hippocampal changes by a comparative MR-analysis of four complementary aspects of hippocampal integrity: total volume, metabolite concentrati...

journal_title：Journal of neurology

authors： Szentkuti A,Guderian S,Schiltz K,Kaufmann J,Münte TF,Heinze HJ,Düzel E

更新日期：2004-11-01 00:00:00

abstract：:Disease management is defined as any medical or pharmaceutical intervention designed to improve both outcomes for the patient and overall cost-effectiveness of the health plan. Disease management focuses on the patient throughout the entire course of the disease, involving both health providers and third-party payers....

journal_title：Journal of neurology

authors： Matheron L,Barrau K,Blin O

更新日期：1998-08-01 00:00:00