De-escalation from natalizumab in multiple sclerosis: recurrence of disease activity despite switching to glatiramer acetate.

abstract：:Global aphasia is described as a unitary syndrome which is characterized by a severe impairment of all linguistic capabilities. Speech production is extremely limited and consists of stereotyped phrases, recurring utterances or a few isolated words which are usually neologistically distorted. The patients are unable t...

journal_title：Journal of neurology

authors： Stachowiak FJ,Huber W,Kerschensteiner M,Poeck K,Weniger D

更新日期：1977-01-13 00:00:00

abstract：:It is now 10 years since the first report of mutations in the presenilin genes that were deterministic for familial autosomal dominant Alzheimer's disease. The most common of these mutations occurs in the presenilin-1 gene (PSEN1) located on chromosome 14. In the ensuing decade, more than 100 PSEN1 mutations have been...

journal_title：Journal of neurology

authors： Larner AJ,Doran M

更新日期：2006-02-01 00:00:00

abstract：:We should like to emphasize the following points: 1. Apathy is defined here as a quantified and observable behavioral syndrome consisting in a quantitative reduction of voluntary (or goal-directed) behaviors; 2. Therefore, apathy occurs when the systems that generate and control voluntary actions are altered; 3. These...

journal_title：Journal of neurology

authors： Levy R,Czernecki V

更新日期：2006-12-01 00:00:00

abstract：:Acquired copper deficiency has been recognised as a rare cause of anaemia and neutropenia for over half a century. Copper deficiency myelopathy (CDM) was only described within the last decade, and represents a treatable cause of non-compressive myelopathy which closely mimics subacute combined degeneration due to vita...

journal_title：Journal of neurology

authors： Jaiser SR,Winston GP

更新日期：2010-06-01 00:00:00

abstract：:Stroke in young adults is not a rare entity, and often provides difficult management decisions for neurologists. The knowledge gained from stroke in older adults does not transfer easily to this younger group given the different causes of stroke observed. Cardiac causes of stroke are common in this group, but often co...

journal_title：Journal of neurology

authors： Cotter PE,Belham M,Martin PJ

更新日期：2010-11-01 00:00:00

abstract：:The polymorphism of the HLA class II genes was investigated in 97 patients with multiple sclerosis (MS) in Hokkaido, the northernmost main island of Japan. Of these, 80 patients were classified as having conventional MS and 17 as having opticospinal MS (OS-MS). Our findings confirmed a previous report that the DPB 1*0...

journal_title：Journal of neurology

authors： Fukazawa T,Kikuchi S,Sasaki H,Yabe I,Miyagishi R,Hamada T,Tashiro K

更新日期：2000-03-01 00:00:00

abstract：INTRODUCTION:Mounting evidence supports the existence of an important feedforward cycle between sleep and neurodegeneration, wherein neurodegenerative diseases cause sleep and circadian abnormalities, which in turn exacerbate and accelerate neurodegeneration. If so, sleep therapies bear important potential to slow prog...

journal_title：Journal of neurology

authors： Voysey Z,Fazal SV,Lazar AS,Barker RA

更新日期：2020-12-23 00:00:00

abstract：:We investigated the visual event-related potentials (ERPs) in two subtypes of multisystem atrophy (MSA) in 15 MSA-C patients, 12 MSA-P patients, and 21 normal control (NC) subjects. We used a visual oddball task to elicit ERPs. No significant changes were seen in N1 or N2 latency, in either MSA-C or MSA-P, compared wi...

journal_title：Journal of neurology

authors： Kamitani T,Kuroiwa Y,Wang L,Li M,Suzuki Y,Takahashi T,Ikegami T,Matsubara S

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Brain tumors cause significant morbidity and mortality due to rapid progression and high recurrence risks. Reliable biomarkers to improve diagnosis thereof are desirable. OBJECTIVE:This work aimed to identify panels of biomarkers for diagnostic purposes using cerebrospinal fluid (CSF)-based metabolomics. M...

journal_title：Journal of neurology

authors： Wang FX,Chen K,Huang FQ,Alolga RN,Ma J,Wu ZX,Fan Y,Ma G,Guan M

更新日期：2020-04-01 00:00:00

abstract：:Inborn errors of metabolism in 40 children have been investigated by computed tomography to obtain data on the degree of cerebral involvement in neurodegenerative and storage disorders: 20 children had various mucopolysaccharidoses, 8 sphingolipidoses , 3 mucolipidoses, 2 oligosaccharidoses , 3 ceroidlipofuscinoses an...

journal_title：Journal of neurology

authors： Wende S,Ludwig B,Kishikawa T,Rochel M,Gehler J

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years. METHODS:Cross-sectional observational cohort study. 389 largely healthy and cognitively normal older adults were recruited from...

journal_title：Journal of neurology

authors： Buchanan SM,Parker TD,Lane CA,Keshavan A,Keuss SE,Lu K,James SN,Murray-Smith H,Wong A,Nicholas J,Cash DM,Malone IB,Coath W,Thomas DL,Sudre C,Fox NC,Richards M,Schott JM

更新日期：2020-11-01 00:00:00

abstract：:Peripheral neuropathies have various causes, both infectious and non-infectious. When we think of "epidemics", we often refer to an infectious or even post-infectious origin. Nevertheless, the history of mankind is marked by episodes of epidemics of peripheral neuropathies of non-infectious nature, either of nutrition...

journal_title：Journal of neurology

authors： Mathis S,Soulages A,Vallat JM,Le Masson G

更新日期：2020-09-11 00:00:00

abstract：:The type and frequency of neurological manifestations of Behçet's disease (BD) vary with ethnicity. We analyzed the neurological manifestations of BD in Japanese patients. All patients undergoing treatment at one of the two Yokohama City University hospitals from July 1991 to December 2007 and who fulfilled the Japane...

journal_title：Journal of neurology

authors： Ideguchi H,Suda A,Takeno M,Kirino Y,Ihata A,Ueda A,Ohno S,Baba Y,Kuroiwa Y,Ishigatsubo Y

更新日期：2010-06-01 00:00:00

abstract：:A man, aged 63, had an illness which lasted 11 months from onset with pain under the left costal margin which radiated to the epigastrium, until his death from cardiac failure. His symptoms consisted principally of parasthesias and proximal weakness of both upper and lower extremities with atrophy of the shoulder and ...

journal_title：Journal of neurology

authors： Zangemeister WH,Schwendemann G,Colmant HJ

更新日期：1978-04-14 00:00:00

abstract：OBJECTIVE:To assess the overlap of and differences between quantitative muscle MRI and ultrasound in characterizing structural changes in leg muscles of facioscapulohumeral muscular dystrophy (FSHD) patients. METHODS:We performed quantitative MRI and quantitative ultrasound of ten leg muscles in 27 FSHD patients and a...

journal_title：Journal of neurology

authors： Mul K,Horlings CGC,Vincenten SCC,Voermans NC,van Engelen BGM,van Alfen N

更新日期：2018-11-01 00:00:00

abstract：:Current findings suggest that multipotent stem cells may be suitable for cell replacement therapies in the treatment of neurodegenerative disorders. Embryonic stem (ES) cells are pluripotent cells isolated from the inner cell mass of the preimplantation blastocyst, which give rise to all cells in the organism. Similar...

journal_title：Journal of neurology

authors： Gerlach M,Braak H,Hartmann A,Jost WH,Odin P,Priller J,Schwarz J

更新日期：2002-10-01 00:00:00

abstract：:In 40 rabbits cerebral ischaemia was induced by autologous blood clot emboli injected into the middle cerebral artery. Autologous blood clot formed spontaneously (within 2 h) in a catheter fixed in the internal carotid artery. The effects of embolization were investigated on arterial blood pressure, respiration, local...

journal_title：Journal of neurology

authors： Fekete I,Hegedüs K,Molnár L

更新日期：1988-05-01 00:00:00

abstract：:Six patients with amyotrophic lateral sclerosis were given from 800 to 4000 micrograms of thyrotropin-releasing hormone (TRH) intrathecally for a period of 2-6 months. The progressive course of this disease, manifested by increasing atrophy, paralysis and disability score, was not altered. This supports the hypothesis...

journal_title：Journal of neurology

authors： Stober T,Schimrigk K,Dietzsch S,Thielen T

更新日期：1985-01-01 00:00:00

abstract：:In fibromyalgia (FM), reduced habituation of laser-evoked potentials (LEPs) suggests a dysfunction of pain processing at a central level. In this study, we aimed to further examine the nociceptive pathways at the peripheral to the central level in a large group of FM patients by means of LEPs and skin biopsy, in light...

journal_title：Journal of neurology

authors： de Tommaso M,Nolano M,Iannone F,Vecchio E,Ricci K,Lorenzo M,Delussi M,Girolamo F,Lavolpe V,Provitera V,Stancanelli A,Lapadula G,Livrea P

更新日期：2014-03-01 00:00:00

abstract：:In vivo nuclear magnetic resonance spectroscopy (MRS) of the human brain is a recently developed technique which allows to assay noninvasively in vivo key molecules of brain metabolism. After a review of the origin of the signals detected by phosphorus and proton MRS of human brain, the impact of MRS on clinical neuro...

journal_title：Journal of neurology

authors： Vion-Dury J,Meyerhoff DJ,Cozzone PJ,Weiner MW

更新日期：1994-05-01 00:00:00

abstract：:Presymptomatic studies in ALS have consistently captured considerable disease burden long before symptom manifestation and contributed important academic insights. With the emergence of genotype-specific therapies, however, there is a pressing need to address practical objectives such as the estimation of age of sympt...

journal_title：Journal of neurology

authors： Chipika RH,Siah WF,McKenna MC,Li Hi Shing S,Hardiman O,Bede P

更新日期：2020-10-31 00:00:00

abstract：BACKGROUND:Volume loss in the deep gray matter (DGM) has been reported in patients with multiple sclerosis (MS) already at early stages of the disease and is thought to progress throughout the disease course. OBJECTIVE:To investigate the impact and predictive value of volume loss in DGM and thalamic subnuclei on disab...

journal_title：Journal of neurology

authors： Magon S,Tsagkas C,Gaetano L,Patel R,Naegelin Y,Amann M,Parmar K,Papadopoulou A,Wuerfel J,Stippich C,Kappos L,Chakravarty MM,Sprenger T

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Spontaneous cervical artery dissections (sCAD) are often preceded by infections. However, existing data about inflammatory parameters remained inconsistent. Remarkably, concurrent information about the coagulation system, whose affection seems also reasonable to cause ischaemic events, are still lacking in s...

journal_title：Journal of neurology

authors： Pelz JO,Harms K,Metze M,Michalski D

更新日期：2018-02-01 00:00:00

abstract：:Unilateral mesial temporal lobe epilepsy (MTLE) has been associated with reduced amygdala responsiveness to fearful faces. However, the effect of unilateral MTLE on empathy-related brain responses in extra-amygdalar regions has not been investigated. Using functional magnetic resonance imaging, we measured empathy-rel...

journal_title：Journal of neurology

authors： Toller G,Adhimoolam B,Grunwald T,Huppertz HJ,Kurthen M,Rankin KP,Jokeit H

更新日期：2015-03-01 00:00:00

abstract：:Brain metastases occur in 20-40% of patients with cancer and their frequency has increased over time. Lung, breast and skin (melanoma) are the commonest sources of brain metastases, and in up to 15% of patients the primary site remains unknown. After the introduction of MRI, multiple lesions have outnumbered single le...

journal_title：Journal of neurology

authors： Soffietti R,Rudā R,Mutani R

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Due to common pathophysiological findings of Alzheimer's disease (AD) with diabetes mellitus (DM), insulin has been suggested as a possible treatment of AD or mild cognitive impairment (MCI). A safe alternative of IV insulin is intranasal (IN) insulin. The aim of this systematic review is to investi...

journal_title：Journal of neurology

authors： Avgerinos KI,Kalaitzidis G,Malli A,Kalaitzoglou D,Myserlis PG,Lioutas VA

更新日期：2018-07-01 00:00:00

abstract：:The International Cooperative Ataxia Rating Scale (ICARS) is a 100-point semiquantitative scale designed primarily to assess cerebellar dysfunction. However, little is known of the metric properties of this scale. We assessed the ICARS by rating the severity of cerebellar dysfunction in 27 patients with spinocerebella...

journal_title：Journal of neurology

authors： Wang PS,Liu RS,Yang BH,Soong BW

更新日期：2007-06-01 00:00:00

abstract：:Recent studies suggest that the risk of cerebral infarction is increased during the puerperium but not during pregnancy itself. Most of the known causes of ischaemic stroke in the young have been reported during pregnancy. In most of these conditions, it is uncertain whether pregnancy is coincidental or plays a role i...

journal_title：Journal of neurology

authors： Mas JL,Lamy C

更新日期：1998-06-01 00:00:00

abstract：:Cognitive deficits mainly involving visuospatial functions have been defined in patients with bilateral and even unilateral vestibular loss (UVL). We compared the cognitive test results of 21 patients with acute UVL with age- and education-matched healthy controls. The diagnosis of UVL was based on the clinical findin...

journal_title：Journal of neurology

authors： Ayar DA,Kumral E,Celebisoy N

更新日期：2020-12-01 00:00:00

abstract：:The emotional and relationship problems associated with MS have not always been fully appreciated by the medical profession, which has tended to concentrate on the physical aspects of this disease. Yet the psychological problems of MS often cause more suffering than physical effects. ...

journal_title：Journal of neurology

authors： Kesselring J,Klement U

更新日期：2001-03-01 00:00:00