Cerebral ischaemia produced by homologous blood clot emboli in rabbit.

abstract：BACKGROUND:Trans-active response DNA-binding protein of 43 kDa (TDP-43) can be detected in up to 63% of autopsy-confirmed Lewy body disease (LBD) cases. It is unclear whether TDP-43 is associated with a decreased likelihood of a clinical diagnosis of probable dementia with Lewy bodies (pDLB) during life. METHODS:In an...

journal_title：Journal of neurology

authors： Buciuc M,Whitwell JL,Boeve BF,Ferman TJ,Graff-Radford J,Savica R,Kantarci K,Fields JA,Knopman DS,Petersen RC,Parisi JE,Murray ME,Dickson DW,Josephs KA

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Crossed aphasia (CA), usually referred to as an acquired language disturbance, is caused by a lesion in the cerebral hemisphere ipsilateral to the dominant hand, and the exact mechanism is not clear. The development of handedness is influenced by education and training and the impact of habitualization, while...

journal_title：Journal of neurology

authors： Tan X,Guo Y,Dun S,Sun H

更新日期：2018-07-01 00:00:00

abstract：:The use of a dopamine agonist with a long duration of action has theoretical advantages in attempting to reduce the motor fluctuations in Parkinson's disease. We report the results of a double-blind controlled study of adding cabergoline, an ergot derivative with potent long-lasting high affinity for the D2 receptor, ...

journal_title：Journal of neurology

authors： Steiger MJ,El-Debas T,Anderson T,Findley LJ,Marsden CD

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Body weight reduction after disease onset is an independent predictor of survival in amyotrophic lateral sclerosis (ALS), but significance of weight variation after diagnosis remains to be established. OBJECTIVE:To investigate weight variation after diagnosis and its prognostic significance in patients with...

journal_title：Journal of neurology

authors： Shimizu T,Nakayama Y,Matsuda C,Haraguchi M,Bokuda K,Ishikawa-Takata K,Kawata A,Isozaki E

更新日期：2019-06-01 00:00:00

abstract：:Cerebral atrophy calculated from serial MRI is a marker of Alzheimer's disease (AD) progression, and a potential outcome measure for therapeutic trials. Reducing within-subject variability in cerebral atrophy rates by acquiring more than two serial scans could allow for shorter clinical trials requiring smaller patien...

journal_title：Journal of neurology

authors： Schott JM,Frost C,Whitwell JL,Macmanus DG,Boyes RG,Rossor MN,Fox NC

更新日期：2006-09-01 00:00:00

abstract：:The International Cooperative Ataxia Rating Scale (ICARS) is a 100-point semiquantitative scale designed primarily to assess cerebellar dysfunction. However, little is known of the metric properties of this scale. We assessed the ICARS by rating the severity of cerebellar dysfunction in 27 patients with spinocerebella...

journal_title：Journal of neurology

authors： Wang PS,Liu RS,Yang BH,Soong BW

更新日期：2007-06-01 00:00:00

abstract：:We examined the effect of bilateral subthalamic nucleus stimulation on levodopa-resistant balance impairment in 14 patients with Parkinson's disease and 18 matched controls. Instability was quantitatively assessed using standardized multidirectional dynamic posturography. Patients were tested after taking a suprathres...

journal_title：Journal of neurology

authors： Visser JE,Allum JH,Carpenter MG,Esselink RA,Speelman JD,Borm GF,Bloem BR

更新日期：2008-02-01 00:00:00

abstract：:We investigated the levels of transforming growth factor beta 1 (TGF-beta 1) in cerebrospinal fluid (CSF) in children with meningitis, with a view to prognostic relevance. CSF TGF-beta 1 levels on admission were measured by a sandwich enzyme immunoassay in children with bacterial meningitis (n = 16), aseptic meningiti...

journal_title：Journal of neurology

authors： Huang CC,Chang YC,Chow NH,Wang ST

更新日期：1997-10-01 00:00:00

abstract：:Six patients with amyotrophic lateral sclerosis were given from 800 to 4000 micrograms of thyrotropin-releasing hormone (TRH) intrathecally for a period of 2-6 months. The progressive course of this disease, manifested by increasing atrophy, paralysis and disability score, was not altered. This supports the hypothesis...

journal_title：Journal of neurology

authors： Stober T,Schimrigk K,Dietzsch S,Thielen T

更新日期：1985-01-01 00:00:00

abstract：:We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This ...

journal_title：Journal of neurology

authors： Bronzova J,van Duijn CM,Havekes LM,de Knijff P,Van Broeckhoven C,Hofman A

更新日期：1996-06-01 00:00:00

abstract：:In recent years, it has been widely recognised that modern doctors are not receiving the training they need to provide appropriate and effective palliative care. Deficiencies in care have been reported in several formal studies and, anecdotally, in many professional and popular lay publications. Doctors themselves hav...

journal_title：Journal of neurology

authors： Doyle D

更新日期：1997-10-01 00:00:00

abstract：:Hereditary neuropathy with liability to pressure palsies (HNPP) is characterized by recurrent sensory and motor neuropathy in individual nerves starting in adolescence or young adulthood, focal conduction abnormalities at entrapment sites on nerve conduction studies, and sausage-like swellings (tomacula) of the myelin...

journal_title：Journal of neurology

authors： Attarian S,Fatehi F,Rajabally YA,Pareyson D

更新日期：2020-08-01 00:00:00

abstract：:Although seizures in brain tumor patients are common, the knowledge on optimal anti-seizure therapy in this patient group is limited. An observational study was carried out using a database of all patients from the neuro-oncology service during the period 2000-2005, with data on seizure characteristics, therapy with A...

journal_title：Journal of neurology

authors： van Breemen MS,Rijsman RM,Taphoorn MJ,Walchenbach R,Zwinkels H,Vecht CJ

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Adequate cerebral blood flow (CBF) is mainly governed by neurovascular coupling (NC) which adapts local CBF to underlying cortical activity,and cerebral autoregulation (CA)that tends to maintain constant CBF despite changes in arterial blood pressure (BP). Since it was suggested that resistance vessels play ...

journal_title：Journal of neurology

authors： Azevedo E,Rosengarten B,Santos R,Freitas J,Kaps M

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. METHODS:We obtained perfusion images on 32 MCI-LB, 30 MCI-AD and 28 healthy subjects of similar age. Perfusion relative t...

journal_title：Journal of neurology

authors： Firbank MJ,O'Brien JT,Durcan R,Allan LM,Barker S,Ciafone J,Donaghy PC,Hamilton CA,Lawley S,Lloyd J,Roberts G,Taylor JP,Thomas AJ

更新日期：2020-10-21 00:00:00

abstract：OBJECTIVE:To determine the response to treatment and the long-term outcome of patients with the antisynthetase syndrome associated with anti-Jo-1-antibodies. PATIENTS AND METHODS:A total of 12 patients with histologically proven myositis and anti-Jo-1-autoantibodies were evaluated over a mean follow-up period of 66.4 ...

journal_title：Journal of neurology

authors： Späth M,Schröder M,Schlotter-Weigel B,Walter MC,Hautmann H,Leinsinger G,Pongratz D,Müller-Felber W

更新日期：2004-07-01 00:00:00

abstract：:Vertigo is frequently associated with migraine, and sometimes it is the cardinal symptom. This type of migraine is called "vestibular migraine", "migrainous vertigo", or "migraine-associated vertigo". Earlier findings on effective prophylactic medication for such migraine attacks and their clinical features are few an...

journal_title：Journal of neurology

authors： Baier B,Winkenwerder E,Dieterich M

更新日期：2009-03-01 00:00:00

abstract：:The production and release of extracellular vesicles (EV) is a property shared by all eukaryotic cells and a phenomenon frequently exacerbated in pathological conditions. The protein cargo of EV, their cell type signature and availability in bodily fluids make them particularly appealing as biomarkers. We recently dem...

journal_title：Journal of neurology

authors： Denis HL,Lamontagne-Proulx J,St-Amour I,Mason SL,Weiss A,Chouinard S,Barker RA,Boilard E,Cicchetti F

更新日期：2018-11-01 00:00:00

abstract：:To disclose the neuropathological progression course of Machado-Joseph disease (MJD), magnetic resonance imaging (MRI) findings of six genetically confirmed MJD cases (four males and two females, including an autopsied female, all unrelated to one another) were further investigated on neurodegeneration. Brain MRI stud...

journal_title：Journal of neurology

authors： Horimoto Y,Matsumoto M,Akatsu H,Kojima A,Yoshida M,Nokura K,Yuasa H,Katada E,Yamamoto T,Kosaka K,Hashizume Y,Yamamoto H,Mitake S

更新日期：2011-09-01 00:00:00

abstract：:Alemtuzumab is an anti-CD52 monoclonal antibody recently licensed for use in relapsing-remitting multiple sclerosis. Here, we report our experience of its use in neuromyelitis optica (NMO) spectrum disorders. A retrospective case review of patients treated with alemtuzumab in Cambridge, UK, was conducted to identify t...

journal_title：Journal of neurology

authors： Azzopardi L,Cox AL,McCarthy CL,Jones JL,Coles AJ

更新日期：2016-01-01 00:00:00

abstract：:Oculomotor dysfunction in Parkinson's disease (PD) is mainly characterized by a fragmentation of memory-guided gaze shifts (target is reached by several hypometric saccades). Since this phenomenon can also be observed in normal subjects, we scrutinized its pathophysiological significance in PD patients. We recorded ho...

journal_title：Journal of neurology

authors： Kimmig H,Haussmann K,Mergner T,Lücking CH

更新日期：2002-06-01 00:00:00

abstract：:We evaluated the health economic burden of patients with Gilles de la Tourette's syndrome (GTS) in Germany over a 3-month observation period. Direct and indirect costs were evaluated in 200 outpatients with GTS (mean age 35 +/- 11.5 years) in Germany. Patients were recruited from three outpatient departments that spec...

journal_title：Journal of neurology

authors： Dodel I,Reese JP,Müller N,Münchau A,Balzer-Geldsetzer M,Wasem J,Oertel WH,Dodel R,Müller-Vahl K

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The frontal assessment battery (FAB) test is a composite tool for assessing executive functions related to the frontal lobe. Neuropsychological and blood-flow studies indicate distinct patterns of deterioration of anterior and posterior cortical function in Alzheimer's disease (AD) and subcortical vascular d...

journal_title：Journal of neurology

authors： Oguro H,Yamaguchi S,Abe S,Ishida Y,Bokura H,Kobayashi S

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Despite advances in the field, diagnosis and management of the wide spectrum of neurological events post allogeneic hematopoietic cell transplantation (alloHCT) remain challenging. Therefore, we investigated their incidence, diagnosis, management and long-term prognosis in alloHCT recipients. METHODS:We ret...

journal_title：Journal of neurology

authors： Sakellari I,Gavriilaki E,Papagiannopoulos S,Gavriilaki M,Batsis I,Mallouri D,Vardi A,Constantinou V,Masmanidou M,Yannaki E,Smias C,Geroukis T,Kazis D,Kimiskidis V,Anagnostopoulos A

更新日期：2019-08-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare late onset neurodegenerative disorder which presents with autonomic failure and a complicated motor syndrome including atypical parkinsonism, ataxia and pyramidal signs. MSA is a glial alpha-synucleinopathy with rapid progression and currently poor therapeutic management. This p...

journal_title：Journal of neurology

authors： Wenning GK,Stefanova N

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:Two population-based studies of neuromyelitis optica (NMO) in non-white populations provided prevalence rates of 0.32 and 3.1 per 100,000 population. OBJECTIVE:To estimate NMO prevalence in the multiethnic Cuban population by nation-wide case ascertainment. METHODS:The study was conducted from October 1,...

journal_title：Journal of neurology

authors： Cabrera-Gómez JA,Kurtzke JF,González-Quevedo A,Lara-Rodríguez R

更新日期：2009-01-01 00:00:00

abstract：:A case of primary autonomic failure (AF) with uncomplicated Parkinson's disease is presented with clinical and neurophysiological data. Special emphasis is placed on new methods of examining impairment of unmyelinated sympathetic and afferent C-fibres. Sympathetic vasoconstrictor responses in the skin induced by deep ...

journal_title：Journal of neurology

authors： Baron R,Feldmann R,Lindner V

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Volume loss in the deep gray matter (DGM) has been reported in patients with multiple sclerosis (MS) already at early stages of the disease and is thought to progress throughout the disease course. OBJECTIVE:To investigate the impact and predictive value of volume loss in DGM and thalamic subnuclei on disab...

journal_title：Journal of neurology

authors： Magon S,Tsagkas C,Gaetano L,Patel R,Naegelin Y,Amann M,Parmar K,Papadopoulou A,Wuerfel J,Stippich C,Kappos L,Chakravarty MM,Sprenger T

更新日期：2020-05-01 00:00:00

abstract：:Two previously healthy women are described who in their late thirties suffered transient strokelike episodes, consisting of initial headache and vomiting, with various subsequent neurological signs that were only partially reversible. Investigations revealed elevated serum creatine kinase, lactic acidosis, hypertrigly...

journal_title：Journal of neurology

authors： Kremer HP,Keyser A,Wintzen AR,Scholte HR,van Hellenberg Hubar JG,Poorthuis BJ,Ruitenbeek W

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The treatment of MS has always been a focus of neurological research. To date, the US Food and Drug Administration has approved 15 medications for modifying the course of multiple sclerosis. In this study, we exami...

journal_title：Journal of neurology

authors： Li H,Hu F,Zhang Y,Li K

更新日期：2020-12-01 00:00:00