当前位置： SCI文献检索 > JOURNAL OF NEUROLOGY期刊下所有文献 > Level of transforming growth factor beta 1 is elevated in cerebrospinal fluid of children with acute bacterial meningitis.

Level of transforming growth factor beta 1 is elevated in cerebrospinal fluid of children with acute bacterial meningitis.

Abstract：

:We investigated the levels of transforming growth factor beta 1 (TGF-beta 1) in cerebrospinal fluid (CSF) in children with meningitis, with a view to prognostic relevance. CSF TGF-beta 1 levels on admission were measured by a sandwich enzyme immunoassay in children with bacterial meningitis (n = 16), aseptic meningitis (n = 12), and control subjects without evidence of central nervous system (CNS) infection (n = 16). Patients were followed up for a mean duration of 13 months, and neurodevelopmental sequelae was determined for those with bacterial meningitis. On admission, CSF TGF-beta 1 levels were significantly higher in children with bacterial meningitis (mean, standard error, 32.92, 2.36 pg/ml) as opposed to those with aseptic meningitis (25.26, 1.72 pg/ml) (P = 0.0155), or control subjects (20.53, 1.05 pg/ml) (P < 0.0001). The CSF TGF-beta 1 levels in children with aseptic meningitis were higher than those in the control group, but without significance (P = 0.02). No apparent correlation existed between CSF TGF-beta 1 levels and CSF protein or cell counts in patients with bacterial meningitis. No significant difference in CSF TGF-beta 1 levels was found between patients with or without major sequelae following bacterial meningitis.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Huang CC,Chang YC,Chow NH,Wang ST

doi

10.1007/s004150050159

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

634-8

issue

10

eissn

0340-5354

issn

1432-1459

journal_volume

244

pub_type

临床试验,杂志文章

相关文献

JOURNAL OF NEUROLOGY文献大全
  • The role of IVIg in autoimmune neuropathies: the latest evidence.

    abstract：:Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) are the major immune neuropathies. Although a detailed understanding of the pathogenesis of these conditions is not yet available, the multiple effects of IVIg on the immune and inflamm...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-008-3003-z

    authors： Hughes R

    更新日期：2008-07-01 00:00:00

  • CHA(2)DS(2)-VASc score and prognosis in ischemic strokes with atrial fibrillation.

    abstract：:The CHA(2)DS(2)-VASc score was developed to improve stroke risk stratification in atrial fibrillation (AF) patients. We sought to analyze the distribution and prognostic value of the CHA(2)DS(2)-VASc score in a cohort of ischemic stroke patients with AF. In total, 439 consecutive stroke patients with AF were studied. ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-011-6259-7

    authors： Giralt-Steinhauer E,Cuadrado-Godia E,Ois Á,Jiménez-Conde J,Rodríguez-Campello A,Planellas L,Jimena-García S,Rubio MÁ,Roquer-González J

    更新日期：2012-04-01 00:00:00

  • Early Parkinson's disease and non-motor issues.

    abstract：:Non motor symptoms (NMS) of PD are a key determinant of health, quality of life and societal cost of PD. Contrary to common perception, many NMS of PD occur early in PD and some may even predate the diagnosis of PD which is based on motor signs. These include olfactory deficit, sleep problems such as REM behaviour dis...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-008-5006-1

    authors： Chaudhuri KR,Naidu Y

    更新日期：2008-09-01 00:00:00

  • Spinal epidural abscess complicating chronic epidural analgesia in 11 cancer patients: clinical findings and magnetic resonance imaging.

    abstract：:We reviewed the records of all patients who had received an epidural catheter for management of chronic cancer pain in a 3-year period (1993-1996). Patients with nervous system infections were identified, and pertinent clinical, radiological (magnetic resonance imaging), and bacteriological data were analyzed. We iden...

    journal_title：Journal of neurology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s004150050460

    authors： Sillevis Smitt P,Tsafka A,van den Bent M,de Bruin H,Hendriks W,Vecht C,Teng-van de Zande F

    更新日期：1999-09-01 00:00:00

  • Extended phenotype description and new molecular findings in late onset glycogen storage disease type II: a northern Italy population study and review of the literature.

    abstract：:Glycogen storage disease type II (GSDII) is a lysosomal storage disorder caused by acid alpha-1,4-glucosidase deficiency and associated with recessive mutations in its coding gene GAA. Few studies have provided so far a detailed phenotypical characterization in late onset GSDII (LO-GSDII) patients. Genotype-phenotype ...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-013-7137-2

    authors： Remiche G,Ronchi D,Magri F,Lamperti C,Bordoni A,Moggio M,Bresolin N,Comi GP

    更新日期：2014-01-01 00:00:00

  • Long-term results from a phase 2 extension study of fingolimod at high and approved dose in relapsing multiple sclerosis.

    abstract：:Fingolimod safety and efficacy data in relapsing-remitting multiple sclerosis (RRMS) are available up to 5 years, from an extension of a randomized, placebo-controlled, double-blind, phase 2 study, at a dose higher (5.0/1.25 mg) than the approved dose of 0.5 mg. The objective of the study is to present the end-of-stud...

    journal_title：Journal of neurology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00415-015-7834-0

    authors： Montalban X,Comi G,Antel J,O'Connor P,de Vera A,Cremer M,Sfikas N,von Rosenstiel P,Kappos L

    更新日期：2015-12-01 00:00:00

  • Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients.

    abstract：:Patients in a minimally conscious state (MCS) show restricted signs of awareness but are unable to communicate. We assessed cerebral glucose metabolism in MCS patients and tested the hypothesis that this entity can be subcategorized into MCS- (i.e., patients only showing nonreflex behavior such as visual pursuit, loca...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-011-6303-7

    authors： Bruno MA,Majerus S,Boly M,Vanhaudenhuyse A,Schnakers C,Gosseries O,Boveroux P,Kirsch M,Demertzi A,Bernard C,Hustinx R,Moonen G,Laureys S

    更新日期：2012-06-01 00:00:00

  • Update on laser-evoked potential findings in fibromyalgia patients in light of clinical and skin biopsy features.

    abstract：:In fibromyalgia (FM), reduced habituation of laser-evoked potentials (LEPs) suggests a dysfunction of pain processing at a central level. In this study, we aimed to further examine the nociceptive pathways at the peripheral to the central level in a large group of FM patients by means of LEPs and skin biopsy, in light...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-013-7211-9

    authors： de Tommaso M,Nolano M,Iannone F,Vecchio E,Ricci K,Lorenzo M,Delussi M,Girolamo F,Lavolpe V,Provitera V,Stancanelli A,Lapadula G,Livrea P

    更新日期：2014-03-01 00:00:00

  • PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.

    abstract：:A linkage and association of the CD45 (protein-tyrosine phosphatase, receptor-type C) C77G polymorphism and multiple sclerosis (MS) has been found in some studies but not in others. We analysed the C77G polymorphism in MS patients from the genetically homogeneous population of Sardinia. Using the transmission disequil...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-004-0485-1

    authors： Cocco E,Murru MR,Melis C,Schirru L,Solla E,Lai M,Rolesu M,Marrosu MG

    更新日期：2004-09-01 00:00:00

  • Unilateral asterixis.

    abstract：:We describe three patients with unilateral asterixis. One diabetic patient with a moderately-sized haematoma in the left putamen initially developed bilateral and symmetrical asterixis, which became confined to the right side as his diabetes mellitus was controlled. Two patients showed unilateral asterixis due to haem...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314766

    authors： Mizutani T,Shiozawa R,Nozawa T,Nozawa Y

    更新日期：1990-12-01 00:00:00

  • Clinical features of CIS of the brainstem/cerebellum of the kind seen in MS.

    abstract：:Recognition of multiple sclerosis (MS) attacks relies mostly on clinical assessment. However, their definition based on McDonald criteria refers mostly to timing and when dealing with clinical features is rather ambiguous: "...of the kind seen in multiple sclerosis." This is heightened in clinically isolated syndromes...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-009-5403-0

    authors： Sastre-Garriga J,Tintoré M,Nos C,Tur C,Río J,Téllez N,Castilló J,Horga A,Perkal H,Comabella M,Rovira A,Montalban X

    更新日期：2010-05-01 00:00:00

  • Macro EMG follow-up study in post-poliomyelitis patients.

    abstract：:We investigated the muscle strength and motor unit (MU) territory of five patients with postpolio syndrome (PPS), six stable patients with prior poliomyelitis, and five healthy volunteers. The MU territory was assessed by measuring amplitudes of motor unit potentials (MUPs) recorded by the macro EMG technique. The inv...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00920572

    authors： Ivanyi B,Ongerboer de Visser BW,Nelemans PJ,de Visser M

    更新日期：1994-12-01 00:00:00

  • Neurological manifestations of Behçet's disease in Japan: a study of 54 patients.

    abstract：:The type and frequency of neurological manifestations of Behçet's disease (BD) vary with ethnicity. We analyzed the neurological manifestations of BD in Japanese patients. All patients undergoing treatment at one of the two Yokohama City University hospitals from July 1991 to December 2007 and who fulfilled the Japane...

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00415-010-5454-2

    authors： Ideguchi H,Suda A,Takeno M,Kirino Y,Ihata A,Ueda A,Ohno S,Baba Y,Kuroiwa Y,Ishigatsubo Y

    更新日期：2010-06-01 00:00:00

  • Hemiparesis with multiple periventricular enhancing lesions on cranial CT.

    abstract：:A 23-year-old woman had progressive right hemiparesis followed by spontaneous clinical remission. The clinical profile and multifocal contrast-enhancing CT lesions in the periventricular region of the cerebrum favored the diagnosis of an acute demyelinating process. Serial examinations showed resolution of CT abnormal...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313759

    authors： Kuroiwa Y,Nishimura Y,Kobayashi S,Mizoguchi K,Honda N

    更新日期：1982-01-01 00:00:00

  • A study of subtle blood brain barrier disruption in a placebo-controlled trial of natalizumab in relapsing remitting multiple sclerosis.

    abstract：:Natalizumab, an anti-alpha4 integrin antibody, significantly reduces the number of visibly enhancing multiple sclerosis (MS) lesions. In this substudy of a 2-year trial of natalizumab monotherapy versus placebo, contrast-enhanced imaging investigated for subtle blood brain barrier (BBB) leakage in relapsing remitting ...

    journal_title：Journal of neurology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00415-006-0356-z

    authors： Soon D,Altmann DR,Fernando KT,Giovannoni G,Barkhof F,Polman CH,O'Connor P,Gray B,Panzara M,Miller DH

    更新日期：2007-03-01 00:00:00

  • Cluster headache: pathophysiology, diagnosis and treatment.

    abstract：:Cluster headache (CH) is characterized by attacks of severe, strictly unilateral pain that is orbital, supraorbital, temporal, or any combination of these, lasts 15-180 min, and occurs from once every other day to eight times a day. The pain is associated with ipsilateral conjunctival injection, lacrimation, nasal con...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-018-9007-4

    authors： Ljubisavljevic S,Zidverc Trajkovic J

    更新日期：2019-05-01 00:00:00

  • Neuroprotection with glatiramer acetate: evidence from the PreCISe trial.

    abstract：:The phase III, multicenter, randomized, placebo-controlled PreCISe trial assessed glatiramer acetate (GA) effects in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS). To assess the neuroprotective effect of GA in a subset of patients in the PreCISe trial, we used proton magnetic ...

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00415-013-6903-5

    authors： Arnold DL,Narayanan S,Antel S

    更新日期：2013-07-01 00:00:00

  • Systematic review of the clinical spectrum of CASPR2 antibody syndrome.

    abstract：BACKGROUND:Contactin-associated protein-like 2 (CASPR2) autoantibody disease has a variable clinical phenotype. We present a case report and performed a systematic review of the literature to summarize: (1) the clinical phenotype of patients with CASPR2 antibodies, (2) the findings in neurological investigations, and (...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09686-2

    authors： Boyko M,Au KLK,Casault C,de Robles P,Pfeffer G

    更新日期：2020-04-01 00:00:00

  • Systemic risk score evaluation in ischemic stroke patients (SCALA): a prospective cross sectional study in 85 German stroke units.

    abstract：BACKGROUND AND PURPOSE:Stratification of patients with transient ischemic attack (TIA) or ischemic stroke (IS) by risk of recurrent stroke can contribute to optimized secondary prevention. We therefore aimed to assess cardiovascular risk factor profiles of consecutive patients hospitalized with TIA/IS to stratify the r...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-007-0590-z

    authors： Weimar C,Goertler M,Röther J,Ringelstein EB,Darius H,Nabavi DG,Kim IH,Theobald K,Diener HC,SCALA Study Group.

    更新日期：2007-11-01 00:00:00

  • Ischaemic supratentorial stroke: angiographic findings in patients examined in the very early phase.

    abstract：:Eighty patients were studied by angiography within 6 h of an ischaemic stroke. Angiography was carried out with digital equipment and was usually limited to the vascular territory responsible for the neurological deficits. In 12 of 19 patients with internal carotid occlusion, the contralateral side was also studied. T...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314376

    authors： Bozzao L,Fantozzi LM,Bastianello S,Bozzao A,Argentino C,Lenzi GL,Fieschi C

    更新日期：1989-09-01 00:00:00

  • Treatment of amyotrophic lateral sclerosis--what is the next step?

    abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which was thought to be untreatable. However, recent evidence in both experimental animals and men indicates that antiglutamatergic strategies are the first to have an influence on its pathogenesis and slow down the disease process. Since the eff...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/BF03161074

    authors： Ludolph AC

    更新日期：2000-12-01 00:00:00

  • The frequency of spinocerebellar ataxia type 23 in a UK population.

    abstract：:Spinocerebellar ataxias (SCA) are a genetically heterogeneous group of neurodegenerative diseases characterised by progressive cerebellar ataxia, dysarthria and oculomotor abnormalities. Recently the prodynorphin (PDYN) gene was identified as the cause of SCA23 in four Dutch families displaying progressive gait and li...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-012-6721-1

    authors： Fawcett K,Mehrabian M,Liu YT,Hamed S,Elahi E,Revesz T,Koutsis G,Herscheson J,Schottlaender L,Wardle M,Morrison PJ,Morris HR,Giunti P,Wood N,Houlden H

    更新日期：2013-03-01 00:00:00

  • Prevalence of epilepsy in northeast Madrid.

    abstract：:During a period of 42 months, we studied the prevalence of epilepsy in a specific health district, composing by four towns with 98,405 inhabitants older than 10 years. This has been accomplished by a two-phase cross-sectional study. The prevalence rate observed was 4.12/1000 inhabitants for all types of epilepsy. No s...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s004150170091

    authors： Luengo A,Parra J,Colás J,Rámos F,Carreras T,Fernández-Pozos MJ,Muñoz A,Hernando V

    更新日期：2001-09-01 00:00:00

  • Lipoic (thioctic) acid increases brain energy availability and skeletal muscle performance as shown by in vivo 31P-MRS in a patient with mitochondrial cytopathy.

    abstract：:A woman affected by chronic progressive external ophthalmoplegia and muscle mitochondrial DNA deletion was studied by phosphorus magnetic resonance spectroscopy (31P-MRS) prior to and after 1 and 7 months of treatment with oral lipoic acid. Before treatment a decreased phosphocreatine (PCr) content was found in the oc...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00873552

    authors： Barbiroli B,Medori R,Tritschler HJ,Klopstock T,Seibel P,Reichmann H,Iotti S,Lodi R,Zaniol P

    更新日期：1995-07-01 00:00:00

  • The effect of mild microembolic injury on the energy metabolism of the cat brain.

    abstract：:Moderate unilateral cerebral ischemia was produced by microembolism in 24 adult cats. Two million plastic microspheres with a diameter of 15 +/- 5 microns were injected into the left common carotid artery via the lingual artery. The physiological and metabolic responses to embolism were accessed by electrocorticograp...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313342

    authors： Sugi T,Schuier FJ,Hossmann KA,Zülch KJ

    更新日期：1980-01-01 00:00:00

  • Hearing and dementia.

    abstract：:Hearing deficits associated with cognitive impairment have attracted much recent interest, motivated by emerging evidence that impaired hearing is a risk factor for cognitive decline. However, dementia and hearing impairment present immense challenges in their own right, and their intersection in the auditory brain re...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-016-8208-y

    authors： Hardy CJ,Marshall CR,Golden HL,Clark CN,Mummery CJ,Griffiths TD,Bamiou DE,Warren JD

    更新日期：2016-11-01 00:00:00

  • Features of intracranial hemorrhage in cerebral venous thrombosis.

    abstract：BACKGROUND:Cerebral venous thrombosis (CVT) is associated with intracranial hemorrhage. AIM:To identify clinical and imaging features of CVT-associated intracranial hemorrhage. We hypothesized that higher clot burden would be associated with a higher risk of intracranial hemorrhage. METHODS:We performed a retrospecti...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10008-0

    authors： Afifi K,Bellanger G,Buyck PJ,Zuurbier SM,Esperon CG,Barboza MA,Costa P,Escudero I,Renard D,Lemmens R,Hinteregger N,Fazekas F,Conde JJ,Giralt-Steinhauer E,Hiltunen S,Arauz A,Pezzini A,Montaner J,Putaala J,Weimar C,

    更新日期：2020-11-01 00:00:00

  • Mastication-induced vertigo and nystagmus.

    abstract：:Even though trigeminovestibular connections are well established in animals, mastication-induced dizziness has been described only as a vascular steal phenomenon in humans. We determined induction or modulation of nystagmus in two index patients with mastication-induced vertigo, 12 normal controls, and 52 additional p...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-013-7221-7

    authors： Park SH,Kim HJ,Kim JS,Koo JW,Oh SW,Kim DU,Kim JT,Welgampola M,Deriu F

    更新日期：2014-03-01 00:00:00

  • Chorea and polycythaemia.

    abstract：:Two patients with chorea and polycythaemia vera are described. The literature on this rare association is reviewed and its pathophysiology discussed. ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313895

    authors： Mas JL,Gueguen B,Bouche P,Derouesné C,Varet B,Castaigne P

    更新日期：1985-01-01 00:00:00

  • Motor neuron disease and malignancies: results of a population-based study.

    abstract：:Eight cases of malignancies with concurrent motor neuron disease (MND), derived from an unselected population representing all cases of MND diagnosed during a 15-year period in two Italian provinces, were studied to verify the existence of paraneoplastic forms of the disease. No statistically significant association b...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314238

    authors： Chiò A,Brignolio F,Meineri P,Rosso MG,Tribolo A,Schiffer D

    更新日期：1988-07-01 00:00:00