Abstract：
:The neutrotrophins stimulate survival and differentiation of a range of target neurons. A wealth of evidence suggests that central cholinergic neurons depend on nerve growth factor (NGF) for trophic support. Grafts of NGF-producing cells rescue axotomized basal forebrain cholinergic neurons and reduce cholinergic cell death in the medial septum. Skeletal muscle cells, immortalized from embryonic day 15 (E15) rat embryos for transplantation purposes, were transfected with a human NGF construct and individual clones tested for NGF production by a biological assay using embryonic sympathetic ganglia. Clone RM22 showed a consistent ability to produce human recombinant NGF in high concentration; RM22 cells were grafted to the rat brain, following fimbria-fornix lesions, in order to examine the influence of these cells on basal forebrain cholinergic neurons. The results suggest that implantation of genetically modified cells, engineered by the introduction of expression plasmids or viral constructs to produce NGF or other neurotrophins may have therapeutic applications in rescuing damaged central cholinergic neurons in senile dementia of the Alzheimer type as well as in providing trophic support for chromaffin tissue grafts in Parkinson's disease. Moreover, the use of genetically engineered cells may be used to study the effects of administering tailor-made neurotrophins with novel activity profiles.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Ebendal T,Lönnerberg P,Pei G,Kylberg A,Kullander K,Persson H,Olson Ldoi
10.1007/BF00939231subject
Has Abstractpub_date
1994-12-01 00:00:00pages
S5-7issue
1 Suppl 1eissn
0340-5354issn
1432-1459journal_volume
242pub_type
杂志文章,评审abstract：:Elevated intracranial intravenous pressure is not routinely measured in clinical practice. Indirect evidence of increased venous pressure is reflected in the size change of the cerebral sinuses and the presence of venous infarctions. The purpose of this study is to evaluate the role of brain perfusion venous time-dens...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-5955-7
更新日期：2011-08-01 00:00:00
abstract：:We describe three patients with a late presentation of congenital muscular torticollis to emphasize that this non-dystonic type of torticollis has to be considered in the differential diagnosis of cervical dystonia, even in adult patients. Surgery is the treatment of choice. Postoperatively, two of our patients had a ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00868411
更新日期：1996-04-01 00:00:00
abstract：:The geste antagoniste is a voluntary maneuver that temporarily reduces the severity of dystonic posture or movements. It is a classical feature of focal and particularly cervical dystonia. However, the precise historical aspects of geste antagoniste still remain obscure. The goals of this review were (1) to clarify th...
journal_title：Journal of neurology
pub_type： 历史文章,杂志文章
doi：10.1007/s00415-011-6380-7
更新日期：2012-08-01 00:00:00
abstract：: ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09192-5
更新日期：2019-03-01 00:00:00
abstract：:Adolescent-onset spastic ataxia is a proposed novel phenotype in compound heterozygous carriers of an intronic mutation (c.1909 + 22G > A) in the POLR3A gene. Here, we present ten new cases of POLR3A-related spastic ataxia and discuss the genetic, clinical and imaging findings. Patients belonged to six pedigrees with ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09574-9
更新日期：2020-02-01 00:00:00
abstract：:In Huntington's disease (HD) atrophy of the caudate nucleus and putamen has been described many years before clinical manifestation. Volume changes of the pallidum, thalamus, brainstem, accumbens nucleus, hippocampus, and amygdala are less well investigated, or reported with contradicting results. The aim of our study...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-010-5768-0
更新日期：2011-03-01 00:00:00
abstract：:Fifteen patients with Sneddon's syndrome presenting since 1979 were re-examined. After a neurological examination, an orienting test of mental ability as well as an electroencephalogram were performed in all patients. In 10 of the 15 patients computed tomography of the brain was performed, too. Preceding reports and t...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314215
更新日期：1989-01-01 00:00:00
abstract：:Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) are the major immune neuropathies. Although a detailed understanding of the pathogenesis of these conditions is not yet available, the multiple effects of IVIg on the immune and inflamm...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-008-3003-z
更新日期：2008-07-01 00:00:00
abstract：:Autosomal recessive cerebellar ataxia type 3 (ARCA3) is a rare inherited disorder caused by mutations in the ANO10 gene. The disease is characterized by slowly progressive spastic ataxia variably associated with motor neuron involvement, epilepsy, and cognitive decline. We performed mutational screening in 80 patients...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-9141-z
更新日期：2019-02-01 00:00:00
abstract：:Eight cases of malignancies with concurrent motor neuron disease (MND), derived from an unselected population representing all cases of MND diagnosed during a 15-year period in two Italian provinces, were studied to verify the existence of paraneoplastic forms of the disease. No statistically significant association b...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314238
更新日期：1988-07-01 00:00:00
abstract：:Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectivel...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09830-3
更新日期：2020-08-01 00:00:00
abstract：:Parkinson's disease (PD) is a progressive neurological disorder characterized by motor symptoms as well as severe deficits in olfactory function and microstructural changes in olfactory brain regions. Because of the evidence of asymmetric neuropathological features in early-stage PD, we examined whether lateralized mi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8555-3
更新日期：2017-07-01 00:00:00
abstract：:The effects of left- and right-sided hemispheric brain infarction on variability in circadian blood pressure and cardiovascular measures were investigated in 35 patients to test for asymmetry of the sympathetic consequences of stroke. No significant differences regarding age, size of infarction or extent and frequency...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00878874
更新日期：1995-05-01 00:00:00
abstract：:Specific mutations in COL6A3 have recently been reported as the cause of isolated recessive dystonia, which is a rare movement disorder. In all patients, at least one mutation was located in Exons 41 and 42. In an attempt to replicate these findings, we assessed by direct sequencing the frequency of rare variants in E...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8046-y
更新日期：2016-04-01 00:00:00
abstract：:This paper summarizes the methods we devised for the treatment of psychosis, orthostatic hypotension, and mood disorders among the various non-motor complications of Parkinson's disease. Psychosis may not manifest when a patient believes in his/her delusions. If left untreated over a prolonged period, however, the del...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-009-5245-9
更新日期：2009-08-01 00:00:00
abstract：:Central nervous system localizations of sarcoidosis may be refractory to conventional treatment such as steroids and immunosuppressive drugs. Infliximab, a TNF-α antagonist chimeric antibody, has been shown to be effective for treatment of these localizations. The aim of this study was to evaluate the efficacy and saf...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8444-9
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:Lamotrigine (LTG) and valproate (VPA) are widely used in the treatment of generalized epilepsies. Nevertheless seizure aggravation with LTG has been reported in juvenile myoclonic epilepsy and epilepsy with myoclonic absences. The aim of this study was to describe clinical features and EEG findings in patients ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0857-3
更新日期：2002-10-01 00:00:00
abstract：:The MS-ID (Multiple Sclerosis Information Dividend) project was initiated by the European Multiple Sclerosis Platform (EMSP) in 2007 in order to identify and address major inequalities of MS treatment and care and thus eliminate disparities across the EU. One major approach to reach these goals in the longer term is t...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-010-5578-4
更新日期：2010-10-01 00:00:00
abstract：:Rodent oligodendrocytes have a unique susceptibility among glia to the lytic effects of complement, due in part to a deficiency in CD59 (protectin), a key surface inhibitor of the complement membrane attack complex (MAC). The possibility that shedding of CD59 by human oligodendrocytes contributes to complement-mediate...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00873519
更新日期：1994-08-01 00:00:00
abstract：:Stroke in young adults is not a rare entity, and often provides difficult management decisions for neurologists. The knowledge gained from stroke in older adults does not transfer easily to this younger group given the different causes of stroke observed. Cardiac causes of stroke are common in this group, but often co...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-010-5647-8
更新日期：2010-11-01 00:00:00
abstract：:Multiple system atrophy and progressive supranuclear palsy are disabling neurodegenerative disorders, also known as atypical parkinsonian syndromes. Currently, no health economic evaluations of these diseases are available. The objective of this study was to evaluate disease-related costs in German patients with multi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6028-7
更新日期：2011-10-01 00:00:00
abstract：:Mitochondrial diseases are due to impairment of the mitochondrial respiratory chain. A plausible pathogenic mechanism leading to cellular dysfunction and phenotypic expression is oxidative stress, but there are surprisingly few clinical studies on this subject. Glutathione (GSH) deficiency has been reported in mitocho...
journal_title：Journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00415-009-5409-7
更新日期：2010-05-01 00:00:00
abstract：:Several studies have reported infection as a possible risk factor for cervical artery dissection (CAD). We retrospectively analyzed several inflammatory parameters of CAD patients with the aim of detecting differences between spontaneous (n = 25) and traumatic (n = 18) CAD. In this case-control study, we observed sign...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0109-z
更新日期：2006-06-01 00:00:00
abstract：:Leukocyte recruitment and inflammatory response play an important patho-physiologic role after cerebral ischemia. This study aimed to evaluate whether leukocyte adhesion molecules can predict clinical outcome in patients after ischemic stroke. We prospectively examined serial changes in p-selectin glycoprotein ligand-...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5117-3
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Single, modifiable risk factors for stroke have extensively been studied. In contrast, differences of their combined effects among stroke and transitoy ischemic attack (TIA) have been rarely investigated. The aim of the present study was to assess single and joint effects of risk factors on the incidence of ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0358-x
更新日期：2007-03-01 00:00:00
abstract：:The transcranial activation and the conduction properties of corticospinal and callosal neurons were investigated in 12 early-treated adolescents (aged 17.3, SD 3.5 years; range 14-27 years) with phenylketonuria (PKU) by focal transcranial magnetic stimulation (fTMS) of the motor cortex. The patients had no functional...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050301
更新日期：1999-01-01 00:00:00
abstract：:In all the sera of four patients with meningoradiculitis of Bannwarth admitted to the neurological department of the University Clinic Grosshadern in Munich in 1983, we found antibodies against Ixodes dammini spirochetes. In three patients antibodies were also present in the CSF. In one patient, we isolated spirochete...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313682
更新日期：1984-01-01 00:00:00
abstract：:Cerebral palsy (CP) continues to be a major problem in India. The present study provides an insight into the various clinical and neuroradiological correlates of CP. The study included 102 children with CP and was subjected to magnetic resonance imaging (MRI) of the brain. Forty-seven (46%) patients belonged to the 1-...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5782-2
更新日期：2011-03-01 00:00:00
abstract：:In contrast to the distal sensory response, the somatosensory evoked response (SSER) is detectable in patients with A-alpha sensory fiber diseases such as Friedreich's ataxia. In four patients with this disease a combined histological and electro-physiological investigation of sensory propagation was performed. The su...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312980
更新日期：1978-12-22 00:00:00
abstract：:Six patients with amyotrophic lateral sclerosis were given from 800 to 4000 micrograms of thyrotropin-releasing hormone (TRH) intrathecally for a period of 2-6 months. The progressive course of this disease, manifested by increasing atrophy, paralysis and disability score, was not altered. This supports the hypothesis...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314033
更新日期：1985-01-01 00:00:00
