Abstract：
:Elevated intracranial intravenous pressure is not routinely measured in clinical practice. Indirect evidence of increased venous pressure is reflected in the size change of the cerebral sinuses and the presence of venous infarctions. The purpose of this study is to evaluate the role of brain perfusion venous time-density curves in the diagnosis of cerebral venous hypertension. A retrospective review of four cases in which increased cerebral intravenous pressure was reflected in abnormal time-density curves on CT brain perfusion studies was completed. The abnormal venous time-density curves correlated with clinically increased intravenous pressure and normalized after treating the underlying pathology. Abnormal venous outflow affects brain perfusion. This could be identified on a CT brain-perfusion study based on characteristic venous time-density curves. These curves may appear quite similar even when the underlying etiologies are different. Normalization of the venous time-density curves may be observed after the underlying pathology was treated.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Darwish RS,Amiridze NSdoi
10.1007/s00415-011-5955-7subject
Has Abstractpub_date
2011-08-01 00:00:00pages
1445-50issue
8eissn
0340-5354issn
1432-1459journal_volume
258pub_type
杂志文章abstract：:In multiple sclerosis (MS), randomly located demyelination lesions may involve a large part of the central nervous system and disturb oculomotor activity, including impairment of saccadic and pursuit systems. The aim of the work was to determine the frequency of smooth pursuit disturbances in MS patients and assess th...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6014-0
更新日期：2011-10-01 00:00:00
abstract：:The aim of our study was to compare the results obtained by intraoperative and postoperative subthalamic nucleus (STN) macrostimulation in Parkinson's disease (PD). One hundred three PD patients implanted with bilateral STN stimulation were included. The thresholds for efficacy and side effects (motor contraction; par...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5543-2
更新日期：2010-09-01 00:00:00
abstract：:Toxoplasma encephalitis, cryptococcal meningitis, progressive multifocal leukoencephalopathy (PML), and cytomegalovirus (CMV) encephalitis are the most common opportunistic infections of the central nervous system (CNS) in HIV-infected patients. They occur at variable degrees of immunosuppression, and their diagnosis ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050341
更新日期：1999-04-01 00:00:00
abstract：INTRODUCTION:The so called "neurodegenerative Langerhans cell histiocytosis" (ND-LCH) is a rare and severe complication of LCH presenting as a progressive cerebellar ataxia associated with pyramidal tract signs, and cognitive impairment. MRI is the gold standard to investigate CNS lesions of ND-LCH but little is known ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0751-8
更新日期：2008-04-01 00:00:00
abstract：:Disability in multiple sclerosis (MS) patients is associated with white matter (WM) and gray matter (GM) pathology, and both processes contribute differently over the disease course. Total and regional GM volume loss can be imaged via voxel-based morphometry (VBM). Here, we retrospectively analyzed a group of 213 MS p...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8114-3
更新日期：2016-06-01 00:00:00
abstract：:Peripheral neuropathies have various causes, both infectious and non-infectious. When we think of "epidemics", we often refer to an infectious or even post-infectious origin. Nevertheless, the history of mankind is marked by episodes of epidemics of peripheral neuropathies of non-infectious nature, either of nutrition...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10216-8
更新日期：2020-09-11 00:00:00
abstract：:The use of a dopamine agonist with a long duration of action has theoretical advantages in attempting to reduce the motor fluctuations in Parkinson's disease. We report the results of a double-blind controlled study of adding cabergoline, an ergot derivative with potent long-lasting high affinity for the D2 receptor, ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00878534
更新日期：1996-01-01 00:00:00
abstract：:Evidence of a significant improvement of IFNB-1b in clinical severity in the older population with RRMS has not been established so far. The aim of this exploratory post hoc analysis of the 250 mcg IFNB-1b group of the BEYOND study is to compare the efficacy and safety of older versus younger patients using a cut-off ...
journal_title：Journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00415-013-6888-0
更新日期：2013-07-01 00:00:00
abstract：:The diagnosis and management of lesions of the brachial roots and of the brachial plexus is improved by appropriate investigation, both in acute and chronic disorders. The choice of investigation should be determined by the clinical problem. Since they are relatively non-invasive, electrophysiological investigations a...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF00314416
更新日期：1986-06-01 00:00:00
abstract：:Cerebrospinal fluid (CSF) levels of interleukin (IL)-6, IL-11 and leukaemia inhibitory factor (LIF) were evaluated in 43 patients with Alzheimer's disease (AD) and 24 patients with frontotemporal lobar degeneration (FTLD) as compared with 30 agematched controls (CON), and correlated with clinical and demographic data ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0737-6
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Studies provide inconclusive results on the question whether loss of mental wellbeing is actually associated with decline in physical function in amyotrophic lateral sclerosis (ALS). The purpose of this study was to determine predictors of mental wellbeing in ALS. METHODS:In total, n = 330 ALS patients were...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10027-x
更新日期：2020-12-01 00:00:00
abstract：:Idiopathic intracranial hypertension is a neurological syndrome determined by a rise in intracranial pressure without a detectable cause. Course and prognosis may be changeable, requiring a multidisciplinary approach for its diagnosis and management. Although its precise pathogenesis is still unknown, many studies hav...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-09943-9
更新日期：2020-05-27 00:00:00
abstract：:Lipids were extracted from brains of a patient with membranous lipodystrophy (ML) and three normal patients and the neutral lipid and sphingolipid constituents were investigated. The storage of a large amount of free fatty acid was observed in the ML brain, but no cholesterol ester was found. Total lipid, cholesterol ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313947
更新日期：1979-03-22 00:00:00
abstract：:The similar localization of intracranial calcification in hypoparathyroidism and in Fahr disease without parathyroid gland disorder suggests that in these two disorders the pathomechanism of calcium phosphate deposition in the brain may be similar. It may be that in Fahr disease some factors, such as chronic respirato...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314315
更新日期：1988-01-01 00:00:00
abstract：:Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to b...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-018-8903-y
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:The main aim was to explore the changes in hand-grip strength in patients with Duchenne muscular dystrophy (DMD) aged 5-29 years. Secondary aims were to test the effect of mutation, ambulatory status and glucocorticoid use on grip strength and its changes over time and to compute the number of subjects needed...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09800-9
更新日期：2020-07-01 00:00:00
abstract：:Somatostatin levels were measured in cerebrospinal fluid of patients with Alzheimer's disease, multi-infarct dementia and normal pressure hydrocephalus and compared with levels from a normal control group. All pathological groups showed a statistically significant decrease of somatostatin with respect to the control g...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00319684
更新日期：1991-06-01 00:00:00
abstract：:Report of a further case with coexisting diabetes mellitus, diabetes insipidus, optic atrophy und neurogenic deafness. It was not possible to find a cause for these symptoms. The cases reported in the literature are brought together and discussed. ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314325
更新日期：1975-08-04 00:00:00
abstract：:Diminished activity of uroporphyrinogen I-synthetase in the liver and other tissues may be regarded to be the primary genetic deficiency of acute intermittent porphyria (AIP). Increased production and renal excretion of delta-aminolevulinic acid (ALA) und porphobilinogen (PBG) are secondary phenomena. The neuropsychia...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00316572
更新日期：1977-03-21 00:00:00
abstract：PURPOSE:Epileptogenic foci exhibit disturbed function at the level of the benzodiazepine receptor. The aim of our study was to investigate the incidence of focal reductions of temporal benzodiazepine receptor binding (BRB) as assessed by scintigraphy with 123I-iomazenil in patients with denovo temporal lobe epilepsy (T...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170136
更新日期：2001-07-01 00:00:00
abstract：:This observational study examined the outcome of two different therapeutic strategies in the treatment of chronic neuropathic pain by including pregabalin (PGB) as mono- or add-on therapy in one of two treatment options. Patients with a pain score of > or =4, refractory to usual care for neuropathic pain for at least ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5504-9
更新日期：2010-08-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8282-1
更新日期：2016-12-01 00:00:00
abstract：:Disease management is defined as any medical or pharmaceutical intervention designed to improve both outcomes for the patient and overall cost-effectiveness of the health plan. Disease management focuses on the patient throughout the entire course of the disease, involving both health providers and third-party payers....
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00014806
更新日期：1998-08-01 00:00:00
abstract：:The relationship between atherosclerosis and cognitive function is less well studied in Chinese populations. In addition, the results among middle-aged adults have been mixed. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cognitive function in middle-a...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8234-9
更新日期：2016-10-01 00:00:00
abstract：:Small fibre neuropathy (SFN) has been demonstrated in sarcoidosis. However, a systematic analysis of neuropathic pain and autonomic symptoms, key features of SFN, has not been performed. Clinimetric evaluation of pain and autonomic symptoms using the neuropathic pain scale (NPS) and the modified Composite Autonomic Sy...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5664-7
更新日期：2010-12-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disease, leaving the patient in a partially or completely deafferented state. In an explorative study, we investigated responses to visual socio-emotional stimuli in ALS patients. Pictures from the International Affective Picture System (IAPS) were verbally judged by 12 m...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0907-8
更新日期：2005-12-01 00:00:00
abstract：:Acyclovir treatment was used in a randomized, double-blind, placebo-controlled clinical trial with parallel groups to test the hypothesis that herpes virus infections are involved in the pathogenesis of multiple sclerosis (MS). Sixty patients with the relapsing-remitting form of MS were randomized to either oral treat...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00868517
更新日期：1996-03-01 00:00:00
abstract：:DWI has been described in some reports to be superior to FLAIR in early stage herpes simple virus encephalitis (HSE). Few data exist on detailed topographical MRI analysis in HSE. Our aim was to study DWI and FLAIR, and analyse topographically these sequences in non-neonatal HSE patients with MRI performed within 60 d...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7818-0
更新日期：2015-09-01 00:00:00
abstract：:A linkage and association of the CD45 (protein-tyrosine phosphatase, receptor-type C) C77G polymorphism and multiple sclerosis (MS) has been found in some studies but not in others. We analysed the C77G polymorphism in MS patients from the genetically homogeneous population of Sardinia. Using the transmission disequil...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-004-0485-1
更新日期：2004-09-01 00:00:00
abstract：:Cerebellar dysfunction is an important contributor to disability in patients with multiple sclerosis (MS), however, few in vivo studies focused on cerebellar volume loss so far. This relates to technical challenges regarding the segmentation of the cerebellum. In this study, we evaluated the semi-automatic ECCET softw...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6569-4
更新日期：2012-12-01 00:00:00
