Abstract:
:Disability in multiple sclerosis (MS) patients is associated with white matter (WM) and gray matter (GM) pathology, and both processes contribute differently over the disease course. Total and regional GM volume loss can be imaged via voxel-based morphometry (VBM). Here, we retrospectively analyzed a group of 213 MS patients [163 relapsing remitting (RR) and 50 secondary progressive (SP)] using semi-automated white matter (WM) lesion mapping and voxel-based morphometry (VBM). Our aim was to assess the association of increasing disability with decreasing total and regional GM volume. As expected, total GM volume and WM lesion load were associated with patients disability, measured with the Expanded Disability Status Scale (EDSS). The more impaired the patients, the greater the statistical association to the total GM volume. Regional volume loss in the cerebellar gray matter was associated with increasing EDSS and WM lesion volume. Furthermore, SPMS patients had significantly more gray matter volume loss in the cerebellum and the hippocampus compared to RRMS patients. Our results confirm histopathological studies emphasizing the important role of the cerebellum and the hippocampus in MS patients' disability.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Grothe M,Lotze M,Langner S,Dressel Adoi
10.1007/s00415-016-8114-3subject
Has Abstractpub_date
2016-06-01 00:00:00pages
1137-45issue
6eissn
0340-5354issn
1432-1459pii
10.1007/s00415-016-8114-3journal_volume
263pub_type
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6497-3
更新日期:2012-07-01 00:00:00
abstract::To disclose the neuropathological progression course of Machado-Joseph disease (MJD), magnetic resonance imaging (MRI) findings of six genetically confirmed MJD cases (four males and two females, including an autopsied female, all unrelated to one another) were further investigated on neurodegeneration. Brain MRI stud...
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abstract:: ...
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pub_type: 信件
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更新日期:2018-12-01 00:00:00
abstract::Acute porphyrias are a group of inherited metabolic disorders representing overproduction syndromes with the formation of neurotoxic haem precursors. Clinical manifestations consist of acute attacks, which include abdominal pain, dysautonomia, mental symptoms, polyneuropathy and seizures mimicking many other acute neu...
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pub_type: 杂志文章
doi:10.1007/s00415-008-0779-9
更新日期:2008-07-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/pl00007849
更新日期:2002-01-01 00:00:00
abstract::Although silent infarcts (SIs) are frequent in stroke patients, their clinical significance remains controversial, and their effect on stroke outcome remains unclear. This study evaluated the prevalence of SI on computed tomography, associated factors, and the effect on outcome in stroke patients. We studied 202 conse...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150170200
更新日期:2001-04-01 00:00:00
abstract::DWI has been described in some reports to be superior to FLAIR in early stage herpes simple virus encephalitis (HSE). Few data exist on detailed topographical MRI analysis in HSE. Our aim was to study DWI and FLAIR, and analyse topographically these sequences in non-neonatal HSE patients with MRI performed within 60 d...
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pub_type: 杂志文章
doi:10.1007/s00415-015-7818-0
更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-020-10271-1
更新日期:2020-10-21 00:00:00
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pub_type: 杂志文章
doi:10.1007/s004150050504
更新日期:1999-11-01 00:00:00
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journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2005-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s00415-003-0972-9
更新日期:2003-02-01 00:00:00
abstract::Multiple System Atrophy (MSA) and idiopathic Parkinson's disease (PD) can be difficult to distinguish. There is an ongoing debate about the diagnostic value of the growth-hormone response to clonidine (CGH-test) in PD and MSA. We investigated whether the CGH-test can identify individual patients in the early stages of...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-002-0809-y
更新日期:2002-09-01 00:00:00
abstract::An autopsy case of Creutzfeld-Jacob disease with widespread amyloid plaques is reported. A 45-year-old Japanese man, whose father had died of a similar disease, had a 5-year illness characterized by progressive cerebellar signs. Mental changes and brain-stem signs developed in the late stage. Myoclonus frequently occu...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314329
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Elective programs for medical students in the last year of their university training are poorly evaluated. The goal of this study was to determine the gain in theoretical and practical skills in a group of students during their elective in neurology. Students were trained by either conventional teaching meth...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-003-0255-5
更新日期:2003-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0790-3
更新日期:2005-08-01 00:00:00
abstract:: ...
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pub_type: 杂志文章
doi:10.1007/s00415-019-09192-5
更新日期:2019-03-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:
更新日期:1977-05-13 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00415-014-7283-1
更新日期:2014-05-01 00:00:00
abstract::Mutations in the SPG3A gene cause a form of pure, early-onset autosomal dominant hereditary spastic paraplegia linked to chromosome 14q. The encoded protein, atlastin, is a putative member of the dynamin superfamily of large GTPases involved in cellular trafficking patterns. We report a new atlastin mutation causing s...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0768-1
更新日期:2005-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314181
更新日期:1988-05-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10265-z
更新日期:2020-10-13 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6521-7
更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s00415-020-10289-5
更新日期:2020-10-31 00:00:00
abstract:BACKGROUND AND OBJECTIVE:An optimal management of vascular risk factors, associated with antithrombotic drugs and carotid surgery when appropriate, reduces the risk of a new vascular event after stroke. Although secondary prevention is not optimal in many patients in practice, the question of whether there is an improv...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0591-8
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:A study of cognitive, psychological and social aspects in benign multiple sclerosis (MS). Methods One hundred and sixty three patients with benign MS (defined as disease duration > or = 15 years and Expanded Disability Status Scale (EDSS) score < or = 3.0 ) underwent neuropsychological testing on the Rao's B...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0161-8
更新日期:2006-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-014-7489-2
更新日期:2014-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314896
更新日期:1989-10-01 00:00:00
abstract::Recessive mutations in GJC2, the gene-encoding connexin 47 (Cx47), cause Pelizaeus-Merzbacher-like disease type 1, a severe dysmyelinating disorder. One recessive mutation (p.Ile33Met) has been associated with a much milder phenotype--hereditary spastic paraplegia type 44. Here, we present evidence that a novel Arg98L...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-014-7429-1
更新日期:2014-10-01 00:00:00
abstract::Magnetisation transfer (MT) imaging provides indirect information on tissue structure abnormalities in areas that otherwise may appear normal on conventional MRI. We determined the evolution of MT changes in normal appearing white matter (NAWM) and lesion on serial examination of 9 multiple sclerosis (MS) patients and...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-003-1115-z
更新日期:2003-08-01 00:00:00
abstract::We report a rare association of spinocerebellar ataxia and motor neuron disease (MND) in a woman with genetically confirmed SCA2 who subsequently developed a rapidly progressive and fatal form of MND. Considering the rarity of these two neurological conditions, it is interesting to note that the concomitant occurrence...
journal_title:Journal of neurology
pub_type: 信件,评审
doi:10.1007/s00415-009-5237-9
更新日期:2009-11-01 00:00:00