Abstract：
:The cause of idiopathic intracranial hypertension (IIH) remains unknown, and no consensus exists on how patients should be monitored and treated. Acetazolamide is a common treatment but has never been examined in a randomised controlled trial. The objectives of this pilot trial are to prospectively evaluate the use of acetazolamide, to explore various outcome measures and to inform the design of a definitive trial in IIH. Fifty patients were recruited from six centres over 23 months and randomised to receive acetazolamide (n = 25) or no acetazolamide (n = 25). Symptoms, body weight, visual function and health-related quality-of-life measures were recorded over a 12-month period. Recruited patients had typical features of mild IIH and most showed improvement, with 44% judged to have IIH in remission at the end of the trial. Difficulties with recruitment were highlighted as well as poor compliance with acetazolamide therapy (12 patients). A composite measure of IIH status was tested, and the strongest concordance with final disease status was seen with perimetry (Somers' D = 0.66) and optic disc appearance (D = 0.59). Based on the study data, a sample size of 320 would be required to demonstrate a 20% treatment effect in a substantive trial. Clinical trials in IIH require pragmatic design to involve sufficiently large numbers of patients. Future studies should incorporate weighted composite scores to reflect the relative importance of common outcome measures in IIH.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Ball AK,Howman A,Wheatley K,Burdon MA,Matthews T,Jacks AS,Lawden M,Sivaguru A,Furmston A,Howell S,Sharrack B,Davies MB,Sinclair AJ,Clarke CEdoi
10.1007/s00415-010-5861-4subject
Has Abstractpub_date
2011-05-01 00:00:00pages
874-81issue
5eissn
0340-5354issn
1432-1459journal_volume
258pub_type
杂志文章,多中心研究,随机对照试验abstract：:Disability in multiple sclerosis (MS) patients is associated with white matter (WM) and gray matter (GM) pathology, and both processes contribute differently over the disease course. Total and regional GM volume loss can be imaged via voxel-based morphometry (VBM). Here, we retrospectively analyzed a group of 213 MS p...
journal_title：Journal of neurology
pub_type： 杂志文章
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abstract：:Four patients from three unrelated families, with clinical and electrophysiological findings compatible with the diagnosis of hereditary motor and sensory neuropathy, are presented. The molecular analysis showed that the affected individuals were homozygous for the mutation in the X25 gene, characteristic of Friedreic...
journal_title：Journal of neurology
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journal_title：Journal of neurology
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journal_title：Journal of neurology
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journal_title：Journal of neurology
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doi：10.1007/s00415-014-7583-5
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journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
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journal_title：Journal of neurology
pub_type： 杂志文章
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更新日期：2006-07-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8282-1
更新日期：2016-12-01 00:00:00
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pub_type： 信件
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pub_type： 杂志文章,评审
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更新日期：1992-01-01 00:00:00
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