Abstract：
BACKGROUND AND PURPOSE:The association between anticardiolipin antibodies (aCL) and thrombosis is well recognized, but its role as an independent risk factor for stroke is not. The study's aim was to investigate the presence of antiphospholipid antibodies (aPL) and ischemic vascular events by using both traditional means the estimation of aCL and glycoprotein (beta(2)GP1) antibodies. Additionally both aCL/beta(2)GP1 and aPLmix/beta(2)GP1 antibodies were measured. The measurement of these two antibodies was determined by using as target antigens, either cardiolipin alone or a mixture of different phospholipids coated with human beta(2)GP1 in order to select only the autoimmune antibodies. One hundred and twenty-two consecutive patients with first-ever acute ischemic cerebrovascular event were included and compared with controls. The presence of aCl in patients (20.5 %) and controls (14.7 %) was not significantly different (p = 0.1). The presence of abeta(2)GP1 (6.5 % versus 4.9 %, p = 0.7) was also not significant, while there were associations for aCL/b2GP1 13.9 % versus 4.9 % (p = 0.02) and aPLmix/beta(2)GP1 15.6 % versus 4.9 % (p = 0.01). These latter tests seem to be useful in assessing the autoimmune and therefore the thrombogenetic antibodies.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Caso V,Parnetti L,Panarelli P,Magni MP,Gallai V,Albi Edoi
10.1007/s00415-003-1045-9keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
593-7issue
5eissn
0340-5354issn
1432-1459journal_volume
250pub_type
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pub_type： 杂志文章
doi：10.1007/BF00314282
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pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
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更新日期：2003-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00415-009-5208-1
更新日期：2009-11-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1007/BF00313048
更新日期：1979-09-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/BF03161079
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
doi：10.1007/s00415-018-8979-4
更新日期：2018-10-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2018-10-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1993-02-01 00:00:00
