Abstract：
:A 57-year-old male was repeatedly admitted to hospital because of complex neurological symptoms, including radicular pain, disturbance of micturition, seizures, and severely impaired mental state. The diagnosis was encephalomyeloradiculitis possibly of viral origin, and treatment with immunosuppressants was initiated. An alternating course with a tendency towards improvement ensued. Two and a half years after the occurrence of the initial symptoms, identification of specific antibodies in the blood and CSF led to the diagnosis of borreliosis with CNS involvement. High-dose therapy with penicillin rapidly reduced the symptoms, beginning with those of radicular pain and followed by an improvement of the mental state. Attention is directed to the wide spectrum of clinical symptoms of chronic borreliosis with CNS involvement. Previous reports that immunosuppression may result in some improvement but with a tendency towards relapse are confirmed. Our encouraging treatment results support those of other reports that penicillin therapy may lead to improvement even at late chronic stages in patients with severe CNS deficits.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Kollikowski HH,Schwendemann G,Schulz M,Wilhelm H,Lehmann HJdoi
10.1007/BF00314303subject
Has Abstractpub_date
1988-01-01 00:00:00pages
140-2issue
3eissn
0340-5354issn
1432-1459journal_volume
235pub_type
杂志文章abstract：BACKGROUND AND PURPOSE:Parkinson's disease (PD) is a neurodegenerative disorder characterized by deposition of intraneural inclusion bodies in the brain as well as the enteric nervous system. Emerging concepts regarding the brain-gut axis have been proposed for neurological disorders. Thus, the present study investigat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09617-1
更新日期：2020-02-01 00:00:00
abstract：:Inherited ataxias are heterogeneous disorders affecting both children and adults, with over 40 different causative genes, making molecular genetic diagnosis challenging. Although recent advances in next-generation sequencing have significantly improved mutation detection, few treatments exist for patients with inherit...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7476-7
更新日期：2014-11-01 00:00:00
abstract：:Non-motor symptoms (NMS) of Parkinson's disease (PD) have only recently been increasingly recognized for their impact on a patient's quality of life. In this study, we applied the validated, comprehensive self-completed NMS questionnaire for PD (NMS Quest) to 101 patients with young-onset PD (onset between 21 and 45 y...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6600-9
更新日期：2013-01-01 00:00:00
abstract：:A retrospective study was performed to investigate seasonal variation in stroke incidence and to evaluate the hypothesis that cold might be a risk factor. Data were obtained from the central registry of the Hospital de S. João, Porto, Portugal, concerning 4048 patients consecutively admitted for cerebrovascular diseas...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00919594
更新日期：1995-03-01 00:00:00
abstract：:Frequent serial EEG investigations of three patients with neuropathologically confirmed Creutzfeldt-Jakob disease lasting 13, 24 and 68 weeks revealed typical periodic activity of short duration with stereotyped bilateral sharp waves at the 7th, 8th, and 12th week, respectively, after the onset of symptoms. During the...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00328506
更新日期：1989-12-01 00:00:00
abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Recent advances in genetics and pathophysiology have led to new insights into the pathogenesis of PD. Ten loci have been linked to hereditary PD. Mutations in alpha-synuclein and ubiquitin carboxy hydrolase L1 (UchL1) cause autosomal domi...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-003-1304-9
更新日期：2003-10-01 00:00:00
abstract：:Four cases of mild botulinus type B intoxication are reported with the clinical neurophysiological studies. Electromyographically tetanic stimulation of the N. ulnaris initially led to tetanic potentiation of the muscle action potential. After an interval without any symptoms tetanic reduction became apparent between ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312957
更新日期：1978-02-14 00:00:00
abstract：PURPOSE:Anti-myelin oligodendrocyte glycoprotein antibodies (anti-MOG), directed against a component of the myelin sheath, are sometimes detected in the blood or cerebrospinal fluid (CSF) of patients with acute demyelinating conditions. Cortical encephalitic presentations in anti-MOG-antibody-positive patients are reco...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10260-4
更新日期：2020-10-14 00:00:00
abstract：:We present evidence that Willy Loman, the protagonist of Arthur Miller's play "Death of a Salesman", meets current diagnostic criteria for probable dementia with Lewy bodies. In particular, he presents with attentional deficits and executive dysfunction (with additional subtle visuoperceptual deficits) in addition to ...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-019-09343-8
更新日期：2019-07-01 00:00:00
abstract：:Our knowledge of the vestibular sensory system, its functional significance for gaze and posture stabilization, and its capability to ensure accurate spatial orientation perception and spatial navigation has greatly benefitted from experimental approaches using a variety of vertebrate species. This review summarizes t...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-015-7909-y
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the survival motor neuron (SMN)1 gene. The nearly identical SMN2 gene plays a disease modifying role. SMA is classified into four different subtypes based on age of onset and clinical course (SMA types 1-4). The natural history of early onse...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0929-0
更新日期：2008-09-01 00:00:00
abstract：:Eighty patients were studied by angiography within 6 h of an ischaemic stroke. Angiography was carried out with digital equipment and was usually limited to the vascular territory responsible for the neurological deficits. In 12 of 19 patients with internal carotid occlusion, the contralateral side was also studied. T...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314376
更新日期：1989-09-01 00:00:00
abstract：:To clarify the changes of cervical (cVEMP) and ocular (oVEMP) vestibular evoked myogenic potentials induced by air-conducted sound (ACS) and bone-conducted vibration (BCV) in patients with vestibular neuritis (VN), patients with VN (n = 30) and normal controls (n = 45) underwent recording of cVEMP and oVEMP in respons...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-6953-8
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:Lamotrigine (LTG) and valproate (VPA) are widely used in the treatment of generalized epilepsies. Nevertheless seizure aggravation with LTG has been reported in juvenile myoclonic epilepsy and epilepsy with myoclonic absences. The aim of this study was to describe clinical features and EEG findings in patients ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0857-3
更新日期：2002-10-01 00:00:00
abstract：:Hereditary peripheral neuropathies present a group of clinically and genetically heterogeneous entities. All known forms, including the various forms of Charcot-Marie-Tooth disease (CMT) are characterized as Mendelian traits and over 35 genes have been identified thus far. The mutational mechanism of the most common C...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5401-2
更新日期：2010-05-01 00:00:00
abstract：:Optic neuritis usually presents with rapid and gradual loss of vision that is either complete or incomplete, and typically associated with retro-orbital pain. To our knowledge there have been no documented reports of optic neuritis presenting with multiple episodes of amaurosis fugax, the sudden and transient loss of ...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-009-5302-4
更新日期：2009-12-01 00:00:00
abstract：:The greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination; doing so restores nerve conduction and prevents neurodegeneration. The biology of remyelination-cent...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-019-09421-x
更新日期：2021-01-01 00:00:00
abstract：:Silver syndrome/SPG17 is a motor manifestation of mutations in the BSCL2 gene and usually presents as a complicated form of hereditary spastic paraplegia (HSP). We present clinical data, follow-up, and genetic results of seven patients with Silver syndrome/SPG17 including a family with a variable intrafamilial phenoty...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8301-2
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:To identify factors that impact on the ability of patients with multiple sclerosis (MS) to remain in work in order to make recommendations for future clinical management. METHODS:Cross-sectional studies using qualitative (phase one) and quantitative (phase two) methods. In phase one, 62 patients were intervi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0765-4
更新日期：2005-08-01 00:00:00
abstract：:The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer's disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patient...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050351
更新日期：1999-04-01 00:00:00
abstract：:This short review summarizes epilepsy papers published in the Journal of Neurology in 2009, covering pathophysiology (inflammation; propagation pathways), new treatments (oxcarbazepine in paediatrics; levetiracetam in status epilepticus), and non-seizure outcomes (violence; foetal/pregnancy). ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-010-5740-z
更新日期：2010-11-01 00:00:00
abstract：:Currently, several disease-modifying therapies for the treatment of multiple sclerosis are established and more are likely to be introduced. These treatment options differ with respect to their application profile, mechanism of action, efficacy, safety, and tolerance. Here, we review current concepts of MS therapies, ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-011-6101-2
更新日期：2011-10-01 00:00:00
abstract：:We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent co...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF02444004
更新日期：1996-02-01 00:00:00
abstract：:Seventy-seven cases of the optic-spinal form of multiple sclerosis (OSMS) were collected from 6 institutes in 3 cities of Japan, and the clinical and MRI features were analyzed. Two-thirds of the OSMS patients had longitudinally extensive spinal cord MRI lesions (LESL), and had clinical features similar to those of re...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-006-0400-z
更新日期：2007-04-01 00:00:00
abstract：:We report the effects of intravenous gamma-globulin (IVGG) in severe Guillain-Barré syndrome (GBS) in a small open study. Seven patients were given IVGG (0.4 g/kg/day) for 5 consecutive days. At the start of treatment all had progressing limb weakness and none could stand unaided. Within 24 h all but one patient start...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00838447
更新日期：1993-01-01 00:00:00
abstract：:Four patients with aphasia due to small circumscribed thalamic lesions are presented. A review of the literature on thalamic aphasia revealed 16 similar cases. While the general consensus that only left-sided thalmic lesions are associated with aphasia is confirmed, analysis of the sites of the thalamic infarctions an...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF00314212
更新日期：1989-01-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS), which is the most serious form of degenerative motor neuron disease in adults, is characterized by upper and lower motor neuron degeneration, skeletal muscle atrophy, paralysis, and death. Some patients with respiratory-dependent ALS die of sudden cardiac arrest or anoxic encephalo...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7005-0
更新日期：2013-09-01 00:00:00
abstract：:Homozygous mutations in the PINK1 gene have been shown to cause early-onset parkinsonism. Here, we describe a novel homozygous mutation (Q126P), identified in two affected German sisters with a clinical phenotype typical for PINK1-associated parkinsonism. We analysed lactate, pyruvate, carnitine and acylcarnitine bloo...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0763-4
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Spontaneous cervical artery dissections (sCAD) are often preceded by infections. However, existing data about inflammatory parameters remained inconsistent. Remarkably, concurrent information about the coagulation system, whose affection seems also reasonable to cause ischaemic events, are still lacking in s...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8696-4
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:A study of cognitive, psychological and social aspects in benign multiple sclerosis (MS). Methods One hundred and sixty three patients with benign MS (defined as disease duration > or = 15 years and Expanded Disability Status Scale (EDSS) score < or = 3.0 ) underwent neuropsychological testing on the Rao's B...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0161-8
更新日期：2006-08-01 00:00:00
