Abstract:
:We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent complications were mental status changes ranging from delirium to coma and seizures. The aetiology was multifactorial, cyclosporin A neurotoxicity being the main cause. Patients with neurological complications had a higher mortality rate than those without. In our series, neurological complications represented a major medical problem with increased morbidity and mortality.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Guarino M,Stracciari A,Pazzaglia P,Sterzi R,Santilli I,Donato F,D'Alessandro Rdoi
10.1007/BF02444004subject
Has Abstractpub_date
1996-02-01 00:00:00pages
137-42issue
2eissn
0340-5354issn
1432-1459journal_volume
243pub_type
杂志文章abstract:OBJECTIVE:To characterize the progression of the cognitive involvement in patients affected by myotonic dystrophy type 1 (DM1) by a longitudinal neuropsychological follow-up study. METHODS:In a previous study we documented an ageing-related decline of frontal and temporal cognitive functions in juvenile/adult forms of...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0017-5
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To investigate possible changes in autonomic cardiovascular regulation and cardiopulmonary baroreflex sensitivity in patients with primary cervical dystonia receiving chronic treatment with botulinum toxin type A. METHODS:Short-term power spectral analysis of heart rate and systolic blood pressure variabilit...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0753-6
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Therapy of autoimmune diseases of the central and peripheral nervous system with intravenous IgG immunoglobulin (IVIg) is well established. Since IVIg is produced from pooled human plasma, autoantibodies can be found in IVIg products and, accordingly, in patient sera after transfusion. The de novo evidence o...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09614-4
更新日期:2020-03-01 00:00:00
abstract::Two siblings with Lafora disease (LD) are described: one with epilepsy, myoclonus, EEG abnormalities, severe dementia and many Lafora bodies (LBs) in muscle and skin tissue; the other with myoclonus, epilepsy, EEG abnormalities and LBs in muscle and in skin tissue, without dementia. The findings suggest that the diagn...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314784
更新日期:1991-07-01 00:00:00
abstract:INTRODUCTION:Intracranial lipomas are rare, mostly congenital lesions. Sporadic case reports suggest an association with focal epilepsy. METHODS:All admissions to our epilepsy monitoring unit who had had brain MRI were reviewed for intracranial lipomas during 6 consecutive years. RESULTS:Five patients with intracrani...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0065-7
更新日期:2006-05-01 00:00:00
abstract::Cerebral atrophy calculated from serial MRI is a marker of Alzheimer's disease (AD) progression, and a potential outcome measure for therapeutic trials. Reducing within-subject variability in cerebral atrophy rates by acquiring more than two serial scans could allow for shorter clinical trials requiring smaller patien...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0173-4
更新日期:2006-09-01 00:00:00
abstract::Apoptotic deletion of autoreactive T-cells is defective in patients with multiple sclerosis (MS). Glatiramer acetate (GA) treatment seems to restore apoptosis of detrimental T-cells. We analyzed the mitochondria membrane pro- (Bax) and anti-apoptotic (Bcl- 2) and cytosolic pro-apoptotic (Cyt-c, APAF-1) proteins expres...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0965-y
更新日期:2006-02-01 00:00:00
abstract::Seventy-seven cases of the optic-spinal form of multiple sclerosis (OSMS) were collected from 6 institutes in 3 cities of Japan, and the clinical and MRI features were analyzed. Two-thirds of the OSMS patients had longitudinally extensive spinal cord MRI lesions (LESL), and had clinical features similar to those of re...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-006-0400-z
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:As metabolic and structural changes in frontotemporal-subcortical pathways have been reported in patients with obsessive-compulsive disorders, we investigated the correlation between complex compulsive behaviour (CCB) and the distribution of atrophy in a group of 90 patients with frontotemporal dementia (FTD)...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150170049
更新日期:2001-11-01 00:00:00
abstract:RATIONALE:Phase I/II studies of autologous hematopoietic stem cell transplantation (HSCT) for multiple sclerosis ( MS) were initiated, based on results of experimental transplantation in animal models of multiple sclerosis and clinical observations in patients treated concomitantly for malignant disease. PATIENTS:Eigh...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00415-002-0800-7
更新日期:2002-08-01 00:00:00
abstract:: ...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-018-9103-5
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The increase in disease-modifying drugs (DMDs) allows individualization of treatment in relapsing multiple sclerosis (RMS); however, the long-term impact of different treatment sequences is not well established. This is particularly relevant for MS patients who may need to postpone more aggressive DMD strate...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-019-09531-6
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To quantify spinal cord atrophy and its impact on clinical disability in spinocerebellar ataxia (SCA) type 3 and 6. METHODS:Atrophy of the upper spinal cord was assessed by high resolution T1-weighted MRI of patients with SCA3 (n = 14) and SCA6 (n = 10). Furthermore, two groups of age- and sex-matched health...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0907-6
更新日期:2008-08-01 00:00:00
abstract::The hereditary spastic paraplegias (HSPs) are a group of genetic conditions in which spastic paralysis of the legs is the principal clinical feature. This is caused by a relatively selective distal axonal degeneration involving the longest axons of the corticospinal tracts. Consequently, these conditions provide an op...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-014-7598-y
更新日期:2015-07-01 00:00:00
abstract::The number of dementia patients requesting euthanasia in the Netherlands has increased over the past five years. The issue is highly controversial. In this contribution we discuss some of the main arguments: the nature of suffering, the voluntariness of the request and the role of the physician. We argue that society ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-016-8095-2
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Determine toxicity and efficacy of autologous hematopoietic stem cell transplantation (HSCT) for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who are dependent on intravenous immunoglobulins or plasmapheresis. METHODS:Unselected peripheral blood stem cells were re-infused on...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10010-6
更新日期:2020-11-01 00:00:00
abstract::This review gives an overview of various neuroimmunological diseases in terms of incidence and prevalence rates, age and sex distribution, and the frequency of subtypes, if applicable. The disorders selected for review are inflammatory muscle disorders (polymyositis, dermatomyositis and inclusion body myositis), myast...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-006-5001-3
更新日期:2006-09-01 00:00:00
abstract::Movement-associated cortical potentials (MP) associated with thumb-opposition or fist-clenching were studied in 20 patients with unilateral cerebral lesions and in 8 healthy subjects. MP was abnormal in 16 patients. The most frequent abnormality was an attenuation of the N component or readiness potential, recorded on...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00312541
更新日期:1975-07-02 00:00:00
abstract:BACKGROUND:Despite advances in the field, diagnosis and management of the wide spectrum of neurological events post allogeneic hematopoietic cell transplantation (alloHCT) remain challenging. Therefore, we investigated their incidence, diagnosis, management and long-term prognosis in alloHCT recipients. METHODS:We ret...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09372-3
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:To estimate the socio-economic impact of multiple sclerosis (MS) in Italy. METHODS:Outpatients with MS were enrolled at 44 centres across Italy. Socio-demographic, clinical and resource utilization data were collected using a validated questionnaire. Each patient completed a weekly diary of expenses due to ...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/pl00007858
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Stroke has a major impact on survivors. Our study was designed to describe the mental status and health-related quality of life (HRQoL) in long-term survivors of TIA or minor ischaemic stroke (MIS) and evaluate associations of mental and physical factors with HR-QoL. METHODS:A random sample of the 10-year s...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0480-9
更新日期:2007-08-01 00:00:00
abstract::Five patients are described who developed unilateral narrowing of the palpebral fissure that was aggravated by smiling. They had ischaemic lesions involving mainly the contralateral lenticulocapsular area. This rare but distinct symptom may be an action induced focal eyelid dystonia, and could be described as'smile-wi...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150170179
更新日期:2001-05-01 00:00:00
abstract::The three main immunoglobulin classes obey the basic principles of passive protein transfer at the blood-CSF barrier and the serum-derived portions could therefore be quantified with the help of the permeability marker albumin. The Ig fractions secreted into the CSF by sessile plasma cell clones have been determined i...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313413
更新日期:1982-01-01 00:00:00
abstract::We should like to emphasize the following points: 1. Apathy is defined here as a quantified and observable behavioral syndrome consisting in a quantitative reduction of voluntary (or goal-directed) behaviors; 2. Therefore, apathy occurs when the systems that generate and control voluntary actions are altered; 3. These...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-006-7012-5
更新日期:2006-12-01 00:00:00
abstract::Dimethyl fumarate (DMF), fingolimod (FTY) and teriflunomide (TFN) are oral disease-modifying therapies (DMTs) approved for relapsing-remitting multiple sclerosis (RRMS) whose efficacy and tolerability have been separately assessed in phase III trials. Conversely, little evidence exists about their head-to-head compari...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8595-8
更新日期:2017-11-01 00:00:00
abstract::The effect of local cooling was studied in 28 patients with myastenia gravis. We stimulated the ulnar nerve with single stimuli and trains at 3/s for 2s and at 50/s for 1.5 s. The compound muscle action potential (MAP), the muscle twitch and the isometric tetanic force of the adductor pollicis were registered. 1. At 3...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314051
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:Gastrointestinal (GI) dysfunction is prevalent in Parkinson's disease (PD). Symptoms are evident throughout the disease course, affect the length of the GI tract and impact on patient quality of life and management. We clarify real-life differences in the frequency and severity of GI symptoms in a cohort of ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09723-5
更新日期:2020-05-01 00:00:00
abstract::Suicide is a leading cause of death in Huntington's disease (HD), following pneumonia. Up to one-fifth of individuals with HD report suicidal ideation. Identifying the risk factors of suicidal ideation in this clinical population is thus pivotal. Here, we review the literature on prevalence rates and risk factors of s...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-018-9013-6
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Neuropsychological impairments are major symptoms of autoimmune limbic encephalitis (LE) epilepsy patients. In LE epilepsy patients with an autoimmune response against intracellular antigens as well as in antibody-negative patients, the antibody findings and magnetic resonance imaging pathology correspond poo...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10158-1
更新日期:2020-08-20 00:00:00
abstract::DWI has been described in some reports to be superior to FLAIR in early stage herpes simple virus encephalitis (HSE). Few data exist on detailed topographical MRI analysis in HSE. Our aim was to study DWI and FLAIR, and analyse topographically these sequences in non-neonatal HSE patients with MRI performed within 60 d...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-015-7818-0
更新日期:2015-09-01 00:00:00