Abstract：
:The effect of local cooling was studied in 28 patients with myastenia gravis. We stimulated the ulnar nerve with single stimuli and trains at 3/s for 2s and at 50/s for 1.5 s. The compound muscle action potential (MAP), the muscle twitch and the isometric tetanic force of the adductor pollicis were registered. 1. At 3/s stimulation the pathological decrement of the MAP decreased after slight cooling. 2. The amplitude of the single MAP was higher at lower temperature when compared to normal temperature. The same increase is however to be found in healthy subjects. 3. After slight cooling, the maximum tetanic force was higher. However, the decrement of the force was higher also, therefore ruling out a practicable application of cooling for the patient. 4. After severe cooling (18-22 degrees C) the tetanic force was much lower and in many cases a complete failure of the neuromuscular transmission occured.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Ricker K,Hertel G,Stodieck Sdoi
10.1007/BF00314051subject
Has Abstractpub_date
1977-11-01 00:00:00pages
273-82issue
4eissn
0340-5354issn
1432-1459journal_volume
216pub_type
杂志文章abstract：:Although post-stroke emotional incontinence (EI) often occurs after lenticulocapsular strokes, what factors determine the development of EI in these patients has not been identified. I prospectively studied the development of EI in 25 patients (13 men and 12 women, mean age 58.5 years) with single, unilateral, first-e...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0714-4
更新日期：2002-07-01 00:00:00
abstract：:Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectivel...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09830-3
更新日期：2020-08-01 00:00:00
abstract：:Non-motor symptoms (NMS) of Parkinson's disease (PD) have only recently been increasingly recognized for their impact on a patient's quality of life. In this study, we applied the validated, comprehensive self-completed NMS questionnaire for PD (NMS Quest) to 101 patients with young-onset PD (onset between 21 and 45 y...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6600-9
更新日期：2013-01-01 00:00:00
abstract：:Spastic paraplegia type 7 (SPG7) is an autosomal recessive form of hereditary spastic paraparesis (ARHSP) caused by mutations in paraplegin, a subunit of an ATP-dependent AAA-protease located within the inner mitochondrial membrane. We have identified a novel paraplegin mutation, c.1047insC, in a non-consanguineous No...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0858-y
更新日期：2008-08-01 00:00:00
abstract：:PNPLA6 mutations, known to be associated with the development of motor neuron phenotypes, have recently been identified in families with Boucher-Neuhäuser syndrome. Boucher-Neuhäuser is a rare autosomal recessive syndrome characterized by the co-occurrence of cerebellar ataxia, hypogonadotropic hypogonadism, and chori...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7516-3
更新日期：2014-12-01 00:00:00
abstract：:The three main immunoglobulin classes obey the basic principles of passive protein transfer at the blood-CSF barrier and the serum-derived portions could therefore be quantified with the help of the permeability marker albumin. The Ig fractions secreted into the CSF by sessile plasma cell clones have been determined i...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313413
更新日期：1982-01-01 00:00:00
abstract：:Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder of progressive heterotopic ossification (HO) caused by a recurrent activating mutation of ACVR1/ALK2, a bone morphogenetic protein (BMP) type I receptor. FOP is characterized by progressive HO, which is associated with inflammation in the setting o...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6563-x
更新日期：2012-12-01 00:00:00
abstract：:Toxoplasma encephalitis, cryptococcal meningitis, progressive multifocal leukoencephalopathy (PML), and cytomegalovirus (CMV) encephalitis are the most common opportunistic infections of the central nervous system (CNS) in HIV-infected patients. They occur at variable degrees of immunosuppression, and their diagnosis ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050341
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVE:To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years. METHODS:Cross-sectional observational cohort study. 389 largely healthy and cognitively normal older adults were recruited from...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10004-4
更新日期：2020-11-01 00:00:00
abstract：:This review summarizes recent findings from clinical trials regarding the prevention of stroke and translates these into therapeutic guidelines. A distinction is made between patients with previous cerebrovascular disease and those without, and between patients with and those without atrial fibrillation. Although the ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050450
更新日期：1999-09-01 00:00:00
abstract：:Alien limb syndrome following stroke within the territory of the posterior cerebral artery is exceedingly rare. A right-handed female experienced left homonymous hemianopia, visuospatial neglect, and proprioceptive loss of her left hemi-body. She experienced unintended, involuntary movements of her left arm and hand, ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09543-2
更新日期：2020-01-01 00:00:00
abstract：:Intravenous immunoglobulins (IVIg) are effective for treating chronic inflammatory demyelinating polyneuropathy (CIDP), although treatment needs are variable and need to be individualized. Dose and frequency requirements are not currently predictable in advance. In Guillain-Barré syndrome, IVIg interpatient pharmacoki...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-6938-7
更新日期：2013-08-01 00:00:00
abstract：:Cerebral venous thrombosis (CVT) affects mainly working-aged individuals. Functional recovery after CVT is generally considered good with about 3/4 of patients achieving short-term independence. However, vascular events, long-term functional outcome, and employment after CVT remain poorly investigated. We identified c...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7996-9
更新日期：2016-03-01 00:00:00
abstract：:Fatigue is an important contributor to quality of life in patients who survive aneurysmal subarachnoid hemorrhage (SAH), but the determinants of this fatigue are unclear. We assessed the occurrence of fatigue 1 year after SAH and its relation to physical or cognitive impairment, passive coping, and emotional problems,...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5891-y
更新日期：2011-06-01 00:00:00
abstract：:Leukocyte recruitment and inflammatory response play an important patho-physiologic role after cerebral ischemia. This study aimed to evaluate whether leukocyte adhesion molecules can predict clinical outcome in patients after ischemic stroke. We prospectively examined serial changes in p-selectin glycoprotein ligand-...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5117-3
更新日期：2009-08-01 00:00:00
abstract：:Knowledge of restless legs syndrome (RLS) has greatly increased in recent years due to the many advances that have been made in diagnosis, management and genetics. Tools have been developed that facilitate the diagnosis and treatment of RLS, in particular the essential diagnostic criteria for RLS have been refined, se...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-0134-9
更新日期：2009-04-01 00:00:00
abstract：:Cerebral atrophy calculated from serial MRI is a marker of Alzheimer's disease (AD) progression, and a potential outcome measure for therapeutic trials. Reducing within-subject variability in cerebral atrophy rates by acquiring more than two serial scans could allow for shorter clinical trials requiring smaller patien...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0173-4
更新日期：2006-09-01 00:00:00
abstract：:Neuropsychological assessment is one of the main fields of activity of clinical neuropsychologists. Goals of this assessment are verification and description of cognitive and affective impairments as the consequence of brain damage. Included are examinations of basal and higher sensory functions, the intellectual prof...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-2004-7
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:To examine the efficacy and safety of the therapeutic regimen using oral and intravenous L-arginine for pediatric and adult patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). METHODS:In the presence and absence of an ictus of stroke-like episodes within 6...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00415-018-9057-7
更新日期：2018-12-01 00:00:00
abstract：AIMS:To investigate the occurrence of symptomatic peroneal neuropathy (PN) in cancer patients, as well as that of cancer in PN patients and to seek possible factors in the aetiology of PN. METHODS:Clinical, neurographical, and myographical data of patients with PN, in two general neurology clinics during a 5-year peri...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050096
更新日期：1997-05-01 00:00:00
abstract：:The neuropsychiatric symptoms and behavioral disorders affecting Parkinson's disease (PD) patients are common and disabling. A PD-specific interview-based 12-item scale, the Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's Disease (SEND-PD), has been developed to assess the severity of neuropsychiatri...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-012-6490-x
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Elective programs for medical students in the last year of their university training are poorly evaluated. The goal of this study was to determine the gain in theoretical and practical skills in a group of students during their elective in neurology. Students were trained by either conventional teaching meth...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-0255-5
更新日期：2003-12-01 00:00:00
abstract：:Thirteen patients with subacute sclerosing panencephalitis (S.S.P.E.) at different stages of the disease were admitted for transfer factor treatment. The transfer factor was prepared from non-selected blood bank donors. The activity of the transfer factor was tested in patients with diseases other than S.S.P.E. and wa...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312462
更新日期：1975-12-02 00:00:00
abstract：:Quality of life is an important issue in the treatment of Parkinson's disease. Both general and disease specific quality of life scales are now being used in interventional trials. In the Sinemet CR First trial, the long-acting preparation was found to be superior to the immediate release preparation in several measur...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/pl00007735
更新日期：1998-05-01 00:00:00
abstract：:Magnetisation transfer (MT) imaging provides indirect information on tissue structure abnormalities in areas that otherwise may appear normal on conventional MRI. We determined the evolution of MT changes in normal appearing white matter (NAWM) and lesion on serial examination of 9 multiple sclerosis (MS) patients and...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-1115-z
更新日期：2003-08-01 00:00:00
abstract：:As there are scarce data regarding the outcomes of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) within 60 min from symptom onset ("golden hour"), we sought to compare outcomes between AIS patients treated within [GH(+)] and outside [GH(-)] the "golden hour" by analyzing propensity s...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8461-8
更新日期：2017-05-01 00:00:00
abstract：:Both neurologists and urologists might encounter patients with acute urinary retention due to benign inflammatory nervous diseases. Based on the mechanism of urinary retention, these disorders can be divided into two subgroups: disorders of the peripheral nervous system (e.g., sacral herpes) or the central nervous sys...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0189-9
更新日期：2006-08-01 00:00:00
abstract：:In this study of patients with spontaneous cervical artery dissections (sCAD) we searched for mutations in ABCC6, the candidate gene for Pseudoxanthoma elasticum (PXE). Genomic DNA samples from 12 sCAD patients with pronounced electron microscopic alterations in their dermal connective tissue and from 2 patients with ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-1139-4
更新日期：2003-08-01 00:00:00
abstract：:Palatal myoclonus is thought to occur after damage to certain brain-stem structures, and with a delay following the causative lesion. A case of palatal myoclonus, probably of epileptic nature, is described. ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00839145
更新日期：1992-04-01 00:00:00
abstract：:Brains from 54 patients with organic dementia were examined systematically. As in previous investigations a predominance of Alzheimer type changes was observed. Seventeen patients showed Lewy bodies in the nucleus basalis, the substantia nigra and the locus coeruleus as well as other lesions of parkinsonian type. In 5...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313858
更新日期：1986-04-01 00:00:00
