Abstract:
AIMS:To investigate the occurrence of symptomatic peroneal neuropathy (PN) in cancer patients, as well as that of cancer in PN patients and to seek possible factors in the aetiology of PN. METHODS:Clinical, neurographical, and myographical data of patients with PN, in two general neurology clinics during a 5-year period (1988-1992) were analysed retrospectively. A population-based cancer registry was consulted for epidemiological data in the area. RESULTS:The catchment population of the two clinics consisted of 433,142 people, and 8,766 new cancer patients were diagnosed. PN was diagnosed in 372 patients, of whom 74 suffered from cancer (in 56 PN was believed to be related to cancer). The crude relative risk of PN in patients with cancer compared with patients without cancer was 8.6. After correction for differences in age and sex between the compared groups, the relative risk dropped to 3.4 (2.8 for women and 3.6 for men). The crude relative risk of cancer for patients with PN relative to people without PN was 7.5. The relative risk, after correction for age and sex, was 2.8 (2.5 for women and 2.9 for men). All relative risks were significant (P < 0.001), but did not differ between the sexes (P > 0.4). Weight loss was established in 35/56 patients, but in 17/56 it was unknown. PN has not been found to be part of a polyneuropathy. Chemotherapy did not play a causal part. In some patients PN preceded the diagnosis of cancer. CONCLUSIONS:The occurrence of PN seems to be higher in patients with cancer than in people without cancer. Cancer was found in patients with PN more often, particularly in elderly men, than would be expected from the occurrence in the total population. PN in patients with cancer is supposed to be due to a combination of metabolic and mechanical factors. The findings justify a prospective study of the relation between PN and cancer.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Koehler PJ,Buscher M,Rozeman CA,Leffers P,Twijnstra Adoi
10.1007/s004150050096subject
Has Abstractpub_date
1997-05-01 00:00:00pages
328-32issue
5eissn
0340-5354issn
1432-1459journal_volume
244pub_type
杂志文章abstract:BACKGROUND:Conflicting findings have been reported on the prognostic significance of serum 25-hydroxyvitamin D level in patients with stroke. The objective of this meta-analysis was to evaluate the prognostic utility of serum 25-hydroxyvitamin D in stroke patients. METHODS:PubMed and Embase databases were systematical...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-019-09599-0
更新日期:2020-11-01 00:00:00
abstract::The transcranial activation and the conduction properties of corticospinal and callosal neurons were investigated in 12 early-treated adolescents (aged 17.3, SD 3.5 years; range 14-27 years) with phenylketonuria (PKU) by focal transcranial magnetic stimulation (fTMS) of the motor cortex. The patients had no functional...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050301
更新日期:1999-01-01 00:00:00
abstract::Activation studies with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) represent a powerful tool to study the functional anatomy of Parkinson's disease (PD). Activation studies offer the opportunity to study regional cerebral function in man in vivo under different conditions with ...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-003-1103-1
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Putaminal iron deposition is a histopathological feature of multiple system atrophy (MSA), which is not observed in patients with idiopathic Parkinson's disease (PD). T2*-weighted magnetic resonance imaging (MRI) gradient echo (GE) sequences are sensitive for paramagnetic susceptibility changes and therefore...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0496-1
更新日期:2007-09-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which was thought to be untreatable. However, recent evidence in both experimental animals and men indicates that antiglutamatergic strategies are the first to have an influence on its pathogenesis and slow down the disease process. Since the eff...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF03161074
更新日期:2000-12-01 00:00:00
abstract::We reviewed the records of all patients who had received an epidural catheter for management of chronic cancer pain in a 3-year period (1993-1996). Patients with nervous system infections were identified, and pertinent clinical, radiological (magnetic resonance imaging), and bacteriological data were analyzed. We iden...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s004150050460
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Thymoma is frequently associated with paraneoplastic diseases (PDs), most commonly with myasthenia gravis (MG). This association is thought to depend on thymoma's capacity to produce and export T lymphocytes. OBJECTIVE:(1) To determine the frequency and characteristics of thymoma-associated PDs other than M...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0429-z
更新日期:2007-06-01 00:00:00
abstract::Pontocerebellar hypoplasia type 2 (PCH2) is a very rare autosomal recessive disorder. We report two unrelated female patients born to consanguineous parents presenting with this condition. Patient 1 showed a classical clinical/neuroradiological phenotype of PCH2 with dyskinesia/dystonia. Patient 2 had a neonatal onset...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150200069
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:There exist controversial and discrepant results on the risk of spontaneous abortions and teratogenesis induced by interferon treatment in people with MS.Aim of this study is to evaluate risks of the administration of INFbeta related not only to the foetus, but also to children development up to 12-months dev...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0909-4
更新日期:2008-08-01 00:00:00
abstract::Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion is affected in MSA patients, and to investigate the relation between g...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-6944-9
更新日期:2013-08-01 00:00:00
abstract::Parkinson's disease (PD) is associated with an increased risk of fragility fracture. FRAX and Qfracture are risk calculators that estimate the 10-year risk of hip and major fractures and guide definitive investigation for osteoporosis using dual X-ray absorptiometry (DEXA) imaging. It is unclear which PD patients shou...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-014-7333-8
更新日期:2014-06-01 00:00:00
abstract::Stroke in young adults is not a rare entity, and often provides difficult management decisions for neurologists. The knowledge gained from stroke in older adults does not transfer easily to this younger group given the different causes of stroke observed. Cardiac causes of stroke are common in this group, but often co...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-010-5647-8
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Spontaneous cervical artery dissections (sCAD) are often preceded by infections. However, existing data about inflammatory parameters remained inconsistent. Remarkably, concurrent information about the coagulation system, whose affection seems also reasonable to cause ischaemic events, are still lacking in s...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8696-4
更新日期:2018-02-01 00:00:00
abstract::During the last few years, deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as a promising therapy, alleviating major motor symptoms of Parkinson's disease (PD). However, in times of growing budgetary limitations, medical decisions are no longer merely based on clinical efficacy, but also on c...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0640-3
更新日期:2005-02-01 00:00:00
abstract::Neuromyelitis optica (NMO) is an inflammatory/demyelinating disorder predominantly affecting the optic nerves and spinal cord. Recent findings showed an underlying humoral abnormality in NMO, characterized by a serum antibody against aquaporin-4 (Aqp-4-Ab). In this study, we evaluated the Aqp-4-Ab status among Turkish...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-010-5780-4
更新日期:2011-03-01 00:00:00
abstract::Adolescent-onset spastic ataxia is a proposed novel phenotype in compound heterozygous carriers of an intronic mutation (c.1909 + 22G > A) in the POLR3A gene. Here, we present ten new cases of POLR3A-related spastic ataxia and discuss the genetic, clinical and imaging findings. Patients belonged to six pedigrees with ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09574-9
更新日期:2020-02-01 00:00:00
abstract::Spinocerebellar ataxia (SCA) type 7 is an autosomal dominant disorder characterized by neural loss, mainly in the cerebellum and regions of the brainstem and particularly the inferior olivary complex. This neurodegeneration disease is associated with expansion of unstable CAG repeats within the 5'-translated region of...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150070131
更新日期:2000-08-01 00:00:00
abstract::Fatigue is a frequent and often severe symptom in multiple sclerosis. Pathogenic mechanisms proposed for fatigue include the release of proinflammatory cytokines, which is thought to have an important effect on changes in the blood-brain barrier (BBB). To investigate whether fatigue is related to BBB disruption we stu...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s004150050382
更新日期:1999-06-01 00:00:00
abstract::The objective of this study was to investigate cognitive dysfunction in 24-60-year-old neuromyelitis optica (NMO) patients, demographically matched healthy subjects, and MS patients. We conducted a comprehensive literature review of the PubMed, Medline, EMBASE, CNKI, Wan Fang Date, Web of Science, and Cochrane Library...
journal_title:Journal of neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00415-016-8345-3
更新日期:2017-08-01 00:00:00
abstract::58 patients with various underlying neurological diseases, who had an impairment of attention, were examined. 12 patients without clinically evident disorders of attention were examined as a control group. The aim of the study was the development of a standardized procedure for the assessment of impaired attention. An...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00630637
更新日期:1975-01-01 00:00:00
abstract::Apraxia of lid opening (ALO) is a non-paralytic inability to open the eyes or sustain lid elevation at will. The exact pathophysiological mechanisms underlying the syndrome are still unknown. ALO has been reported in patients with Parkinson's disease (PD) after subthalamic nucleus (STN) deep brain stimulation (DBS), s...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6447-0
更新日期:2012-09-01 00:00:00
abstract::Corticobasal degeneration (CBD) was first described by Rebeiz et al. in 1967, and was called corticodentatonigral degeneration with neuronal achromasia [1]. Since then, our knowledge of the clinical features and underlying tau pathology has grown tremendously. Clinical antemortem diagnosis of CBD pathology remains cha...
journal_title:Journal of neurology
pub_type: 历史文章,杂志文章
doi:10.1007/s00415-017-8644-3
更新日期:2018-02-01 00:00:00
abstract::In Parkinson's disease (PD), nonmotor symptoms manifest before motor symptoms. In this report, we present a remarkable case of a semiprofessional painter with PD whose painting style dramatically changed from abstract painting to realism before he developed motor, psychiatric, and autonomic nerve disorders. This case ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-011-6271-y
更新日期:2012-05-01 00:00:00
abstract::During recent years, evidence has come up that bipedal locomotion is based on a quadrupedal limb coordination. A task-dependent neuronal coupling of upper and lower limbs allows one to involve the arms during gait but to uncouple this connection during voluntarily guided arm/hand movements. Hence, despite the evolutio...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-011-6063-4
更新日期:2011-08-01 00:00:00
abstract::A rare form of plasma cell dyscrasia characterized by associated polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes has been termed the POEMS syndrome. The pathophysiology is unknown; plasma cell dyscrasia is essential; secondary manifestations are unexplained. We report a 67-year-old man with a ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00839213
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Due to common pathophysiological findings of Alzheimer's disease (AD) with diabetes mellitus (DM), insulin has been suggested as a possible treatment of AD or mild cognitive impairment (MCI). A safe alternative of IV insulin is intranasal (IN) insulin. The aim of this systematic review is to investi...
journal_title:Journal of neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00415-018-8768-0
更新日期:2018-07-01 00:00:00
abstract::Serial magnetic resonance imaging (MRI) detects substantial subclinical disease activity in multiple sclerosis (MS) and is presently included in most treatment trials as an objective outcome measure. Our current knowledge of the role of MRI in MS treatment trials is derived from very limited patient studies, and the a...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050053
更新日期:1997-02-01 00:00:00
abstract::Cerebellar dysfunction is an important contributor to disability in patients with multiple sclerosis (MS), however, few in vivo studies focused on cerebellar volume loss so far. This relates to technical challenges regarding the segmentation of the cerebellum. In this study, we evaluated the semi-automatic ECCET softw...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6569-4
更新日期:2012-12-01 00:00:00
abstract::The objective was to identify factors associated with decisions made by patients with amyotrophic lateral sclerosis (ALS) to accept or decline non-invasive ventilation (NIV) and/or gastrostomy in a prospective population-based study. Twenty-one people with ALS, recruited from the South-East ALS Register who made an in...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-015-7665-z
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Patients with classic ataxia-telangiectasia (A-T) generally die in the second or third decade of life. Clinical descriptions of A-T tend to focus on the symptoms at presentation. However, during the course of the disease, other symptoms and complications emerge. As long-term survivors with classic A-T develop...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09641-1
更新日期:2020-03-01 00:00:00