Fatigue and magnetic resonance imaging activity in multiple sclerosis.

abstract：:Horizontal eye-movement responses of four patients with Alzheimer-type dementia were recorded using the infrared oculographic technique. Abnormally frequent saccadic intrusions occurred during the fixation and slow, smooth pursuit tasks in all four patients. Saccadic intrusions have previously been reported in the lit...

journal_title：Journal of neurology

authors： Jones A,Friedland RP,Koss B,Stark L,Thompkins-Ober BA

更新日期：1983-01-01 00:00:00

abstract：:Based on the observation of bilateral temporoparietal hypoperfusion in Alzheimer's disease (AD), single photon emission computed tomography (SPECT) is advocated by some as a powerful diagnostic tool in the evaluation of demented patients. We studied whether routine brain SPECT in elderly, mildly demented outpatients i...

journal_title：Journal of neurology

authors： Van Gool WA,Walstra GJ,Teunisse S,Van der Zant FM,Weinstein HC,Van Royen EA

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:We characterised the clinical and neuro-otological characteristics of patients with Susac syndrome. METHODS:The medical records of 30 patients with Susac syndrome were reviewed for details of their clinical presentation and course, neuro-otological symptoms, investigation results including audiology and vest...

journal_title：Journal of neurology

authors： Hardy TA,Taylor RL,Qiu J,O'Brien B,Gopinath S,Trewin B,Spring PJ,Shaffi M,Bolitho SJ,Garsia RJ,Roxburgh R,Mason DF,Ip J,Chan F,Chen L,Wilson I,Beadnall HN,Barnett MH,Parratt JDE,Watson JDG,Welgampola MS,Reddel S

更新日期：2020-12-01 00:00:00

abstract：:Quality of life is an important issue in the treatment of Parkinson's disease. Both general and disease specific quality of life scales are now being used in interventional trials. In the Sinemet CR First trial, the long-acting preparation was found to be superior to the immediate release preparation in several measur...

journal_title：Journal of neurology

authors： Wasielewski PG,Koller WC

更新日期：1998-05-01 00:00:00

abstract：:We assessed the prevalence of vertebral artery (VA) stenosis or occlusion and its influence on outcome in patients with acute basilar artery occlusion (BAO). We studied 141 patients with acute BAO enrolled in the Basilar Artery International Cooperation Study (BASICS) registry of whom baseline CT angiography (CTA) of ...

journal_title：Journal of neurology

authors： Compter A,van der Hoeven EJ,van der Worp HB,Vos JA,Weimar C,Rueckert CM,Kappelle LJ,Algra A,Schonewille WJ,BASICS Study Group.

更新日期：2015-02-01 00:00:00

abstract：:Hearing deficits associated with cognitive impairment have attracted much recent interest, motivated by emerging evidence that impaired hearing is a risk factor for cognitive decline. However, dementia and hearing impairment present immense challenges in their own right, and their intersection in the auditory brain re...

journal_title：Journal of neurology

authors： Hardy CJ,Marshall CR,Golden HL,Clark CN,Mummery CJ,Griffiths TD,Bamiou DE,Warren JD

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:To estimate the socio-economic impact of multiple sclerosis (MS) in Italy. METHODS:Outpatients with MS were enrolled at 44 centres across Italy. Socio-demographic, clinical and resource utilization data were collected using a validated questionnaire. Each patient completed a weekly diary of expenses due to ...

journal_title：Journal of neurology

authors： Amato MP,Battaglia MA,Caputo D,Fattore G,Gerzeli S,Pitaro M,Reggio A,Trojano M,Mu. S. I. C. Study Group.

更新日期：2002-02-01 00:00:00

abstract：:The spinocerebellar ataxias (SCAs) with autosomal dominant inheritance are a clinically and genetically heterogeneous group of neurological disorders with overlapping as well as highly variable phenotypes primarily affecting the cerebellum. To date, 28 different loci have been identified. Nine SCAs are caused by repea...

journal_title：Journal of neurology

authors： Edener U,Kurth I,Meiner A,Hoffmann F,Hübner CA,Bernard V,Gillessen-Kaesbach G,Zühlke C

更新日期：2009-11-01 00:00:00

abstract：:The polymorphism of the HLA class II genes was investigated in 97 patients with multiple sclerosis (MS) in Hokkaido, the northernmost main island of Japan. Of these, 80 patients were classified as having conventional MS and 17 as having opticospinal MS (OS-MS). Our findings confirmed a previous report that the DPB 1*0...

journal_title：Journal of neurology

authors： Fukazawa T,Kikuchi S,Sasaki H,Yabe I,Miyagishi R,Hamada T,Tashiro K

更新日期：2000-03-01 00:00:00

abstract：:The objective was to identify factors associated with decisions made by patients with amyotrophic lateral sclerosis (ALS) to accept or decline non-invasive ventilation (NIV) and/or gastrostomy in a prospective population-based study. Twenty-one people with ALS, recruited from the South-East ALS Register who made an in...

journal_title：Journal of neurology

authors： Greenaway LP,Martin NH,Lawrence V,Janssen A,Al-Chalabi A,Leigh PN,Goldstein LH

更新日期：2015-01-01 00:00:00

abstract：:Recent studies reported mutations in the gene encoding the proline-rich transmembrane protein 2 (PRRT2) to be causative for paroxysmal kinesigenic dyskinesia (PKD), PKD combined with infantile seizures (ICCA), and benign familial infantile seizures (BFIS). PRRT2 is a presynaptic protein which seems to play an importan...

journal_title：Journal of neurology

authors： Becker F,Schubert J,Striano P,Anttonen AK,Liukkonen E,Gaily E,Gerloff C,Müller S,Heußinger N,Kellinghaus C,Robbiano A,Polvi A,Zittel S,von Oertzen TJ,Rostasy K,Schöls L,Warner T,Münchau A,Lehesjoki AE,Zara F,Lerch

更新日期：2013-05-01 00:00:00

abstract：:PNPLA6 mutations, known to be associated with the development of motor neuron phenotypes, have recently been identified in families with Boucher-Neuhäuser syndrome. Boucher-Neuhäuser is a rare autosomal recessive syndrome characterized by the co-occurrence of cerebellar ataxia, hypogonadotropic hypogonadism, and chori...

journal_title：Journal of neurology

authors： Deik A,Johannes B,Rucker JC,Sánchez E,Brodie SE,Deegan E,Landy K,Kajiwara Y,Scelsa S,Saunders-Pullman R,Paisán-Ruiz C

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To determine the response to treatment and the long-term outcome of patients with the antisynthetase syndrome associated with anti-Jo-1-antibodies. PATIENTS AND METHODS:A total of 12 patients with histologically proven myositis and anti-Jo-1-autoantibodies were evaluated over a mean follow-up period of 66.4 ...

journal_title：Journal of neurology

authors： Späth M,Schröder M,Schlotter-Weigel B,Walter MC,Hautmann H,Leinsinger G,Pongratz D,Müller-Felber W

更新日期：2004-07-01 00:00:00

abstract：:In this work, we investigated motor network structure in patients affected by essential tremor (ET) with or without resting tremor, using probabilistic tractography of the cerebello-thalamo-basal ganglia-cortical loop. Twenty-five patients with ET, twenty-two patients with ET associated with resting tremor (rET), and ...

journal_title：Journal of neurology

authors： Caligiuri ME,Arabia G,Barbagallo G,Lupo A,Morelli M,Nisticò R,Novellino F,Quattrone A,Salsone M,Vescio B,Cherubini A,Quattrone A

更新日期：2017-09-01 00:00:00

abstract：:The mechanism underlying the motor fluctuations that develop after long-term L-dopa therapy is not fully known. It has been speculated that malabsorption of L-dopa from the small intestine occurs. It was reported that gastric retention in Parkinson's disease (PD) patients with motor fluctuations is increased as compar...

journal_title：Journal of neurology

authors： Tanaka Y,Kato T,Nishida H,Araki H,Murase M,Nagaki M,Moriwaki H,Inuzuka T

更新日期：2009-12-01 00:00:00

abstract：:The neuropsychiatric symptoms and behavioral disorders affecting Parkinson's disease (PD) patients are common and disabling. A PD-specific interview-based 12-item scale, the Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's Disease (SEND-PD), has been developed to assess the severity of neuropsychiatri...

journal_title：Journal of neurology

authors： Martinez-Martin P,Frades-Payo B,Agüera-Ortiz L,Ayuga-Martinez A

更新日期：2012-11-01 00:00:00

abstract：:Few regional and seasonal Guillain-Barré syndrome (GBS) clusters have been reported so far. It is unknown whether patients suffering from sporadic GBS differ from GBS clusters with respect to clinical and paraclinical parameters, HLA association and antibody response to glycosphingolipids and Campylobacter jejuni (Cj)...

journal_title：Journal of neurology

authors： Schirmer L,Worthington V,Solloch U,Loleit V,Grummel V,Lakdawala N,Grant D,Wassmuth R,Schmidt AH,Gebhardt F,Andlauer TF,Sauter J,Berthele A,Lunn MP,Hemmer B

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:The variants of primary progressive aphasia (PPA) are predominantly diagnosed on the basis of specific profiles of language impairments. Deficits in other cognitive domains and their evolution over time are less well documented. This study examined the cognitive profiles of the PPA variants over time and dete...

journal_title：Journal of neurology

authors： Foxe D,Irish M,Hu A,Carrick J,Hodges JR,Ahmed RM,Burrell JR,Piguet O

更新日期：2021-01-08 00:00:00

abstract：:An autopsy case of Creutzfeld-Jacob disease with widespread amyloid plaques is reported. A 45-year-old Japanese man, whose father had died of a similar disease, had a 5-year illness characterized by progressive cerebellar signs. Mental changes and brain-stem signs developed in the late stage. Myoclonus frequently occu...

journal_title：Journal of neurology

authors： Yagishita S,Iwabuchi K,Amano N,Yokoi S

更新日期：1989-03-01 00:00:00

abstract：:Migraine is a common debilitating neurological disease characterised by attacks of severe headache with or without preceding aura. Its aetiology remains elusive; however it is clear that an interplay of genetic and environmental components play an important role. Familial hemiplegic migraine (FHM) is a rare and severe...

journal_title：Journal of neurology

authors： Ramagopalan SV,Ramscar NE,Cader MZ

更新日期：2007-12-01 00:00:00

abstract：:Acid maltase deficiency is described in non-identical adult twins. The onset of the disease can be traced into late infancy; the clinical picture is one of severe muscular dystrophy; respiratory insuficiency was the cause of death in one case. The autopsy showed the central nervous system, heart and liver to be spared...

journal_title：Journal of neurology

authors： Martin JJ,de Barsy T,den Tandt WR

更新日期：1976-08-06 00:00:00

abstract：:Silver syndrome/SPG17 is a motor manifestation of mutations in the BSCL2 gene and usually presents as a complicated form of hereditary spastic paraplegia (HSP). We present clinical data, follow-up, and genetic results of seven patients with Silver syndrome/SPG17 including a family with a variable intrafamilial phenoty...

journal_title：Journal of neurology

authors： Musacchio T,Zaum AK,Üçeyler N,Sommer C,Pfeifroth N,Reiners K,Kunstmann E,Volkmann J,Rost S,Klebe S

更新日期：2017-01-01 00:00:00

abstract：:This study of frontotemporal dementia (FTD) was carried out to determine whether MR spectroscopy can provide an in vivo marker for the neuronal loss and gliosis that occur in this condition. We compared spectra in frontal and temporal regions known to be affected early in the course of the disease with spectra in the ...

journal_title：Journal of neurology

authors： Coulthard E,Firbank M,English P,Welch J,Birchall D,O'Brien J,Griffiths TD

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Protein Z (PZ), a vitamin Kdependent protein, plays a role in inhibiting coagulation. Its plasma level or PZ gene polymorphisms have been discussed as risk factors for stroke with conflicting results reported between various studies. Only one of these polymorphisms was studied in a cohort of pati...

journal_title：Journal of neurology

authors： Le Cam-Duchez V,Bagan-Triquenot A,Barbay V,Mihout B,Borg JY

更新日期：2008-10-01 00:00:00

abstract：:Altered cerebral vasoreactivity (CVR) has been implicated in migraine. To test this hypothesis, we studied CVR as measured by transcranial Doppler ultrasound (TCD) in 11 migraineurs and 12 healthy controls of similar age. Mean flow velocities (MFV) in the middle cerebral artery (MCA) were recorded during a cognitive a...

journal_title：Journal of neurology

authors： Thie A,Carvajal-Lizano M,Schlichting U,Spitzer K,Kunze K

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:Epileptogenic foci exhibit disturbed function at the level of the benzodiazepine receptor. The aim of our study was to investigate the incidence of focal reductions of temporal benzodiazepine receptor binding (BRB) as assessed by scintigraphy with 123I-iomazenil in patients with denovo temporal lobe epilepsy (T...

journal_title：Journal of neurology

authors： Matheja P,Lüdemann P,Kuwert T,Weckesser M,Kellinghaus C,Weitemeyer L,Diehl B,Schuierer G,Ringelstein EB,Schober O

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:To characterize the relation between brain functional connectivity and disability in patients with multiple sclerosis; to investigate the existence of critical values of both disability and functional connectivity corresponding to exhaustion of functional adaptive mechanisms. METHODS:Hundred-and-nineteen pat...

journal_title：Journal of neurology

authors： Tommasin S,De Giglio L,Ruggieri S,Petsas N,Giannì C,Pozzilli C,Pantano P

更新日期：2018-12-01 00:00:00

abstract：:Acquired copper deficiency has been recognised as a rare cause of anaemia and neutropenia for over half a century. Copper deficiency myelopathy (CDM) was only described within the last decade, and represents a treatable cause of non-compressive myelopathy which closely mimics subacute combined degeneration due to vita...

journal_title：Journal of neurology

authors： Jaiser SR,Winston GP

更新日期：2010-06-01 00:00:00

abstract：:Whereas the effect of interferons (IFNs) on magnetic resonance imaging (MRI) outcome measures in patients with multiple sclerosis (MS) has been convincingly shown, little work has been done to define the between-patient heterogeneity of treatment response. Our aim was to assess the distribution of the effect of IFNbet...

journal_title：Journal of neurology

authors： Sormani MP,Bruzzi P,Beckmann K,Kappos L,Miller DH,Polman C,Pozzilli C,Thompson AJ,Wagner K,Filippi M

更新日期：2005-12-01 00:00:00

abstract：:Long-term treatment studies with any antiparkinsonian drug are rather limited. Especially, double-blind, randomized and multicenter studies do not exist except for some rare exceptions. Nonetheless, such studies are mandatory to prove certain therapy regimens. This overview reports on the comparison between dopamine a...

journal_title：Journal of neurology

authors： Reichmann H

更新日期：2000-09-01 00:00:00