Stroke prevention: which drugs to use and when?

abstract：:The greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination; doing so restores nerve conduction and prevents neurodegeneration. The biology of remyelination-cent...

journal_title：Journal of neurology

authors： Cunniffe N,Coles A

更新日期：2021-01-01 00:00:00

abstract：:We studied the diagnostic value of computed tomographic angiography (CTA) in the posterior circulation as a noninvasive substitute for intra-arterial digital subtraction angiography (DSA). We prospectively investigated 103 patients with acute stroke in the posterior circulation. All patients underwent CTA and Doppler ...

journal_title：Journal of neurology

authors： Graf J,Skutta B,Kuhn FP,Ferbert A

更新日期：2000-10-01 00:00:00

abstract：:The occurrence of spontaneous internal carotid or vertebral artery dissection after childbirth remains rare. To our knowledge, seven cases of arterial dissection in the postpartum period have been described in the literature as single case reports. We report four additional cases of internal carotid and vertebral arte...

journal_title：Journal of neurology

authors： Gasecki AP,Kwiecinski H,Lyrer PA,Lynch TG,Baxter T

更新日期：1999-08-01 00:00:00

abstract：:Adolescent-onset spastic ataxia is a proposed novel phenotype in compound heterozygous carriers of an intronic mutation (c.1909 + 22G > A) in the POLR3A gene. Here, we present ten new cases of POLR3A-related spastic ataxia and discuss the genetic, clinical and imaging findings. Patients belonged to six pedigrees with ...

journal_title：Journal of neurology

authors： Infante J,Serrano-Cárdenas KM,Corral-Juan M,Farré X,Sánchez I,de Lucas EM,García A,Martín-Gurpegui JL,Berciano J,Matilla-Dueñas A

更新日期：2020-02-01 00:00:00

abstract：:Diminished activity of uroporphyrinogen I-synthetase in the liver and other tissues may be regarded to be the primary genetic deficiency of acute intermittent porphyria (AIP). Increased production and renal excretion of delta-aminolevulinic acid (ALA) und porphobilinogen (PBG) are secondary phenomena. The neuropsychia...

journal_title：Journal of neurology

authors： Flügel KA,Druschky KF

更新日期：1977-03-21 00:00:00

abstract：BACKGROUND:Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the survival motor neuron (SMN)1 gene. The nearly identical SMN2 gene plays a disease modifying role. SMA is classified into four different subtypes based on age of onset and clinical course (SMA types 1-4). The natural history of early onse...

journal_title：Journal of neurology

authors： Piepers S,van den Berg LH,Brugman F,Scheffer H,Ruiterkamp-Versteeg M,van Engelen BG,Faber CG,de Visser M,van der Pol WL,Wokke JH

更新日期：2008-09-01 00:00:00

abstract：:Untreated sleep disorders may contribute to secondary causes of uncontrolled hypertension, cardiovascular disease (CVD), and stroke. Restless legs syndrome, or Willis-Ekbom Disease (RLS/WED), is a common sensorimotor disorder with a circadian rhythmicity defined by an uncontrollable urge to move the legs that worsens ...

journal_title：Journal of neurology

authors： Ferini-Strambi L,Walters AS,Sica D

更新日期：2014-06-01 00:00:00

abstract：:Twenty-nine cases of both clinically and neuropathologically diagnosed dementia with Lewy bodies (DLB) were retrospectively examined for autonomic symptoms. Twenty-eight cases showed some kind of autonomic dysfunction. Urinary incontinence (97 %) and constipation (83 %) were the two most common. Although urinary reten...

journal_title：Journal of neurology

authors： Horimoto Y,Matsumoto M,Akatsu H,Ikari H,Kojima K,Yamamoto T,Otsuka Y,Ojika K,Ueda R,Kosaka K

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Sleep disorders can occur in early Parkinson's disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not been fully explored. OBJECTIVE:To describe the frequency, coexistence, and longitudinal change in excessive daytime sleepiness (EDS), insomnia,...

journal_title：Journal of neurology

authors： Xu Z,Anderson KN,Saffari SE,Lawson RA,Chaudhuri KR,Brooks D,Pavese N

更新日期：2021-01-01 00:00:00

abstract：:We report the familial occurrence and apparent autosomal dominant inheritance of Sneddon's syndrome with variable clinical expression. The proband, a 40-year-old woman, presented with livedo reticularis and progressive neurological deterioration following a stroke. The diagnosis was confirmed by cerebral angiogram and...

journal_title：Journal of neurology

authors： Lossos A,Ben-Hur T,Ben-Nariah Z,Enk C,Gomori M,Soffer D

更新日期：1995-02-01 00:00:00

abstract：:We report the case of a 17.5-year old girl with generalized myasthenia gravis (MG). When she was 13, she started to complain of episodic diplopia, ptosis and mild fatigability of upper and lower extremity muscles. She was diagnosed with MG 3 years later, after exacerbation of her limb muscle weakness. Acetylcholine re...

journal_title：Journal of neurology

authors： Kostera-Pruszczyk A,Kwiecinski H

更新日期：2009-10-01 00:00:00

abstract：:Somatostatin levels were measured in cerebrospinal fluid of patients with Alzheimer's disease, multi-infarct dementia and normal pressure hydrocephalus and compared with levels from a normal control group. All pathological groups showed a statistically significant decrease of somatostatin with respect to the control g...

journal_title：Journal of neurology

authors： Molins A,Catalán R,Sahuquillo J,Castellanos JM,Codina A,Galard R

更新日期：1991-06-01 00:00:00

abstract：:Motor tests were performed in 50 HIV-infected patients in all stages according to the current CDC classification, but without any clinically evident central nervous system deficit, and the results compared with an age-matched control group. Patients were excluded from the study if there was alcohol or drug abuse, feve...

journal_title：Journal of neurology

authors： Arendt G,Hefter H,Elsing C,Strohmeyer G,Freund HJ

更新日期：1990-10-01 00:00:00

abstract：:Mutations in C19orf12 have been recently identified as the molecular genetic cause of a subtype of neurodegeneration with brain iron accumulation (NBIA). Given the mitochondrial localization of the gene product the new NBIA subtype was designated mitochondrial membrane protein-associated neurodegeneration. Frequent fe...

journal_title：Journal of neurology

authors： Deschauer M,Gaul C,Behrmann C,Prokisch H,Zierz S,Haack TB

更新日期：2012-11-01 00:00:00

abstract：:Cerebral palsy (CP) continues to be a major problem in India. The present study provides an insight into the various clinical and neuroradiological correlates of CP. The study included 102 children with CP and was subjected to magnetic resonance imaging (MRI) of the brain. Forty-seven (46%) patients belonged to the 1-...

journal_title：Journal of neurology

authors： Prasad R,Verma N,Srivastava A,Das BK,Mishra OP

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Considerable studies have reported inconsistent relationships between ischemic stroke and a large number of factors. These uncertainties may reflect the susceptibility to confounding in observational studies. We aimed to assess genetic correlations and causal relationships between ischemic stroke...

journal_title：Journal of neurology

authors： Cai H,Cai B,Liu Z,Wu W,Chen D,Fang L,Chen L,Sun W,Liang J,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:Postpartum lower limb motor and/or sensory deficit is an uncommon obstetrical complication. We aimed to identify its incidence, etiology, and precipitating factors, as well as the neurological prognosis by retrospectively analyzing the successive neurological evaluations, electrophysiological, and MRI data from all th...

journal_title：Journal of neurology

authors： Richard A,Vellieux G,Abbou S,Benifla JL,Lozeron P,Kubis N

更新日期：2017-03-01 00:00:00

abstract：:A haplotype marker consisting of three biallelic restriction fragment length polymorphism (RFLP) loci from the VH-2 variable gene family was examined in 124 families with sibling pairs concordant for multiple sclerosis, 178 unrelated patients and 159 unaffected controls to investigate the role of the immunoglobulin he...

journal_title：Journal of neurology

authors： Wood NW,Sawcer SJ,Kellar-Wood HF,Holmans P,Clayton D,Robertson N,Compston DA

更新日期：1995-10-01 00:00:00

abstract：:We present evidence that Willy Loman, the protagonist of Arthur Miller's play "Death of a Salesman", meets current diagnostic criteria for probable dementia with Lewy bodies. In particular, he presents with attentional deficits and executive dysfunction (with additional subtle visuoperceptual deficits) in addition to ...

journal_title：Journal of neurology

authors： Fearon C,Taylor JP,O'Dowd S

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Recent research has convincingly shown that the ability to work mainly depends on the cognitive status in multiple sclerosis (MS). An international committee of experts recommended a brief neuropsychological battery to evaluate cognitive performance in MS. BICAMS comprises three tests, the Symbol Digit Modal...

journal_title：Journal of neurology

authors： Filser M,Schreiber H,Pöttgen J,Ullrich S,Lang M,Penner IK

更新日期：2018-11-01 00:00:00

abstract：:Recognition of multiple sclerosis (MS) attacks relies mostly on clinical assessment. However, their definition based on McDonald criteria refers mostly to timing and when dealing with clinical features is rather ambiguous: "...of the kind seen in multiple sclerosis." This is heightened in clinically isolated syndromes...

journal_title：Journal of neurology

authors： Sastre-Garriga J,Tintoré M,Nos C,Tur C,Río J,Téllez N,Castilló J,Horga A,Perkal H,Comabella M,Rovira A,Montalban X

更新日期：2010-05-01 00:00:00

abstract：:A 23-year-old woman had progressive right hemiparesis followed by spontaneous clinical remission. The clinical profile and multifocal contrast-enhancing CT lesions in the periventricular region of the cerebrum favored the diagnosis of an acute demyelinating process. Serial examinations showed resolution of CT abnormal...

journal_title：Journal of neurology

authors： Kuroiwa Y,Nishimura Y,Kobayashi S,Mizoguchi K,Honda N

更新日期：1982-01-01 00:00:00

abstract：:Specific mutations in COL6A3 have recently been reported as the cause of isolated recessive dystonia, which is a rare movement disorder. In all patients, at least one mutation was located in Exons 41 and 42. In an attempt to replicate these findings, we assessed by direct sequencing the frequency of rare variants in E...

journal_title：Journal of neurology

authors： Lohmann K,Schlicht F,Svetel M,Hinrichs F,Zittel S,Graf J,Lohnau T,Schmidt A,Mir P,Krause P,Lang AE,Jabusch HC,Wolters A,Kamm C,Zeuner KE,Altenmüller E,Naz S,Chung SJ,Kostic VS,Münchau A,Kühn AA,Brüggemann N,Kl

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Duchenne muscular dystrophy (DMD) is induced by a wide spectrum of mutations such as exon deletions, duplications and small mutations in the dystrophin gene. This is the first study on the mutational spectrum in a cohort of DMD children from India, with an emphasis to compare the mutations in familial and ...

journal_title：Journal of neurology

authors： Polavarapu K,Preethish-Kumar V,Sekar D,Vengalil S,Nashi S,Mahajan NP,Thomas PT,Sadasivan A,Warrier M,Gupta A,Arunachal G,Debnath M,Keerthipriya MS,Pradeep-Chandra-Reddy C,Puttegowda A,John AP,Tavvala A,Gunasekaran S,S

更新日期：2019-09-01 00:00:00

abstract：:Electrophysiological findings in 40 cases of non-progressive myopathies are reported, and compared with a group of 20 cases of Duchenne progressive muscular dystrophy and a control group. In all cases the electrophysiological changes were of the mild s. c. myogenic type. The involvement of proximal and distal muscles ...

journal_title：Journal of neurology

authors： Hausmanowa-Petrusewicz I,Ryniewicz B

更新日期：1976-02-13 00:00:00

abstract：:This article describes the clinical features of anterior semicircular canal benign paroxysmal positional vertigo (AC-BPPV) and a new therapeutic maneuver for its management. Our study was a retrospective review of cases from an ambulatory tertiary referral center. Thirteen patients afflicted with positional paroxysmal...

journal_title：Journal of neurology

authors： Yacovino DA,Hain TC,Gualtieri F

更新日期：2009-11-01 00:00:00

abstract：:Although multiple sclerosis (MS) is considered to be an inflammatory demyelinating disease, increasing evidence indicates that it is also an axonal pathology; indeed, studies of experimental allergic encephalitis showed that several neuronal proteins such as synapsins take part in the pathogenesis of the axonal dysfun...

journal_title：Journal of neurology

authors： Liguori M,Cittadella R,Manna I,Valentino P,La Russa A,Serra P,Trojano M,Messina D,Ruscica F,Andreoli V,Romeo N,Livrea P,Quattrone A

更新日期：2004-02-01 00:00:00

abstract：:Chronic neuropathy is the most frequent condition affecting the peripheral nervous system. It includes symmetrical polyneuropathies, multifocal mononeuropathies, mononeuropathies and radiculopathies. Mononeuropathies are mainly due to compression or entrapment and are not discussed in this review, which focuses on pol...

journal_title：Journal of neurology

authors： Léger JM

更新日期：1999-03-01 00:00:00

abstract：:Natalizumab (TYSABRI(®)), a specific α4-integrin antagonist, is approved as a second-line treatment of relapsing-remitting MS (RRMS) patients who fail therapy with interferons or as first-line treatment of patients with highly active relapsing-remitting disease. Since the market introduction of natalizumab as a monoth...

journal_title：Journal of neurology

authors： Hellwig K,Gold R

更新日期：2011-11-01 00:00:00

abstract：:Altered cerebral vasoreactivity (CVR) has been implicated in migraine. To test this hypothesis, we studied CVR as measured by transcranial Doppler ultrasound (TCD) in 11 migraineurs and 12 healthy controls of similar age. Mean flow velocities (MFV) in the middle cerebral artery (MCA) were recorded during a cognitive a...

journal_title：Journal of neurology

authors： Thie A,Carvajal-Lizano M,Schlichting U,Spitzer K,Kunze K

更新日期：1992-07-01 00:00:00