Abstract：
:Untreated sleep disorders may contribute to secondary causes of uncontrolled hypertension, cardiovascular disease (CVD), and stroke. Restless legs syndrome, or Willis-Ekbom Disease (RLS/WED), is a common sensorimotor disorder with a circadian rhythmicity defined by an uncontrollable urge to move the legs that worsens during periods of inactivity or at rest in the evening, often resulting in sleep disruptions. Sleep disorders such as insomnia and obstructive sleep apnea (OSA) are established risk factors for increased risk of hypertension and vascular diseases. This literature review outlines the lessons learned from studies demonstrating insomnia and OSA as risk factors for hypertension and vascular diseases to support the epidemiologic and physiologic evidence suggesting a similar increase in hypertension and vascular disease risk due to RLS. Understanding the relationships between RLS and hypertension, CVD, and stroke has important implications for reducing the risks associated with these diseases.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Ferini-Strambi L,Walters AS,Sica Ddoi
10.1007/s00415-013-7065-1subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1051-68issue
6eissn
0340-5354issn
1432-1459journal_volume
261pub_type
杂志文章,评审abstract：:We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent co...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF02444004
更新日期：1996-02-01 00:00:00
abstract：:Alexander disease (AD) is a rare genetic disorder of the central nervous system due to a dysfunction of astrocytes. The most common infantile form presents as a progressive leukodystrophy with macrocephalus. Recently, heterozygous de novo mutations in the gene encoding glial fibrillary acidic protein (GFAP) have been ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-0995-2
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:Myelin oligodendrocyte glycoprotein immunoglobulin G associated optic neuritis (MOG-ON) is a recently described entity. Recent studies have shown that MOG-ON has a more severe clinical presentation than classic optic neuritis (ON). OBJECTIVE:This study aimed to define morphological characteristics of MOG-ON...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10097-x
更新日期：2021-01-01 00:00:00
abstract：:Cerebellar syndrome is one of the most disabling developments in multiple sclerosis (MS). In neurodegenerative disorders, cerebellar syndrome is thought to be related to a neurochemical deficit of 5-hydroxytryptamine (5-HT). Previous studies found that a levorotatory form of 5-hydroxytryptophan, a 5-HT precursor, and ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00415-003-0176-3
更新日期：2003-10-01 00:00:00
abstract：:Hereditary neuropathy with liability to pressure palsies (HNPP) is characterized by recurrent sensory and motor neuropathy in individual nerves starting in adolescence or young adulthood, focal conduction abnormalities at entrapment sites on nerve conduction studies, and sausage-like swellings (tomacula) of the myelin...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-019-09319-8
更新日期：2020-08-01 00:00:00
abstract：:The course of multiple sclerosis (MS) can be monitored by measuring changes in brain volume, but consensus is still lacking on the best strategy to be adopted. We compared the reproducibility and sensitivity of volume measurements from different brain portions for detecting changes on magnetic resonance imaging (MRI) ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150070054
更新日期：2000-12-01 00:00:00
abstract：:Autosomal recessive cerebellar ataxia type 3 (ARCA3) is a rare inherited disorder caused by mutations in the ANO10 gene. The disease is characterized by slowly progressive spastic ataxia variably associated with motor neuron involvement, epilepsy, and cognitive decline. We performed mutational screening in 80 patients...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-9141-z
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare early onset neurodegenerative disease that typically results in ataxia, upper motor neuron dysfunction and sensorimotor peripheral neuropathy. Dysarthria and dysphagia are anecdotally described as key features of ARSACS but the natu...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8950-4
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:Crossed aphasia (CA), usually referred to as an acquired language disturbance, is caused by a lesion in the cerebral hemisphere ipsilateral to the dominant hand, and the exact mechanism is not clear. The development of handedness is influenced by education and training and the impact of habitualization, while...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8901-0
更新日期：2018-07-01 00:00:00
abstract：:The neuropsychiatric symptoms and behavioral disorders affecting Parkinson's disease (PD) patients are common and disabling. A PD-specific interview-based 12-item scale, the Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's Disease (SEND-PD), has been developed to assess the severity of neuropsychiatri...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-012-6490-x
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:To analyse clinical and therapeutic aspects of epilepsy secondary to ulegyria in adults. PATIENTS:Out of 1,020 consecutive patients studied at a tertiary care epilepsy centre, eight cases of ulegyria were identified. All patients had comprehensive clinical evaluation, neuropsychological testing, interictal E...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0829-5
更新日期：2005-10-01 00:00:00
abstract：:Apoptotic deletion of autoreactive T-cells is defective in patients with multiple sclerosis (MS). Glatiramer acetate (GA) treatment seems to restore apoptosis of detrimental T-cells. We analyzed the mitochondria membrane pro- (Bax) and anti-apoptotic (Bcl- 2) and cytosolic pro-apoptotic (Cyt-c, APAF-1) proteins expres...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0965-y
更新日期：2006-02-01 00:00:00
abstract：:Alien limb syndrome following stroke within the territory of the posterior cerebral artery is exceedingly rare. A right-handed female experienced left homonymous hemianopia, visuospatial neglect, and proprioceptive loss of her left hemi-body. She experienced unintended, involuntary movements of her left arm and hand, ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09543-2
更新日期：2020-01-01 00:00:00
abstract：:Three cases of Fahr's syndrome are described. All patients had disturbances of calcium metabolism and had had a meningoencephalitis in childhood. It is suggested that gliovascular changes, induced by cerebral inflammation, can later facilitate the occurrence of calcification of the striopallidodentate system when abno...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313985
更新日期：1986-02-01 00:00:00
abstract：:The age-related structural changes of the human hippocampus are not entirely understood. The goal of the present investigation was to understand better the nature of age-related hippocampal changes by a comparative MR-analysis of four complementary aspects of hippocampal integrity: total volume, metabolite concentrati...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-004-0540-y
更新日期：2004-11-01 00:00:00
abstract：:Polymerase chain reaction (PCR) based automated high-resolution fragment analysis of rearranged immunoglobulin heavy-chain genes is a highly sensitive means for identifying clonal B-cell responses. We used this technique to distinguish polyclonal inflammatory from monoclonal neoplastic B-cell populations in the cerebr...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150170247
更新日期：2001-02-01 00:00:00
abstract：:The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer's disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patient...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050351
更新日期：1999-04-01 00:00:00
abstract：:Additional autoimmune diseases in people with multiple sclerosis (MS) and their relatives have been studied many times. Studies have employed different designs, and yielded conflicting results. We performed a systematic review, and calculated overall risk of additional autoimmune diseases in people with MS and their f...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00415-012-6790-1
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:The so called "neurodegenerative Langerhans cell histiocytosis" (ND-LCH) is a rare and severe complication of LCH presenting as a progressive cerebellar ataxia associated with pyramidal tract signs, and cognitive impairment. MRI is the gold standard to investigate CNS lesions of ND-LCH but little is known ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0751-8
更新日期：2008-04-01 00:00:00
abstract：:The clinicopathological findings of a 50-year-old man, who developed cervicothoracic syringomyelia at the age of 25 are presented. He was given radiation therapy at the age of 33. At the age of 57 he developed a foramen jugulare syndrome on the left, caused by a low grade leiomyosarcoma. Etiologically, the most attrac...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313150
更新日期：1980-01-01 00:00:00
abstract：:The influence of portal-systemic shunting on maximal motor nerve conduction velocity (MCV) was analyzed in rats with portacaval shunts. At 3 and 8 weeks after the shunting there was a marked but transient fall in MCV. This was not prevented by colectomy. At 16 weeks the MCV had almost normalized, despite sustained por...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313181
更新日期：1980-01-01 00:00:00
abstract：:Frequent serial EEG investigations of three patients with neuropathologically confirmed Creutzfeldt-Jakob disease lasting 13, 24 and 68 weeks revealed typical periodic activity of short duration with stereotyped bilateral sharp waves at the 7th, 8th, and 12th week, respectively, after the onset of symptoms. During the...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00328506
更新日期：1989-12-01 00:00:00
abstract：:Myasthenia gravis patients usually present with fluctuating, asymmetrical stress-dependent weakness in the absence of other neurological disturbances. In weak patients psychopathological disturbances are frequently reported and misdiagnosed as a psychiatric disorder. The question to what extent psychiatric symptoms ar...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-2022-5
更新日期：2007-05-01 00:00:00
abstract：:Infectious agents have been proposed as potential causes of Alzheimer's disease (AD). Recently, we documented a high prevalence of Helicobacter pylori (Hp) infection in patients with AD. We aim to access the effect of Hp eradication on the AD cognitive (MMSE: Mini Mental State Examination and CAMCOG: Cambridge Cogniti...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-009-5011-z
更新日期：2009-05-01 00:00:00
abstract：:Long-term treatment studies with any antiparkinsonian drug are rather limited. Especially, double-blind, randomized and multicenter studies do not exist except for some rare exceptions. Nonetheless, such studies are mandatory to prove certain therapy regimens. This overview reports on the comparison between dopamine a...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00007768
更新日期：2000-09-01 00:00:00
abstract：:A 40-year-old man suffered for 5 years from a progressive proximal myopathy mimicking an atypical limb-girdle dystrophy. A "myopathic" pattern with myotonic and pseudomyotonic discharges was determined by electromyography. Enzyme histochemical and ultrastructural investigations of muscle and liver biopsies pointed to ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312870
更新日期：1976-01-01 00:00:00
abstract：BACKGROUND:Cerebral venous thrombosis (CVT) is associated with intracranial hemorrhage. AIM:To identify clinical and imaging features of CVT-associated intracranial hemorrhage. We hypothesized that higher clot burden would be associated with a higher risk of intracranial hemorrhage. METHODS:We performed a retrospecti...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10008-0
更新日期：2020-11-01 00:00:00
abstract：:A woman affected by chronic progressive external ophthalmoplegia and muscle mitochondrial DNA deletion was studied by phosphorus magnetic resonance spectroscopy (31P-MRS) prior to and after 1 and 7 months of treatment with oral lipoic acid. Before treatment a decreased phosphocreatine (PCr) content was found in the oc...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00873552
更新日期：1995-07-01 00:00:00
abstract：:Reduced level of consciousness is a common clinical finding in acutely sick patients. In the majority of cases a cause for the encephalopathy is readily identifiable,whilst in a minority the aetiology is more difficult to ascertain. Frequently the onset of encephalopathy is associated with, or follows, infection. The ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-006-0092-4
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to identify clinical, magnetic resonance imaging (MRI) and biological markers predictive of long-term clinical response to interferon beta (IFN beta) therapy in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS:Sixty-eight patients treated with IFN beta were foll...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-005-0979-5
更新日期：2006-03-01 00:00:00
