Abstract：
:Reduced level of consciousness is a common clinical finding in acutely sick patients. In the majority of cases a cause for the encephalopathy is readily identifiable,whilst in a minority the aetiology is more difficult to ascertain. Frequently the onset of encephalopathy is associated with, or follows, infection. The mechanisms through which infection leads to encephalopathy are diverse. They range from direct microbial invasion of the brain or its supporting structures, to remote, infection-triggered mechanisms such as acute disseminated encephalomyelitis. Most common however, is the encephalopathy caused through a remote effect of systemic sepsis-septic encephalopathy. This article discusses the clinical presentation and underlying pathogeneses of the acute encephalopathies associated with infection, aiming to aid both their recognition and treatment.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Davies NW,Sharief MK,Howard RSdoi
10.1007/s00415-006-0092-4subject
Has Abstractpub_date
2006-07-01 00:00:00pages
833-45issue
7eissn
0340-5354issn
1432-1459journal_volume
253pub_type
杂志文章,评审abstract：:The objective of this study is to determine the current distribution of clinical phenotypes and to estimate future trends of ALS incidence in Western societies. We report on a clinical-epidemiological registry with a capture-recapture rate of >80% and population-based case-control study in ALS patients in South Wester...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8413-3
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Glatiramer acetate (GA) therapy following brief, low-dose induction with mitoxantrone was safe and more effective than GA alone in suppressing inflammatory disease activity, as determined by a significant reduction in gadolinium (Gd)- enhancing MRI lesions, in a 15- month, randomized, single-blind study of r...
journal_title：Journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00415-008-0911-x
更新日期：2008-10-01 00:00:00
abstract：:Nystagmus is a rhythmical rotation of the eyeball. Its characteristics can be defined mathematically by the axis of rotation and the angular velocity around this axis. We analysed the axis of rotation for the nystagmus in benign paroxysmal positional vertigo (BPPV) to elucidate its pathophysiology. Thirteen patients w...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0905-z
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:An upper motor neuron (UMN) lesion in amyotrophic lateral sclerosis (ALS) is often difficult to identify because clinical signs may be discrete or masked by severe simultaneous LMN lesions. We compared the diagnostic sensitivity of transcranial magnetic stimulation (TMS) to cranial muscles and limb muscles i...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150170068
更新日期：2001-10-01 00:00:00
abstract：:Discontinuation of natalizumab can lead to severe rebound of disease activity in patients with relapsing-remitting multiple sclerosis (RRMS); nevertheless, the treatment regimen in this clinical situation remains controversial. We report the case of a 25-year-old male patient with RRMS who was clinically stable under ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8622-9
更新日期：2017-12-01 00:00:00
abstract：:Current findings suggest that multipotent stem cells may be suitable for cell replacement therapies in the treatment of neurodegenerative disorders. Embryonic stem (ES) cells are pluripotent cells isolated from the inner cell mass of the preimplantation blastocyst, which give rise to all cells in the organism. Similar...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-002-1307-y
更新日期：2002-10-01 00:00:00
abstract：:Mutations in the SPG3A gene cause a form of pure, early-onset autosomal dominant hereditary spastic paraplegia linked to chromosome 14q. The encoded protein, atlastin, is a putative member of the dynamin superfamily of large GTPases involved in cellular trafficking patterns. We report a new atlastin mutation causing s...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0768-1
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Gastrointestinal (GI) dysfunction is prevalent in Parkinson's disease (PD). Symptoms are evident throughout the disease course, affect the length of the GI tract and impact on patient quality of life and management. We clarify real-life differences in the frequency and severity of GI symptoms in a cohort of ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09723-5
更新日期：2020-05-01 00:00:00
abstract：:A case of a patient with hyperinsulinism due to insulinoma associated with neurological and psychiatric disturbances including EEG alterations is reported. The hunger test as well as the i.v. tolbutamid test proved to be of diagnostic importance. In addition, the electroencephalographic studies combined with blood sug...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00329161
更新日期：1976-04-23 00:00:00
abstract：:Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectivel...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09830-3
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:The mechanisms of early neurologic deterioration (END) and prevention strategies for END are not completely understood. The aim of this study was to investigate the association between CYP2C19*2 variants and END, and the effectiveness of antiplatelet therapy for prevention of END according to CYP2C19*2 genot...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00415-018-8998-1
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Due to common pathophysiological findings of Alzheimer's disease (AD) with diabetes mellitus (DM), insulin has been suggested as a possible treatment of AD or mild cognitive impairment (MCI). A safe alternative of IV insulin is intranasal (IN) insulin. The aim of this systematic review is to investi...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00415-018-8768-0
更新日期：2018-07-01 00:00:00
abstract：:Despite the fact that almost one-third of patients suffer from visual deficits following brain damage; neuro-visual rehabilitation to compensate for visual field deficits is relatively neglected in the clinical setting. This is in contrast to physio and speech therapies, which are the bread and butter of rehabilitativ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-016-8291-0
更新日期：2017-06-01 00:00:00
abstract：:During the last few years, deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as a promising therapy, alleviating major motor symptoms of Parkinson's disease (PD). However, in times of growing budgetary limitations, medical decisions are no longer merely based on clinical efficacy, but also on c...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0640-3
更新日期：2005-02-01 00:00:00
abstract：:We investigated the muscle strength and motor unit (MU) territory of five patients with postpolio syndrome (PPS), six stable patients with prior poliomyelitis, and five healthy volunteers. The MU territory was assessed by measuring amplitudes of motor unit potentials (MUPs) recorded by the macro EMG technique. The inv...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00920572
更新日期：1994-12-01 00:00:00
abstract：:In this work, we investigated motor network structure in patients affected by essential tremor (ET) with or without resting tremor, using probabilistic tractography of the cerebello-thalamo-basal ganglia-cortical loop. Twenty-five patients with ET, twenty-two patients with ET associated with resting tremor (rET), and ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8553-5
更新日期：2017-09-01 00:00:00
abstract：UNLABELLED:To systematically and comprehensively describe functioning and disability in Multiple sclerosis (MS), practical tools based on the International Classification of Functioning, Disability and Health (ICF), such as ICF Core Sets, are needed. OBJECTIVE:To report on the results of an evidence-based Internationa...
journal_title：Journal of neurology
pub_type： 共识发展会议,杂志文章
doi：10.1007/s00415-011-5963-7
更新日期：2011-08-01 00:00:00
abstract：:Relapses are a characteristic clinical feature of multiple sclerosis (MS), but an appreciation of factors that cause them remains elusive. In this study, we have examined seasonal variation of relapse in a large population-based MS cohort and correlated observed patterns with age, sex, disease course, and climatic fac...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8485-0
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to identify clinical, magnetic resonance imaging (MRI) and biological markers predictive of long-term clinical response to interferon beta (IFN beta) therapy in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS:Sixty-eight patients treated with IFN beta were foll...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-005-0979-5
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:As metabolic and structural changes in frontotemporal-subcortical pathways have been reported in patients with obsessive-compulsive disorders, we investigated the correlation between complex compulsive behaviour (CCB) and the distribution of atrophy in a group of 90 patients with frontotemporal dementia (FTD)...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170049
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Volume loss in the deep gray matter (DGM) has been reported in patients with multiple sclerosis (MS) already at early stages of the disease and is thought to progress throughout the disease course. OBJECTIVE:To investigate the impact and predictive value of volume loss in DGM and thalamic subnuclei on disab...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09740-4
更新日期：2020-05-01 00:00:00
abstract：:Cortical tubers are very common in tuberous sclerosis complex (TSC) and widely vary in size, appearance and location. The relationship between tuber features and clinical phenotype is unclear. The aim of the study is to propose a classification of tuber types along a spectrum of severity, using magnetic resonance imag...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5535-2
更新日期：2010-08-01 00:00:00
abstract：:We report the case of a 17.5-year old girl with generalized myasthenia gravis (MG). When she was 13, she started to complain of episodic diplopia, ptosis and mild fatigability of upper and lower extremity muscles. She was diagnosed with MG 3 years later, after exacerbation of her limb muscle weakness. Acetylcholine re...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-009-5215-2
更新日期：2009-10-01 00:00:00
abstract：:Twenty-four patients with unilateral facial weakness of various aetiologies were investigated using a magnetic stimulator to stimulate the proximal segment of the facial nerve directly (short latency response) and also to activate the facial motoneurons bilaterally via corticonuclear pathways by placing the stimulatin...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314405
更新日期：1989-02-01 00:00:00
abstract：:A woman affected by chronic progressive external ophthalmoplegia and muscle mitochondrial DNA deletion was studied by phosphorus magnetic resonance spectroscopy (31P-MRS) prior to and after 1 and 7 months of treatment with oral lipoic acid. Before treatment a decreased phosphocreatine (PCr) content was found in the oc...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00873552
更新日期：1995-07-01 00:00:00
abstract：:The purpose of this study was to evaluate the contribution of posterior circulation to memory function by comparing memory scores between patients with and without a foetal-type posterior cerebral artery (FTP) during the intracarotid amobarbital procedure (IAP) in epilepsy patients. Patients undergoing bilateral IAP b...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6391-4
更新日期：2012-08-01 00:00:00
abstract：:A total of 15 patients affected by idiopathic dystonia (7 with generalized and 8 with focal or segmental dystonia) were subjected to therapy with bromocriptine at low doses, pimozide and trihexyphenidyl. The symptoms were evaluated by giving a progressive score in relation to the intensity of the dystonic symptom to e...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313391
更新日期：1982-01-01 00:00:00
abstract：:Deep brain stimulation of the subthalamic nucleus (STN) is an effective treatment modality for motor symptoms of advanced Parkinson's disease. Recent studies focus on exploring its possible effects on cognition and behavior. We present a case with acute cognitive dysfunction due to misalignment of the electrodes to th...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-009-5103-9
更新日期：2009-08-01 00:00:00
abstract：INTRODUCTION:Mal de Debarquement Syndrome (MdDS) is the rare condition of enduring rocking sensations and subjective unsteadiness following a lengthy exposure to passive motion. The pathogenesis of MdDS is unknown and the available treatment is limited. Here, we developed an experimental model of MdDS that may facilita...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09345-6
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:Determine toxicity and efficacy of autologous hematopoietic stem cell transplantation (HSCT) for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who are dependent on intravenous immunoglobulins or plasmapheresis. METHODS:Unselected peripheral blood stem cells were re-infused on...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10010-6
更新日期：2020-11-01 00:00:00
