Abstract：
:In this work, we investigated motor network structure in patients affected by essential tremor (ET) with or without resting tremor, using probabilistic tractography of the cerebello-thalamo-basal ganglia-cortical loop. Twenty-five patients with ET, twenty-two patients with ET associated with resting tremor (rET), and twenty-five age- and sex-matched healthy controls were included in the study. All participants underwent whole-brain 3D T1-weighted and diffusion-weighted MRI, and DAT-SPECT. Probabilistic tractography was performed on diffusion data in network mode, reconstructing connections between the different structures of the cerebello-thalamo-basal ganglia-cortical loop. All patients with ET, regardless of the presence of resting tremor, had normal DAT-SPECT, but showed significantly decreased connectivity in the cerebello-thalamo-precentral cortex network bilaterally, compared to healthy controls. In addition, patients with rET showed reduced connectivity in a pathway connecting globus pallidus, caudate, and supplementary motor area, compared to ET and controls. This latter circuit was significantly damaged in the hemisphere contralateral to the side clinically most affected by resting tremor. These findings provide insights upon structural changes underlying the different clinical presentations of ET. Our study demonstrates that ET and rET share common alterations in the cerebello-thalamo-precentral cortex circuit, while rET patients are characterized by specific damage to additional structures of motor network, such as globus pallidus, caudate nucleus, and supplementary motor area. Our findings suggest that ET and rET are different subtypes of the same neurodegenerative disorder.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Caligiuri ME,Arabia G,Barbagallo G,Lupo A,Morelli M,Nisticò R,Novellino F,Quattrone A,Salsone M,Vescio B,Cherubini A,Quattrone Adoi
10.1007/s00415-017-8553-5subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1865-1874issue
9eissn
0340-5354issn
1432-1459pii
10.1007/s00415-017-8553-5journal_volume
264pub_type
杂志文章abstract：:Vertigo is frequently associated with migraine, and sometimes it is the cardinal symptom. This type of migraine is called "vestibular migraine", "migrainous vertigo", or "migraine-associated vertigo". Earlier findings on effective prophylactic medication for such migraine attacks and their clinical features are few an...
journal_title：Journal of neurology
pub_type： 杂志文章
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journal_title：Journal of neurology
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journal_title：Journal of neurology
pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1007/s00415-005-0912-y
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journal_title：Journal of neurology
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journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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journal_title：Journal of neurology
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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