当前位置： SCI文献检索 > JOURNAL OF NEUROLOGY期刊下所有文献 > Levodopa, bromocriptine and selegiline modify cardiovascular responses in Parkinson's disease.

Levodopa, bromocriptine and selegiline modify cardiovascular responses in Parkinson's disease.

Abstract：

:Autonomic nervous system (ANS) involvement is frequently found in Parkinson's disease (PD), but its causal relationship to the disease itself and its medication is unclear. We evaluated the effects of PD medications on cardiovascular ANS functions. Heart rate (HR) responses to normal and deep breathing, the Valsalva manoeuvre and tilting, and blood pressure (BP) responses to tilting and isometric work were measured prospectively in 60 untreated PD patients randomised to receive either levodopa (n = 20), bromocriptine (n = 20) or selegiline (n = 20) as their initial treatment. The results were compared with those of 28 healthy controls. The responses were recorded at baseline, after 6 months on medication and following a 6-week washout period. At baseline HR responses to normal breathing, deep breathing and tilting were already lower and the fall in the systolic BP immediately and at 5 min after tilting was more pronounced in the PD patients than in the controls. Six months' levodopa treatment diminished the systolic BP fall after tilting when compared to baseline, whereas bromocriptine and selegiline increased the fall in systolic BP after tilting and selegiline diminished the BP responses to isometric work. The BP responses returned to the baseline values during the washout period. The drugs induced no change in the HR responses. Thus PD itself causes autonomic dysfunction leading to abnormalities in HR and BP regulation and the PD medications seem to modify ANS responses further. Bromocriptine and selegiline, in contrast to levodopa, increase the orthostatic BP fall and suppress the BP response to isometric exercise reflecting mainly impairment of the sympathetic regulation.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Haapaniemi TH,Kallio MA,Korpelainen JT,Suominen K,Tolonen U,Sotaniemi KA,Myllylä VV

doi

10.1007/s004150070075

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

868-74

issue

11

eissn

0340-5354

issn

1432-1459

journal_volume

247

pub_type

临床试验,杂志文章,随机对照试验

相关文献

JOURNAL OF NEUROLOGY文献大全
  • Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients.

    abstract：:Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion is affected in MSA patients, and to investigate the relation between g...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-013-6944-9

    authors： Ozawa T,Tokunaga J,Arakawa M,Ishikawa A,Takeuchi R,Mezaki N,Miura T,Sakai N,Hokari M,Takeshima A,Utsumi K,Kondo T,Yokoseki A,Nishizawa M

    更新日期：2013-08-01 00:00:00

  • Paraneoplastic diseases associated with thymoma.

    abstract：BACKGROUND:Thymoma is frequently associated with paraneoplastic diseases (PDs), most commonly with myasthenia gravis (MG). This association is thought to depend on thymoma's capacity to produce and export T lymphocytes. OBJECTIVE:(1) To determine the frequency and characteristics of thymoma-associated PDs other than M...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-006-0429-z

    authors： Evoli A,Minicuci GM,Vitaliani R,Battaglia A,Della Marca G,Lauriola L,Fattorossi A

    更新日期：2007-06-01 00:00:00

  • Bright tongue sign in patients with late-onset Pompe disease.

    abstract：BACKGROUND:Late-onset Pompe disease (LOPD) is an often misdiagnosed inherited myopathy for which treatment exists. We noticed a bright tongue sign on brain MRIs of two patients who were admitted to the ICU for respiratory failure of unclear origin, and who were eventually diagnosed with LOPD. This led us to systematica...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09455-1

    authors： Karam C,Dimitrova D,Yutan E,Chahin N

    更新日期：2019-10-01 00:00:00

  • Longitudinal evaluation of quality of life in 288 patients with neurofibromatosis 2.

    abstract：:Advances in molecular biology have resulted in novel therapy for neurofibromatosis 2-related (NF2) tumours, highlighting the need for robust outcome measures. The disease-focused NF2 impact on quality of life (NFTI-QOL) patient questionnaire was assessed as an outcome measure for treatment in a multi-centre study. NFT...

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00415-014-7303-1

    authors： Ferner RE,Shaw A,Evans DG,McAleer D,Halliday D,Parry A,Raymond FL,Durie-Gair J,Hanemann CO,Hornigold R,Axon P,Golding JF

    更新日期：2014-05-01 00:00:00

  • Diagnosing Alzheimer's disease in elderly, mildly demented patients: the impact of routine single photon emission computed tomography.

    abstract：:Based on the observation of bilateral temporoparietal hypoperfusion in Alzheimer's disease (AD), single photon emission computed tomography (SPECT) is advocated by some as a powerful diagnostic tool in the evaluation of demented patients. We studied whether routine brain SPECT in elderly, mildly demented outpatients i...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00868397

    authors： Van Gool WA,Walstra GJ,Teunisse S,Van der Zant FM,Weinstein HC,Van Royen EA

    更新日期：1995-06-01 00:00:00

  • Differentiation of herpes simplex virus 1 and 2 in cerebrospinal fluid of patients with HSV encephalitis and meningitis by stringent hybridization of PCR-amplified DNAs.

    abstract：:Differentiation of herpes simplex virus (HSV) types 1 and 2 in cerebrospinal fluid of 17 patients with serologically diagnosed HSV encephalitis and meningitis or acute limbic encephalitis was determined by stringent hybridization of polymerase chain reaction--amplified DNAs. Ten of 17 patients were positive; six with ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00873514

    authors： Shoji H,Koga M,Kusuhara T,Kaji M,Ayabe M,Hino H,Hondo R

    更新日期：1994-08-01 00:00:00

  • Anger, hostility and risk of stroke: a meta-analysis of cohort studies.

    abstract：OBJECTIVE:A growing number of studies have been conducted on the relationship between anger and hostility and the risk of stroke, and their conclusions are not consistent. Accordingly, we performed a meta-analysis to evaluate the relationship between anger and hostility and the risk of stroke. METHODS:We searched the ...

    journal_title：Journal of neurology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00415-019-09231-1

    authors： Chen H,Zhang B,Xue W,Li J,Li Y,Fu K,Chen X,Sun M,Shi H,Tian L,Teng W

    更新日期：2019-04-01 00:00:00

  • Right mesial temporal lobe epilepsy impairs empathy-related brain responses to dynamic fearful faces.

    abstract：:Unilateral mesial temporal lobe epilepsy (MTLE) has been associated with reduced amygdala responsiveness to fearful faces. However, the effect of unilateral MTLE on empathy-related brain responses in extra-amygdalar regions has not been investigated. Using functional magnetic resonance imaging, we measured empathy-rel...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-014-7622-2

    authors： Toller G,Adhimoolam B,Grunwald T,Huppertz HJ,Kurthen M,Rankin KP,Jokeit H

    更新日期：2015-03-01 00:00:00

  • Pharmacodynamics of interferon beta in multiple sclerosis patients with or without serum neutralizing antibodies.

    abstract：:To analyze the in vivo biological effect of anti-interferon beta (IFN-beta) neutralizing antibodies (NABs), blood concentrations of neopterin, beta2microglobulin (Beta2-MG), mRNA-dependent myxovirusresistant protein A (MxA) and dsRNA-dependent protein kinase (PKR) were measured before (predose) and 24 hours after (pos...

    journal_title：Journal of neurology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00415-006-0332-7

    authors： Scagnolari C,Duda P,Bagnato F,De Vito G,Alberelli A,Lavolpe V,Girardi E,Durastanti V,Trojano M,Kappos L,Antonelli G

    更新日期：2007-05-01 00:00:00

  • Risk factors for critical illness polyneuromyopathy.

    abstract：:Although numerous clinical, laboratory, and pharmacological variables have been reported as significant risk factors for critical illness polyneuromyopathy (CIPM), there is still no consensus on the aetiology of this condition. Objectives of the study were to assess the clinical and electrophysiological incidence and ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-005-0654-x

    authors： Bednarík J,Vondracek P,Dusek L,Moravcova E,Cundrle I

    更新日期：2005-03-01 00:00:00

  • Correction to: The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland.

    abstract：:The article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran...

    journal_title：Journal of neurology

    pub_type： 已发布勘误

    doi：10.1007/s00415-020-10256-0

    authors： Glasmacher SA,Larraz J,Mehta AR,Kearns PKA,Wong M,Newton J,Davenport R,Gorrie G,Morrison I,Carod Artal J,Chandran S,Pal S,CARE-MND Consortium.

    更新日期：2020-10-20 00:00:00

  • Discrepancy between clinical and pathological diagnoses of CBD and PSP.

    abstract：:Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are often clinically confused with each other. Moreover, the discrepancy between clinical and pathological diagnoses of CBD and PSP are still controversial. We report here two atypical cases of PSP and CBD. A 73-year old woman was admitted with r...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-005-0718-y

    authors： Mizuno T,Shiga K,Nakata Y,Nagura J,Nakase T,Ueda Y,Takanashi Y,Urasaki K,Oyamada Y,Fushiki S,Nishikawa J,Yasuhara M,Nakajima K,Nakagawa M

    更新日期：2005-06-01 00:00:00

  • The costs and prognostic characteristics of ischaemic neurological deficit due to subarachnoid haemorrhage in the United Kingdom. Evidence from the MRC International Subarachnoid Aneurysm Trial.

    abstract：BACKGROUND:Delayed ischaemic neurological deficit (DID) following subarachnoid haemorrhage from aneurysm rupture (aSAH) is a serious complication and a major cause of mortality and morbidity. No empirical estimates of resource use and costs of patients with delayed ischaemic deficit compared to those without have been ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-009-0034-z

    authors： Rivero-Arias O,Wolstenholme J,Gray A,Molyneux AJ,Kerr RS,Yarnold JA,Sneade M

    更新日期：2009-03-01 00:00:00

  • Changes in peripheral blood lymphocyte subset frequencies in myasthenia gravis patients are related to immunosuppression.

    abstract：:Surface antigens on peripheral blood lymphocytes from myasthenia gravis patients were investigated. The expression of DR+ and CD8+/DR+ T lymphocytes was increased and the expression of CD4+ T cells reduced. Neither thymectomy, clinical condition nor anti-acetylcholine receptor antibody titre correlated with any of the...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00863771

    authors： Crosti F,Armanini M,Confalonieri P,Antozzi C,Mantegazza R

    更新日期：1994-02-01 00:00:00

  • Treatment of chronic relapsing inflammatory demyelinating polyneuropathy by cyclosporin A and plasma exchange. A case report.

    abstract：:A patient with chronic relapsing inflammatory demyelinating polyneuropathy was successfully treated with plasma exchanges and cyclosporin A (CsA). Dynamometric measurements of hand force during the time of CsA treatment showed a highly significant correlation between hand force and CsA blood levels. The largest influe...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314752

    authors： Hefter H,Sprenger KB,Arendt G,Hafner D

    更新日期：1990-08-01 00:00:00

  • Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort.

    abstract：OBJECTIVE:To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years. METHODS:Cross-sectional observational cohort study. 389 largely healthy and cognitively normal older adults were recruited from...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10004-4

    authors： Buchanan SM,Parker TD,Lane CA,Keshavan A,Keuss SE,Lu K,James SN,Murray-Smith H,Wong A,Nicholas J,Cash DM,Malone IB,Coath W,Thomas DL,Sudre C,Fox NC,Richards M,Schott JM

    更新日期：2020-11-01 00:00:00

  • Classic ataxia-telangiectasia: the phenotype of long-term survivors.

    abstract：OBJECTIVE:Patients with classic ataxia-telangiectasia (A-T) generally die in the second or third decade of life. Clinical descriptions of A-T tend to focus on the symptoms at presentation. However, during the course of the disease, other symptoms and complications emerge. As long-term survivors with classic A-T develop...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09641-1

    authors： van Os NJH,van Deuren M,Weemaes CMR,van Gaalen J,Hijdra H,Taylor AMR,van de Warrenburg BPC,Willemsen MAAP

    更新日期：2020-03-01 00:00:00

  • On the effect of brain phospholipase A1 on specifically labelled glycerophospholipids in the course of subacute sclerosing panencephalitis.

    abstract：:The effect of phospholipase A1 of human brain on 1,2-diacyl-sn-glycero-3-phosphorylcholine, -ethanolamine and -serine, specifically labelled with different fatty acids at either the 1 or 2 position, was determined in subacute sclerosing panencephalitis. An increase of approximately 40% in the specific activity of phos...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00312524

    authors： Morgott UJ,Woelk H

    更新日期：1975-01-01 00:00:00

  • Stroke in pregnancy and the puerperium.

    abstract：:Recent studies suggest that the risk of cerebral infarction is increased during the puerperium but not during pregnancy itself. Most of the known causes of ischaemic stroke in the young have been reported during pregnancy. In most of these conditions, it is uncertain whether pregnancy is coincidental or plays a role i...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s004150050224

    authors： Mas JL,Lamy C

    更新日期：1998-06-01 00:00:00

  • Prognostic criteria in an epidemiological group of patients with multiple sclerosis: an exploratory study.

    abstract：:Demographic and clinical features and data on medical history and prior environmental exposure collected during an epidemiological long-term study of multiple sclerosis (MS) were tested for their possible prognostic value. Fifty-two benign MS patients were compared with 29 patients having a malignant course. A primary...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00862981

    authors： Lauer K,Firnhaber W

    更新日期：1992-02-01 00:00:00

  • Differences in morphology and visual function of myelin oligodendrocyte glycoprotein antibody and multiple sclerosis associated optic neuritis.

    abstract：BACKGROUND:Myelin oligodendrocyte glycoprotein immunoglobulin G associated optic neuritis (MOG-ON) is a recently described entity. Recent studies have shown that MOG-ON has a more severe clinical presentation than classic optic neuritis (ON). OBJECTIVE:This study aimed to define morphological characteristics of MOG-ON...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10097-x

    authors： Vicini R,Brügger D,Abegg M,Salmen A,Grabe HM

    更新日期：2021-01-01 00:00:00

  • Blink reflex in patients with an ischaemic lesion of the brain-stem verified by MRI.

    abstract：:The electrically elicited blink reflex was investigated in 25 patients with ischaemic lesions of the pons or the medulla oblongata. Only patients with a lesion on MRI appropriate to the clinical syndrome were included. Twenty patients had an infarction of the pons, bilateral in 5. Additional 5 patients had an infarcti...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00870670

    authors： Meincke U,Ferbert A

    更新日期：1993-11-01 00:00:00

  • New therapeutic maneuver for anterior canal benign paroxysmal positional vertigo.

    abstract：:This article describes the clinical features of anterior semicircular canal benign paroxysmal positional vertigo (AC-BPPV) and a new therapeutic maneuver for its management. Our study was a retrospective review of cases from an ambulatory tertiary referral center. Thirteen patients afflicted with positional paroxysmal...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-009-5208-1

    authors： Yacovino DA,Hain TC,Gualtieri F

    更新日期：2009-11-01 00:00:00

  • Functional imaging in Parkinson's disease: activation studies with PET, fMRI and SPECT.

    abstract：:Activation studies with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) represent a powerful tool to study the functional anatomy of Parkinson's disease (PD). Activation studies offer the opportunity to study regional cerebral function in man in vivo under different conditions with ...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-003-1103-1

    authors： Ceballos-Baumann AO

    更新日期：2003-02-01 00:00:00

  • Recent advances in the diagnosis, genetics and treatment of restless legs syndrome.

    abstract：:Knowledge of restless legs syndrome (RLS) has greatly increased in recent years due to the many advances that have been made in diagnosis, management and genetics. Tools have been developed that facilitate the diagnosis and treatment of RLS, in particular the essential diagnostic criteria for RLS have been refined, se...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-009-0134-9

    authors： Trenkwalder C,Högl B,Winkelmann J

    更新日期：2009-04-01 00:00:00

  • Comparison of monoclonal gammopathy of undetermined significance-associated neuropathy and chronic inflammatory demyelinating polyneuropathy patients.

    abstract：OBJECTIVES:There are varying reports on whether monoclonal gammopathy of undetermined significance-associated neuropathy (MGUSN) patients are distinguishable from those with chronic inflammatory demyelinating polyneuropathy (CIDP) and whether specific MGUSN subclasses are associated with specific clinical phenotypes. ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-014-7357-0

    authors： Alkhawajah NM,Dunnigan SK,Bril V

    更新日期：2014-08-01 00:00:00

  • The presymptomatic phase of amyotrophic lateral sclerosis: are we merely scratching the surface?

    abstract：:Presymptomatic studies in ALS have consistently captured considerable disease burden long before symptom manifestation and contributed important academic insights. With the emergence of genotype-specific therapies, however, there is a pressing need to address practical objectives such as the estimation of age of sympt...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-020-10289-5

    authors： Chipika RH,Siah WF,McKenna MC,Li Hi Shing S,Hardiman O,Bede P

    更新日期：2020-10-31 00:00:00

  • MRI and motor evoked potential findings in nondisabled multiple sclerosis patients with and without symptoms of fatigue.

    abstract：:Fatigue is a common symptom of multiple sclerosis (MS) even in the early phases of the disease, when neurological disability is usually still not present. To investigate the pathophysiology of fatigue we compared neurophysiological (motor evoked potentials of the four limbs, MEPs) and brain magnetic resonance imaging ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s004150070148

    authors： Colombo B,Martinelli Boneschi F,Rossi P,Rovaris M,Maderna L,Filippi M,Comi G

    更新日期：2000-07-01 00:00:00

  • Cluster headache: pathophysiology, diagnosis and treatment.

    abstract：:Cluster headache (CH) is characterized by attacks of severe, strictly unilateral pain that is orbital, supraorbital, temporal, or any combination of these, lasts 15-180 min, and occurs from once every other day to eight times a day. The pain is associated with ipsilateral conjunctival injection, lacrimation, nasal con...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-018-9007-4

    authors： Ljubisavljevic S,Zidverc Trajkovic J

    更新日期：2019-05-01 00:00:00

  • Fatty acid dietary intake and the risk of ischaemic stroke: a multicentre case-control study. UFA Study Group.

    abstract：:A low dietary intake of unsaturated fatty acids has been found in male patients with stroke as compared with controls in Italy, and a high consumption of meat has been associated with an increased risk of stroke in Australia. We present a case-control study, comparing the unsaturated and saturated fatty acids content ...

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s004150050102

    authors： Ricci S,Celani MG,Righetti E,Caruso A,De Medio G,Trovarelli G,Romoli S,Stragliotto E,Spizzichino L

    更新日期：1997-06-01 00:00:00