Fatty acid dietary intake and the risk of ischaemic stroke: a multicentre case-control study. UFA Study Group.

Abstract:

:A low dietary intake of unsaturated fatty acids has been found in male patients with stroke as compared with controls in Italy, and a high consumption of meat has been associated with an increased risk of stroke in Australia. We present a case-control study, comparing the unsaturated and saturated fatty acids content of red cell membranes (which reflects the dietary intake of saturated and unsaturated fats) in 89 patients with ischaemic stroke and 89 controls matched for age and sex. In univariate analysis, besides hypertension, atrial fibrillation, ischaemic changes in ECG and hypercholesterolaemia, stroke patients showed a lower level of oleic acid (P = 0.000), but a higher level of eicosatrienoic acid (P = 0.009). Conditional logistic regression (dependent variable; being a case) showed that the best model included atrial fibrillation, hypertension, oleic acid and eicosatrienoic acids. These results confirm a possible protective role of unsaturated fatty acids against vascular diseases; however, we did not find any difference in the content of omega3 acids, which have been considered in the past to protect against coronary heart disease. We conclude that the preceding diet of patients with ischaemic stroke may be poor in unsaturated fatty acids (namely, oleic acid), and this defect is independent of other vascular risk factors. Only further studies will show whether changes in diet and/or supplement of unsaturated fatty acids might reduce the incidence of ischaemic stroke.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Ricci S,Celani MG,Righetti E,Caruso A,De Medio G,Trovarelli G,Romoli S,Stragliotto E,Spizzichino L

doi

10.1007/s004150050102

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

360-4

issue

6

eissn

0340-5354

issn

1432-1459

journal_volume

244

pub_type

杂志文章,多中心研究
  • Neuropsychological assessment.

    abstract::Neuropsychological assessment is one of the main fields of activity of clinical neuropsychologists. Goals of this assessment are verification and description of cognitive and affective impairments as the consequence of brain damage. Included are examinations of basal and higher sensory functions, the intellectual prof...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-007-2004-7

    authors: Sturm W

    更新日期:2007-05-01 00:00:00

  • Utility of measuring vitamin B12 and its active fraction, holotranscobalamin, in neurological vitamin B12 deficiency syndromes.

    abstract::Vitamin B(12) (VitB(12), cobalamin) deficiency has been associated with various neuropsychiatric conditions, such as peripheral neuropathy, subacute combined degeneration, affective disorders, and cognitive impairment. Current assays analyze vitamin B(12), of which only a small percentage is metabolically active. Meas...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-010-5764-4

    authors: Schrempf W,Eulitz M,Neumeister V,Siegert G,Koch R,Reichmann H,Storch A

    更新日期:2011-03-01 00:00:00

  • Evaluation of a new approach for semi-automatic segmentation of the cerebellum in patients with multiple sclerosis.

    abstract::Cerebellar dysfunction is an important contributor to disability in patients with multiple sclerosis (MS), however, few in vivo studies focused on cerebellar volume loss so far. This relates to technical challenges regarding the segmentation of the cerebellum. In this study, we evaluated the semi-automatic ECCET softw...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-012-6569-4

    authors: Weier K,Beck A,Magon S,Amann M,Naegelin Y,Penner IK,Thürling M,Aurich V,Derfuss T,Radue EW,Stippich C,Kappos L,Timmann D,Sprenger T

    更新日期:2012-12-01 00:00:00

  • Mental status and health-related quality of life in an elderly population 15 years after limited cerebral ischaemia.

    abstract:BACKGROUND:Stroke has a major impact on survivors. Our study was designed to describe the mental status and health-related quality of life (HRQoL) in long-term survivors of TIA or minor ischaemic stroke (MIS) and evaluate associations of mental and physical factors with HR-QoL. METHODS:A random sample of the 10-year s...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-006-0480-9

    authors: van Wijk I,Gorter JW,Lindeman E,Kappelle LJ,van Gijn J,Koudstaal PJ,Algra A

    更新日期:2007-08-01 00:00:00

  • Idiopathic dystonia: neuropharmacological study.

    abstract::A total of 15 patients affected by idiopathic dystonia (7 with generalized and 8 with focal or segmental dystonia) were subjected to therapy with bromocriptine at low doses, pimozide and trihexyphenidyl. The symptoms were evaluated by giving a progressive score in relation to the intensity of the dystonic symptom to e...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313391

    authors: Girotti F,Scigliano G,Nardocci N,Angelini L,Broggi G,Giovannini P,Caraceni T

    更新日期:1982-01-01 00:00:00

  • Stroke in pregnancy and the puerperium.

    abstract::Recent studies suggest that the risk of cerebral infarction is increased during the puerperium but not during pregnancy itself. Most of the known causes of ischaemic stroke in the young have been reported during pregnancy. In most of these conditions, it is uncertain whether pregnancy is coincidental or plays a role i...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s004150050224

    authors: Mas JL,Lamy C

    更新日期:1998-06-01 00:00:00

  • The role of global and regional gray matter volume decrease in multiple sclerosis.

    abstract::Disability in multiple sclerosis (MS) patients is associated with white matter (WM) and gray matter (GM) pathology, and both processes contribute differently over the disease course. Total and regional GM volume loss can be imaged via voxel-based morphometry (VBM). Here, we retrospectively analyzed a group of 213 MS p...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-016-8114-3

    authors: Grothe M,Lotze M,Langner S,Dressel A

    更新日期:2016-06-01 00:00:00

  • Predictors of outcome in HSV encephalitis.

    abstract::This study aims to explore the clinical features, radiological findings, management and the factors influencing prognosis in PCR-confirmed herpes simplex virus encephalitis (HSE). This is a retrospective review of consecutive patients diagnosed with HSE at Mayo Clinic, Rochester, MN, between January 1995 and December ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-015-7960-8

    authors: Singh TD,Fugate JE,Hocker S,Wijdicks EFM,Aksamit AJ Jr,Rabinstein AA

    更新日期:2016-02-01 00:00:00

  • Computed tomographic angiography findings in 103 patients following vascular events in the posterior circulation: potential and clinical relevance.

    abstract::We studied the diagnostic value of computed tomographic angiography (CTA) in the posterior circulation as a noninvasive substitute for intra-arterial digital subtraction angiography (DSA). We prospectively investigated 103 patients with acute stroke in the posterior circulation. All patients underwent CTA and Doppler ...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s004150070089

    authors: Graf J,Skutta B,Kuhn FP,Ferbert A

    更新日期:2000-10-01 00:00:00

  • Long-term outcomes of refractory neurosarcoidosis treated with infliximab.

    abstract::Central nervous system localizations of sarcoidosis may be refractory to conventional treatment such as steroids and immunosuppressive drugs. Infliximab, a TNF-α antagonist chimeric antibody, has been shown to be effective for treatment of these localizations. The aim of this study was to evaluate the efficacy and saf...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-017-8444-9

    authors: Cohen Aubart F,Bouvry D,Galanaud D,Dehais C,Mathey G,Psimaras D,Haroche J,Pottier C,Hie M,Mathian A,Devilliers H,Nunes H,Valeyre D,Amoura Z

    更新日期:2017-05-01 00:00:00

  • Further observation of Japanese Creutzfeldt-Jacob disease with widespread amyloid plaques.

    abstract::An autopsy case of Creutzfeld-Jacob disease with widespread amyloid plaques is reported. A 45-year-old Japanese man, whose father had died of a similar disease, had a 5-year illness characterized by progressive cerebellar signs. Mental changes and brain-stem signs developed in the late stage. Myoclonus frequently occu...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314329

    authors: Yagishita S,Iwabuchi K,Amano N,Yokoi S

    更新日期:1989-03-01 00:00:00

  • Conservative treatments of children with episodic tension-type headache. A systematic review.

    abstract:OBJECTIVE:We aimed to assess the effectiveness of conservative treatments in children with tension-type headaches (TTH). METHOD:We searched Medline, Embase and the Cochrane Library and performed reference checking. Two independent authors assessed trial quality and extracted data. Analysis was carried out according to...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-005-0940-7

    authors: Verhagen AP,Damen L,Berger MY,Passchier J,Merlijn V,Koes BW

    更新日期:2005-10-01 00:00:00

  • 5-Hydroxytryptamine and the pathophysiology of migraine.

    abstract::5-Hydroxytryptamine (5-HT; serotonin) has long been implicated in the aetiology of migraine but the evidence remains circumstantial and certainly not definitive. Numerous papers have reviewed the background which is briefly outlined here. Although the continued belief in the primary involvement of 5-HT in the genesis ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/BF01642905

    authors: Humphrey PP

    更新日期:1991-01-01 00:00:00

  • The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects.

    abstract::Recently, a frequent prion protein gene (PRNP) polymorphism consisting of a methionine (M) for valine (V) substitution at codon 129 has been associated with cognitive impairment in elderly individuals. Down syndrome (DS) is associated with mental retardation and development of Alzheimer-like brain abnormalities. In th...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-003-1057-5

    authors: Del Bo R,Comi GP,Giorda R,Crimi M,Locatelli F,Martinelli-Boneschi F,Pozzoli U,Castelli E,Bresolin N,Scarlato G

    更新日期:2003-06-01 00:00:00

  • Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson's disease.

    abstract::Cerebello-thalamo-cortical circuit has been indicated important for tremor in Parkinson's disease (PD), but the role of dentate nucleus (DN) in parkinsonian tremor remains unclear. To investigate whether DN plays a role in PD tremor, we recruited 50 PD and 29 age-matched health controls (HC). The patients were divided...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-015-7835-z

    authors: Ma H,Chen H,Fang J,Gao L,Ma L,Wu T,Hou Y,Zhang J,Feng T

    更新日期:2015-10-01 00:00:00

  • Ataxia telangiectasia in identical twins: unusual features.

    abstract::The cases of identical twins with ataxia telangiectasia, early intellectual impairment and progressive spasticity are reported. Immunological tests revealed reduced levels of serum and salivary IgA, increased B cells, reduced T cells and raised alpha-fetoprotein. CT scan performed in one of the twins was normal. The p...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314163

    authors: Meshram CM,Sawhney IM,Prabhakar S,Chopra JS

    更新日期:1986-10-01 00:00:00

  • The neurological sequelae of pandemics and epidemics.

    abstract::Neurological manifestations in pandemics frequently cause short and long-term consequences which are frequently overlooked. Despite advances in the treatment of infectious diseases, nervous system involvement remains a challenge, with limited treatments often available. The under-recognition of neurological manifestat...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-020-10261-3

    authors: Valerio F,Whitehouse DP,Menon DK,Newcombe VFJ

    更新日期:2020-10-26 00:00:00

  • Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study.

    abstract:RATIONALE:Phase I/II studies of autologous hematopoietic stem cell transplantation (HSCT) for multiple sclerosis ( MS) were initiated, based on results of experimental transplantation in animal models of multiple sclerosis and clinical observations in patients treated concomitantly for malignant disease. PATIENTS:Eigh...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s00415-002-0800-7

    authors: Fassas A,Passweg JR,Anagnostopoulos A,Kazis A,Kozak T,Havrdova E,Carreras E,Graus F,Kashyap A,Openshaw H,Schipperus M,Deconinck E,Mancardi G,Marmont A,Hansz J,Rabusin M,Zuazu Nagore FJ,Besalduch J,Dentamaro T,Fouill

    更新日期:2002-08-01 00:00:00

  • Endovascular vs. medical therapy in symptomatic vertebral artery stenosis: a meta-analysis.

    abstract::This meta-analysis aims to compare percutaneous transluminal angioplasty (PTA) to medical treatment (MT) for symptomatic vertebral artery stenosis (SVAS) treatment. We searched PubMed, Springer, Google Scholar, Clinical Trials, Cochrane Central, Chinese National Knowledge Infrastructure, and China Biological Medicine ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00415-016-8267-0

    authors: Feng H,Xie Y,Mei B,Liu Y,Li B,Yin C,Wang T,Liu Y

    更新日期:2017-05-01 00:00:00

  • Missense exchanges in the TTBK2 gene mutated in SCA11.

    abstract::The spinocerebellar ataxias (SCAs) with autosomal dominant inheritance are a clinically and genetically heterogeneous group of neurological disorders with overlapping as well as highly variable phenotypes primarily affecting the cerebellum. To date, 28 different loci have been identified. Nine SCAs are caused by repea...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-009-5209-0

    authors: Edener U,Kurth I,Meiner A,Hoffmann F,Hübner CA,Bernard V,Gillessen-Kaesbach G,Zühlke C

    更新日期:2009-11-01 00:00:00

  • MS patient management: the Analog Model.

    abstract::The Analog Model was developed for use in patients with multiple sclerosis (MS) at an international roundtable meeting in 2001. Three key disease components are monitored, namely relapses, disability progression and magnetic resonance imaging activity. Its use provides a rapid, straightforward means of assessing the e...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-004-1512-y

    authors: Sharief MK

    更新日期:2004-09-01 00:00:00

  • Friedreich's ataxia mimicking hereditary motor and sensory neuropathy.

    abstract::Four patients from three unrelated families, with clinical and electrophysiological findings compatible with the diagnosis of hereditary motor and sensory neuropathy, are presented. The molecular analysis showed that the affected individuals were homozygous for the mutation in the X25 gene, characteristic of Friedreic...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-002-0902-2

    authors: Panas M,Kalfakis N,Karadima G,Davaki P,Vassilopoulos D

    更新日期:2002-11-01 00:00:00

  • Cold: a risk factor for stroke?

    abstract::A retrospective study was performed to investigate seasonal variation in stroke incidence and to evaluate the hypothesis that cold might be a risk factor. Data were obtained from the central registry of the Hospital de S. João, Porto, Portugal, concerning 4048 patients consecutively admitted for cerebrovascular diseas...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00919594

    authors: Azevedo E,Ribeiro JA,Lopes F,Martins R,Barros H

    更新日期:1995-03-01 00:00:00

  • Effect of levodopa on handwriting tasks of different complexity in Parkinson's disease: a kinematic study.

    abstract::Levodopa treatment does improve Parkinson's disease (PD) dysgraphia, but previous research is not in agreement about which aspects are most responsive. This study investigated the effect of levodopa on the kinematics of writing. Twenty-four patients with PD of less than 10 years duration and 25 age-matched controls we...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09268-2

    authors: Zham P,Kumar D,Viswanthan R,Wong K,Nagao KJ,Arjunan SP,Raghav S,Kempster P

    更新日期:2019-06-01 00:00:00

  • Auditory function in individuals within Leber's hereditary optic neuropathy pedigrees.

    abstract::The aims of this study are to investigate whether auditory dysfunction is part of the spectrum of neurological abnormalities associated with Leber's hereditary optic neuropathy (LHON) and to determine the perceptual consequences of auditory neuropathy (AN) in affected listeners. Forty-eight subjects confirmed by genet...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-011-6230-7

    authors: Rance G,Kearns LS,Tan J,Gravina A,Rosenfeld L,Henley L,Carew P,Graydon K,O'Hare F,Mackey DA

    更新日期:2012-03-01 00:00:00

  • Botulinum toxin in multiple sclerosis.

    abstract::Local administration of botulinum toxin (BoTx) inhibits presynaptic acetylcholine release. All cholinergically innervated muscles and glands can be paralyzed accordingly. Studies on the application of BoTx in multiple sclerosis have shown good results for focal spasticity, in particular, of the extremities. The first ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-006-1104-0

    authors: Jost WH

    更新日期:2006-02-01 00:00:00

  • Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy.

    abstract::Familial amyloid polyneuropathy (FAP) is a progressive systemic autosomal dominant disease caused by pathogenic mutations in the transthyretin (TTR) gene. We studied clinical, electrophysiological, histopathological, and genetic characteristics in 15 (13 late-onset and two early-onset) patients belonging to 14 familie...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-013-7124-7

    authors: Dohrn MF,Röcken C,De Bleecker JL,Martin JJ,Vorgerd M,Van den Bergh PY,Ferbert A,Hinderhofer K,Schröder JM,Weis J,Schulz JB,Claeys KG

    更新日期:2013-12-01 00:00:00

  • Cerebral ischaemia produced by homologous blood clot emboli in rabbit.

    abstract::In 40 rabbits cerebral ischaemia was induced by autologous blood clot emboli injected into the middle cerebral artery. Autologous blood clot formed spontaneously (within 2 h) in a catheter fixed in the internal carotid artery. The effects of embolization were investigated on arterial blood pressure, respiration, local...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314181

    authors: Fekete I,Hegedüs K,Molnár L

    更新日期:1988-05-01 00:00:00

  • Extended phenotype description and new molecular findings in late onset glycogen storage disease type II: a northern Italy population study and review of the literature.

    abstract::Glycogen storage disease type II (GSDII) is a lysosomal storage disorder caused by acid alpha-1,4-glucosidase deficiency and associated with recessive mutations in its coding gene GAA. Few studies have provided so far a detailed phenotypical characterization in late onset GSDII (LO-GSDII) patients. Genotype-phenotype ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-013-7137-2

    authors: Remiche G,Ronchi D,Magri F,Lamperti C,Bordoni A,Moggio M,Bresolin N,Comi GP

    更新日期:2014-01-01 00:00:00

  • Lactate production upon short-term non-ischemic forearm exercise in mitochondrial disorders and other myopathies.

    abstract:BACKGROUND:The nonischemic forearm exercise test (NIFET) has been shown to be as effective as the classic ischemic forearm exercise test (IFET) in the diagnosis of patients with McArdle disease. Recently, the lactate increase normalized to the mechanical energy production in NIFET was suggested to have a intermediate s...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00415-006-0101-7

    authors: Hanisch F,Eger K,Bork S,Lehnich H,Deschauer M,Zierz S

    更新日期:2006-06-01 00:00:00