Abstract:
:The Analog Model was developed for use in patients with multiple sclerosis (MS) at an international roundtable meeting in 2001. Three key disease components are monitored, namely relapses, disability progression and magnetic resonance imaging activity. Its use provides a rapid, straightforward means of assessing the efficacy of disease-modifying therapy and the need for treatment change. The Analog Model thus assists in optimising the management of patients with MS.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Sharief MKdoi
10.1007/s00415-004-1512-ykeywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
v74-v78eissn
0340-5354issn
1432-1459journal_volume
251 Suppl 5pub_type
杂志文章,评审abstract::Out of 72 patients treated for Borrelia burgdorferi meningopolyradiculoneuritis facial palsies occurred in 22 (12 unilateral, 10 bilateral). Eleven of the 32 pareses were initially complete. By the follow-up examination patients had recovered well with slight sequelae in 22% without cosmetically disfiguring pareses or...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00838171
更新日期:1993-05-01 00:00:00
abstract::Hereditary neuropathy with liability to pressure palsies (HNPP) is characterized by recurrent sensory and motor neuropathy in individual nerves starting in adolescence or young adulthood, focal conduction abnormalities at entrapment sites on nerve conduction studies, and sausage-like swellings (tomacula) of the myelin...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-019-09319-8
更新日期:2020-08-01 00:00:00
abstract::Acute porphyrias are a group of inherited metabolic disorders representing overproduction syndromes with the formation of neurotoxic haem precursors. Clinical manifestations consist of acute attacks, which include abdominal pain, dysautonomia, mental symptoms, polyneuropathy and seizures mimicking many other acute neu...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0779-9
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:Two population-based studies of neuromyelitis optica (NMO) in non-white populations provided prevalence rates of 0.32 and 3.1 per 100,000 population. OBJECTIVE:To estimate NMO prevalence in the multiethnic Cuban population by nation-wide case ascertainment. METHODS:The study was conducted from October 1,...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-0009-0
更新日期:2009-01-01 00:00:00
abstract::Autonomic nervous system (ANS) involvement is frequently found in Parkinson's disease (PD), but its causal relationship to the disease itself and its medication is unclear. We evaluated the effects of PD medications on cardiovascular ANS functions. Heart rate (HR) responses to normal and deep breathing, the Valsalva m...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s004150070075
更新日期:2000-11-01 00:00:00
abstract::A total of 15 patients affected by idiopathic dystonia (7 with generalized and 8 with focal or segmental dystonia) were subjected to therapy with bromocriptine at low doses, pimozide and trihexyphenidyl. The symptoms were evaluated by giving a progressive score in relation to the intensity of the dystonic symptom to e...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313391
更新日期:1982-01-01 00:00:00
abstract::A 40-year-old man suffered for 5 years from a progressive proximal myopathy mimicking an atypical limb-girdle dystrophy. A "myopathic" pattern with myotonic and pseudomyotonic discharges was determined by electromyography. Enzyme histochemical and ultrastructural investigations of muscle and liver biopsies pointed to ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00312870
更新日期:1976-01-01 00:00:00
abstract::We explored how changes in visual attention impacted postural motor performance in healthy elders and adults post-stroke within a virtual reality environment, including when vestibular information was not perceptible. Visual dependence in 13 healthy (50-80 years) and 13 adults post-stroke (49-70 years) was assessed wi...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6566-7
更新日期:2012-12-01 00:00:00
abstract::We describe three patients with unilateral asterixis. One diabetic patient with a moderately-sized haematoma in the left putamen initially developed bilateral and symmetrical asterixis, which became confined to the right side as his diabetes mellitus was controlled. Two patients showed unilateral asterixis due to haem...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314766
更新日期:1990-12-01 00:00:00
abstract::Windmill nystagmus is characterized by a clock-like rotation of the beating direction of a jerk nystagmus suggesting separate horizontal and vertical oscillators, usually 90° out of phase. We report oculographic characteristics in three patients with variants of windmill nystagmus in whom the common denominator was pr...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-016-8152-x
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:A growing number of studies have been conducted on the relationship between anger and hostility and the risk of stroke, and their conclusions are not consistent. Accordingly, we performed a meta-analysis to evaluate the relationship between anger and hostility and the risk of stroke. METHODS:We searched the ...
journal_title:Journal of neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00415-019-09231-1
更新日期:2019-04-01 00:00:00
abstract::Parvalbumin (a calcium-binding protein)-immunoreactive (PV-Ir) neurons in the cerebral cortex were examined in 20 postmortem brains obtained from elderly controls and patients with Pick's disease (PD). The type of PV-Ir neurons and their distribution in control and PD brains were similar. The number of PV-Ir neurons i...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314780
更新日期:1991-07-01 00:00:00
abstract::Stavudine (2',3'-didehydro-3'deoxythymidine) is a pyrimidine analogue that may be of great value in combination antiretroviral therapy (ART) for treating patients infected with human immunodeficiency virus type 1 (HIV-1). We assessed potential neurotoxic side effects by comparing peripheral nerve function in patients ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050336
更新日期:1999-03-01 00:00:00
abstract::Diminished activity of uroporphyrinogen I-synthetase in the liver and other tissues may be regarded to be the primary genetic deficiency of acute intermittent porphyria (AIP). Increased production and renal excretion of delta-aminolevulinic acid (ALA) und porphobilinogen (PBG) are secondary phenomena. The neuropsychia...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00316572
更新日期:1977-03-21 00:00:00
abstract:OBJECTIVE:To determine the prevalence and characteristics of the cricopharyngeal bar (CPB), defined as marked protrusion with lacking relaxation and stricture of the upper esophageal sphincter on videofluoroscopy, in patients with inclusion body myositis (IBM). METHODS:We conducted a case-control study of comprehensiv...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10241-7
更新日期:2020-09-26 00:00:00
abstract::The effect of furosemide (Lasix) therapy on a standardized experimental cerebral edema, induced in rats by applying a cooling stamp to the right side of the skull over the right coronal suture by means of a stereotactic instrument, was examined. The hemispherically separated water and electrolyte contents of the brain...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00705536
更新日期:1979-05-02 00:00:00
abstract::Serial magnetic resonance imaging (MRI) detects substantial subclinical disease activity in multiple sclerosis (MS) and is presently included in most treatment trials as an objective outcome measure. Our current knowledge of the role of MRI in MS treatment trials is derived from very limited patient studies, and the a...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050053
更新日期:1997-02-01 00:00:00
abstract::Neurological complications in the acquired immunodeficiency syndrome (AIDS) are an important aspect of this new infectious disease and occur frequently. The existence of neurotropic variants of the human immunodeficiency virus (HIV), the causative agent of AIDS, is probable. Direct infection of the nervous system with...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF00314279
更新日期:1987-06-01 00:00:00
abstract::The number of dementia patients requesting euthanasia in the Netherlands has increased over the past five years. The issue is highly controversial. In this contribution we discuss some of the main arguments: the nature of suffering, the voluntariness of the request and the role of the physician. We argue that society ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-016-8095-2
更新日期:2016-07-01 00:00:00
abstract::Ten female patients suffering from catamenial epilepsy were treated with a synthetic analogue of the gonadotrophin releasing hormone (GnRH) in addition to antiepileptic drugs. Three of the patients became seizure free, in four patients seizure frequency decreased and in one patient seizures were of shorter duration. I...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00810354
更新日期:1992-05-01 00:00:00
abstract::A comparative study of clinical and morphological findings in three fatal cases of acute necrotizing hemorrhagic encephalomyelitis (ANHE) and hyperacute experimental allergic encephalomyelitis (HEAE) in rhesus monkeys is reported. In all cases ANHE was characterized clinically by definite prodromal respiratory infecti...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313109
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Anti-epileptic drug (AED) prophylaxis in the first-seven days post-traumatic brain injury (TBI) is known to reduce seizure frequency acutely. AED efficacy is equivalent; therefore, choice of AED may rest with their side-effects. We hypothesise that AEDs that impair balance will prolong recovery, shown by a l...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09769-5
更新日期:2020-06-01 00:00:00
abstract::An 8-year-old boy with galactose-1-phosphate uridyl transferase (GALT) deficiency presented with hypotonia, muscle hypotrophy, hepatomegaly, bilateral cataract and mild mental retardation. Two brothers showed a GALT activity consistent with a homozygotic condition and both parents were found to be heterozygotes for th...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00838160
更新日期:1993-05-01 00:00:00
abstract::We investigated the muscle strength and motor unit (MU) territory of five patients with postpolio syndrome (PPS), six stable patients with prior poliomyelitis, and five healthy volunteers. The MU territory was assessed by measuring amplitudes of motor unit potentials (MUPs) recorded by the macro EMG technique. The inv...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00920572
更新日期:1994-12-01 00:00:00
abstract::18FDG-positron emission tomography performed at different stages in the course of subacute sclerosing panencephalitis revealed a changing pattern of metabolic disturbance. In clinical stage II patients the inflammation in the basal ganglia appeared to lead to neuronal excitation accompanied by hypermetabolism. Widespr...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00833917
更新日期:1992-03-01 00:00:00
abstract::Two patients with chorea and polycythaemia vera are described. The literature on this rare association is reviewed and its pathophysiology discussed. ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313895
更新日期:1985-01-01 00:00:00
abstract::There have been few reports on facioscapulohumeral dystrophy (FSHD) without 4q35 deletion. Most of them had either only mild FSHD phenotype or so called "borderline" EcoRI-fragments (35-38 kb). We analysed the clinical, electrophysiological, histological and genetic features of 46 consecutive patients from 31 families...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-003-0158-5
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:More research is needed to understand the contribution of comorbidities to MS symptomatology. OBJECTIVES:To examine the dose-response relationship between the number of comorbidities and severity of MS symptoms and to assess the relative contribution of comorbidity groups and individual comorbidities to the...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10192-z
更新日期:2020-09-02 00:00:00
abstract::Cognitive deficits mainly involving visuospatial functions have been defined in patients with bilateral and even unilateral vestibular loss (UVL). We compared the cognitive test results of 21 patients with acute UVL with age- and education-matched healthy controls. The diagnosis of UVL was based on the clinical findin...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09829-w
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Elective programs for medical students in the last year of their university training are poorly evaluated. The goal of this study was to determine the gain in theoretical and practical skills in a group of students during their elective in neurology. Students were trained by either conventional teaching meth...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-003-0255-5
更新日期:2003-12-01 00:00:00