Abstract:
:Vitamin B(12) (VitB(12), cobalamin) deficiency has been associated with various neuropsychiatric conditions, such as peripheral neuropathy, subacute combined degeneration, affective disorders, and cognitive impairment. Current assays analyze vitamin B(12), of which only a small percentage is metabolically active. Measurement of its active fraction, holotranscobalamin, might be of greater relevance, but data in populations with neuropsychiatric populations are lacking. In this study, in order to validate VitB(12) and holotranscobalamin (holoTC) serum levels for the detection of VitB(12) deficiency in neuropsychiatric conditions, we compared the validity of VitB(12) and holoTC in a patient cohort with neuropsychiatric conditions suspicious for VitB(12) deficiency. The cohort included all patients admitted to the Department of Neurology at our university between 2005 and 2009 with at least two parameters of the VitB(12) metabolism available (n = 1,279). We used elevated methylmalonic acid as the external validation criterion for VitB(12) deficiency and restricted our analyses to subjects with normal renal function. Among all normal renal function patients, 13.2% had VitB(12) deficiency. In receiver operating characteristic curve (ROC) analysis, correlation of VitB(12) and holoTC with vitamin B(12) deficiency was generally weak, and the areas under the curve (AUC) were not significantly different for holoTC compared to vitamin B(12) in all subjects (AUC: 0.66 [95%CI: 0.51-0.82]; p = 0.04 vs. 0.72 [0.65-0.78], p < 0.0001) and in subcohorts of patients with classical VitB(12) deficiency syndromes. The positive predictive values for holoTC and vitamin B(12) were low (14.7 vs. 21.0%) and both were associated with more false-positive than true-positive test results. holoTC does not show superior diagnostic accuracy compared to VitB(12) for the detection of VitB(12) deficiency in subjects with neuropsychiatric conditions. Neither test can be recommended to diagnose VitB(12) deficiency in subjects with neuropsychiatric disorders.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Schrempf W,Eulitz M,Neumeister V,Siegert G,Koch R,Reichmann H,Storch Adoi
10.1007/s00415-010-5764-4subject
Has Abstractpub_date
2011-03-01 00:00:00pages
393-401issue
3eissn
0340-5354issn
1432-1459journal_volume
258pub_type
杂志文章abstract::Cerebellar syndrome is one of the most disabling developments in multiple sclerosis (MS). In neurodegenerative disorders, cerebellar syndrome is thought to be related to a neurochemical deficit of 5-hydroxytryptamine (5-HT). Previous studies found that a levorotatory form of 5-hydroxytryptophan, a 5-HT precursor, and ...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Augmented spinal nociception during the "off" phase has been observed early in Parkinson's disease further increasing with disease duration. To find out whether increased spinal nociception represents a premotor feature, experimental pain sensitivity was assessed in idiopathic REM-sleep behavior disorder (IRBD) patien...
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1007/s00415-018-9082-6
更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00839145
更新日期:1992-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00878524
更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00873514
更新日期:1994-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-018-9105-3
更新日期:2019-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1007/s00415-015-7829-x
更新日期:2015-09-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09718-2
更新日期:2020-05-01 00:00:00
abstract::The seasonal occurrence of relapses was analysed retrospectively in a group of 53 patients with treated dermatomyositis (DM) or polymyositis (PM). In DM, the incidence of both myositic and cutaneous relapses was highest in summer whereas in the PM group relapses was more evenly distributed throughout the seasons but l...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150200036
更新日期:2002-04-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-008-4002-9
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Myelin oligodendrocyte glycoprotein immunoglobulin G associated optic neuritis (MOG-ON) is a recently described entity. Recent studies have shown that MOG-ON has a more severe clinical presentation than classic optic neuritis (ON). OBJECTIVE:This study aimed to define morphological characteristics of MOG-ON...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10097-x
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journal_title:Journal of neurology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s00415-015-7665-z
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10086-0
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-7124-7
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abstract::Discontinuation of natalizumab can lead to severe rebound of disease activity in patients with relapsing-remitting multiple sclerosis (RRMS); nevertheless, the treatment regimen in this clinical situation remains controversial. We report the case of a 25-year-old male patient with RRMS who was clinically stable under ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8622-9
更新日期:2017-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
abstract::Out of 72 patients treated for Borrelia burgdorferi meningopolyradiculoneuritis facial palsies occurred in 22 (12 unilateral, 10 bilateral). Eleven of the 32 pareses were initially complete. By the follow-up examination patients had recovered well with slight sequelae in 22% without cosmetically disfiguring pareses or...
journal_title:Journal of neurology
pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314035
更新日期:1985-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-015-7682-y
更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00