Abstract：
:Discontinuation of natalizumab can lead to severe rebound of disease activity in patients with relapsing-remitting multiple sclerosis (RRMS); nevertheless, the treatment regimen in this clinical situation remains controversial. We report the case of a 25-year-old male patient with RRMS who was clinically stable under 3 years of natalizumab before treatment was stopped due to progressive multifocal leucencephalopathy (PML) safety concerns. After initiation of daclizumab, the patient suffered from disease reactivation, which was ultimately controlled by intravenous methylprednisolone and alemtuzumab treatment. Therefore, in some patients, daclizumab might not be sufficient to control disease activity after discontinuing natalizumab treatment.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Uphaus T,Oberwittler C,Groppa S,Zipp F,Bittner Sdoi
10.1007/s00415-017-8622-9subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2491-2494issue
12eissn
0340-5354issn
1432-1459pii
10.1007/s00415-017-8622-9journal_volume
264pub_type
杂志文章abstract：:Magnetisation transfer (MT) imaging provides indirect information on tissue structure abnormalities in areas that otherwise may appear normal on conventional MRI. We determined the evolution of MT changes in normal appearing white matter (NAWM) and lesion on serial examination of 9 multiple sclerosis (MS) patients and...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-1115-z
更新日期：2003-08-01 00:00:00
abstract：:Levodopa therapy is essential for patients in the advanced stages of Parkinson's disease. However, at early stages, DA agonist therapy has similar efficacy in the treatment of parkinsonism and a lower incidence of motor complications compared to levodopa therapy several years after the initiation of the therapy. The m...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-002-1205-3
更新日期：2002-09-01 00:00:00
abstract：:Fatigue is an important contributor to quality of life in patients who survive aneurysmal subarachnoid hemorrhage (SAH), but the determinants of this fatigue are unclear. We assessed the occurrence of fatigue 1 year after SAH and its relation to physical or cognitive impairment, passive coping, and emotional problems,...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5891-y
更新日期：2011-06-01 00:00:00
abstract：:Movement disorder emergencies include any movement disorder which evolves over hours to days, in which failure to appropriately diagnose and manage can result in patient morbidity or mortality. It is crucial that doctors recognize these emergencies with accuracy and speed by obtaining the proper history and by being f...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-008-4002-9
更新日期：2008-08-01 00:00:00
abstract：:The recent discovery of disease specific and pathogenic autoantibodies in neuromyelitis optica (NMO, Devic's disease) has revived the interest in this intriguing yet often devastating condition. While the history of classic multiple sclerosis has been studied extensively, only very little is known so far about the ear...
journal_title：Journal of neurology
pub_type： 历史文章,杂志文章
doi：10.1007/s00415-011-6355-8
更新日期：2012-07-01 00:00:00
abstract：:Normal pressure hydrocephalus (NPH) is characterised by gait disturbance, urinary incontinence and dementia. Even though dementia is a cardinal symptom of NPH, there is few data available concerning cognitive functioning. The aim of this observational case-control study was to evaluate the use of neuropsychological (N...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7489-2
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:Whether different mechanisms, particularly ocular pathology, could lead to the emergence of visual hallucinations (VH) (defined as false perceptions with no external stimulus) versus visual illusions (VI) (defined as a misperception of a real stimulus) in Parkinson's disease (PD) remains debated. We assess...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09925-x
更新日期：2020-10-01 00:00:00
abstract：:The transcranial activation and the conduction properties of corticospinal and callosal neurons were investigated in 12 early-treated adolescents (aged 17.3, SD 3.5 years; range 14-27 years) with phenylketonuria (PKU) by focal transcranial magnetic stimulation (fTMS) of the motor cortex. The patients had no functional...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050301
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Despite advances in the field, diagnosis and management of the wide spectrum of neurological events post allogeneic hematopoietic cell transplantation (alloHCT) remain challenging. Therefore, we investigated their incidence, diagnosis, management and long-term prognosis in alloHCT recipients. METHODS:We ret...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09372-3
更新日期：2019-08-01 00:00:00
abstract：:Apoptotic deletion of autoreactive T-cells is defective in patients with multiple sclerosis (MS). Glatiramer acetate (GA) treatment seems to restore apoptosis of detrimental T-cells. We analyzed the mitochondria membrane pro- (Bax) and anti-apoptotic (Bcl- 2) and cytosolic pro-apoptotic (Cyt-c, APAF-1) proteins expres...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0965-y
更新日期：2006-02-01 00:00:00
abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Recent advances in genetics and pathophysiology have led to new insights into the pathogenesis of PD. Ten loci have been linked to hereditary PD. Mutations in alpha-synuclein and ubiquitin carboxy hydrolase L1 (UchL1) cause autosomal domi...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-003-1304-9
更新日期：2003-10-01 00:00:00
abstract：:Several studies have reported infection as a possible risk factor for cervical artery dissection (CAD). We retrospectively analyzed several inflammatory parameters of CAD patients with the aim of detecting differences between spontaneous (n = 25) and traumatic (n = 18) CAD. In this case-control study, we observed sign...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0109-z
更新日期：2006-06-01 00:00:00
abstract：:In order to identify the precise location of the primary motor area for the diaphragm with respect to the classical motor homunculus, functional magnetic resonance imaging (fMRI) experiments were performed utilizing independent component-cross correlation- sequential epoch (ICS) analysis on a high-field (3.0 Tesla) sy...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-004-0413-4
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:Determine toxicity and efficacy of autologous hematopoietic stem cell transplantation (HSCT) for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who are dependent on intravenous immunoglobulins or plasmapheresis. METHODS:Unselected peripheral blood stem cells were re-infused on...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10010-6
更新日期：2020-11-01 00:00:00
abstract：:This study aimed at identifying gender-specific differences in stroke knowledge, stroke risk perception and the educational effects of a multimodal educational intervention. We performed computer-assisted telephone surveys among an average sample of 500 members of the general public (44.0% male, 56.0% female), before ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5326-9
更新日期：2010-03-01 00:00:00
abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is the third most common muscular dystrophy and usually follows an autosomal dominant trait. Clinically, FSHD affects facial muscles and proximal upper limb and girdle muscles, but may present with variable clinical phenotypes even within the same family. Most genetically ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5471-1
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Since the detection of autoantibodies against neuronal surface antigens, autoimmune encephalitis (AE) has been more frequently diagnosed, especially in patients with symptoms typical of limbic encephalitis, such as seizures, short-term memory deficits, or psychosis. However, the clinical spectrum of AE may b...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-018-9105-3
更新日期：2019-01-01 00:00:00
abstract：:Clinical diagnosis of amyotrophic lateral sclerosis (ALS) in patients presenting with cramps and fasciculations may not be evident at the first consultation. Sequential reviews, clinical and neurophysiological, form an important part of clinical practice in such cases. Recent attempts to delineate a more benign group ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5791-1
更新日期：2011-04-01 00:00:00
abstract：:Cognition and gait appear to be closely related. The chronological interplay between cognitive decline and gait dysfunction is not fully understood. The aim of the present prospective study is investigating whether the dysfunction of specific gait parameters, during specific task and medication conditions, may predict...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8973-x
更新日期：2018-10-01 00:00:00
abstract：:We hypothesize that cerebral microbleeds (CMB) in patients with different neuropsychological profiles (amnestic or non-amnestic) and MRI features of vascular damage could provide important information on the underlying pathological process in early Alzheimer's disease. The study was performed at two trial sites. We st...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8220-2
更新日期：2016-10-01 00:00:00
abstract：:A patient with an infarct limited to the paramedian thalamus and upper mesencephalon on the right side suffered a conjugate upgaze palsy associated with a monocular paresis of downward gaze in the ipsilateral eye (vertical "one-and-a-half" syndrome). This paresis involved tonic and phasic components. Vertical oculocep...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313651
更新日期：1984-01-01 00:00:00
abstract：:Chronic neuropathy is the most frequent condition affecting the peripheral nervous system. It includes symmetrical polyneuropathies, multifocal mononeuropathies, mononeuropathies and radiculopathies. Mononeuropathies are mainly due to compression or entrapment and are not discussed in this review, which focuses on pol...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050326
更新日期：1999-03-01 00:00:00
abstract：:It is now 10 years since the first report of mutations in the presenilin genes that were deterministic for familial autosomal dominant Alzheimer's disease. The most common of these mutations occurs in the presenilin-1 gene (PSEN1) located on chromosome 14. In the ensuing decade, more than 100 PSEN1 mutations have been...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-005-0019-5
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:Near occlusion (NO) of the internal carotid artery (ICA) with full collapse (NOFC) is a rare condition, with a prevalence of around 1%. Guidelines on carotid stenosis recommend a conservative treatment in patients with a single-event ipsilateral to a NOFC, but the optimal treatment for patients with recurrent...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8939-z
更新日期：2018-08-01 00:00:00
abstract：:Uric acid (UA) is reduced in multiple sclerosis (MS), and possibly relates to MS outcomes, with lower UA levels in subjects experiencing a relapse or presenting higher disability scores. The present retrospective longitudinal study evaluated UA variations in MS, in relation to clinical relapses, disability progression...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7666-y
更新日期：2015-01-01 00:00:00
abstract：:A patient with haemorrhage in the right tegmentum of the pons demonstrated ipsilateral disturbance of taste on both the anterior two-thirds and posterior one-third of the tongue. The contralateral medial lemniscus was not disturbed, contrary to the early descriptions that the secondary gustatory neurons from the nucle...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313454
更新日期：1983-01-01 00:00:00
abstract：:Psychiatric complaints are common in Parkinson's disease (PD), and have a significant influence in disease outcome and quality of life. Little attention has been paid to psychiatric symptoms at early stage disease. We aimed to screen a population of early stage PD patients for psychiatric symptoms and to study the rel...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6140-8
更新日期：2012-01-01 00:00:00
abstract：:Two unusual cases of cerebral toxoplasmosis in AIDS patients are presented. Two homosexual males aged 33 and 52 years in CDC stage IV C1 complained of memory loss during the past 6 months, as well as weight loss and mild fever. They showed severe intellectual deterioration and discrete basal ganglia dysfunction. Motor...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314650
更新日期：1991-12-01 00:00:00
abstract：:A recently developed technique is used to study the permeation of water through membranes of human erythrocyte ghosts. The method, based on the difference of the indices of refraction of H2O and D2O, is briefly described. Comparative measurements on erythrocyte ghosts from normal donors and from patients with Huntingt...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313655
更新日期：1984-01-01 00:00:00
abstract：:Neurological complications in the acquired immunodeficiency syndrome (AIDS) are an important aspect of this new infectious disease and occur frequently. The existence of neurotropic variants of the human immunodeficiency virus (HIV), the causative agent of AIDS, is probable. Direct infection of the nervous system with...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF00314279
更新日期：1987-06-01 00:00:00
