Fasciculations and cramps: how benign? Report of four cases progressing to ALS.

Abstract:

:Clinical diagnosis of amyotrophic lateral sclerosis (ALS) in patients presenting with cramps and fasciculations may not be evident at the first consultation. Sequential reviews, clinical and neurophysiological, form an important part of clinical practice in such cases. Recent attempts to delineate a more benign group with cramps and fasciculations have lacked information on the long term profile, both clinical and neurophysiological. Four patients who were initially diagnosed as suffering from benign cramps and fasciculations, but who subsequently progressed to ALS, are described. We propose that a diagnosis of benign cramps and fasciculations should not be considered secure without a minimum follow up of 4-5 years.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Singh V,Gibson J,McLean B,Boggild M,Silver N,White R

doi

10.1007/s00415-010-5791-1

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

573-8

issue

4

eissn

0340-5354

issn

1432-1459

journal_volume

258

pub_type

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