On the exchange of H2O/D2O molecules across membranes of erythrocyte ghosts from patients with Huntington's disease and from normal individuals.

abstract：:Myasthenia gravis (MG) is the archetypic disorder of both the neuromuscular junction and autoantibody-mediated disease. In most patients, IgG1-dominant antibodies to acetylcholine receptors cause fatigable weakness of skeletal muscles. In the rest, a variable proportion possesses antibodies to muscle-specific tyrosine...

journal_title：Journal of neurology

authors： Binks S,Vincent A,Palace J

更新日期：2016-04-01 00:00:00

abstract：:Serial magnetic resonance imaging (MRI) detects substantial subclinical disease activity in multiple sclerosis (MS) and is presently included in most treatment trials as an objective outcome measure. Our current knowledge of the role of MRI in MS treatment trials is derived from very limited patient studies, and the a...

journal_title：Journal of neurology

authors： Barkhof F,Filippi M,Miller DH,Tofts P,Kappos L,Thompson AJ

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Single, modifiable risk factors for stroke have extensively been studied. In contrast, differences of their combined effects among stroke and transitoy ischemic attack (TIA) have been rarely investigated. The aim of the present study was to assess single and joint effects of risk factors on the incidence of ...

journal_title：Journal of neurology

authors： Weikert C,Berger K,Heidemann C,Bergmann MM,Hoffmann K,Klipstein-Grobusch K,Boeing H

更新日期：2007-03-01 00:00:00

abstract：:We aimed to assess the intrasubject reproducibility of a technology-based levodopa (LD) therapeutic monitoring protocol administered in supervised versus unsupervised conditions in patients with Parkinson's disease (PD). The study design was pilot, intrasubject, single center, open and prospective. Twenty patients wer...

journal_title：Journal of neurology

authors： Lopane G,Mellone S,Corzani M,Chiari L,Cortelli P,Calandra-Buonaura G,Contin M

更新日期：2018-06-01 00:00:00

abstract：:Clinical data and the serum and cerebrospinal fluid (CSF) findings of 71 patients with Guillain-Barré syndrome (GBS), 7 with Fisher syndrome and 24 with chronic inflammatory polyradiculoneuropathy (CIP), were analysed. Isoelectric focusing of serum and CSF together with different formulae and diagrams were applied to ...

journal_title：Journal of neurology

authors： Segurado OG,Krüger H,Mertens HG

更新日期：1986-08-01 00:00:00

abstract：:A double-blind, placebo-controlled multicentre study was carried out to evaluate the efficacy and tolerability of 100, 200 and 300 mg sumatriptan, a selective 5-hydroxytryptamine (5-HT)1-like receptor agonist, given in an oral dispersible form in the acute treatment of migraine attacks. A total of 1130 patients were r...

journal_title：Journal of neurology

authors： Patten JP

更新日期：1991-01-01 00:00:00

abstract：:Cerebral palsy (CP) continues to be a major problem in India. The present study provides an insight into the various clinical and neuroradiological correlates of CP. The study included 102 children with CP and was subjected to magnetic resonance imaging (MRI) of the brain. Forty-seven (46%) patients belonged to the 1-...

journal_title：Journal of neurology

authors： Prasad R,Verma N,Srivastava A,Das BK,Mishra OP

更新日期：2011-03-01 00:00:00

abstract：:This review summarizes recent findings from clinical trials regarding the prevention of stroke and translates these into therapeutic guidelines. A distinction is made between patients with previous cerebrovascular disease and those without, and between patients with and those without atrial fibrillation. Although the ...

journal_title：Journal of neurology

authors： Koudstaal PJ

更新日期：1999-09-01 00:00:00

abstract：:Glucocorticoids are the standard of care for multiple sclerosis (MS) relapses, but the most desirable route of administration is still matter of debate. The aim of the study was to compare the efficacy and safety of oral versus intravenous steroids for treatment of acute relapses in patients with MS. Randomized or qua...

journal_title：Journal of neurology

authors： Lattanzi S,Cagnetti C,Danni M,Provinciali L,Silvestrini M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Tumefactive demyelinating lesions of the central nervous system can be the initial presentation in various pathological entities [multiple sclerosis (the most common), Balo's concentric sclerosis, Schilder's disease and acute disseminated encephalomyelitis] with overlapping clinical presentation. The aim of ...

journal_title：Journal of neurology

authors： Balloy G,Pelletier J,Suchet L,Lebrun C,Cohen M,Vermersch P,Zephir H,Duhin E,Gout O,Deschamps R,Le Page E,Edan G,Labauge P,Carra-Dallieres C,Rumbach L,Berger E,Lejeune P,Devos P,N'Kendjuo JB,Coustans M,Auffray-Calv

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Brain tumors cause significant morbidity and mortality due to rapid progression and high recurrence risks. Reliable biomarkers to improve diagnosis thereof are desirable. OBJECTIVE:This work aimed to identify panels of biomarkers for diagnostic purposes using cerebrospinal fluid (CSF)-based metabolomics. M...

journal_title：Journal of neurology

authors： Wang FX,Chen K,Huang FQ,Alolga RN,Ma J,Wu ZX,Fan Y,Ma G,Guan M

更新日期：2020-04-01 00:00:00

abstract：:Posterior leukoencephalopathy typically denotes neurotoxicity from immunosuppressive agents, malignant hypertension or eclampsia. It has not been documented in central nervous system angiitis. We present three cases associated with isolated cerebral angiitis after review of all cases of isolated CNS angiitis from 1998...

journal_title：Journal of neurology

authors： Wijdicks EF,Manno EM,Fulgham JR,Giannini C

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Rapid eye movement sleep behavior disorder (RBD) is highly comorbid with Parkinson's disease (PD). Emerging evidence suggests that dopamine-replacement therapies (DRTs) for PD may modify the course of RBD, yet the nature of the association between DRTs and RBD remains unclear. To begin addressing this issue,...

journal_title：Journal of neurology

authors： Meloni M,Bortolato M,Cannas A,Laccu I,Figorilli M,Congiu P,Defazio G,Meloni F,Puligheddu M

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Children with neuromuscular disorders have been assumed to be a particularly vulnerable population since the beginning of COVID-19. Although this is a plausible hypothesis, there is no evidence that complications or mortality rates in neuromuscular patients are higher than in the general population. The aim o...

journal_title：Journal of neurology

authors： Natera-de Benito D,Aguilera-Albesa S,Costa-Comellas L,García-Romero M,Miranda-Herrero MC,Rúbies Olives J,García-Campos Ó,Martínez Del Val E,Martinez Garcia MJ,Medina Martínez I,Cancho-Candela R,Fernandez-Garcia MA,Pascual-Pascual

更新日期：2021-01-02 00:00:00

abstract：:The bulbocavernosus reflex (BCR) was examined in 39 normal potent men and in 252 patients with impaired potency of varying aetiology. For BCR evaluation minimum, maximum and mean latencies, the temporal dispersion in ten successive responses, together with minimum and maximum side differences from simultaneous recordi...

journal_title：Journal of neurology

authors： Tackmann W,Porst H,van Ahlen H

更新日期：1988-03-01 00:00:00

abstract：:Presently, there are more than 50 possible indications for the application of botulinum toxin. In some indications the use of botulinum toxin has already been approved; others are about to be approved. For most of these indications a sufficient number of studies have been published. For rare indications, an insufficie...

journal_title：Journal of neurology

authors： Jost WH,Kohl A

更新日期：2001-04-01 00:00:00

abstract：:Currently, several disease-modifying therapies for the treatment of multiple sclerosis are established and more are likely to be introduced. These treatment options differ with respect to their application profile, mechanism of action, efficacy, safety, and tolerance. Here, we review current concepts of MS therapies, ...

journal_title：Journal of neurology

authors： Buck D,Hemmer B

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:We aimed to assess the effectiveness of conservative treatments in children with tension-type headaches (TTH). METHOD:We searched Medline, Embase and the Cochrane Library and performed reference checking. Two independent authors assessed trial quality and extracted data. Analysis was carried out according to...

journal_title：Journal of neurology

authors： Verhagen AP,Damen L,Berger MY,Passchier J,Merlijn V,Koes BW

更新日期：2005-10-01 00:00:00

abstract：:To determine the epidemiological, clinical, and genetic characteristics of congenital hypomyelinating leukodystrophies, including Pelizaeus-Merzbacher disease (PMD), we conducted a nationwide epidemiological survey in Japan. A two-step survey targeting all medical institutions specializing in pediatric neurology and c...

journal_title：Journal of neurology

authors： Numata Y,Gotoh L,Iwaki A,Kurosawa K,Takanashi J,Deguchi K,Yamamoto T,Osaka H,Inoue K

更新日期：2014-04-01 00:00:00

abstract：:Gilles de la Tourette's syndrome (GTS) and restless legs syndrome (RLS) are two different neurological disorders with common features such as involuntary movements. In both disorders a disturbance of the dopaminergic system has been considered among other possible mechanisms. Since periodic leg movements (PLMS) during...

journal_title：Journal of neurology

authors： Voderholzer U,Müller N,Haag C,Riemann D,Straube A

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:The cerebellum is a predilection site of pathology in progressive multiple sclerosis (PMS) patients, contributing to cognitive deficits. Aim of this study was to investigate lobular cerebellar functional connectivity (FC) in PMS patients in relation to cognition. METHODS:In this cross-sectional study, resti...

journal_title：Journal of neurology

authors： Cocozza S,Pontillo G,Russo C,Russo CV,Costabile T,Pepe A,Tedeschi E,Lanzillo R,Brescia Morra V,Brunetti A,Inglese M,Petracca M

更新日期：2018-10-01 00:00:00

abstract：:Multifocal motor neuropathy (MMN) can be differentiated from motor neuron disease by electrophysiological evidence of conduction block. To increase the probability of recording conduction block, we studied the whole nerve length including proximal segments in 84 patients with pure motor syndromes, using a special stim...

journal_title：Journal of neurology

authors： Jaspert A,Claus D,Grehl H,Neundörfer B

更新日期：1996-10-01 00:00:00

abstract：:Dementia has a reversible cause in some cases, and these should be diagnosed without over-investigating the many patients with irreversible disease. We prospectively studied the prevalence of reversible dementia in a memory clinic, determined the added value of investigations compared with clinical examination and ass...

journal_title：Journal of neurology

authors： Walstra GJ,Teunisse S,van Gool WA,van Crevel H

更新日期：1997-01-01 00:00:00

abstract：:In this review, we describe the wide clinical spectrum of features that can be seen in multiple system atrophy (MSA) with a focus on the premotor phase and the non-motor symptoms providing an up-to-date overview of the current understanding in this fast-growing field. First, we highlight the non-motor features at dise...

journal_title：Journal of neurology

authors： Chelban V,Catereniuc D,Aftene D,Gasnas A,Vichayanrat E,Iodice V,Groppa S,Houlden H

更新日期：2020-09-01 00:00:00

abstract：:Weight loss is a common symptom of Parkinson's disease and is associated with impaired quality of life. Predictors of weight loss have not been studied in large clinical cohorts. We previously observed an association between change in body mass index and change in Unified Parkinson's Disease Rating Scale (UPDRS) motor...

journal_title：Journal of neurology

authors： Wills AM,Li R,Pérez A,Ren X,Boyd J,NINDS NET-PD Investigators.

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Glatiramer acetate (GA) therapy following brief, low-dose induction with mitoxantrone was safe and more effective than GA alone in suppressing inflammatory disease activity, as determined by a significant reduction in gadolinium (Gd)- enhancing MRI lesions, in a 15- month, randomized, single-blind study of r...

journal_title：Journal of neurology

authors： Arnold DL,Campagnolo D,Panitch H,Bar-Or A,Dunn J,Freedman MS,Gazda SK,Vollmer T

更新日期：2008-10-01 00:00:00

abstract：:To analyze the in vivo biological effect of anti-interferon beta (IFN-beta) neutralizing antibodies (NABs), blood concentrations of neopterin, beta2microglobulin (Beta2-MG), mRNA-dependent myxovirusresistant protein A (MxA) and dsRNA-dependent protein kinase (PKR) were measured before (predose) and 24 hours after (pos...

journal_title：Journal of neurology

authors： Scagnolari C,Duda P,Bagnato F,De Vito G,Alberelli A,Lavolpe V,Girardi E,Durastanti V,Trojano M,Kappos L,Antonelli G

更新日期：2007-05-01 00:00:00

abstract：:The safety and efficacy of intravenous thrombolysis (IVT) in dissection-related ischemic stroke (DRIS) has not been established. We sought to determine safety and recovery rates of IVT in DRIS using prospective, international, multicenter data and by conducting a comprehensive meta-analysis of reported case series. We...

journal_title：Journal of neurology

authors： Tsivgoulis G,Zand R,Katsanos AH,Sharma VK,Goyal N,Krogias C,Safouris A,Vadikolias K,Voumvourakis K,Alexandrov AW,Malkoff MD,Alexandrov AV

更新日期：2015-09-01 00:00:00

abstract：:Among 234 hemophiliacs, 14 patients (5.9%) with intracranial and 1 patient (0.4%) with intramedullary hemorrhage were observed and examined. The average age at the time of hemorrhage was 17 years in patients with severe hemophilia and 43 years in patients with moderate hemophilia. The patients with mild hemophilia and...

journal_title：Journal of neurology

authors： Mamoli B,Sonneck G,Lechner K

更新日期：1976-01-14 00:00:00

abstract：:Dementia is reversible in a minority of patients, and these should be diagnosed but without subjecting the majority with irreversible disease to an excessive set of investigations. Should a battery of ancillary investigations be performed routinely in dementia? Or can these tests be carried out as clinically indicated...

journal_title：Journal of neurology

authors： van Crevel H,van Gool WA,Walstra GJ

更新日期：1999-02-01 00:00:00