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COVID-19 in children with neuromuscular disorders.

Abstract：

OBJECTIVE:Children with neuromuscular disorders have been assumed to be a particularly vulnerable population since the beginning of COVID-19. Although this is a plausible hypothesis, there is no evidence that complications or mortality rates in neuromuscular patients are higher than in the general population. The aim of this study is to describe the clinical characteristics and outcome of COVID-19 in children with neuromuscular disorders. METHODS:A registry of children with neuromuscular conditions and laboratory-confirmed-SARS-CoV-2 infection was set up by the Neuromuscular Working Group of the Spanish Pediatric Neurology Society (SENEP). Data to be collected were focused on the characteristics and baseline status of the neuromuscular condition and the course of COVID-19. RESULTS:Severe complications were not observed in our series of 29 children with neuromuscular disorders infected by SARS-CoV-2. Eighty-nine percent of patients were clinically categorized as asymptomatic or mild cases and 10% as moderate cases. Patients with a relatively more severe course of COVID-19 had SMA type 1 and were between 1 and 3 years. CONCLUSIONS:The course of COVID-19 in children with neuromuscular disorders may not be as severe as expected. The protective role of young age seems to outweigh the risk factors that are common in neuromuscular patients, such as a decreased respiratory capacity or a weak cough. Further studies are needed to know if this finding can be generalized to children with other chronic diseases.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Natera-de Benito D,Aguilera-Albesa S,Costa-Comellas L,García-Romero M,Miranda-Herrero MC,Rúbies Olives J,García-Campos Ó,Martínez Del Val E,Martinez Garcia MJ,Medina Martínez I,Cancho-Candela R,Fernandez-Garcia MA,Pascual-Pascual

doi

10.1007/s00415-020-10339-y

subject

Has Abstract

pub_date

2021-01-02 00:00:00

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-020-10339-y

pub_type

杂志文章

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