High-dose intravenous immunoglobulin in the treatment of Guillain-Barré syndrome: a preliminary open study.

Abstract:

:We report the effects of intravenous gamma-globulin (IVGG) in severe Guillain-Barré syndrome (GBS) in a small open study. Seven patients were given IVGG (0.4 g/kg/day) for 5 consecutive days. At the start of treatment all had progressing limb weakness and none could stand unaided. Within 24 h all but one patient started to improve, without the expected plateau phase, and progress was maintained with a mean time to independent walking of 14 days. One patient started treatment 9 h prior to ventilation for 15 days but was walking independently 31 days after admission. This study provides further evidence that IVGG is a promising therapeutic alternative to plasmapheresis in GBS. The rapidity of the response to IVGG raises the possibility that a single dose regimen might be equally or more effective.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Jackson MC,Godwin-Austen RB,Whiteley AM

doi

10.1007/BF00838447

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

51-3

issue

1

eissn

0340-5354

issn

1432-1459

journal_volume

240

pub_type

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