当前位置： SCI文献检索 > JOURNAL OF NEUROLOGY期刊下所有文献 > StartReact during gait initiation reveals differential control of muscle activation and inhibition in patients with corticospinal degeneration.

StartReact during gait initiation reveals differential control of muscle activation and inhibition in patients with corticospinal degeneration.

Abstract：

:Corticospinal lesions cause impairments in voluntary motor control. Recent findings suggest that some degree of voluntary control may be taken over by a compensatory pathway involving the reticulospinal tract. In humans, evidence for this notion mainly comes from StartReact studies. StartReact is the acceleration of reaction times by a startling acoustic stimulus (SAS) simultaneously presented with the imperative stimulus. As previous StartReact studies mainly focused on isolated single-joint movements, the question remains whether the reticulospinal tract can also be utilized for controlling whole-body movements. To investigate reticulospinal control, we applied the StartReact paradigm during gait initiation in 12 healthy controls and 12 patients with 'pure' hereditary spastic paraplegia (HSP; i.e., retrograde axonal degeneration of corticospinal tract). Participants performed three consecutive steps in response to an imperative visual stimulus. In 25% of 16 trials a SAS was applied. We determined reaction times of muscle (de)activation, anticipatory postural adjustments (APA) and steps. Without SAS, we observed an overall delay in HSP patients compared to controls. Administration of the SAS accelerated tibialis anterior and rectus femoris onsets in both groups, but more so in HSP patients, resulting in (near-)normal latencies. Soleus offsets were accelerated in controls, but not in HSP patients. The SAS also accelerated APA and step reaction times in both groups, yet these did not normalize in the HSP patients. The reticulospinal tract is able to play a compensatory role in voluntary control of whole-body movements, but seems to lack the capacity to inhibit task-inappropriate muscle activity in patients with corticospinal lesions.

journal_name

J Neurol

journal_title

Journal of neurology

authors

van Lith BJH,Coppens MJM,Nonnekes J,van de Warrenburg BPC,Geurts AC,Weerdesteyn V

doi

10.1007/s00415-018-9027-0

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

2531-2539

issue

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-018-9027-0

journal_volume

265

pub_type

杂志文章

在线工具

StartReact during gait initiation reveals differential control of muscle activation and inhibition in patients with corticospinal degeneration.