Abstract:
:An 8-year-old boy with galactose-1-phosphate uridyl transferase (GALT) deficiency presented with hypotonia, muscle hypotrophy, hepatomegaly, bilateral cataract and mild mental retardation. Two brothers showed a GALT activity consistent with a homozygotic condition and both parents were found to be heterozygotes for this defect. Histological and ultrastructural examination of muscle biopsy specimens showed several necrotic fibres. GALT activity was undetectable in skeletal muscle and muscle tissue cultures; myotubes converted galactose to CO2 at a lower rate than controls. Galactose-1-phosphate was increased in the patient's red cells and muscle tissue. GALT deficiency, not previously described in muscle, may be of pathogenic relevance in determining the myopathic features present in GALT deficiency syndrome.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Bresolin N,Comi GP,Fortunato F,Meola G,Gallanti A,Tajana A,Velicogna M,Gonano EF,Ninfali P,Pifferi Sdoi
10.1007/BF00838160subject
Has Abstract,Author List Incompletepub_date
1993-05-01 00:00:00pages
272-7issue
5eissn
0340-5354issn
1432-1459journal_volume
240pub_type
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