Abstract:
:We examined the morphology of spinal accessory motoneurons and immunoreactivity to neurotrophins, brain-derived neurotropic factor (BDNF) and neurotrophin (NT)-3, as well as the presence of reactive astrocytosis in 70 tiptoe walking Yoshimura (twy) mice that develop calcification at C1-C2 vertebral level compressing the spinal cord. At the level of compression, the area of neuronal soma and total length of dendrites of wheat germ agglutinin-horseradish peroxidase (WGA-HRP)-labelled accessory motoneurons in the medial cell pool decreased significantly with decrement in motoneuron population, relative to the control. In contrast, at sites rostral to the compressive lesion, a significant enlargement of the neuron soma and dendritic elongation were noted, associated with increased motoneuron population and decreased transverse area of the cord at the level of compression. At this site, enhanced BDNF and NT-3 immunoreactivities were evident in the anterior horn cells. In mice with a more severe degree of compression, astrocyte-like cells showing BDNF immunoreactivity became abundant and axons in the anterior column demonstrated a marked NT-3 immunoreactivity. Our results suggest increased functional activity of anterior horn cells at levels rostra] to the site of compression. We speculate that the presence of BDNF and NT-3 in neurons and astrocyte-like cells is proportionate to the severity of chronic mechanical compression and may contribute to the heterotropic neuronal reserve and survival.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Uchida K,Baba H,Maezawa Y,Furukawa S,Furusawa N,Imura Sdoi
10.1007/s004150050287subject
Has Abstractpub_date
1998-12-01 00:00:00pages
781-93issue
12eissn
0340-5354issn
1432-1459journal_volume
245pub_type
杂志文章abstract::Spinocerebellar ataxias (SCA) are a genetically heterogeneous group of neurodegenerative diseases characterised by progressive cerebellar ataxia, dysarthria and oculomotor abnormalities. Recently the prodynorphin (PDYN) gene was identified as the cause of SCA23 in four Dutch families displaying progressive gait and li...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6721-1
更新日期:2013-03-01 00:00:00
abstract::Genetic evidence indicates a central role of cerebral accumulation of beta-amyloid (Abeta) in the pathogenesis of Alzheimer's disease (AD). Beside presenilin 1 and 2, three other recently discovered proteins (Aph 1, PEN 2 and nicastrin) are associated with gamma-secretase activity, the enzymatic complex generating Abe...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0799-7
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:We report a clinical description of pure sensory stroke based on data collected from a prospective acute stroke registry. METHODS:From 2500 acute stroke patients included in a hospital-based prospective stroke registry over a 12-year period, 99 were identified as having pure sensory stroke. RESULTS:Pure sen...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0622-5
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Rehabilitation seems to promote brain plasticity, but objective measures of efficacy are lacking and there is a limited understanding of the mechanisms underlying functional recovery. OBJECTIVE:To study functional and structural brain changes induced by gait rehabilitation. METHODS:We enrolled MS inpatient...
journal_title:Journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00415-018-8859-y
更新日期:2018-06-01 00:00:00
abstract::Eighteen patients with dural arteriovenous fistulas or intradural arteriovenous malformations underwent clinical and neurophysiological examination. Bladder disturbances, pain, sensory abnormalities and involvement of both upper and lower motor neurons were commonly observed. Abnormal findings were obtained both in el...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00878524
更新日期:1996-01-01 00:00:00
abstract::Mutations in SCN2A cause epilepsy syndromes of variable severity including neonatal-infantile seizures. In one case, we previously described additional childhood-onset episodic ataxia. Here, we corroborate and detail the latter phenotype in three further cases. We describe the clinical characteristics, identify the ca...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-015-7984-0
更新日期:2016-02-01 00:00:00
abstract::Urate is a natural antioxidant, and high serum urate levels could be protective against the development of amyotrophic lateral sclerosis (ALS). To determine if serum urate concentrations were lower in ALS patients than in healthy controls, we compared serum urate levels in 132 ALS patients and 337 age/sex-matched cont...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-010-5735-9
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To identify factors that impact on the ability of patients with multiple sclerosis (MS) to remain in work in order to make recommendations for future clinical management. METHODS:Cross-sectional studies using qualitative (phase one) and quantitative (phase two) methods. In phase one, 62 patients were intervi...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0765-4
更新日期:2005-08-01 00:00:00
abstract::A 37-year-old man presented with an acute amnestic syndrome of Korsakoff's type and an upper brain-stem oculomotor syndrome. After a moderate improvement with steroid therapy, he developed progressive behavioural changes due to a frontal lobe syndrome, in addition to motor and visual impairment. Memory performance was...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00315338
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVE:Children with neuromuscular disorders have been assumed to be a particularly vulnerable population since the beginning of COVID-19. Although this is a plausible hypothesis, there is no evidence that complications or mortality rates in neuromuscular patients are higher than in the general population. The aim o...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10339-y
更新日期:2021-01-02 00:00:00
abstract::Motor tests were performed in 50 HIV-infected patients in all stages according to the current CDC classification, but without any clinically evident central nervous system deficit, and the results compared with an age-matched control group. Patients were excluded from the study if there was alcohol or drug abuse, feve...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00315660
更新日期:1990-10-01 00:00:00
abstract::Prognosis of patients with ischemic stroke requiring mechanical ventilation (MV) has been reported to be poor. However, longterm survival and functional outcome have scarcely been studied and nothing is known about the prevalence of cognitive impairment or depression in survivors and their quality of life (QoL). We id...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s00415-005-0711-5
更新日期:2005-06-01 00:00:00
abstract::A 73-year-old woman presented with multifocal cerebral dysfunction of 1 month's duration. Cranial CT scanning revealed unusual widespread abnormalities. Brain biopsy showed amyloid angiopathy affecting vessels in the meninges and cerebral cortex, with associated granulomatous angiitis. There was no clinical evidence o...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314491
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVES:Recent retrospective studies found sleep disorders, including obstructive sleep apnea and its symptoms to occur more often in patients following aneurysmal subarachnoid hemorrhage, but studies investigating the incidence of subarachnoid hemorrhage in patients with diagnosed obstructive sleep apnea [OSA] comp...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09265-5
更新日期:2019-06-01 00:00:00
abstract::We describe three patients in whom an isolated sixth nerve palsy was the only clinical symptom or sign of multiple sclerosis (MS). Data were collected prospectively over 6 years on these three patients, who showed no other signs of brainstem dysfunction or prior symptoms; in addition. Retrospective analysis of all pat...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s004150070114
更新日期:2000-09-01 00:00:00
abstract::Biomarkers beyond clinical assessment are needed in patients who suffer from amyotrophic lateral sclerosis (ALS). Here, single-voxel proton magnetic resonance spectroscopy ((1)H MRS) of the gray matter of the motor cortex and the white matter including the pyramidal tracts was used to investigate concentrations of N-a...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0495-2
更新日期:2007-08-01 00:00:00
abstract::We evaluated cyclosporine A (CsA) treatment in 9 patients (6 female and 3 male), 16-63 years old, with severe myasthenia gravis (MG) for a mean period of 2 years (range 16-36 months). All of the patients had been previously treated either with corticosteroids or by combined immunotherapy, and 5 needed periodic plasma ...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s004150050141
更新日期:1997-09-01 00:00:00
abstract::Two siblings with multiple intracranial haemangiomatosis are reported, each having psychomotor retardation, epilepsy and gyriform type calcification in the occipital and frontal lobes. There were haemangiomas in one autopsy case with calcification in the deep layers of the cortex and subcortical white matter. ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313911
更新日期:1985-01-01 00:00:00
abstract::Sexuality in patients with amyotrophic lateral sclerosis (ALS) has received little attention so far. Although sexual function is not directly affected by the disease process, several patients have reported problems within their sexual relationship. We performed a questionnaire survey to ascertain the extent and clinic...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-004-0351-1
更新日期:2004-04-01 00:00:00
abstract::Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease with an estimated incidence of 1 in 8000 and is the most common form of muscular dystrophy affecting adults. An unstable, untranslated part of the myotonic dystrophy protein kinase gene on the long arm of chromosome 19, composed of CTG repeats, is ...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s004150050220
更新日期:1998-05-01 00:00:00
abstract:INTRODUCTION:The present study aimed to survey the prevalence of prodromal symptoms of Parkinson's disease (PD) in Japanese health checkup examinees, for identifying at-risk subjects. METHODS:We conducted a questionnaire survey of annual health checkup examinees without neurological symptoms using the following self-r...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09714-6
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-8790-2
更新日期:2018-05-01 00:00:00
abstract::Migraine is a common debilitating neurological disease characterised by attacks of severe headache with or without preceding aura. Its aetiology remains elusive; however it is clear that an interplay of genetic and environmental components play an important role. Familial hemiplegic migraine (FHM) is a rare and severe...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-007-0641-5
更新日期:2007-12-01 00:00:00
abstract::We analysed the CACNA1A gene, located on chromosome 19p13, in three unrelated families and one sporadic case with episodic ataxia type 2 (EA-2). In two of the families and the sporadic patient, novel truncating mutations, which disrupt the reading frame and result in a premature stop of the CACNA1A protein, were ident...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-002-0860-8
更新日期:2002-11-01 00:00:00
abstract::Cerebral amyloid angiopathy (CAA) was found in 57% of 123 autopsy brains removed from patients aged 59-101 years. The incidence of CAA increased with age. CAA was seen most frequently in the occipital cortex. Immunohistochemically, amyloid of CAA was positive for amyloid P component and negative for human AA protein a...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314080
更新日期:1987-08-01 00:00:00
abstract::We explored how changes in visual attention impacted postural motor performance in healthy elders and adults post-stroke within a virtual reality environment, including when vestibular information was not perceptible. Visual dependence in 13 healthy (50-80 years) and 13 adults post-stroke (49-70 years) was assessed wi...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6566-7
更新日期:2012-12-01 00:00:00
abstract::We report three members of a single family with an apparently autosomal dominant, nonparoxysmal, hyperkinetic movement disorder with onset in adolescence. The proband, a 56-year-old woman, manifested dystonia, tremor and myoclonus; one of her daughters exhibited myoclonus with tremor, and the other demonstrated myoclo...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050116
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Little is known about the change in prevalence of comorbidities during the disease course of people with multiple sclerosis (MS) and whether the prevalences vary by MS onset type. OBJECTIVE:To calculate the change in prevalence of comorbidities between symptom onset and the time of study, to compare the pre...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10194-x
更新日期:2020-09-03 00:00:00
abstract:INTRODUCTION:Two population-based studies of neuromyelitis optica (NMO) in non-white populations provided prevalence rates of 0.32 and 3.1 per 100,000 population. OBJECTIVE:To estimate NMO prevalence in the multiethnic Cuban population by nation-wide case ascertainment. METHODS:The study was conducted from October 1,...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-0009-0
更新日期:2009-01-01 00:00:00
abstract::The objective of the study was to identify differences in treatment strategies for anti-NMDA receptor encephalitis based on specialty of treating physicians, geographic location, and years in practice. We conducted an anonymous worldwide electronic survey through the Practice Current section of Neurology® Clinical Pra...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8407-1
更新日期:2017-04-01 00:00:00