Abstract：
:The neurochemical abnormalities underlying vascular parkinsonism (VP) have not been well characterised. A better understanding may help to optimize pharmacological interventions. Since VP patients generally have a poorer response to l-Dopa than Parkinson's disease (PD) patients, we investigated whether levels of relevant CSF neurotransmitter metabolites may be differentially altered in VP and PD and assessed the potential of neurotransmitter metabolites as biomarkers. We compared CSF levels of homovanillic acid (HVA), 5-hydroxyindolacetic acid, and 3-methoxy-4-hydroxyphenylethyleneglycol, in 16 VP patients, 57 PD patients and 60 non-neurological controls. We found that levels of HVA were reduced in PD compared with both VP and controls but did not differ significantly between VP and controls indicating that dopamine deficiency was less pronounced in VP.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Herbert MK,Kuiperij H,Bloem BR,Verbeek MMdoi
10.1007/s00415-013-7126-5subject
Has Abstractpub_date
2013-12-01 00:00:00pages
3129-33issue
12eissn
0340-5354issn
1432-1459journal_volume
260pub_type
杂志文章abstract：:A method for the preparation of a potent and specific peroxidase-labelled antihuman IgG antibody is described. CSF cells from patients with various neurological diseases were stained. Only in cases of inflammatory diseases was IgG detectable. The stained cells were so-called lymphoid cells. As the demonstrable IgG can...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313346
更新日期：1980-01-01 00:00:00
abstract：:The primary cause of neurological syndromes with antibodies against glutamic acid decarboxylase 65 (GAD65-Ab) is unknown, but genetic predisposition may exist as it is suggested by the co-occurrence in patients and their relatives of other organ-specific autoimmune diseases, notably type 1 diabetes mellitus (T1DM), an...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09782-8
更新日期：2020-07-01 00:00:00
abstract：:The mechanism underlying the motor fluctuations that develop after long-term L-dopa therapy is not fully known. It has been speculated that malabsorption of L-dopa from the small intestine occurs. It was reported that gastric retention in Parkinson's disease (PD) patients with motor fluctuations is increased as compar...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5220-5
更新日期：2009-12-01 00:00:00
abstract：:Parvalbumin (a calcium-binding protein)-immunoreactive (PV-Ir) neurons in the cerebral cortex were examined in 20 postmortem brains obtained from elderly controls and patients with Pick's disease (PD). The type of PV-Ir neurons and their distribution in control and PD brains were similar. The number of PV-Ir neurons i...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314780
更新日期：1991-07-01 00:00:00
abstract：:A boy was suspected of having meningoencephalitis probably of viral origin, although all microbiological, including virological, tests were negative. Postmortem examination revealed a dissecting aortic aneurysm and disseminated intravascular coagulation involving the central nervous system exclusively. The clinical ev...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313465
更新日期：1981-01-01 00:00:00
abstract：:Multiple mononeuropathy (MM) occurs rarely during systemic lupus erythematosus (SLE) but may lead to major disability. The aim of this study was to investigate the clinic-pathological presentations of MM during SLE, as well as long-term outcomes. We conducted a multicentric retrospective study that included patients r...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-017-8519-7
更新日期：2017-06-01 00:00:00
abstract：:We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00900501
更新日期：1996-06-01 00:00:00
abstract：:Hereditary peripheral neuropathies present a group of clinically and genetically heterogeneous entities. All known forms, including the various forms of Charcot-Marie-Tooth disease (CMT) are characterized as Mendelian traits and over 35 genes have been identified thus far. The mutational mechanism of the most common C...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5401-2
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:In vascular dementia (VaD), assessment of cerebral blood flow by single photon emission computed tomography (CBF SPECT) has been used to detect a patchy decrease of blood flow or a frontal reduction. In addition to reduced blood flow, the heterogeneous distribution of cerebral blood flow is often observed in...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-003-0972-9
更新日期：2003-02-01 00:00:00
abstract：:Local administration of botulinum toxin (BoTx) inhibits presynaptic acetylcholine release. All cholinergically innervated muscles and glands can be paralyzed accordingly. Studies on the application of BoTx in multiple sclerosis have shown good results for focal spasticity, in particular, of the extremities. The first ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-006-1104-0
更新日期：2006-02-01 00:00:00
abstract：:Two cases of Addison's disease associated with myasthenia gravis are reported. This association has been described only rarely in the literature. In the first case, there were marked immunological abnormalities. It is most likely that the origin of the adrenocortical insufficiency in the second case is tuberculous. Th...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313835
更新日期：1985-01-01 00:00:00
abstract：:We examined the effect of bilateral subthalamic nucleus stimulation on levodopa-resistant balance impairment in 14 patients with Parkinson's disease and 18 matched controls. Instability was quantitatively assessed using standardized multidirectional dynamic posturography. Patients were tested after taking a suprathres...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0636-x
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:The variability of the severity and regional distribution of pathological process in basal ganglia (BG) and brainstem-cerebellar systems results in clinical heterogeneity and represents the motor subtype of multiple system atrophy (MSA). This study aimed to quantify spatial patterns of multimodal MRI abnormal...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8874-z
更新日期：2018-07-01 00:00:00
abstract：:Non-motor symptoms (NMS) of Parkinson's disease (PD) have only recently been increasingly recognized for their impact on a patient's quality of life. In this study, we applied the validated, comprehensive self-completed NMS questionnaire for PD (NMS Quest) to 101 patients with young-onset PD (onset between 21 and 45 y...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6600-9
更新日期：2013-01-01 00:00:00
abstract：:Silver syndrome/SPG17 is a motor manifestation of mutations in the BSCL2 gene and usually presents as a complicated form of hereditary spastic paraplegia (HSP). We present clinical data, follow-up, and genetic results of seven patients with Silver syndrome/SPG17 including a family with a variable intrafamilial phenoty...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8301-2
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:Patients with classic ataxia-telangiectasia (A-T) generally die in the second or third decade of life. Clinical descriptions of A-T tend to focus on the symptoms at presentation. However, during the course of the disease, other symptoms and complications emerge. As long-term survivors with classic A-T develop...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09641-1
更新日期：2020-03-01 00:00:00
abstract：:Small subcortical infarctions resulting from large-vessel disease are often observed. It is important to distinguish these from pure lacunar infarction resulting from small-vessel disease because the investigations and examinations differ. We investigated the differences on brain magnetic resonance imaging (MRI) betwe...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050584
更新日期：2000-04-01 00:00:00
abstract：:Nerve conduction studies (NCS) and electromyography (EMG), often shortened to 'EMGs', are a useful adjunct to clinical examination of the peripheral nervous system and striated skeletal muscle. NCS provide an efficient and rapid method of quantifying nerve conduction velocity (CV) and the amplitude of both sensory ner...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6497-3
更新日期：2012-07-01 00:00:00
abstract：:Autonomic nervous system (ANS) involvement is frequently found in Parkinson's disease (PD), but its causal relationship to the disease itself and its medication is unclear. We evaluated the effects of PD medications on cardiovascular ANS functions. Heart rate (HR) responses to normal and deep breathing, the Valsalva m...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s004150070075
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:One of the goals in treating subarachnoid hemorrhage patients is to prevent or minimize vasospasm-induced ischemia. Intracerebral microdialysis is a rapidly developing tool to monitor physiological and pathophysiological changes in chemical processes associated with ischemia. OBJECTIVE:To determine the diag...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-003-1079-z
更新日期：2003-07-01 00:00:00
abstract：INTRODUCTION:Ataxic polyneuropathy, which occurs in endemic form in an area in southwest Nigeria, is attributed to exposure to cyanide from cassava foods. Exposure to cyanide from cassava is, however, not exclusive to this endemic area. In this study, the occurrence of ataxic polyneuropathy was compared in two communit...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0779-0
更新日期：2002-08-01 00:00:00
abstract：:The diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy (PML) in multiple sclerosis patients in an asymptomatic stage is crucial since it is associated with better clinical outcome measures. Current diagnostic criteria on PML diagnosis in asymptomatic patients require the detection of JC vir...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7336-5
更新日期：2014-06-01 00:00:00
abstract：:The three main immunoglobulin classes obey the basic principles of passive protein transfer at the blood-CSF barrier and the serum-derived portions could therefore be quantified with the help of the permeability marker albumin. The Ig fractions secreted into the CSF by sessile plasma cell clones have been determined i...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313413
更新日期：1982-01-01 00:00:00
abstract：:Vitamin B(12) (VitB(12), cobalamin) deficiency has been associated with various neuropsychiatric conditions, such as peripheral neuropathy, subacute combined degeneration, affective disorders, and cognitive impairment. Current assays analyze vitamin B(12), of which only a small percentage is metabolically active. Meas...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5764-4
更新日期：2011-03-01 00:00:00
abstract：:Several studies have reported infection as a possible risk factor for cervical artery dissection (CAD). We retrospectively analyzed several inflammatory parameters of CAD patients with the aim of detecting differences between spontaneous (n = 25) and traumatic (n = 18) CAD. In this case-control study, we observed sign...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0109-z
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Body weight reduction after disease onset is an independent predictor of survival in amyotrophic lateral sclerosis (ALS), but significance of weight variation after diagnosis remains to be established. OBJECTIVE:To investigate weight variation after diagnosis and its prognostic significance in patients with...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09276-2
更新日期：2019-06-01 00:00:00
abstract：:Cerebellar ataxia can have many genetic causes among which are the congenital disorders of glycosylation type I (CDG-I). In this group of disorders, a multisystem phenotype is generally observed including the involvement of many organs, the endocrine, hematologic and central nervous systems. A few cases of CDG-Ia have...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-0546-3
更新日期：2007-10-01 00:00:00
abstract：:Hirayama's disease is a benign juvenile form of focal amyotrophy affecting the upper limbs. Previous studies have suggested that the disorder is a neck flexion induced cervical myelopathy. We report clinical and magnetic resonance imaging findings in nine patients with Hirayama's disease. Cervical imaging of seven pat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050514
更新日期：1999-11-01 00:00:00
abstract：:Horizontal eye-movement responses of four patients with Alzheimer-type dementia were recorded using the infrared oculographic technique. Abnormally frequent saccadic intrusions occurred during the fixation and slow, smooth pursuit tasks in all four patients. Saccadic intrusions have previously been reported in the lit...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313742
更新日期：1983-01-01 00:00:00
abstract：:A total of 15 patients affected by idiopathic dystonia (7 with generalized and 8 with focal or segmental dystonia) were subjected to therapy with bromocriptine at low doses, pimozide and trihexyphenidyl. The symptoms were evaluated by giving a progressive score in relation to the intensity of the dystonic symptom to e...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313391
更新日期：1982-01-01 00:00:00
