Abstract:
:The three main immunoglobulin classes obey the basic principles of passive protein transfer at the blood-CSF barrier and the serum-derived portions could therefore be quantified with the help of the permeability marker albumin. The Ig fractions secreted into the CSF by sessile plasma cell clones have been determined in various inflammatory diseases of the central nervous system. The humoral immune response in multiple sclerosis and chronic encephalitis of unknown cause was dominated by IgG antibodies. In most other inflammatory diseases IgA and IgM were concomitantly synthesized, e.g. in neurosyphilis and meningoencephalitis caused by viruses of the herpes group. In tick-borne meningopolyneuritis Bannwarth, only IgM and in bacterial meningitis only IgA may be produced locally. The detection of a secretory immunoglobulin fraction in the CSF may be the sole laboratory parameter in chronic inflammatory processes of the nervous system.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Felgenhauer Kdoi
10.1007/BF00313413subject
Has Abstractpub_date
1982-01-01 00:00:00pages
223-37issue
4eissn
0340-5354issn
1432-1459journal_volume
228pub_type
杂志文章abstract::The INCOMIN study (INdependent COMparison of INterferons) lends further support to the growing body of evidence that both dose and frequency of interferon beta (IFNbeta) administration are important in the treatment of multiple sclerosis (MS). High-dose, high-frequency IFNbeta (IFNbeta-1b 250 microg eod sc and IFNbeta...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-005-2016-0
更新日期:2005-09-01 00:00:00
abstract::We report three members of a single family with an apparently autosomal dominant, nonparoxysmal, hyperkinetic movement disorder with onset in adolescence. The proband, a 56-year-old woman, manifested dystonia, tremor and myoclonus; one of her daughters exhibited myoclonus with tremor, and the other demonstrated myoclo...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050116
更新日期:1997-07-01 00:00:00
abstract::Polymerase chain reaction (PCR) based automated high-resolution fragment analysis of rearranged immunoglobulin heavy-chain genes is a highly sensitive means for identifying clonal B-cell responses. We used this technique to distinguish polyclonal inflammatory from monoclonal neoplastic B-cell populations in the cerebr...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s004150170247
更新日期:2001-02-01 00:00:00
abstract::Degeneration of central dopaminergic neurons is the most characteristic pathological feature of Parkinson's disease. It remains to be established to what extent these lesions explain the motor, cognitive and affective disorders observed in patients, but there are now some interesting clues to a possible solution. ...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF00819560
更新日期:1992-01-01 00:00:00
abstract::In vivo nuclear magnetic resonance spectroscopy (MRS) of the human brain is a recently developed technique which allows to assay noninvasively in vivo key molecules of brain metabolism. After a review of the origin of the signals detected by phosphorus and proton MRS of human brain, the impact of MRS on clinical neuro...
journal_title:Journal of neurology
pub_type: 社论,评审
doi:10.1007/BF02033352
更新日期:1994-05-01 00:00:00
abstract::Cerebellar syndrome is one of the most disabling developments in multiple sclerosis (MS). In neurodegenerative disorders, cerebellar syndrome is thought to be related to a neurochemical deficit of 5-hydroxytryptamine (5-HT). Previous studies found that a levorotatory form of 5-hydroxytryptophan, a 5-HT precursor, and ...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00415-003-0176-3
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Dysarthria may be classified as flaccid, spastic, ataxic, hypokinetic, choreatic, dystonic, or mixed. We hypothesized that in routine neurological practice the reliability and accuracy of perceptual analysis alone in the classification of dysarthria is low and that this classification is mainly based on the ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0978-4
更新日期:2008-10-01 00:00:00
abstract::This review gives an overview of various neuroimmunological diseases in terms of incidence and prevalence rates, age and sex distribution, and the frequency of subtypes, if applicable. The disorders selected for review are inflammatory muscle disorders (polymyositis, dermatomyositis and inclusion body myositis), myast...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-006-5001-3
更新日期:2006-09-01 00:00:00
abstract::In contrast to other neurodegenerative diseases, sporadic Creutzfeldt-Jakob disease (sCJD) is rarely diagnosed in patients older than 75 years. Data describing the characteristics of sCJD in the very old are rare and inconclusive. Therefore, a historical cohort study was designed to evaluate clinical, cerebrospinal fl...
journal_title:Journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00415-014-7283-1
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of acupuncture on stroke recovery compared to an inert placebo. DESIGN:Placebo-controlled, randomised, clinical trial. SETTING:Post-stroke rehabilitation wards in five NHS hospitals in the UK. SUBJECTS:Patients between 4 and 10 days after their first stroke. INTERVENTIONS AND O...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00415-008-0790-1
更新日期:2008-06-01 00:00:00
abstract::Migraine is a common and disabling nervous system disease with a significant genetic predisposition. The sex hormones play an important role in the pathogenesis of migraine. However, the conclusions of the previous genetic relation studies are conflicting. The aim of this study is to determine whether variants in gene...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-016-8321-y
更新日期:2017-01-01 00:00:00
abstract::The type and frequency of neurological manifestations of Behçet's disease (BD) vary with ethnicity. We analyzed the neurological manifestations of BD in Japanese patients. All patients undergoing treatment at one of the two Yokohama City University hospitals from July 1991 to December 2007 and who fulfilled the Japane...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-010-5454-2
更新日期:2010-06-01 00:00:00
abstract::An ultrastructural study of biopsied muscles was performed in seven patients with rimmed vacuolar distal myopathy, which was characterized by prominent rimmed vacuoles in the muscle fibers. The earliest changes noted were focal proliferation of the Golgi's apparatus and mitochondrial degeneration with myofibrillar los...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314132
更新日期:1987-04-01 00:00:00
abstract::The concentration of neopterin was measured in serum samples taken from individuals infected with HTLV-I: 5 from asymptomatic individuals, 1 from a patient with adult T-cell leukaemia and 30 from patients with tropical spastic paraparesis (TSP). In addition, cerebrospinal fluid (CSF) was available from 22 of the TSP p...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00810351
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Sleep disorders can occur in early Parkinson's disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not been fully explored. OBJECTIVE:To describe the frequency, coexistence, and longitudinal change in excessive daytime sleepiness (EDS), insomnia,...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10140-x
更新日期:2021-01-01 00:00:00
abstract::Epileptic syndromes are distinctive disorders with specific features, which when taken together, permit a specific diagnosis. There is actually a debate on that medial temporal lobe epilepsy with hippocampal sclerosis is an epileptic syndrome. To address this issue, we searched for discriminative semiological features...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8441-z
更新日期:2017-05-01 00:00:00
abstract::X-linked adrenoleukodystrophy (XALD), a neurological disorder caused by mutations in the peroxisomal membrane protein gene ABCD1, presents as a rapidly progressing, inflammatory cerebral demyelination (cerebral cases) or a slowly progressing, distal axonopathy (non-cerebral cases). Specific ABCD1 defects do not explai...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-011-6371-8
更新日期:2012-07-01 00:00:00
abstract::Fingolimod safety and efficacy data in relapsing-remitting multiple sclerosis (RRMS) are available up to 5 years, from an extension of a randomized, placebo-controlled, double-blind, phase 2 study, at a dose higher (5.0/1.25 mg) than the approved dose of 0.5 mg. The objective of the study is to present the end-of-stud...
journal_title:Journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00415-015-7834-0
更新日期:2015-12-01 00:00:00
abstract::Cerebral atrophy calculated from serial MRI is a marker of Alzheimer's disease (AD) progression, and a potential outcome measure for therapeutic trials. Reducing within-subject variability in cerebral atrophy rates by acquiring more than two serial scans could allow for shorter clinical trials requiring smaller patien...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0173-4
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:D-dimer levels are used in several clinical settings, such as in predicting venous thrombosis, cardioembolic stroke and cancer status. In the present study, we investigated the associations between plasma D-dimer levels at admission, clinical characteristics and mortality at discharge in cryptogenic stroke p...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-8742-x
更新日期:2018-03-01 00:00:00
abstract::SARS-CoV2 infection is responsible for a complex clinical syndrome, named Coronavirus Disease 2019 (COVID-19), whose main consequences are severe pneumonia and acute respiratory distress syndrome. Occurrence of acute and subacute neurological manifestations (encephalitis, stroke, headache, seizures, Guillain-Barrè syn...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-020-10131-y
更新日期:2020-08-27 00:00:00
abstract::Specific mutations in COL6A3 have recently been reported as the cause of isolated recessive dystonia, which is a rare movement disorder. In all patients, at least one mutation was located in Exons 41 and 42. In an attempt to replicate these findings, we assessed by direct sequencing the frequency of rare variants in E...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-016-8046-y
更新日期:2016-04-01 00:00:00
abstract::We investigated the levels of transforming growth factor beta 1 (TGF-beta 1) in cerebrospinal fluid (CSF) in children with meningitis, with a view to prognostic relevance. CSF TGF-beta 1 levels on admission were measured by a sandwich enzyme immunoassay in children with bacterial meningitis (n = 16), aseptic meningiti...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s004150050159
更新日期:1997-10-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) of hand movements in amyotrophic lateral sclerosis (ALS) has repeatedly demonstrated increased activation in cortical and subcortical areas, whereas a single study has suggested decreased rather than increased activations for tongue movements in patients with bulbar involve...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-010-5842-7
更新日期:2011-05-01 00:00:00
abstract::Clinical and experimental investigations have shown that magnesium depletion causes a marked irritability of the nervous system, eventually resulting in epileptic seizures. Although magnesium deficiency as a cause of epilepsy is uncommon, its recognition and correction may prove life-saving. Two case reports are prese...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00319737
更新日期:1991-08-01 00:00:00
abstract::Based on the observation of bilateral temporoparietal hypoperfusion in Alzheimer's disease (AD), single photon emission computed tomography (SPECT) is advocated by some as a powerful diagnostic tool in the evaluation of demented patients. We studied whether routine brain SPECT in elderly, mildly demented outpatients i...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00868397
更新日期:1995-06-01 00:00:00
abstract::Corticospinal lesions cause impairments in voluntary motor control. Recent findings suggest that some degree of voluntary control may be taken over by a compensatory pathway involving the reticulospinal tract. In humans, evidence for this notion mainly comes from StartReact studies. StartReact is the acceleration of r...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-9027-0
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and characteristics of the cricopharyngeal bar (CPB), defined as marked protrusion with lacking relaxation and stricture of the upper esophageal sphincter on videofluoroscopy, in patients with inclusion body myositis (IBM). METHODS:We conducted a case-control study of comprehensiv...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10241-7
更新日期:2020-09-26 00:00:00
abstract::Central nervous system (CNS) involvement in systemic lupus erythematosus (SLE) remains difficult to diagnose, particularly since structural abnormalities may not be revealed by magnetic resonance imaging (MRI). Glucose utilisation was measured by positron emission tomography (PET) in 35 SLE patients to detect signs of...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050071
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To identify the most responsive and sensitive clinical outcome measures in GNE myopathy. METHODS:ClinBio-GNE is a natural history study in GNE myopathy. Patients were assessed prospectively by clinical, functional and quantitative nuclear magnetic resonance imaging (qNMRI) evaluations. Strengt...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09569-6
更新日期:2020-01-01 00:00:00