Abstract:
:Migraine is a common and disabling nervous system disease with a significant genetic predisposition. The sex hormones play an important role in the pathogenesis of migraine. However, the conclusions of the previous genetic relation studies are conflicting. The aim of this study is to determine whether variants in genes involved in estrogen receptor and estrogen hormone metabolism are related to Chinese migraine. By employing a case-control approach, 8 SNPs in the ESR1, ESR2, and CYP19A1 genes are studied in a cohort of 494 migraine cases and 533 controls. In addition, genotyping is performed using Sequenom MALDI-TOF mass spectrometry iPLEX platform. Univariate and multivariate analyses are carried out by logistic regression. The corresponding haplotypes are studied with the Haploview software and gene-gene interaction is assessed using the Generalized Multifactor Dimensionality Reduction (GMDR) analysis. There are significant differences in allelic distributions for rs2234693 and rs9340799 in ESR1 gene between patients with migraine and control subjects. Univariate logistic analysis shows that rs2234693 and rs9340799 are risk factors for migraine, but multivariate analysis reveals that only rs2234693 is significant associated with migraine. In the subgroup analysis, rs2234693 in ESR1 gene is found associated with menstrually related migraine. Further haplotypic analysis shows that rs2234693-rs9340799 TA haplotype serves as risk haplotype for migraine. The GMDR analysis identifies rs2234693 in ESR1 alone to be a crucial candidate in migraine susceptibility. This study is in agreement with the previous studies that variants in the ESR1 gene are associated with migraine suggesting that it plays a role in the migraine process.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
An X,Fang J,Lin Q,Lu C,Ma Q,Qu Hdoi
10.1007/s00415-016-8321-ysubject
Has Abstractpub_date
2017-01-01 00:00:00pages
81-87issue
1eissn
0340-5354issn
1432-1459pii
10.1007/s00415-016-8321-yjournal_volume
264pub_type
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journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s00415-006-0332-7
更新日期:2007-05-01 00:00:00
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更新日期:2013-11-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
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更新日期:2006-09-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313543
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pub_type: 杂志文章
doi:10.1007/s00415-020-10172-3
更新日期:2020-08-31 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00