Abstract:
:The diagnosis of Hallervorden-Spatz disease (HSD) has usually been made post mortem, although the recent description of characteristic abnormalities in the globus pallidus has suggested the possibility of an in vivo diagnosis. We present the clinical histories, neurological features and MRI findings of 11 patients, diagnosed as having HSD. Generalized dystonia with predominance of oromandibular involvement, behavioural changes followed by dementia and retinal degeneration were present in all the patients. MRI pallidal abnormalities consisted of decreased signal intensity in T2-weighted images, compatible with iron deposits, and of a small area of hyperintensity in its internal segment ("eye of the tiger" sign). We propose that the combination of these neurological signs with these MRI findings could be considered as highly suggestive of a diagnosis of HSD in living patients.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Angelini L,Nardocci N,Rumi V,Zorzi C,Strada L,Savoiardo Mdoi
10.1007/BF00856805keywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
417-25issue
8eissn
0340-5354issn
1432-1459journal_volume
239pub_type
杂志文章abstract::The transcranial activation and the conduction properties of corticospinal and callosal neurons were investigated in 12 early-treated adolescents (aged 17.3, SD 3.5 years; range 14-27 years) with phenylketonuria (PKU) by focal transcranial magnetic stimulation (fTMS) of the motor cortex. The patients had no functional...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050301
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abstract:PURPOSE:Anti-myelin oligodendrocyte glycoprotein antibodies (anti-MOG), directed against a component of the myelin sheath, are sometimes detected in the blood or cerebrospinal fluid (CSF) of patients with acute demyelinating conditions. Cortical encephalitic presentations in anti-MOG-antibody-positive patients are reco...
journal_title:Journal of neurology
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doi:10.1007/s00415-011-6407-0
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doi:10.1007/s00415-003-1021-4
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doi:10.1007/s00415-014-7524-3
更新日期:2015-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00870670
更新日期:1993-11-01 00:00:00
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doi:10.1007/s00415-018-9034-1
更新日期:2018-11-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-004-1504-y
更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-002-0779-0
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pub_type: 杂志文章
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更新日期:1996-06-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314221
更新日期:1989-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-002-0825-y
更新日期:2002-09-01 00:00:00
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pub_type: 信件,评审
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pub_type: 杂志文章,评审
doi:10.1007/s004150070114
更新日期:2000-09-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,meta分析
doi:10.1007/s00415-005-0064-0
更新日期:2006-05-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314238
更新日期:1988-07-01 00:00:00
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doi:10.1007/s00415-020-10241-7
更新日期:2020-09-26 00:00:00
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doi:10.1007/s00415-008-0737-6
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更新日期:2007-10-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-020-10353-0
更新日期:2021-01-07 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313858
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:In vascular dementia (VaD), assessment of cerebral blood flow by single photon emission computed tomography (CBF SPECT) has been used to detect a patchy decrease of blood flow or a frontal reduction. In addition to reduced blood flow, the heterogeneous distribution of cerebral blood flow is often observed in...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-7124-7
更新日期:2013-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-006-0347-0
更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-020-09964-4
更新日期:2020-06-05 00:00:00
abstract::The polymorphism of the HLA class II genes was investigated in 97 patients with multiple sclerosis (MS) in Hokkaido, the northernmost main island of Japan. Of these, 80 patients were classified as having conventional MS and 17 as having opticospinal MS (OS-MS). Our findings confirmed a previous report that the DPB 1*0...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050558
更新日期:2000-03-01 00:00:00