Is there neuroprotection in Parkinson syndrome?

abstract：:Few regional and seasonal Guillain-Barré syndrome (GBS) clusters have been reported so far. It is unknown whether patients suffering from sporadic GBS differ from GBS clusters with respect to clinical and paraclinical parameters, HLA association and antibody response to glycosphingolipids and Campylobacter jejuni (Cj)...

journal_title：Journal of neurology

authors： Schirmer L,Worthington V,Solloch U,Loleit V,Grummel V,Lakdawala N,Grant D,Wassmuth R,Schmidt AH,Gebhardt F,Andlauer TF,Sauter J,Berthele A,Lunn MP,Hemmer B

更新日期：2016-10-01 00:00:00

abstract：:To investigate the role of endogenous opioid peptides in the pathophysiology of cerebral ischaemia, the CSF levels of immunoreactive beta-endorphin and leu-enkephalin in 16 patients with cerebral infarction were measured. Both the CSF beta-endorphin and leu-enkephalin levels in the acute stage of cerebral infarction w...

journal_title：Journal of neurology

authors： Kobari M,Ishihara N,Yunoki K

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Sleep disorders can occur in early Parkinson's disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not been fully explored. OBJECTIVE:To describe the frequency, coexistence, and longitudinal change in excessive daytime sleepiness (EDS), insomnia,...

journal_title：Journal of neurology

authors： Xu Z,Anderson KN,Saffari SE,Lawson RA,Chaudhuri KR,Brooks D,Pavese N

更新日期：2021-01-01 00:00:00

abstract：:The objective of this study was to assess the effect of secukinumab, a monoclonal antibody that inhibits interleukin (IL)-17A, on number of new active brain magnetic resonance imaging (MRI) lesions in subjects with relapsing-remitting multiple sclerosis (MS). Subjects (N = 73) were randomized 1:1 to secukinumab 10 mg/...

journal_title：Journal of neurology

authors： Havrdová E,Belova A,Goloborodko A,Tisserant A,Wright A,Wallstroem E,Garren H,Maguire RP,Johns DR

更新日期：2016-07-01 00:00:00

abstract：:Surface antigens on peripheral blood lymphocytes from myasthenia gravis patients were investigated. The expression of DR+ and CD8+/DR+ T lymphocytes was increased and the expression of CD4+ T cells reduced. Neither thymectomy, clinical condition nor anti-acetylcholine receptor antibody titre correlated with any of the...

journal_title：Journal of neurology

authors： Crosti F,Armanini M,Confalonieri P,Antozzi C,Mantegazza R

更新日期：1994-02-01 00:00:00

abstract：:We conducted an open-labeled clinical trial of interferon beta-1b (IFNB) treatment in 20 patients with primary progressive multiple sclerosis (PPMS) and longitudinally monitored autoantibodies against double-stranded DNA (dsDNA), thyroid peroxidase (TPO),myelin basic protein (MBP), myelin oligodendrocyte glycoprotein ...

journal_title：Journal of neurology

authors： Bitsch A,Dressel A,Meier K,Bogumil T,Deisenhammer F,Tumani H,Kitze B,Poser S,Weber F

更新日期：2004-12-01 00:00:00

abstract：:Although seizures in brain tumor patients are common, the knowledge on optimal anti-seizure therapy in this patient group is limited. An observational study was carried out using a database of all patients from the neuro-oncology service during the period 2000-2005, with data on seizure characteristics, therapy with A...

journal_title：Journal of neurology

authors： van Breemen MS,Rijsman RM,Taphoorn MJ,Walchenbach R,Zwinkels H,Vecht CJ

更新日期：2009-09-01 00:00:00

abstract：:The mechanism underlying the motor fluctuations that develop after long-term L-dopa therapy is not fully known. It has been speculated that malabsorption of L-dopa from the small intestine occurs. It was reported that gastric retention in Parkinson's disease (PD) patients with motor fluctuations is increased as compar...

journal_title：Journal of neurology

authors： Tanaka Y,Kato T,Nishida H,Araki H,Murase M,Nagaki M,Moriwaki H,Inuzuka T

更新日期：2009-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which was thought to be untreatable. However, recent evidence in both experimental animals and men indicates that antiglutamatergic strategies are the first to have an influence on its pathogenesis and slow down the disease process. Since the eff...

journal_title：Journal of neurology

authors： Ludolph AC

更新日期：2000-12-01 00:00:00

abstract：:Toxoplasma encephalitis, cryptococcal meningitis, progressive multifocal leukoencephalopathy (PML), and cytomegalovirus (CMV) encephalitis are the most common opportunistic infections of the central nervous system (CNS) in HIV-infected patients. They occur at variable degrees of immunosuppression, and their diagnosis ...

journal_title：Journal of neurology

authors： Roullet E

更新日期：1999-04-01 00:00:00

abstract：:Intrathecal IgG synthesis has been investigated by determining the IgG index and by isoelectric focusing in 30 cases of definite multiple sclerosis, in 15 cases of probable multiple sclerosis and in 128 patients affected by other neurological diseases. The blood-brain barrier function was evaluated at the same time by...

journal_title：Journal of neurology

authors： Poloni M,Rocchelli B,Scelsi R,Pinelli P

更新日期：1979-10-01 00:00:00

abstract：OBJECTIVE:To investigate whether intracranial arachnoid cysts (AC) compromise visual attention and if so, whether surgical cyst decompression leads to improvement in visual attention performance. METHODS:The experiments were carried out on 27 patients with temporal (n=21) or frontal (n=6) AC, and 27 healthy control su...

journal_title：Journal of neurology

authors： Gundersen H,Helland CA,Raeder MB,Hugdahl K,Wester K

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:To date, insertable cardiac monitors (ICMs) are the most effective method for the detection of occult atrial fibrillation (AF) in cryptogenic stroke. The overall detection rate after 12 months, however, is low and ranges between 12.4 and 33.3%, even if clinical predictors are considered. Ischemic stroke pati...

journal_title：Journal of neurology

authors： Vollmuth C,Stoesser S,Neugebauer H,Hansel A,Dreyhaupt J,Ludolph AC,Kassubek J,Althaus K

更新日期：2019-12-01 00:00:00

abstract：:Hirayama's disease is a benign juvenile form of focal amyotrophy affecting the upper limbs. Previous studies have suggested that the disorder is a neck flexion induced cervical myelopathy. We report clinical and magnetic resonance imaging findings in nine patients with Hirayama's disease. Cervical imaging of seven pat...

journal_title：Journal of neurology

authors： Schröder R,Keller E,Flacke S,Schmidt S,Pohl C,Klockgether T,Schlegel U

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:The main aim was to explore the changes in hand-grip strength in patients with Duchenne muscular dystrophy (DMD) aged 5-29 years. Secondary aims were to test the effect of mutation, ambulatory status and glucocorticoid use on grip strength and its changes over time and to compute the number of subjects needed...

journal_title：Journal of neurology

authors： Hogrel JY,Decostre V,Ledoux I,de Antonio M,Niks EH,de Groot I,Straub V,Muntoni F,Ricotti V,Voit T,Seferian A,Gidaro T,Servais L

更新日期：2020-07-01 00:00:00

abstract：:Advances in molecular biology have resulted in novel therapy for neurofibromatosis 2-related (NF2) tumours, highlighting the need for robust outcome measures. The disease-focused NF2 impact on quality of life (NFTI-QOL) patient questionnaire was assessed as an outcome measure for treatment in a multi-centre study. NFT...

journal_title：Journal of neurology

authors： Ferner RE,Shaw A,Evans DG,McAleer D,Halliday D,Parry A,Raymond FL,Durie-Gair J,Hanemann CO,Hornigold R,Axon P,Golding JF

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Cognitive impairment is a debilitating symptom experienced by ~ 50% of multiple sclerosis patients, with processing speed (PS) and memory most affected. Until now, the field has considered cognition in a binary fashion: patients are designated as impaired or not impaired. This designation is typically arrive...

journal_title：Journal of neurology

authors： Leavitt VM,Tosto G,Riley CS

更新日期：2018-03-01 00:00:00

abstract：:The emotional and relationship problems associated with MS have not always been fully appreciated by the medical profession, which has tended to concentrate on the physical aspects of this disease. Yet the psychological problems of MS often cause more suffering than physical effects. ...

journal_title：Journal of neurology

authors： Kesselring J,Klement U

更新日期：2001-03-01 00:00:00

abstract：:Little is known about the pattern of subacute cognitive domain impairments after ischaemic stroke, nor the temporal evolution of such impairments. Our objective was to investigate the pattern of cognitive impairment in different neuropsychological domains up to a year after ischaemic stroke. We included prospectively ...

journal_title：Journal of neurology

authors： Hurford R,Charidimou A,Fox Z,Cipolotti L,Werring DJ

更新日期：2013-01-01 00:00:00

abstract：:Peduncular hallucinosis (PH) is a syndrome of hallucinations and brainstem symptoms which has only been described in single case reports. A detailed analysis of five patients was undertaken to investigate the clincial characteristics, hallucinations and behavioural abnormalities of PH in greater detail. Frequent clini...

journal_title：Journal of neurology

authors： Benke T

更新日期：2006-12-01 00:00:00

abstract：:Acanthocytosis occurs because of ultrastructural abnormalities of the erythrocyte membranous skeleton resulting in reduced membrane fluidity. At least three hereditary neurological conditions are associated with it, although as yet the pathogenesis of the neurological features is unknown. In abetalipoproteinaemia, an ...

journal_title：Journal of neurology

authors： Stevenson VL,Hardie RJ

更新日期：2001-02-01 00:00:00

abstract：:Cerebellar dysfunction is an important contributor to disability in patients with multiple sclerosis (MS), however, few in vivo studies focused on cerebellar volume loss so far. This relates to technical challenges regarding the segmentation of the cerebellum. In this study, we evaluated the semi-automatic ECCET softw...

journal_title：Journal of neurology

authors： Weier K,Beck A,Magon S,Amann M,Naegelin Y,Penner IK,Thürling M,Aurich V,Derfuss T,Radue EW,Stippich C,Kappos L,Timmann D,Sprenger T

更新日期：2012-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disease, leaving the patient in a partially or completely deafferented state. In an explorative study, we investigated responses to visual socio-emotional stimuli in ALS patients. Pictures from the International Affective Picture System (IAPS) were verbally judged by 12 m...

journal_title：Journal of neurology

authors： Lulé D,Kurt A,Jürgens R,Kassubek J,Diekmann V,Kraft E,Neumann N,Ludolph AC,Birbaumer N,Anders S

更新日期：2005-12-01 00:00:00

abstract：:A 37-year-old man presented with an acute amnestic syndrome of Korsakoff's type and an upper brain-stem oculomotor syndrome. After a moderate improvement with steroid therapy, he developed progressive behavioural changes due to a frontal lobe syndrome, in addition to motor and visual impairment. Memory performance was...

journal_title：Journal of neurology

authors： Vighetto A,Charles N,Salzmann M,Confavreux C,Aimard G

更新日期：1991-09-01 00:00:00

abstract：:We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent co...

journal_title：Journal of neurology

authors： Guarino M,Stracciari A,Pazzaglia P,Sterzi R,Santilli I,Donato F,D'Alessandro R

更新日期：1996-02-01 00:00:00

abstract：:Among the hereditary cerebellar ataxias (CAs), there are at least 36 different forms of autosomal dominant cerebellar ataxia (ADCAs), 20 autosomal recessive cerebellar ataxias (ARCAs), two X-linked ataxias, and several forms of ataxia associated with mitochondrial defects. Despite the steady increase in the number of ...

journal_title：Journal of neurology

authors： Mancuso M,Orsucci D,Siciliano G,Bonuccelli U

更新日期：2014-09-01 00:00:00

abstract：:Fifteen patients with Sneddon's syndrome presenting since 1979 were re-examined. After a neurological examination, an orienting test of mental ability as well as an electroencephalogram were performed in all patients. In 10 of the 15 patients computed tomography of the brain was performed, too. Preceding reports and t...

journal_title：Journal of neurology

authors： Weissenborn K,Lubach D,Schwabe C,Becker H

更新日期：1989-01-01 00:00:00

abstract：:Recognition of multiple sclerosis (MS) attacks relies mostly on clinical assessment. However, their definition based on McDonald criteria refers mostly to timing and when dealing with clinical features is rather ambiguous: "...of the kind seen in multiple sclerosis." This is heightened in clinically isolated syndromes...

journal_title：Journal of neurology

authors： Sastre-Garriga J,Tintoré M,Nos C,Tur C,Río J,Téllez N,Castilló J,Horga A,Perkal H,Comabella M,Rovira A,Montalban X

更新日期：2010-05-01 00:00:00

abstract：:Brain metastasis is a common complication occurring in about 15-20% of all cancer patients. For the initial management, distinguishing between three types of presentation is essential: de novo brain metastasis, simultaneous presentation of both brain metastasis and the primary tumour (usually lung carcinoma), and the ...

journal_title：Journal of neurology

authors： Vecht CJ

更新日期：1998-03-01 00:00:00

abstract：:Corticospinal lesions cause impairments in voluntary motor control. Recent findings suggest that some degree of voluntary control may be taken over by a compensatory pathway involving the reticulospinal tract. In humans, evidence for this notion mainly comes from StartReact studies. StartReact is the acceleration of r...

journal_title：Journal of neurology

authors： van Lith BJH,Coppens MJM,Nonnekes J,van de Warrenburg BPC,Geurts AC,Weerdesteyn V

更新日期：2018-11-01 00:00:00