Abstract:
:A 37-year-old man presented with an acute amnestic syndrome of Korsakoff's type and an upper brain-stem oculomotor syndrome. After a moderate improvement with steroid therapy, he developed progressive behavioural changes due to a frontal lobe syndrome, in addition to motor and visual impairment. Memory performance was investigated on several occasions during an 11-year follow-up. Diagnosis of laboratory-supported definite multiple sclerosis was established and magnetic resonance imaging showed disseminated white matter lesions, especially in both medial temporal lobes. No other cause than multiple sclerosis was found for the amnestic syndrome. Among the rare cases of Korsakoff's syndrome in the course of multiple sclerosis, this is to our knowledge the first case in which a memory deficit was the initial manifestation of the disease.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Vighetto A,Charles N,Salzmann M,Confavreux C,Aimard Gdoi
10.1007/BF00315338subject
Has Abstractpub_date
1991-09-01 00:00:00pages
351-4issue
6eissn
0340-5354issn
1432-1459journal_volume
238pub_type
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