Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients.

Abstract:

BACKGROUND:Anti-epileptic drug (AED) prophylaxis in the first-seven days post-traumatic brain injury (TBI) is known to reduce seizure frequency acutely. AED efficacy is equivalent; therefore, choice of AED may rest with their side-effects. We hypothesise that AEDs that impair balance will prolong recovery, shown by a longer hospital stay. We compared length of hospital stay (and reported dizziness) in TBI patients receiving the commonest AEDs used in our TBI patients, Phenytoin (which may cause imbalance), and Levetiracetam (which does not affect balance). METHOD:A retrospective observational study was performed on TBI patients admitted to a Major Trauma Unit between October 2013 and June 2018. 100 of 278 patients treated with phenytoin or levetiracetam monotherapy for seizure prophylaxis were included. The inclusion criteria of admission Glasgow Coma Score of 14 or more and length of stay less than 3 weeks minimised confounding variables such as non-ambulant patients. Length of hospital stay and incidence of dizziness were assessed. RESULTS:The length of hospital stay was longer for patients on Phenytoin versus Levetiracetam, i.e., 10.74 vs. 7.58 days (p = 0.015; unpaired, two-sided t test). Dizziness reported by patients on phenytoin was 24% and levetiracetam was 8% (p = 0.018; Chi-squared test). CONCLUSION:In this cohort, using Phenytoin for acute TBI, seizure prophylaxis was associated with longer length of stay and more dizziness compared to Levetiracetam. Given their equivalent AED efficacy in acute TBI seizure prophylaxis, our data suggest that Levetiracetam is preferable to Phenytoin for early seizure prophylaxis in TBI. This requires evaluation in larger, prospective studies.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Harris L,Hateley S,Tsang KT,Wilson M,Seemungal BM

doi

10.1007/s00415-020-09769-5

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

1774-1779

issue

6

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-020-09769-5

journal_volume

267

pub_type

杂志文章
  • The utility of polysomnography for the diagnosis of NREM parasomnias: an observational study over 4 years of clinical practice.

    abstract::Polysomnography (PSG) is considered the gold standard for diagnosis of non-rapid eye movement (NREM) parasomnias, however its diagnostic yield has been rarely reported. We aimed to assess the diagnostic value of polysomnography in different categories of patients with suspected NREM parasomnia and define variables tha...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-014-7578-2

    authors: Fois C,Wright MA,Sechi G,Walker MC,Eriksson SH

    更新日期:2015-02-01 00:00:00

  • Cerebellum and cognition in progressive MS patients: functional changes beyond atrophy?

    abstract:BACKGROUND:The cerebellum is a predilection site of pathology in progressive multiple sclerosis (PMS) patients, contributing to cognitive deficits. Aim of this study was to investigate lobular cerebellar functional connectivity (FC) in PMS patients in relation to cognition. METHODS:In this cross-sectional study, resti...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-018-8985-6

    authors: Cocozza S,Pontillo G,Russo C,Russo CV,Costabile T,Pepe A,Tedeschi E,Lanzillo R,Brescia Morra V,Brunetti A,Inglese M,Petracca M

    更新日期:2018-10-01 00:00:00

  • A new non-radioactive method for the screening and prenatal diagnosis of myotonic dystrophy patients.

    abstract::Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease with an estimated incidence of 1 in 8000 and is the most common form of muscular dystrophy affecting adults. An unstable, untranslated part of the myotonic dystrophy protein kinase gene on the long arm of chromosome 19, composed of CTG repeats, is ...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s004150050220

    authors: Brugnoni R,Morandi L,Brambati B,Briscioli V,Cornelio F,Mantegazza R

    更新日期:1998-05-01 00:00:00

  • The sleep and circadian problems of Huntington's disease: when, why and their importance.

    abstract:INTRODUCTION:Mounting evidence supports the existence of an important feedforward cycle between sleep and neurodegeneration, wherein neurodegenerative diseases cause sleep and circadian abnormalities, which in turn exacerbate and accelerate neurodegeneration. If so, sleep therapies bear important potential to slow prog...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10334-3

    authors: Voysey Z,Fazal SV,Lazar AS,Barker RA

    更新日期:2020-12-23 00:00:00

  • Accepting or declining non-invasive ventilation or gastrostomy in amyotrophic lateral sclerosis: patients' perspectives.

    abstract::The objective was to identify factors associated with decisions made by patients with amyotrophic lateral sclerosis (ALS) to accept or decline non-invasive ventilation (NIV) and/or gastrostomy in a prospective population-based study. Twenty-one people with ALS, recruited from the South-East ALS Register who made an in...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-015-7665-z

    authors: Greenaway LP,Martin NH,Lawrence V,Janssen A,Al-Chalabi A,Leigh PN,Goldstein LH

    更新日期:2015-01-01 00:00:00

  • Serum and CSF neurofilament light chain levels in antibody-mediated encephalitis.

    abstract::Circulating and cerebrospinal fluid (CSF) neurofilament light chain (NfL) levels represent a reliable indicator of disease activity and axonal damage in different neuroinflammatory conditions. Recently, high CSF NfL levels have been detected in active autoimmune encephalitis, as opposed to significant lower levels aft...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09306-z

    authors: Mariotto S,Gajofatto A,Zuliani L,Zoccarato M,Gastaldi M,Franciotta D,Cantalupo G,Piardi F,Polo A,Alberti D,Sartori S,Zanusso G,Agrò L,Demurtas R,Sechi G,Sechi E,Monaco S,Ferrari S

    更新日期:2019-07-01 00:00:00

  • Comparative efficacy and acceptability of disease-modifying therapies in patients with relapsing-remitting multiple sclerosis: a systematic review and network meta-analysis.

    abstract:BACKGROUND:Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The treatment of MS has always been a focus of neurological research. To date, the US Food and Drug Administration has approved 15 medications for modifying the course of multiple sclerosis. In this study, we exami...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-019-09395-w

    authors: Li H,Hu F,Zhang Y,Li K

    更新日期:2020-12-01 00:00:00

  • Are white matter lesions directly associated with cognitive impairment in patients with lacunar infarcts?

    abstract::Forty-four patients (mean age 66, SD 8 years) with either clinical evidence of a focal lacunar syndrome (n = 36) or with disorders of memory or gait (n = 8) in the presence of a lacunar infarct on CT were studied for cognitive functioning and for the presence of white matter lesions on MRI. MR images were assessed by ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF02444014

    authors: van Swieten JC,Staal S,Kappelle LJ,Derix MM,van Gijn J

    更新日期:1996-02-01 00:00:00

  • Risk of Parkinson's disease after colectomy: longitudinal follow-up study using a national sample cohort.

    abstract:BACKGROUND AND PURPOSE:Parkinson's disease (PD) is a neurodegenerative disorder characterized by deposition of intraneural inclusion bodies in the brain as well as the enteric nervous system. Emerging concepts regarding the brain-gut axis have been proposed for neurological disorders. Thus, the present study investigat...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09617-1

    authors: Kim YJ,Lee CM,Kim S,Jang JW,Lee SY,Lee SH

    更新日期:2020-02-01 00:00:00

  • POLR3A-related spastic ataxia: new mutations and a look into the phenotype.

    abstract::Adolescent-onset spastic ataxia is a proposed novel phenotype in compound heterozygous carriers of an intronic mutation (c.1909 + 22G > A) in the POLR3A gene. Here, we present ten new cases of POLR3A-related spastic ataxia and discuss the genetic, clinical and imaging findings. Patients belonged to six pedigrees with ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09574-9

    authors: Infante J,Serrano-Cárdenas KM,Corral-Juan M,Farré X,Sánchez I,de Lucas EM,García A,Martín-Gurpegui JL,Berciano J,Matilla-Dueñas A

    更新日期:2020-02-01 00:00:00

  • Tetrahydroaminoacridine and lecithin in the treatment of Alzheimer's disease. Effect on cognition, functioning in daily life, behavioural disturbances and burden experienced by the carers.

    abstract::In 12 ambulant patients with a clinical diagnosis of probable Alzheimer's disease, a 12-week, double-blind, placebo-controlled study with 100 mg/day tetrahydroaminoacridine (THA) and 10 g/day lecithin is reported. The aim of the study was to find whether treatment would result in an improvement of cognition, of functi...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00319708

    authors: Weinstein HC,Teunisse S,van Gool WA

    更新日期:1991-02-01 00:00:00

  • Transcranial direct current stimulation for post-stroke dysphagia: a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) has been investigated as a tool for dysphagia recovery after stroke in several single-center randomized controlled trials (RCT). OBJECTIVE:The aim of this investigation was to quantitatively evaluate the effect of tDCS on dysphagia recovery after a stroke utili...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10142-9

    authors: Marchina S,Pisegna JM,Massaro JM,Langmore SE,McVey C,Wang J,Kumar S

    更新日期:2021-01-01 00:00:00

  • Basal ganglia volume and clinical correlates in 'preclinical' Huntington's disease.

    abstract:OBJECTIVE:To establish differences in basal ganglia and thalamic volume between preclinical carriers and non-carriers of the Huntington's disease (HD) gene and to link the volume to motor, cognitive and behavioural characteristics in carriers. METHODS:Sixteen HD gene carriers without overt clinical motor signs and 14 ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-008-0050-4

    authors: Jurgens CK,van de Wiel L,van Es AC,Grimbergen YM,Witjes-Ané MN,van der Grond J,Middelkoop HA,Roos RA

    更新日期:2008-11-01 00:00:00

  • Hallervorden-Spatz disease: clinical and MRI study of 11 cases diagnosed in life.

    abstract::The diagnosis of Hallervorden-Spatz disease (HSD) has usually been made post mortem, although the recent description of characteristic abnormalities in the globus pallidus has suggested the possibility of an in vivo diagnosis. We present the clinical histories, neurological features and MRI findings of 11 patients, di...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00856805

    authors: Angelini L,Nardocci N,Rumi V,Zorzi C,Strada L,Savoiardo M

    更新日期:1992-10-01 00:00:00

  • Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling.

    abstract:OBJECTIVE:To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. METHODS:We obtained perfusion images on 32 MCI-LB, 30 MCI-AD and 28 healthy subjects of similar age. Perfusion relative t...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10271-1

    authors: Firbank MJ,O'Brien JT,Durcan R,Allan LM,Barker S,Ciafone J,Donaghy PC,Hamilton CA,Lawley S,Lloyd J,Roberts G,Taylor JP,Thomas AJ

    更新日期:2020-10-21 00:00:00

  • Correction to: Diagnostic accuracy of a smartphone bedside test to assess the fixation suppression of the vestibulo‑ocular reflex: when nothing else matters.

    abstract::The article Diagnostic accuracy of a smartphone bedside test to assess the fixation suppression of the vestibulo‑ocular reflex: when nothing else matters, written by Florin Gandor, Manfred Tesch, Hannelore Neuhauser, Doreen Gruber, Hans‑Jochen Heinze, Georg Ebersbach and Thomas Lempert, was originally published electr...

    journal_title:Journal of neurology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00415-020-10035-x

    authors: Gandor F,Tesch M,Neuhauser H,Gruber D,Heinze HJ,Ebersbach G,Lempert T

    更新日期:2020-10-01 00:00:00

  • Cognitive functions in acute unilateral vestibular loss.

    abstract::Cognitive deficits mainly involving visuospatial functions have been defined in patients with bilateral and even unilateral vestibular loss (UVL). We compared the cognitive test results of 21 patients with acute UVL with age- and education-matched healthy controls. The diagnosis of UVL was based on the clinical findin...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-09829-w

    authors: Ayar DA,Kumral E,Celebisoy N

    更新日期:2020-12-01 00:00:00

  • Upgaze palsy and monocular paresis of downward gaze from ipsilateral thalamo-mesencephalic infarction: a vertical "one-and-a-half" syndrome.

    abstract::A patient with an infarct limited to the paramedian thalamus and upper mesencephalon on the right side suffered a conjugate upgaze palsy associated with a monocular paresis of downward gaze in the ipsilateral eye (vertical "one-and-a-half" syndrome). This paresis involved tonic and phasic components. Vertical oculocep...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313651

    authors: Bogousslavsky J,Regli F

    更新日期:1984-01-01 00:00:00

  • Domain-specific trends in cognitive impairment after acute ischaemic stroke.

    abstract::Little is known about the pattern of subacute cognitive domain impairments after ischaemic stroke, nor the temporal evolution of such impairments. Our objective was to investigate the pattern of cognitive impairment in different neuropsychological domains up to a year after ischaemic stroke. We included prospectively ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-012-6625-0

    authors: Hurford R,Charidimou A,Fox Z,Cipolotti L,Werring DJ

    更新日期:2013-01-01 00:00:00

  • Increased risk for subarachnoid hemorrhage in patients with sleep apnea.

    abstract:OBJECTIVES:Recent retrospective studies found sleep disorders, including obstructive sleep apnea and its symptoms to occur more often in patients following aneurysmal subarachnoid hemorrhage, but studies investigating the incidence of subarachnoid hemorrhage in patients with diagnosed obstructive sleep apnea [OSA] comp...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09265-5

    authors: Zaremba S,Albus L,Schuss P,Vatter H,Klockgether T,Güresir E

    更新日期:2019-06-01 00:00:00

  • Carotid intima-media thickness and cognitive function in a middle-aged and older adult community: a cross-sectional study.

    abstract::The relationship between atherosclerosis and cognitive function is less well studied in Chinese populations. In addition, the results among middle-aged adults have been mixed. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cognitive function in middle-a...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-016-8234-9

    authors: Wang A,Chen G,Su Z,Liu X,Yuan X,Jiang R,Cao Y,Chen S,Luo Y,Guo X,Wu S,Zhao X

    更新日期:2016-10-01 00:00:00

  • Auditory function in individuals within Leber's hereditary optic neuropathy pedigrees.

    abstract::The aims of this study are to investigate whether auditory dysfunction is part of the spectrum of neurological abnormalities associated with Leber's hereditary optic neuropathy (LHON) and to determine the perceptual consequences of auditory neuropathy (AN) in affected listeners. Forty-eight subjects confirmed by genet...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-011-6230-7

    authors: Rance G,Kearns LS,Tan J,Gravina A,Rosenfeld L,Henley L,Carew P,Graydon K,O'Hare F,Mackey DA

    更新日期:2012-03-01 00:00:00

  • Association between Synapsin III gene promoter polymorphisms and multiple sclerosis.

    abstract::Although multiple sclerosis (MS) is considered to be an inflammatory demyelinating disease, increasing evidence indicates that it is also an axonal pathology; indeed, studies of experimental allergic encephalitis showed that several neuronal proteins such as synapsins take part in the pathogenesis of the axonal dysfun...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-004-0293-7

    authors: Liguori M,Cittadella R,Manna I,Valentino P,La Russa A,Serra P,Trojano M,Messina D,Ruscica F,Andreoli V,Romeo N,Livrea P,Quattrone A

    更新日期:2004-02-01 00:00:00

  • Visual attention in patients with intracranial arachnoid cysts.

    abstract:OBJECTIVE:To investigate whether intracranial arachnoid cysts (AC) compromise visual attention and if so, whether surgical cyst decompression leads to improvement in visual attention performance. METHODS:The experiments were carried out on 27 patients with temporal (n=21) or frontal (n=6) AC, and 27 healthy control su...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00415-006-0280-2

    authors: Gundersen H,Helland CA,Raeder MB,Hugdahl K,Wester K

    更新日期:2007-01-01 00:00:00

  • Three-dimensional topographic analysis of spinal accessory motoneurons under chronic mechanical compression: an experimental study in the mouse.

    abstract::We investigated the effect of chronic mechanical compression of the cervical spinal cord on the number of spinal accessory motoneurons in 25 tiptoe-walking Yoshimura mice. The animals had calcified deposits in the atlantoaxial membrane at the C1-C2 vertebral level, compressing the spinal cord posterolaterally. Motoneu...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s004150050076

    authors: Baba H,Maezawa Y,Uchida K,Imura S,Kawahara N,Tomita K,Kudo M

    更新日期:1997-04-01 00:00:00

  • Magnetic resonance imaging, risk factors and co-morbidities in children with cerebral palsy.

    abstract::Cerebral palsy (CP) continues to be a major problem in India. The present study provides an insight into the various clinical and neuroradiological correlates of CP. The study included 102 children with CP and was subjected to magnetic resonance imaging (MRI) of the brain. Forty-seven (46%) patients belonged to the 1-...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-010-5782-2

    authors: Prasad R,Verma N,Srivastava A,Das BK,Mishra OP

    更新日期:2011-03-01 00:00:00

  • Polyneuropathy with osteosclerotic myeloma--POEMS syndrome. A case report.

    abstract::A rare form of plasma cell dyscrasia characterized by associated polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes has been termed the POEMS syndrome. The pathophysiology is unknown; plasma cell dyscrasia is essential; secondary manifestations are unexplained. We report a 67-year-old man with a ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00839213

    authors: Vidaković A,Simić P,Stojisavljević N,Elezović I,Trikić R,Apostolski S

    更新日期:1992-01-01 00:00:00

  • Further observation of Japanese Creutzfeldt-Jacob disease with widespread amyloid plaques.

    abstract::An autopsy case of Creutzfeld-Jacob disease with widespread amyloid plaques is reported. A 45-year-old Japanese man, whose father had died of a similar disease, had a 5-year illness characterized by progressive cerebellar signs. Mental changes and brain-stem signs developed in the late stage. Myoclonus frequently occu...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314329

    authors: Yagishita S,Iwabuchi K,Amano N,Yokoi S

    更新日期:1989-03-01 00:00:00

  • Seasonal occurrence of relapses in inflammatory myopathies: a preliminary study.

    abstract::The seasonal occurrence of relapses was analysed retrospectively in a group of 53 patients with treated dermatomyositis (DM) or polymyositis (PM). In DM, the incidence of both myositic and cutaneous relapses was highest in summer whereas in the PM group relapses was more evenly distributed throughout the seasons but l...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s004150200036

    authors: Phillips BA,Zilko PJ,Garlepp MJ,Mastaglia FL

    更新日期:2002-04-01 00:00:00

  • Distinct neuromuscular phenotypes in myotonic dystrophy types 1 and 2 : a whole body highfield MRI study.

    abstract::Myotonic Dystrophy Type 1 (DM1) and 2 (DM2) present with distinct though overlapping clinical phenotypes. Comparative imaging data on skeletal muscle involvement are not at present available. We used the novel technique of whole body 3.0 Tesla (T) Magnetic Resonance Imaging (MRI) to further characterize musculoskeleta...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-006-0111-5

    authors: Kornblum C,Lutterbey G,Bogdanow M,Kesper K,Schild H,Schröder R,Wattjes MP

    更新日期:2006-06-01 00:00:00