Abstract:
:The influence of portal-systemic shunting on maximal motor nerve conduction velocity (MCV) was analyzed in rats with portacaval shunts. At 3 and 8 weeks after the shunting there was a marked but transient fall in MCV. This was not prevented by colectomy. At 16 weeks the MCV had almost normalized, despite sustained portal-systemic shunting. When examined at 3 weeks postoperatively, MCV was less affected by ischaemia than in control animals. The results favour hepatocellular failure as the more important pathophysiological mechanism in hepatic neuropathy.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Hindfelt B,Holmin Tdoi
10.1007/BF00313181subject
Has Abstractpub_date
1980-01-01 00:00:00pages
171-5issue
3eissn
0340-5354issn
1432-1459journal_volume
223pub_type
杂志文章abstract::A method for the preparation of a potent and specific peroxidase-labelled antihuman IgG antibody is described. CSF cells from patients with various neurological diseases were stained. Only in cases of inflammatory diseases was IgG detectable. The stained cells were so-called lymphoid cells. As the demonstrable IgG can...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313346
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Due to common pathophysiological findings of Alzheimer's disease (AD) with diabetes mellitus (DM), insulin has been suggested as a possible treatment of AD or mild cognitive impairment (MCI). A safe alternative of IV insulin is intranasal (IN) insulin. The aim of this systematic review is to investi...
journal_title:Journal of neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00415-018-8768-0
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, autoimmune-inflammatory disease of the peripheral nervous system. Recently, various immunoglobulin G4 (IgG4) type auto-antibodies have been described in patients with CIDP which can effectively be removed by immunoadsorption (IA). Therefore, ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-9082-6
更新日期:2018-12-01 00:00:00
abstract::Neuropsychological deficits and the relationship to brain pathology were examined in 13 primary progressive (PP) and 12 secondary progressive (SP) multiple sclerosis patients with a similar duration of the progressive phase and comparable physical disability. A battery of neuropsychological tests to assess attention, ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/pl00007804
更新日期:2000-02-01 00:00:00
abstract::Weight loss is a common symptom of Parkinson's disease and is associated with impaired quality of life. Predictors of weight loss have not been studied in large clinical cohorts. We previously observed an association between change in body mass index and change in Unified Parkinson's Disease Rating Scale (UPDRS) motor...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00415-017-8562-4
更新日期:2017-08-01 00:00:00
abstract::Early identification of cardiogenic vertigo (CV) is necessary to prevent serious complications of cardiovascular diseases. However, the literature is limited to case reports without detailed clinical features or diagnostic criteria. The aim of this study was to define characteristics of CV and propose diagnostic crite...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10252-4
更新日期:2020-10-06 00:00:00
abstract::Alexander disease (AD) is a rare genetic disorder of the central nervous system due to a dysfunction of astrocytes. The most common infantile form presents as a progressive leukodystrophy with macrocephalus. Recently, heterozygous de novo mutations in the gene encoding glial fibrillary acidic protein (GFAP) have been ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-003-0995-2
更新日期:2003-03-01 00:00:00
abstract::Disease management is defined as any medical or pharmaceutical intervention designed to improve both outcomes for the patient and overall cost-effectiveness of the health plan. Disease management focuses on the patient throughout the entire course of the disease, involving both health providers and third-party payers....
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/pl00014806
更新日期:1998-08-01 00:00:00
abstract::In Parkinson's disease (PD), nonmotor symptoms manifest before motor symptoms. In this report, we present a remarkable case of a semiprofessional painter with PD whose painting style dramatically changed from abstract painting to realism before he developed motor, psychiatric, and autonomic nerve disorders. This case ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-011-6271-y
更新日期:2012-05-01 00:00:00
abstract::From a family with essential familial myoclonus, 150 members in eight generations were studied. Twenty-five of them suffered from myoclonus of varying severity. The findings in routine examinations of blood, urine and cerebrospinal fluid, EEG and skull radiographs were normal. Therapeutic trials did not produce lastin...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313626
更新日期:1983-01-01 00:00:00
abstract::Several viruses have the capacity to cause serious infections of the nervous system in patients who are immunosuppressed. Individuals may be immunosuppressed because of primary inherited immunodeficiency, secondary immunodeficiency due to particular diseases such as malignancy, administration of immunosuppressant drug...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10265-z
更新日期:2020-10-13 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which was thought to be untreatable. However, recent evidence in both experimental animals and men indicates that antiglutamatergic strategies are the first to have an influence on its pathogenesis and slow down the disease process. Since the eff...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF03161074
更新日期:2000-12-01 00:00:00
abstract::The objective of this study was to assess the effect of secukinumab, a monoclonal antibody that inhibits interleukin (IL)-17A, on number of new active brain magnetic resonance imaging (MRI) lesions in subjects with relapsing-remitting multiple sclerosis (MS). Subjects (N = 73) were randomized 1:1 to secukinumab 10 mg/...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00415-016-8128-x
更新日期:2016-07-01 00:00:00
abstract::Cerebellar syndrome is one of the most disabling developments in multiple sclerosis (MS). In neurodegenerative disorders, cerebellar syndrome is thought to be related to a neurochemical deficit of 5-hydroxytryptamine (5-HT). Previous studies found that a levorotatory form of 5-hydroxytryptophan, a 5-HT precursor, and ...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00415-003-0176-3
更新日期:2003-10-01 00:00:00
abstract::The objective of this study is to determine the current distribution of clinical phenotypes and to estimate future trends of ALS incidence in Western societies. We report on a clinical-epidemiological registry with a capture-recapture rate of >80% and population-based case-control study in ALS patients in South Wester...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8413-3
更新日期:2017-04-01 00:00:00
abstract::Carbon monoxide (CO) intoxication leads to acute and chronic neurological deficits, but little is known about the specific noxious mechanisms. (1)H magnetic resonance spectroscopy (MRS) may allow insight into the pathophysiology of CO poisoning by monitoring neurochemical disturbances, yet only limited information is ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5057-y
更新日期:2009-06-01 00:00:00
abstract::We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent co...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF02444004
更新日期:1996-02-01 00:00:00
abstract::The Euro-Esli study was an exploratory pooled analysis of data from 14 European clinical practice studies, which was conducted to audit the real-world effectiveness, safety, and tolerability of eslicarbazepine acetate (ESL) as an adjunctive treatment for partial-onset seizures. Retention and effectiveness were assesse...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-017-8618-5
更新日期:2017-11-01 00:00:00
abstract::The bulbocavernosus reflex (BCR) was examined in 39 normal potent men and in 252 patients with impaired potency of varying aetiology. For BCR evaluation minimum, maximum and mean latencies, the temporal dispersion in ten successive responses, together with minimum and maximum side differences from simultaneous recordi...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314350
更新日期:1988-03-01 00:00:00
abstract::Two cases of Addison's disease associated with myasthenia gravis are reported. This association has been described only rarely in the literature. In the first case, there were marked immunological abnormalities. It is most likely that the origin of the adrenocortical insufficiency in the second case is tuberculous. Th...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313835
更新日期:1985-01-01 00:00:00
abstract::Temporal lobe epilepsy has been usually associated with progressive brain atrophy due to neuronal cell loss. However, recent animal models demonstrated a dual effect of epileptic seizures with initial enhancement of hippocampal neurogenesis followed by abnormal astrocyte proliferation and neurogenesis depletion in the...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09546-z
更新日期:2019-12-01 00:00:00
abstract::We investigated the levels of transforming growth factor beta 1 (TGF-beta 1) in cerebrospinal fluid (CSF) in children with meningitis, with a view to prognostic relevance. CSF TGF-beta 1 levels on admission were measured by a sandwich enzyme immunoassay in children with bacterial meningitis (n = 16), aseptic meningiti...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s004150050159
更新日期:1997-10-01 00:00:00
abstract::Hearing deficits associated with cognitive impairment have attracted much recent interest, motivated by emerging evidence that impaired hearing is a risk factor for cognitive decline. However, dementia and hearing impairment present immense challenges in their own right, and their intersection in the auditory brain re...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-016-8208-y
更新日期:2016-11-01 00:00:00
abstract::In order to identify the precise location of the primary motor area for the diaphragm with respect to the classical motor homunculus, functional magnetic resonance imaging (fMRI) experiments were performed utilizing independent component-cross correlation- sequential epoch (ICS) analysis on a high-field (3.0 Tesla) sy...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-004-0413-4
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:The mechanisms of early neurologic deterioration (END) and prevention strategies for END are not completely understood. The aim of this study was to investigate the association between CYP2C19*2 variants and END, and the effectiveness of antiplatelet therapy for prevention of END according to CYP2C19*2 genot...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00415-018-8998-1
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:As metabolic and structural changes in frontotemporal-subcortical pathways have been reported in patients with obsessive-compulsive disorders, we investigated the correlation between complex compulsive behaviour (CCB) and the distribution of atrophy in a group of 90 patients with frontotemporal dementia (FTD)...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150170049
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:To examine the efficacy and safety of the therapeutic regimen using oral and intravenous L-arginine for pediatric and adult patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). METHODS:In the presence and absence of an ictus of stroke-like episodes within 6...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00415-018-9057-7
更新日期:2018-12-01 00:00:00
abstract::In idiopathic rapid eye movement sleep behaviour disorder (RBD), an association with visuoperceptive disorders has been described. However, such an association has not been clearly established in RBD secondary to Parkinson's disease (PD). We compared visuoperceptive function in four groups of non-demented patients (pa...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5328-7
更新日期:2010-03-01 00:00:00
abstract::A boy was suspected of having meningoencephalitis probably of viral origin, although all microbiological, including virological, tests were negative. Postmortem examination revealed a dissecting aortic aneurysm and disseminated intravascular coagulation involving the central nervous system exclusively. The clinical ev...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313465
更新日期:1981-01-01 00:00:00
abstract::A frequently observed local measurement artifact with spectral domain OCT is caused by the void signal of the retinal vasculature. This study investigated the effect of suppression of blood vessel artifacts with and without retinal hyperaemia. Spectral domain OCT scans, centred on the optic nerve head, were performed ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-7226-2
更新日期:2014-03-01 00:00:00